scholarly journals Synthesis of the Bacteriostatic Poly(L-Lactide) by Using Zinc (II)[(acac)(L)H2O] (L = Aminoacid-Based Chelate Ligands) as an Effective ROP Initiator

2021 ◽  
Vol 22 (13) ◽  
pp. 6950
Author(s):  
Renata Barczyńska-Felusiak ◽  
Małgorzata Pastusiak ◽  
Piotr Rychter ◽  
Bożena Kaczmarczyk ◽  
Michał Sobota ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Antibacterial Properties ◽  
Antimicrobial Effect ◽  
Zinc Complexes ◽  
Antibacterial And Antifungal Activities ◽  
Aspergillus Brasiliensis ◽  
Acetylacetonate Complex ◽  
Distorted Trigonal Bipyramid ◽  
Composition Structure ◽  
Antibacterial And Antifungal

The paper presents a synthesis of poly(l-lactide) with bacteriostatic properties. This polymer was obtained by ring-opening polymerization of the lactide initiated by selected low-toxic zinc complexes, Zn[(acac)(L)H2O], where L represents N-(pyridin-4-ylmethylene) tryptophan or N-(2-pyridin-4-ylethylidene) phenylalanine. These complexes were obtained by reaction of Zn[(acac)2 H2O] and Schiff bases, , the products of the condensation of amino acids and 4-pyridinecarboxaldehyde. The composition, structure, and geometry of the synthesized complexes were determined by NMR and FTIR spectroscopy, elemental analysis, and molecular modeling. Both complexes showed the geometry of a distorted trigonal bipyramid. The antibacterial and antifungal activities of both complexes were found to be much stronger than those of the primary Schiff bases. The present study showed a higher efficiency of polymerization when initiated by the obtained zinc complexes than when initiated by the zinc(II) acetylacetonate complex. The synthesized polylactide showed antibacterial properties, especially the product obtained by polymerization initiated by a zinc(II) complex with a ligand based on l-phenylalanine. The polylactide showed a particularly strong antimicrobial effect against Pseudomonas aeruginosa, Staphylococcus aureus, and Aspergillus brasiliensis. At the same time, this polymer does not exhibit fibroblast cytotoxicity.

scholarly journals Synthesis of Novel Azo Schiff Bases and Their Antibacterial and Antifungal Activities

Molecules ◽  
2004 ◽  
Vol 9 (10) ◽  
pp. 815-824 ◽  
Author(s):  
A. Jarrahpour ◽  
M. Motamedifar ◽  
K. Pakshir ◽  
N. Hadi ◽  
M. Zarei
Keyword(s):  
Schiff Bases ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

scholarly journals Synthesis, Spectral Characterization and Biological Studies of Lanthanum(III) Complexes with 3-Substituted-4-Amino-5-Mercapo-1,4-Triazoles Schiff Bases

2013 ◽  
Vol 17 ◽  
pp. 94-104
Author(s):  
Mallikarjun S. Yadawe ◽  
Shrishila N. Unki ◽  
Sangamesh A. Patil
Keyword(s):  
Chemical Analysis ◽  
Metal Complexes ◽  
Organic Solvents ◽  
Schiff Bases ◽  
Metal Salt ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Biological Studies ◽  
Antibacterial And Antifungal

Some lanthanum(III) complexes have been synthesized by reacting lanthanum(III) metal salt with Schiff bases derived from 3-substituted-4-amino-5-mercapto-1,2,4-triazole and glyoxal/biacetyl/benzyl. All these complexes are not soluble in common organic solvents. However sparingly soluble in DMF and DMSO. The chemical analysis of the complexes confirmed to the stoichiometry of the type La(III)LNO3·H2O. La(III)LCl·H2O and La(III)LNCS·H2O respectively. The chelation of the complexes has been proposed in the light of analytical, spectral studies. The measured molar conductance values indicate that, the complexes are non-electrolytes. The Schiff bases and their complexes have been screened for their antibacterial and antifungal activities. The results of these studies show the metal complexes to be more antibacterial and antifungal as compared to the uncomplexed coumarins.

scholarly journals Synthesis of disulphide-Schiff base derivatives and investigations of in vitro antimicrobial activities against some human pathogens

