scholarly journals Association Between Celiac Disease and Cancer

2020 ◽  
Vol 21 (11) ◽  
pp. 4155
Author(s):  
Irene Marafini ◽  
Giovanni Monteleone ◽  
Carmine Stolfi
Keyword(s):  
Celiac Disease ◽  
Gastrointestinal Tract ◽  
Life Expectancy ◽  
Complete Resolution ◽  
Benign Disease ◽  
Current Evidence ◽  
Western World ◽  
Gluten Free ◽  
Increased Risk ◽  
Intestinal Lymphomas

Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.

scholarly journals Hematologic manifestations of celiac disease

Blood ◽  
2006 ◽  
Vol 109 (2) ◽  
pp. 412-421 ◽  
Author(s):  
Thorvardur R. Halfdanarson ◽  
Mark R. Litzow ◽  
Joseph A. Murray
Keyword(s):  
Celiac Disease ◽  
T Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Iga Deficiency ◽  
Gluten Free ◽  
Strict Adherence ◽  
Increased Risk ◽  
Systemic Disorder ◽  
Iron Folic Acid

AbstractCeliac disease is a common systemic disorder that can have multiple hematologic manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematologic problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid, and/or vitamin B12 is a common complication of celiac disease and many patients have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism, and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis, but strict adherence to a gluten-free diet may prevent its occurrence.

scholarly journals Occult Celiac Disease in an Octogenarian Presenting with a Small Intestinal Adenocarcinoma

1994 ◽  
Vol 8 (6) ◽  
pp. 354-357 ◽  
Author(s):  
Hugh James Freeman
Keyword(s):  
Elderly Patient ◽  
Celiac Disease ◽  
Gastrointestinal Tract ◽  
Gluten Free ◽  
Duodenal Adenocarcinoma ◽  
Histological Studies ◽  
Small Bowel Carcinoma ◽  
Small Intestinal ◽  
Upper Gastrointestinal ◽  
Small Intestinal Adenocarcinoma

An 85-year-old male initially presented with an obstructed upper gastrointestinal tract associated with a duodenal adenocarcinoma. Subsequent histological studies revealed occult celiac disease, an associated condition that otherwise would not have been recognized in this elderly patient. The celiac disease responded to a gluten-free diet, even in the presence of an intestinal adenocarcinoma. This report suggests that celiac disease and small bowel carcinoma may coexist more frequently than is appreciated.

scholarly journals Evaluation and Management of Skeletal Health in Celiac Disease: Position Statement

2012 ◽  
Vol 26 (11) ◽  
pp. 819-829 ◽  
Author(s):  
Mona A Fouda ◽  
Aliya A Khan ◽  
Muhammad Sultan ◽  
Lorena P Rios ◽  
Karen McAssey ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Position Statement ◽  
Current Evidence ◽  
Mineral Density ◽  
High Fracture ◽  
Skeletal Health ◽  
X Ray ◽  
Increased Risk ◽  
One Year

OBJECTIVE: To review the evaluation and management of skeletal health in patients with celiac disease (CD), and to make recommendations on screening, diagnosis, treatment and follow-up of low bone mineral density (BMD) in CD patients.METHODS: A multidisciplinary team developed clinically relevant questions for review. An electronic search of the literature was conducted using the MEDLINE and EMBASE databases from 1996 to 2010. All original studies, reviews and guidelines, both pediatric and adult, were included. A document summarizing the results of the review and proposed recommendations was prepared and underwent multiple revisions until consensus was reached.RESULTS: At diagnosis, approximately one-third of adult CD patients have osteoporosis, one-third have osteopenia and one-third have normal BMD. Children with CD have low bone mass at diagnosis. Adult and pediatric CD patients are at increased risk of fractures.DISCUSSION: For adults, serum calcium, albumin, 25(OH) vitamin D3, parathyroid hormone and 24 h urine calcium testing should be performed at diagnosis; patients with ‘classic’ CD and those at risk for osteoporosis should undergo a dual x-ray absorptiometry scan. An abnormal baseline dual x-ray absorptiometry scan should be repeated one to two years after initiation of a gluten-free diet (GFD). For children, BMD should be assessed one year after diagnosis if GFD adherence is not strict. A GFD is the most important treatment for bone loss. Supplemental antiresorptives may be justified in those who remain at high fracture risk (eg, postmenopausal women, older men) after implementation of a GFD.CONCLUSION: Current evidence does not support the screening of all CD patients for low BMD at diagnosis. Follow-up BMD assessment should be performed one to two years after initiation of a GFD.

scholarly journals Compliance to a Gluten-Free Diet in Swedish Children with Type 1 Diabetes and Celiac Disease

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4444
Author(s):  
Hanna Söderström ◽  
Julia Rehn ◽  
Matti Cervin ◽  
Cathrine Ahlstermark ◽  
Mara Cerqueiro Bybrant ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Older Children ◽  
Southern Sweden ◽  
Increased Risk ◽  
Iga Antibodies

