scholarly journals The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review

2019 ◽  
Vol 20 (11) ◽  
pp. 2757 ◽  
Author(s):  
Weronika Dymara-Konopka ◽  
Marzena Laskowska
Keyword(s):  
Nitric Oxide ◽  
Asymmetric Dimethylarginine ◽  
Disease Process ◽  
Endothelial Activation ◽  
Morbidity And Mortality ◽  
Clinical Implications ◽  
Target Tissue ◽  
Vessel Involvement

Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound aetiology. It affects 3–6% of expecting mothers worldwide and it persists as a leading cause of maternal and foetal morbidity and mortality. In fact, hallmark features of preeclampsia (PE) result from vessel involvement and demonstrate maternal endothelium as a target tissue. Growing evidence suggests that chronic placental hypoperfusion triggers the production and release of certain agents that are responsible for endothelial activation and injury. In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications.

Role of Image-Guided Percutaneous Drainage in Pancreatic Collections

2018 ◽  
Vol 02 (02) ◽  
pp. 125-130
Author(s):  
Katayoun Samadi ◽  
Ronald Arellano
Keyword(s):  
United States ◽  
Acute Pancreatitis ◽  
Percutaneous Drainage ◽  
Hospital Admissions ◽  
Disease Process ◽  
The United States ◽  
Morbidity And Mortality ◽  
Image Guided ◽  
Gastrointestinal Conditions

AbstractAcute pancreatitis is one of the major gastrointestinal conditions that lead to around 300,000 hospital admissions per year in the United States. While mild inflammation of the pancreas is often managed conservatively, progression of the disease process to necrosis significantly increases the overall morbidity and mortality and often requires surgical or other interventional techniques for management. The purpose of this review is to describe the role of percutaneous drainage for the management of complicated pancreatitis.

The Role of Nitric Oxide Synthase Inhibition by Asymmetric Dimethylarginine in the Pathophysiology of Preeclampsia

2010 ◽  
Vol 69 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Rainer H. Böger ◽  
Anke Diemert ◽  
Edzard Schwedhelm ◽  
Nicole Lüneburg ◽  
Renke Maas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Asymmetric Dimethylarginine ◽  
Oxide Synthase

Prominent role of NF-κB in the induction of endothelial activation by endogenous nitric oxide inhibition

Nitric Oxide ◽  
2009 ◽  
Vol 21 (3-4) ◽  
pp. 184-191 ◽  
Author(s):  
Guido Lazzerini ◽  
Serena Del Turco ◽  
Giuseppina Basta ◽  
Ana O’Loghlen ◽  
Antonella Zampolli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Activation ◽  
Nitric Oxide Inhibition ◽  
Endogenous Nitric Oxide ◽  
Oxide Inhibition

scholarly journals Asymmetric dimethylarginine (ADMA) accelerates cell senescence

2005 ◽  
Vol 10 (1_suppl) ◽  
pp. S65-S71 ◽  
Author(s):  
Stefanie M Bode-Böger ◽  
Fortunato Scalera ◽  
Jens Martens-Lobenhoffer
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Asymmetric Dimethylarginine ◽  
Telomerase Activity ◽  
Oxygen Free Radical ◽  
Cell Senescence ◽  
Slowing Down ◽  
Chemotactic Protein ◽  
Oxide Synthase

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and its accumulation has been associated with cardiovascular disease. We aimed to investigate the role of ADMA in endothelial cell senescence. Endothelial cells were cultured until the tenth passage. ADMA was replaced every 48 hours starting at the fourth passage. ADMA significantly accelerated senescence- associated β-galactosidase activity. Additionally, the shortening of telomere length was significantly speeded up and telomerase activity was significantly reduced. This effect was associated with an increase of oxidative stress: both allantoin, a marker of oxygen free radical generation, and intracellular reactive oxygen species increased significantly after ADMA treatment compared with control, whereas nitric oxide syn thesis decreased. Furthermore, ADMA-increased oxidative stress was accompanied by a decrease in the activity of dimethylarginine dimethylaminohydrolase, the enzyme that degrades ADMA, which could be prevented by the antioxidant pyrroli dine dithiocarbamate. Exogenous ADMA also stimulated secretion of monocyte chemotactic protein-1 and interleukin-8. Co-incubation with the methyltransferase inhibitor S-adenosylhomocysteine abolished the effects of ADMA. These data suggest that ADMA accelerates senescence, probably via increased oxygen radical formation by inhibiting nitric oxide elaboration. This study provides evidence that modest changes of intracellular ADMA levels are associated with significant effects on slowing down endothelial senescence.

scholarly journals Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Mohammad Badran ◽  
Saeid Golbidi ◽  
Najib Ayas ◽  
Ismail Laher
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Asymmetric Dimethylarginine ◽  
Critical Role ◽  
Middle Aged ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men and is considered an independent risk factor for cerebrovascular and cardiovascular diseases. Nitric oxide (NO) is an important endothelium derived vasodilating substance that plays a critical role in maintaining vascular homeostasis. Low levels of NO are associated with impaired endothelial function. Asymmetric dimethylarginine (ADMA), an analogue of L-arginine, is a naturally occurring product of metabolism found in the human circulation. Elevated levels of ADMA inhibit NO synthesis while oxidative stress decreases its bioavailability, so impairing endothelial function and promoting atherosclerosis. Several clinical trials report increased oxidative stress and ADMA levels in patients with OSA. This review discusses the role of oxidative stress and increased ADMA levels in cardiovascular disease resulting from OSA.

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