2017 ◽  
Vol 1 (3) ◽  
pp. 230-234 ◽  
Author(s):  
Sefa Durmuş ◽  
Aslıhan Dalmaz ◽  
Görkem Dülger ◽  
Duygu Bircan Kadıoğlu
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Control Group ◽  
Human Pathogens ◽  
Antibacterial And Antifungal Activities ◽  
Schiff Base Derivatives ◽  
Antibacterial And Antifungal

Abstract Thio-Schiff bases are becoming increasingly widespread in various branches such as the preparation of certain medicines, cosmetic products, and polymer production. In particular, the presence of antibacterial, antifungal, antiviral, antitumor and antimalarial properties of Schiff bases containing sulfur in the structure has made these compounds attractive in different disciplines. In this study, different derivatives of dimeric disulfide-Schiff bases have been synthesized. The antibacterial and antifungal activities of the synthesized these compounds were investigated in vitro against some human pathogens (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans, C. tropicalis, C. guilliermondii and C. glabrata). Test microorganisms were isolated from the patients appyling to Medical Faculty Hospital of Duzce University were used. Diffusion method was used to determine the antimicrobial activities of the compounds.standard antibacterial (Cefotaxime, Amoxicillin/clavulanicacid) and antifungal (Posaconazole) antibiotics were used as the control group and the results were compared. The result indicated that antimicrobial activity of Disulphide-Schiff Base Derivatives exhibited less activity against bacteria as compared to AMC30 (Amoxicillin/clavulanicacid), but highly effective against bacteria as compared to CTX30 (Cefotaxime). In addition, the compounds exhibited less activity against yeast.

scholarly journals Phytochemical analysis and antibacterial properties of Calotropis procera against bacterial phytopathogens

2021 ◽  
Vol 6 (2) ◽  
pp. 1
Author(s):  
Najma Sabzal ◽  
Saima Mehr ◽  
Haneef Ur Rehman
Keyword(s):  
Antibacterial Properties ◽  
Soxhlet Extraction ◽  
Antioxidant Property ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Bioactive Metabolites ◽  
Calotropis Procera ◽  
Phytochemical Analysis ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Calotropis procera, is known as crown flower or giant milkweed and belongs to the family Asclepiadacea. It has been traditionally used for various medicinal purposes. In the present study, the phytochemical analysis, antioxidant property, and antimicrobial activity of C. procera were evaluated. Methanol was used as a solvent for the extract preparation using soxhlet extraction. The extracts were subjected to the analysis of the different secondary bioactive metabolites. Furthermore, the antimicrobial activities of these extracts were determined against various pathogens. The qualitative analysis of plant extracts of leaves stems, and roots showed the presence of phenolic compounds, alkaloids, carbohydrates, glycosidic, protein, phytosterols, steroid, saponin, and flavonoid compounds. The leaf extract of C. procera plants inhibited 95% 2,2-diphenyl-1-picrylhydrazyl (DDPH) activity at 0.8 mg/mL Methanol extract of C. procera showed the maximum antibacterial and antifungal activities against the tested plant pathogen of bacterial and fungal strains. This research explored the various phytochemicals, including carbohydrates, glycosides, alkaloids, steroid, saponins, amino acids, phenols, and flavonoids, present in the stem, leave, root, and flower of the indigenous C. procera plant. The study gave a systematic base for the isolation of the novel bioactive phytochemicals with the antioxidant and antibacterial activities from the Calotropis species of Balochistan

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL QUINOLINE BASED 2-AZETIDINONES AND 4-THIAZOLIDINONES

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (09) ◽  
pp. 15-23
Author(s):  
K. Govindarao ◽  
◽  
N. Srinivasan ◽  
R. Suresh ◽  
K Ravi Shankar
Keyword(s):  
Spectral Data ◽  
Schiff Bases ◽  
Vilsmeier Reaction ◽  
Standard Drug ◽  
Reference Drug ◽  
Spectrophotometric Methods ◽  
Antibacterial And Antifungal Activities ◽  
Starting Compound ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

