scholarly journals Macrophages/Microglia in the Glioblastoma Tumor Microenvironment

2021 ◽  
Vol 22 (11) ◽  
pp. 5775
Author(s):  
Jun Ma ◽  
Clark C. Chen ◽  
Ming Li
Keyword(s):  
Tumor Microenvironment ◽  
Myeloid Cells ◽  
Complex Interaction ◽  
Key Factors ◽  
Cell Markers ◽  
Tumor Associated Macrophage ◽  
Recent Advances ◽  
Definition Of

The complex interaction between glioblastoma and its microenvironment has been recognized for decades. Among various immune profiles, the major population is tumor-associated macrophage, with microglia as its localized homolog. The present definition of such myeloid cells is based on a series of cell markers. These good sentinel cells experience significant changes, facilitating glioblastoma development and protecting it from therapeutic treatments. Huge, complicated mechanisms are involved during the overall processes. A lot of effort has been dedicated to crack the mysterious codes in macrophage/microglia recruiting, activating, reprogramming, and functioning. We have made our path. With more and more key factors identified, a lot of new therapeutic methods could be explored to break the ominous loop, to enhance tumor sensitivity to treatments, and to improve the prognosis of glioblastoma patients. However, it might be a synergistic system rather than a series of clear, stepwise events. There are still significant challenges before the light of truth can shine onto the field. Here, we summarize recent advances in this field, reviewing the path we have been on and where we are now.

Reason Analysis of Runway Incursions Based on Grey Theory

2011 ◽  
Vol 328-330 ◽  
pp. 2400-2404
Author(s):  
Zi Qi Ju
Keyword(s):  
Gray Relational Analysis ◽  
Grey Theory ◽  
Prevention Measures ◽  
Key Factors ◽  
Class Ab ◽  
Relational Analysis ◽  
Definition Of ◽  
Grey Relational ◽  
Runway Incursions ◽  
Runway Incursion

To prevent runway incursions, we should have the corresponding systematic prevent ideas. Based on the definition of runway incursions and classification of relevant criteria, it analyzed the runway incursion system, put forward the closed-loop management ideas to prevent runway incursions, and found the main contradictions of preventing runway incursions using the gray relational analysis. With the example of runway incursion dates of U.S.A, by means of Grey Relational Analysis of different severities and different factors for runway incursions, it have shown that the key factors leading to the class AB and class CD runway incursions are Vehicle/Pedestrian Deviations and Pilot Deviations respectively. Meanwhile, it proposed integrated prevention measures of runway incursions.

scholarly journals Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Linbang Wang ◽  
Tao He ◽  
Jingkun Liu ◽  
Jiaojiao Tai ◽  
Bing Wang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Cell ◽  
Hub Genes ◽  
Tumor Associated Macrophage ◽  
Molecular Features ◽  
Receptor Interactions ◽  
Tumor Types ◽  
Pan Cancer

Abstract Background Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment (TME). However, their contribution to the immunosuppressive status of the TME remains unclear. Methods We integrated single-cell sequencing and transcriptome data from different tumor types to uncover the molecular features of TAMs. In vitro experiments and prospective clinical tests confirmed the results of these analysis. Results We first detected intra- and inter-tumoral heterogeneities between TAM subpopulations and their functions, with CD86+ TAMs playing a crucial role in tumor progression. Next, we focused on the ligand-receptor interactions between TAMs and tumor cells in different TME phenotypes and discovered that aberrant expressions of six hub genes, including FLI1, are involved in this process. A TAM-tumor cell co-culture experiment proved that FLI1 was involved in tumor cell invasion, and FLI1 also showed a unique pattern in patients. Finally, TAMs were discovered to communicate with immune and stromal cells. Conclusion We determined the role of TAMs in the TME by focusing on their communication pattern with other TME components. Additionally, the screening of hub genes revealed potential therapeutic targets.