Children with type 1 diabetes (T1D) are at increased risk of celiac disease (CD). The replacement of insulin in T1D, and the exclusion of gluten in CD, are lifelong, burdensome treatments. Compliance to a gluten-free diet (GFD) in children with CD is reported to be high, while compliance in children with both diseases has scarcely been studied. To examine compliance to a GFD in children with both T1D and CD, we analyzed tissue transglutaminase IgA-antibodies (tTGA). Moreover, associations between compliance and age, sex, glycemic control, ketoacidosis (DKA), body mass index (BMI), and time of CD diagnosis were investigated. Of the 743 children diagnosed with T1D in southern Sweden between 2005 and 2012, 9% were also diagnosed with CD. Of these, 68% showed good compliance to a GFD, 18% showed intermediate compliance, and 14% were classified as non-compliant. Higher age, poorer HbA1c, and more DKAs were significantly (p < 0.05) associated with poorer compliance. In conclusion, we found that compliance to a GFD in children with T1D and CD is likely be lower than in children with CD only. Our results indicate that children with both T1D and CD could need intensified dietary support and that older children and children with poor metabolic control are especially vulnerable subgroups.

Celiac Disease Causing NASH with Complete Resolution Following a Gluten-Free Diet

2006 ◽  
Vol 101 ◽  
pp. S351-S352
Author(s):  
M. Louay Omran ◽  
Janet R. Todorczuk ◽  
Timothy Smith ◽  
Elizabeth M. Brunt ◽  
Bruce R. Bacon
Keyword(s):  
Celiac Disease ◽  
Complete Resolution ◽  
Gluten Free Diet ◽  
Gluten Free

scholarly journals Flour-free Gluten-free Compositions Influence on Qualitative Indicators of Cookies from Biscuits Dough

2021 ◽  
Vol 4 (1) ◽  
pp. 122-136
Author(s):  
Karyna Svidlo ◽  
Tatiana Gavrish ◽  
Olga Danylenko ◽  
Serhii Krasovkyi
Keyword(s):  
Celiac Disease ◽  
Gluten Free Diet ◽  
Seed Meal ◽  
Gluten Free ◽  
Organoleptic Evaluation ◽  
Pumpkin Seed ◽  
Strict Adherence ◽  
Risk Of Death ◽  
Increased Risk

The topicality. According to the World Organization of Gastroenterologists (FOG-OMGE), patients with active (clinically severe) celiac disease have an increased risk of death compared to the general population; patients with celiac disease should definitely not eat wheat, rye or barley in any form. However, there is the increased risk of death resumes after three to five years of strict adherence to a gluten-free diet, so it becomes especially important to develop technologies for confectionery products based on gluten-free flour compositions and study their quality indicators. The purpose of the article is to determine the influence of gluten-free flour compositions based on flaxseed, rice, sesame, pumpkin seed meal, sugar substitute on the quality of cupcakes. Research methods. The dependence of stress on the shear rate of biscuit dough based on gluten-free flour compositions has been determined using a Brookfield viscometer. The adhesive stress of the dough masses from the effects of different concentrations of the model system based on gluten-free flour compositions has been performed on a bursting machine МТ-140/RV2. Results. The data of research of gluten-free flour compositions influence on qualitative properties of biscuit cake dough are resulted. An organoleptic evaluation of cupcakes for a gluten-free diet was carried out and the daily requirement for vitamins of people aged 18-59 when consuming this confectionery has been determined. Conclusions and discussions. Determining the effect of gluten-free compositions on the quality of biscuit dough and finished products makes it possible to offer for a gluten-free diet three recipes for cupcakes based on compositions of rice-flax flour, sesame-flax flour and flax flour with pumpkin seed meal, added bougainvillea, carrot and pumpkin. Developed cupcakes for a gluten-free diet can be used in the diet of people aged 18-59 years for both dietary nutrition and general disease prevention.

scholarly journals Non-Celiac Gluten Sensitivity in the Context of Functional Gastrointestinal Disorders

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3735
Author(s):  
Maria Raffaella Barbaro ◽  
Cesare Cremon ◽  
Diana Wrona ◽  
Daniele Fuschi ◽  
Giovanni Marasco ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Functional Gastrointestinal Disorders ◽  
Self Report ◽  
Western World ◽  
Gastrointestinal Disorders ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Double Blind ◽  
Irritable Bowel

Gluten-free diets are increasingly chosen in the Western world, even in the absence of a diagnosis of celiac disease. Around 10% of people worldwide self-report gluten-related complaints, including intestinal and extra-intestinal symptoms. In most cases, these subjects would be labeled as patients suffering from irritable bowel syndrome (IBS) who place themselves on a gluten-free diet even in the absence of celiac disease. In some instances, patients report a clear benefit by avoiding gluten from their diet and/or symptom worsening upon gluten reintroduction. This clinical entity has been termed non-celiac gluten sensitivity (NCGS). The symptoms referred by these patients are both intestinal and extra-intestinal, suggesting that similarly to functional gastrointestinal disorders, NCGS is a disorder of gut–brain interaction. It remains unclear if gluten is the only wheat component involved in NCGS. The mechanisms underlying symptom generation in NCGS remain to be fully clarified, although in the past few years, the research has significantly moved forward with new data linking NCGS to changes in gut motility, permeability and innate immunity. The diagnosis is largely based on the self-reported reaction to gluten by the patient, as there are no available biomarkers, and confirmatory double-blind challenge protocols are unfeasible in daily clinical practice. Some studies suggest that a small proportion of patients with IBS have an intolerance to gluten. However, the benefits of gluten-free or low-gluten diets in non-celiac disease-related conditions are limited, and the long-term consequences of this practice may include nutritional and gut microbiota unbalance. Here, we summarize the role of gluten in the clinical features, pathophysiology, and management of NCGS and disorders of gut–brain interaction.