The present work describes the synthesis of a series of quinoline based 4-thiazolidinone and 2-azetidinone derivatives from Schiff bases obtained from the condensation of 2-chloro-3-formylquinoline and 3-4-aminoacetophenones. Quinoline based 4-thiazolidinone and 2-azetidinone derivatives have been prepared by the reaction of various substituted Schiff base with thioglycholic acid and chloroacetyl chloride, respectively. The intermediate Schiff bases were synthesized by the condensation of different quinoline aldehydes with amino acetophenones. The starting compound i.e aldehyde was synthesized through Vilsmeier reaction from respective acetanilides. The synthesized compounds were characterized by their physical and spectral data. The synthesized compounds were screened for their antibacterial and antifungal activities by using cup plate method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, 25, 50, 100 μg/mL concentration using ciprofloxacin as reference standard drug and Aspergillus niger, Candida albicans as same concentration using clotrimazole as reference drug, respectively. The spectral data of synthesized compounds of (3a-f), (4a-e) and (5a-f) were characterized by ES Mass, 1H-NMR, IR spectrophotometric methods. The antimicrobial results revealed that the quinoline based Schiff bases, azitidinone and thiazolodinones analogues showed good activity towards Gram (+) bacteria as compared to ciprofloxacin. These compounds showed decent activity against Gram (-) bacteria.

Search of Compounds with Antibacterial and Antifungal Activities Among New Derivatives of 3-benzylxanthine

10.12737/2720 ◽  
2013 ◽  
Vol 20 (4) ◽  
pp. 25-28
Author(s):  
Шкода ◽  
A. Shkoda ◽  
Александрова ◽  
E. Aleksandrova ◽  
Левич ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Single Molecule ◽  
Antibacterial Properties ◽  
Large Variability ◽  
Antibacterial And Antifungal Activities ◽  
Antistaphylococcal Activity ◽  
Wide Range ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Pharmaceutical Practice

Antimicrobial therapy is a significant element of modern medical and pharmaceutical practice. To create more effective medicines the researches are carried out among different classes of organic substances. One of the key strategies in this field is combination of several pharmacophores in a single molecule. In this aspect, the authors´ attention was attracted derivatives xantina, with a wide range of paid activity, and the large variability of the possibility of chemical modification. Objects of the study were derivatives of 3-benzyl-8-methylxanthinyl-7-acetic acid, synthesized by authors´ group previously. Antibacterial properties of these compounds were studied on Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity on Candida albicans. It was found that the most active against Staphylococcus aureus compound was substance A-18, which according to this indicator significantly exceeded the Ampicillin. Compounds A-4, A-9, A-ll, A-13, A-19 by antistaphylococcal activity are not inferior to the Am-picillin. Ylidenhydrazide A-16 and S-substituted triazolylmethylxanthines A-22 and A-23 - surpassed it. It was also found that hydra-zide A-3, ylidenhydrazides A-6, A-ll - A-14 and A-17 showed fungistatic properties comparable to the Nystatin.

Antibacterial/Antifungal Activity of Extracted Chitosan From American Cockroach (Dictyoptera: Blattidae) and German Cockroach (Blattodea: Blattellidae)

2019 ◽  
Vol 56 (5) ◽  
pp. 1208-1214 ◽  
Author(s):  
Hamidreza Basseri ◽  
Ronak Bakhtiyari ◽  
Sayed Jamal Hashemi ◽  
Mojgan Baniardelani ◽  
Hadi Shahraki ◽  
...  
Keyword(s):  
Periplaneta Americana ◽  
Micrococcus Luteus ◽  
Blattella Germanica ◽  
Antimicrobial Effect ◽  
German Cockroach ◽  
Inhibitory Effect ◽  
American Cockroach ◽  
Antibacterial And Antifungal Activities ◽  
Cockroach Blattella Germanica ◽  
Antibacterial And Antifungal

Abstract We investigated bactericidal and fungicidal properties of chitosan extracted from adults and nymphs from both German cockroach, Blattella germanica (Blattodea: Blattellidae) and American cockroach, Periplaneta americana (Dictyoptera: Blattidae). The cuticle of adults and nymphs extracted from both cockroaches were dried and ground. The powders were demineralized and deproteinized followed by deacetylation using NaOH. Finally, the chitosan yields were examined for antibacterial and antifungal activities. The degree of deacetylation (DD) was different between adults and nymph stages. The antimicrobial effect of American cockroach chitosan (ACC) and German cockroach chitosan (GCC) was tested against four bacteria and four fungi. The extracted chitosans from American cockroach, Periplaneta americana and German Cockroach, Blattella germanica suppressed the growth of Gram-negative/positive bacteria except Micrococcus luteus. The growth of Aspergillus flavus and Aspergillus niger were notability inhibited by the extracted chitosans. The antimicrobial effect of the chitosan depended on the cockroach species, with chitosan of the American cockroach showing more inhibitory effect. This difference may be due to differences in the structure of chitin between the two cockroach species.

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