scholarly journals Serum retinol binding protein 4 is not decreased in congenital generalized lipodystrophy: a case series

2011 ◽  
Vol 55 (4) ◽  
pp. 279-283
Author(s):  
Amélio F. Godoy-Matos ◽  
Rodrigo O. Moreira ◽  
Renata MacDowell ◽  
Izidro Bendet
Keyword(s):  
Adipose Tissue ◽  
Binding Protein ◽  
Case Series ◽  
The Other ◽  
Retinol Binding Protein ◽  
Control Group ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Congenital Generalized Lipodystrophy ◽  
Healthy Control

INTRODUCTION: Previous studies have suggested that Retinol Binding Protein 4 (RPB4), a protein produced by the adipose tissue, is associated with insulin resistance (IR). Congenital Generalized Lipodystrophy (CGL) is a rare disease characterized by IR and paucity of adipose tissue. Our objective was to determine RBP4 levels in patients with CGL. SUBJECTS AND METHODS: Six (6) patients with CGL and a healthy control group were selected to participate in the study. Anthropometric and biochemical variables were compared between groups. RESULTS: No difference was observed in RBP4 levels between the two groups (CGL 42.5 [12.5 - 127] vs. control 57.4 [15.9 - 165]; p = 0.78). On the other hand, leptin levels were significantly lower in CGL patients (CGL 0.65 [0.2 - 0.7] vs. control 10.9 [0.9 - 38.6]; p = 0.015). No correlation was found between RBP-4 and waist circunference (r = 0.18, p = 0.57), or BMI (r = 0.24, p = 0.45). CONCLUSION: RBP4 is not decreased in CGL. These results suggest that adipose tissue may not be the main source of RBP4.

scholarly journals Pioglitazone Lowers Serum Retinol Binding Protein 4 by Suppressing its Expression in Adipose Tissue of Obese Rats

2015 ◽  
Vol 35 (2) ◽  
pp. 778-788 ◽  
Author(s):  
Chaoyu Zhu ◽  
Yuanyuan Xiao ◽  
Xiaohua Liu ◽  
Junfeng Han ◽  
Jianmei Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Oral Glucose ◽  
Serum Retinol ◽  
Retinol Binding Protein 4 ◽  
Obese Rats ◽  
Pioglitazone Treatment

Background/Aims: Pioglitazone, a peroxisome proliferator-activated receptor γ activator, is clinically used to treat insulin resistance. However, the underlying mechanism of pioglitazone's action remains unclear. We investigated whether, and how, pioglitazone modulates serum level of retinol binding protein 4 (RBP4), an adipocytokine associated with obesity and insulin resistance. Methods: Insulin sensitivity was determined by oral glucose tolerance test, and RBP4 expression was detected by RT-PCR and Western blotting. Results: Pioglitazone treatment significantly decreased serum RBP4 levels in obese rats, which was correlated with reduced body weight and increased insulin sensitivity. Moreover, pioglitazone greatly decreased RBP4 mRNA and protein levels in adipose tissue but not in the liver. Consistently, pioglitazone treatment significantly reduced RBP4 protein expression in 3T3-L1 adipocytes but not in HepG2 cells. Conclusion: These results demonstrate that pioglitazone inhibits the level of serum RPB4 by suppressing RBP4 expression in adipose tissue of obese rats, suggesting that inhibiting RBP4 expression in adipocytes may provide a mechanism by which pioglitazone improves insulin sensitivity in insulin-resistant subjects.

scholarly journals Serum Retinol-Binding Protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes

2010 ◽  
Vol 43 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Beverly J. Tepper ◽  
Youn-Kyung Kim ◽  
Varsha Shete ◽  
Elena Shabrova ◽  
Loredana Quadro
Keyword(s):  
Gestational Diabetes ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Obese Women ◽  
Serum Retinol ◽  
Retinol Binding Protein 4

scholarly journals Serum retinol-binding protein 4 concentrations in response to short-term overfeeding in normal-weight, overweight, and obese men

2007 ◽  
Vol 86 (5) ◽  
pp. 1310-1315 ◽  
Author(s):  
Jennifer Shea ◽  
Edward Randell ◽  
Sudesh Vasdev ◽  
Peizhong Peter Wang ◽  
Barbara Roebothan ◽  
...  
Keyword(s):  
Binding Protein ◽  
Normal Weight ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Short Term ◽  
Retinol Binding Protein 4

Serum retinol-binding protein 4 is associated with insulin resistance in patients with early and untreated rheumatoid arthritis

2019 ◽  
Vol 86 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Yanlin Wei ◽  
Nannan Xia ◽  
Weifeng Zhang ◽  
Jiashu Huang ◽  
Zhijuan Ren ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Insulin Resistance ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Retinol Binding Protein 4
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