Recent Advances in the Management of Cardiogenic Shock

2021 ◽  
Author(s):  
Christine M. Gasperetti
Keyword(s):  
Mortality Rate ◽  
Cardiogenic Shock ◽  
Case Studies ◽  
Mechanical Circulatory Support ◽  
Early Recognition ◽  
Dynamic State ◽  
Circulatory Support ◽  
Mechanical Support ◽  
Recent Advances ◽  
Definition Of

For decades, the cardiogenic shock has remained one of the cardiac illnesses with the highest mortality, as high as 50%. Recent advances have lowered this mortality rate by use of early recognition of shock as well as an increased understanding of both advanced mechanical support and the hemodynamics of myocardial support. Included are the new definition of shock, results of a study of inotropic medications in shock, description, and case studies of mechanical circulatory support, all providing a framework for the overall goal in the management of cardiogenic shock as one to recognize shock, follow its dynamic state, and maximize support to patients toward recovery.

scholarly journals Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Gabor J. Szebeni ◽  
Csaba Vizler ◽  
Klara Kitajka ◽  
Laszlo G. Puskas
Keyword(s):  
Tumor Microenvironment ◽  
Macrophage Polarization ◽  
Myeloid Cells ◽  
Therapeutic Interventions ◽  
Tumor Associated Macrophages ◽  
Poor Survival ◽  
Cell Functions ◽  
Intracellular Signals ◽  
Ontogenetic Diversity ◽  
Cell Dissemination

One of the hallmarks of cancer-related inflammation is the recruitment of monocyte-macrophage lineage cells to the tumor microenvironment. These tumor infiltrating myeloid cells are educated by the tumor milieu, rich in cancer cells and stroma components, to exert functions such as promotion of tumor growth, immunosuppression, angiogenesis, and cancer cell dissemination. Our review highlights the ontogenetic diversity of tumor-associated macrophages (TAMs) and describes their main phenotypic markers. We cover fundamental molecular players in the tumor microenvironment including extra- (CCL2, CSF-1, CXCL12, IL-4, IL-13, semaphorins, WNT5A, and WNT7B) and intracellular signals. We discuss how these factors converge on intracellular determinants (STAT3, STAT6, STAT1, NF-κB, RORC1, and HIF-1α) of cell functions and drive the recruitment and polarization of TAMs. Since microRNAs (miRNAs) modulate macrophage polarization key miRNAs (miR-146a, miR-155, miR-125a, miR-511, and miR-223) are also discussed in the context of the inflammatory myeloid tumor compartment. Accumulating evidence suggests that high TAM infiltration correlates with disease progression and overall poor survival of cancer patients. Identification of molecular targets to develop new therapeutic interventions targeting these harmful tumor infiltrating myeloid cells is emerging nowadays.

scholarly journals Aberrant PGE2 metabolism in bladder tumor microenvironment promotes immunosuppressive phenotype of tumor-infiltrating myeloid cells

2011 ◽  
Vol 11 (7) ◽  
pp. 848-855 ◽  
Author(s):  
Evgeniy Eruslanov ◽  
Irina Daurkin ◽  
Johannes Vieweg ◽  
Yehia Daaka ◽  
Sergei Kusmartsev
Keyword(s):  
Tumor Microenvironment ◽  
Bladder Tumor ◽  
Myeloid Cells

scholarly journals АНАЛІЗ СПІВРОБІТНИКІВ КОМПАНІЇ ЯК НОСІЇВ КОРПОРАТИВНОЇ КУЛЬТУРИ

2019 ◽  
Vol 125 (4) ◽  
pp. 62-68
Author(s):  
Олена Миколаївна Афанасьєва ◽  
Валерія Вячеславівна Кошарна
Keyword(s):  
Staff Development ◽  
Corporate Culture ◽  
Social Life ◽  
Wide Spectrum ◽  
Equity Capital ◽  
Key Factors ◽  
Factors Affecting ◽  
Remuneration Policy ◽  
Business Structures ◽  
Definition Of