scholarly journals Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease—Celiac Trait

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 320 ◽  
Author(s):  
Alina Popp ◽  
Markku Mäki
Keyword(s):  
Celiac Disease ◽  
Disease Stage ◽  
Gluten Free ◽  
Stage Disease ◽  
Increased Risk ◽  
Latent Disease ◽  
Small Intestinal ◽  
Mucosal Morphology ◽  
End Stage

Celiac disease patients may suffer from a number of extra-intestinal diseases related to long-term gluten ingestion. The diagnosis of celiac disease is based on the presence of a manifest small intestinal mucosal lesion. Individuals with a normal biopsy but an increased risk of developing celiac disease are referred to as potential celiac disease patients. However, these patients are not treated. This review highlights that patients with normal biopsies may suffer from the same extra-intestinal gluten-induced complications before the disease manifests at the intestinal level. We discuss diagnostic markers revealing true potential celiac disease. The evidence-based medical literature shows that these potential patients, who are “excluded” for celiac disease would in fact benefit from gluten-free diets. The question is why wait for an end-stage disease to occur when it can be prevented? We utilize research on dermatitis herpetiformis, which is a model disease in which a gluten-induced entity erupts in the skin irrespective of the state of the small intestinal mucosal morphology. Furthermore, gluten ataxia can be categorized as its own entity. The other extra-intestinal manifestations occurring in celiac disease are also found at the latent disease stage. Consequently, patients with celiac traits should be identified and treated.

scholarly journals Prevalence of Thyroid Autoimmunity in Children with Celiac Disease Compared to Healthy 12-Year Olds

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Maria van der Pals ◽  
Anneli Ivarsson ◽  
Fredrik Norström ◽  
Lotta Högberg ◽  
Johan Svensson ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Autoimmune Diseases ◽  
Thyroid Autoimmunity ◽  
Thyroid Peroxidase ◽  
Gluten Free ◽  
Disease Group ◽  
Disease Treatment ◽  
Blood Samples ◽  
Increased Risk ◽  
Untreated Celiac Disease

Objectives. Studies have suggested a correlation between untreated celiac disease and risk for other autoimmune diseases. We investigated the prevalence of thyroid autoimmunity in 12-year-old children (i) with symptomatic celiac disease diagnosed and treated with a gluten-free diet, (ii) with screening-detected untreated celiac disease, and (iii) without celiac disease.Methods. Blood samples from 12632 children were collected. All celiac disease cases, previously diagnosed and newly screening-detected, were identified. Per case, 4 referents were matched. Blood samples were analyzed for autoantibodies against thyroid peroxidase (TPOAb). The cut-off value for TPO positivity was set to 100 U/mL.Results. Altogether, 335 celiac disease cases were found. In the entire celiac disease group, 7.2% (24/335) had elevated titers of TPOAb compared to 2.8% (48/1695) of the referents. Among the previously diagnosed celiac disease cases, 7.5% (7/93, OR 2.8, 95% CI 1.2–6.4) was TPOAb positive and among screening-detected cases, 7.0% (17/242, OR 2.6, 95% CI 1.5–4.6) was TPOAb positive.Conclusion. Children with celiac disease showed a higher prevalence of thyroid autoimmunity. We could not confirm the hypothesis that untreated celiac disease is associated with increased risk of developing thyroid autoimmunity. Early initiation of celiac disease treatment might not lower the risk for other autoimmune diseases.

scholarly journals Probióticos en enfermedad celíaca: ¿estamos listos para su aplicación en la práctica clínica?

2021 ◽  
Vol 51 (4) ◽  
Author(s):  
Gastón H Rueda ◽  
M Inés Pinto-Sánchez
Keyword(s):  
Celiac Disease ◽  
Immune System ◽  
Gastrointestinal Symptoms ◽  
Mechanisms Of Action ◽  
Current Evidence ◽  
Future Research ◽  
Preclinical Studies ◽  
Gluten Free ◽  
Review Of The Literature ◽  
Areas Of Interest

Probiotics, live microorganisms that produce a beneficial effect on health, are a possible supplement to a gluten-free diet in the treatment of celiac disease. Several clinical studies have shown that celiac patients treated with probiotics improved their gastrointestinal symptoms. Although the mechanisms of probiotics in celiac disease are unclear, preclinical studies in mice suggest different mechanisms, such as the modulation of the intestinal microbiota and the immune system, or through the production of proteases. We conducted a review of the literature to address the current evidence on the efficacy of probiotics in the treatment of celiac disease, possible mechanisms of action, and areas of interest for future research studies.

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