scholarly journals Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?

2020 ◽  
Vol 21 (15) ◽  
pp. 5229 ◽  
Author(s):  
Anna Maria Rychter ◽  
Marzena Skrzypczak-Zielińska ◽  
Aleksandra Zielińska ◽  
Piotr Eder ◽  
Eliana B. Souto ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Adipose Tissue ◽  
Current Knowledge ◽  
Binding Protein ◽  
Intima Media Thickness ◽  
Epidemiological Data ◽  
Retinol Binding Protein ◽  
Diagnostic Tools ◽  
Retinol Binding Protein 4 ◽  
Atherosclerotic Process

Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group. In our review, we summarized the current knowledge about RBP4 and its association with essential aspects of cardiovascular disease—lipid profile, intima-media thickness, atherosclerotic process, and diet. We also discussed the RBP4 gene polymorphisms essential from a cardiovascular perspective.

scholarly journals Retinol-binding protein 4 in obesity

2020 ◽  
Author(s):  
Anna Maria Rychter ◽  
Marzena Skrzypczak-Zielinska ◽  
Aleksandra Zielińska ◽  
Piotr Eder ◽  
Eliana B. Souto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Binding Protein ◽  
Epidemiological Data ◽  
Retinol Binding Protein ◽  
Diagnostic Tools ◽  
Retinol Binding Protein 4 ◽  
Causative Factors ◽  
Causes Of Deaths ◽  
Excessive Accumulation

Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group.

Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness

2010 ◽  
Vol 213 (2) ◽  
pp. 549-551 ◽  
Author(s):  
Thomas Bobbert ◽  
Jens Raila ◽  
Franziska Schwarz ◽  
Knut Mai ◽  
Andrea Henze ◽  
...  
Keyword(s):  
Binding Protein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Retinol Binding Protein ◽  
Retinol Binding Protein 4 ◽  
Media Thickness

Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases

2008 ◽  
Vol 114 (4) ◽  
pp. 275-288 ◽  
Author(s):  
Herbert Tilg ◽  
Alexander R. Moschen
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Clinical Medicine ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Acid Oxidation ◽  
Endothelial Cell Function ◽  
Retinol Binding Protein 4 ◽  
Associated Diseases ◽  
Anti Inflammatory

Obesity and obesity-related disorders play an important role in clinical medicine. Adipose tissue, with its soluble mediators called adipocytokines, has emerged as a major endocrine organ. These adipocytokines comprise many mediators such as adiponectin, PBEF (pre-B-cell-enhancing factor)/visfatin, leptin, resistin, retinol-binding protein-4 and others. They play major roles in key aspects of metabolism, such as insulin resistance, fatty acid oxidation, inflammation and immunity. Adiponectin, a prototypic adipocytokine, is of importance in the regulation of insulin resistance, as circulating levels are decreased in obesity and diseases associated with insulin resistance. Besides its major role in regulation of insulin sensitivity, recent evidence suggests potent anti-inflammatory functions for adiponectin. These effects are paralleled by other immune-regulatory properties, such as regulation of endothelial cell function. The in vitro effects of adiponectin have been corroborated by several studies demonstrating potent in vivo anti-inflammatory effects. Many other adipocytokines, such as PBEF/visfatin, leptin, resistin or retinol binding protein-4, are involved in the physiology and pathophysiology of adipocytes, adipose tissue and related diseases. PBEF/visfatin, another recently characterized adipocytokine, has been linked to several inflammatory disease states beyond insulin resistance, such as acute lung injury or inflammatory bowel diseases. It has been recognized for many decades that obesity is accompanied by an increase in cancer and potentially some immune-mediated diseases. Understanding this new exciting world of adipocytokines will be of importance in the development of novel therapies for obesity-associated diseases.

scholarly journals Associations between Tissue Visfatin/Nicotinamide, Phosphoribosyltransferase (Nampt), Retinol Binding Protein-4, and Vaspin Concentrations and Insulin Resistance in Morbidly Obese Subjects

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Zeynep Goktas ◽  
Shannon Owens ◽  
Mallory Boylan ◽  
David Syn ◽  
Chwan-Li Shen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Morbidly Obese ◽  
Tissue Samples ◽  
Blood Concentrations ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Retinol Binding Protein 4 ◽  
Obese Subjects

Visfatin/Nampt, vaspin, and retinol binding protein-4 (RBP-4) play an important role in insulin resistance. The objectives of this study were to measure visfatin/Nampt, vaspin, and RBP-4 concentrations in blood, liver, muscle, subcutaneous, omental, and mesenteric adipose tissues in morbidly obese subjects and investigate their relationship to insulin resistance. Blood and tissue samples were collected from 38 morbidly obese subjects during Roux-en-Y surgery. Insulin resistance biomarkers were measured using standard kits. Visfatin/Nampt, vaspin, and RBP-4 gene expression levels in tissues were measured using real-time PCR. Their protein concentrations in blood and tissues were measured using ELISA kits. Diabetic subjects had significantly higher homeostasis model of assessment-insulin resistance and age and lower blood HDL-cholesterol concentrations than nondiabetic and prediabetic subjects. Diabetic and prediabetic subjects had significantly higher blood concentrations of visfatin/Nampt and vaspin than nondiabetic subjects. Liver RBP-4 concentrations were positively associated with blood glucose concentrations. Blood insulin resistance biomarker levels were positively associated with visfatin/Nampt concentrations in omental adipose tissue and liver, and vaspin concentrations in mesenteric adipose tissue. In conclusion, the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent.

scholarly journals Serum retinol binding protein 4 is not decreased in congenital generalized lipodystrophy: a case series

2011 ◽  
Vol 55 (4) ◽  
pp. 279-283
Author(s):  
Amélio F. Godoy-Matos ◽  
Rodrigo O. Moreira ◽  
Renata MacDowell ◽  
Izidro Bendet
Keyword(s):  
Adipose Tissue ◽  
Binding Protein ◽  
Case Series ◽  
The Other ◽  
Retinol Binding Protein ◽  
Control Group ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Congenital Generalized Lipodystrophy ◽  
Healthy Control

INTRODUCTION: Previous studies have suggested that Retinol Binding Protein 4 (RPB4), a protein produced by the adipose tissue, is associated with insulin resistance (IR). Congenital Generalized Lipodystrophy (CGL) is a rare disease characterized by IR and paucity of adipose tissue. Our objective was to determine RBP4 levels in patients with CGL. SUBJECTS AND METHODS: Six (6) patients with CGL and a healthy control group were selected to participate in the study. Anthropometric and biochemical variables were compared between groups. RESULTS: No difference was observed in RBP4 levels between the two groups (CGL 42.5 [12.5 - 127] vs. control 57.4 [15.9 - 165]; p = 0.78). On the other hand, leptin levels were significantly lower in CGL patients (CGL 0.65 [0.2 - 0.7] vs. control 10.9 [0.9 - 38.6]; p = 0.015). No correlation was found between RBP-4 and waist circunference (r = 0.18, p = 0.57), or BMI (r = 0.24, p = 0.45). CONCLUSION: RBP4 is not decreased in CGL. These results suggest that adipose tissue may not be the main source of RBP4.

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