The paper explores the key factors affecting the corporate culture formation and development. Recently, the issues of corporate culture, especially in large organizations, trigger the focused attention of a number of management theorists and practitioners. It is a relatively new and insufficiently researched concept, both in this country and abroad. People make the foundation of any company, conversely any organization directs its activities towards a person fostering a multifaceted diversity of organizational culture brought in by each employee. This wide spectrum of variety is shaped by the uniqueness of each individual. Each person’s genetic background is exceptional which stems from people’s diversity of the universe. Ukrainian national individualism specified by the nature of social life plays a dual role in building a corporate culture domain of domestic business structures. Given the equity capital formation under the indirect ownership-based principle of “from individual to collective”, this feature of a national character contributes to corporate philosophy tailoring. The paper suggests a definition of the “corporate culture” concept as a set of values, beliefs, opinions, perceptions, expectations, symbols as well as behavior norms and patterns, traditions, rituals, etc. that have developed in the organization or its divisions during its life cycle and which are accepted by the majority of employees. The system of leadership based on encouraging practices is proved to be most effective. Diligent, initiative performance of management instructions, hard creative work in this case depend on the remuneration policy. Thus, incentives should be meaningful for a performer and feasible for a firm. Insights to a range of theoretical and practical aspects in building employee’s corporate culture are provided. The personnel particular role in facilitating the enterprise performance efficiency is revealed. The paper verifies the need to implement coaching in terms of effective training practices for staff development.

scholarly journals Concepts And Features Of The Corporate Contract

2019 ◽  
pp. 121-134
Author(s):  
R.S. Lukashov
Keyword(s):  
Civil Law ◽  
Limited Liability ◽  
Limited Liability Company ◽  
Key Factors ◽  
Legal Entity ◽  
Legal Nature ◽  
The Subject ◽  
Definition Of ◽  
Contractual Structures

The article is devoted to the theoretical and legal analyses of the place of a corporate agreement in the system of civil contracts. The article identifies the key factors that justify a separate place of the corporate agreement among existing contractual structures of civil law. The article deals with scientific views on the concept and legal nature of the corporate agreement, outlines the subject of the corporate agreement, which is concluded between the participants of the legal entity of corporate type, as well as analyzed the latest legislation on the definition of the concept, subject and content of the corporate agreement, which is concluded between the members of the limited liability company.  

scholarly journals ON THE ORIGINS OF SOME ENGLISH IDIOMS AND THE ADEQUACY OF THEIR DEFINITIONS IN THE GEORGIAN DICTIONARIES (II PART)

2019 ◽  
Vol 4 ◽  
pp. 30-36
Author(s):  
Nino Dvalidze
Keyword(s):  
Complex Interaction ◽  
Bilingual Dictionaries ◽  
Idiomatic Expressions ◽  
Definition Of ◽  
The Right ◽  
The Guardian ◽  
Exact Definition

The aim of this article is to fill the informative gap and to overcome those difficulties which arise in case of not having the adequate interpetation or exact definition of the English idioms in the Georgian dictionaries.This paper investigates some idiomatic expressions and observes how often they are used in the modern English publicist texts from “The Guardian”, “Fortune”, “The Scotsman”, “The Independent” etc. whether they have preserved their original meanings or obtained some other new senses and coloring. More than this, the goal is to research if there is an adequate translation or interpretation of those English idioms in the Georgian language bilingual dictionaries. If there is not any, then the objective is how to make their adequate Georgian equivalents and, as a result to compose a new mini-dictionary of idioms. The urgent need for etymological study of idioms is also stimulated by the fact that the phraseology condensates the complex interaction of the culture and psychology of people, national self-being and their unique metaphoric mentality The reaserch value is dectated by its outcome, namely, it will be the research not only of those idioms which have the adequate definitions in the Georgian dictionaries, but find out some cases of not having the right definition and in result to compile the mini be-lingual dictionary of idioms. It can be assumed, that it will make a siginificant contribution to the development of lexicography in Georgia.

scholarly journals Muscle, myeloid cells, and complement: a complex interaction

2018 ◽  
Vol 15 (11) ◽  
pp. 992-993
Author(s):  
Jessy J. Alexander ◽  
Richard J. Quigg
Keyword(s):  
Myeloid Cells ◽  
Complex Interaction
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