scholarly journals Alveologenesis: What Governs Secondary Septa Formation

2021 ◽  
Vol 22 (22) ◽  
pp. 12107
Author(s):  
Alexandra L. Rippa ◽  
Elena V. Alpeeva ◽  
Andrey V. Vasiliev ◽  
Ekaterina A. Vorotelyak
Keyword(s):  
Mesenchymal Cells ◽  
Retinoic Acid Signaling ◽  
Deep Insight ◽  
Therapeutic Approaches ◽  
Cellular Functions ◽  
Developmental Context ◽  
Cell Subpopulations ◽  
Actomyosin Cytoskeleton ◽  
Insight Into

The simplification of alveoli leads to various lung pathologies such as bronchopulmonary dysplasia and emphysema. Deep insight into the process of emergence of the secondary septa during development and regeneration after pneumonectomy, and into the contribution of the drivers of alveologenesis and neo-alveolarization is required in an efficient search for therapeutic approaches. In this review, we describe the formation of the gas exchange units of the lung as a multifactorial process, which includes changes in the actomyosin cytoskeleton of alveocytes and myofibroblasts, elastogenesis, retinoic acid signaling, and the contribution of alveolar mesenchymal cells in secondary septation. Knowledge of the mechanistic context of alveologenesis remains incomplete. The characterization of the mechanisms that govern the emergence and depletion of αSMA will allow for an understanding of how the niche of fibroblasts is changing. Taking into account the intense studies that have been performed on the pool of lung mesenchymal cells, we present data on the typing of interstitial fibroblasts and their role in the formation and maintenance of alveoli. On the whole, when identifying cell subpopulations in lung mesenchyme, one has to consider the developmental context, the changing cellular functions, and the lability of gene signatures.

scholarly journals Characterization of Karyopherin Cargoes Reveals Unique Mechanisms of Kap121p-Mediated Nuclear Import

2004 ◽  
Vol 24 (19) ◽  
pp. 8487-8503 ◽  
Author(s):  
Deena M. Leslie ◽  
Wenzhu Zhang ◽  
Benjamin L. Timney ◽  
Brian T. Chait ◽  
Michael P. Rout ◽  
...  
Keyword(s):  
Nuclear Localization ◽  
Nuclear Import ◽  
Ribosome Biogenesis ◽  
Nuclear Transport ◽  
Protein Family ◽  
Cellular Functions ◽  
Transport Pathways ◽  
Nuclear Localization Signals ◽  
Insight Into

ABSTRACT In yeast there are at least 14 members of the β-karyopherin protein family that govern the movement of a diverse set of cargoes between the nucleus and cytoplasm. Knowledge of the cargoes carried by each karyopherin and insight into the mechanisms of transport are fundamental to understanding constitutive and regulated transport and elucidating how they impact normal cellular functions. Here, we have focused on the identification of nuclear import cargoes for the essential yeast β-karyopherin, Kap121p. Using an overlay blot assay and coimmunopurification studies, we have identified 30 putative Kap121p cargoes. Among these were Nop1p and Sof1p, two essential trans-acting protein factors required at the early stages of ribosome biogenesis. Characterization of the Kap121p-Nop1p and Kap121p-Sof1p interactions demonstrated that, in addition to lysine-rich nuclear localization signals (NLSs), Kap121p recognizes a unique class of signals distinguished by the abundance of arginine and glycine residues and consequently termed rg-NLSs. Kap104p is also known to recognize rg-NLSs, and here we show that it compensates for the loss of Kap121p function. Sof1p is also transported by Kap121p; however, its import can be mediated by a piggyback mechanism with Nop1p bridging the interaction between Sof1p and Kap121p. Together, our data elucidate additional levels of complexity in these nuclear transport pathways.

scholarly journals Preliminary characterization of the prehistoric mine of chocolate flint in Poręba Dzierżna, site 24 (Wolbrom commune, Lesser Poland voivodeship)

2021 ◽  
Vol 73 (2) ◽  
Author(s):  
Magdalena Sudoł-Procyk ◽  
Maciej Krajcarz ◽  
Magdalena Malak ◽  
Dagmara H. Werra
Keyword(s):  
Central Europe ◽  
Raw Materials ◽  
Upper Jurassic ◽  
Deep Insight ◽  
Preliminary Characterization ◽  
The Past ◽  
Trading Routes ◽  
Insight Into ◽  
Spoil Heaps

Researches on prehistoric flint mines are currently widely developing, as they allow a deep insight into the past economy, early industry, and the network of trading routes and inter-regional contacts. In the territory of Poland and in general, Central Europe, one of the most important flint raw materials was an Upper Jurassic chert, so-called chocolate flint. In this paper are presented preliminary results of the research of chocolate flint mine in Poręba Dzierżna, site 24 (Kraków-Częstochowa Upland, southern Poland). The outcrop, and anthropogenic relief indicating the activity of prehistoric miners, were discovered in 2013. Recently excavations undertaken on the site recorded the remains of mining shafts, spoil heaps, and rich traces of workshops. The deposits of chocolate flint were previously known only in the Holy Cross Mountains, 130 km to the NE. The research undertaken has therefore a significant impact on the existing interpretations related to the extraction, use, and distribution of chocolate flint by prehistoric communities in Central Europe.

scholarly journals EFD and CFD Characterization of a CLT Propeller

2012 ◽  
Vol 2012 ◽  
pp. 1-22 ◽  
Author(s):  
Daniele Bertetta ◽  
Stefano Brizzolara ◽  
Edward Canepa ◽  
Stefano Gaggero ◽  
Michele Viviani
Keyword(s):  
Numerical Analysis ◽  
Experimental Analysis ◽  
Panel Method ◽  
Deep Insight ◽  
Comparison Of Results ◽  
Cavitation Tunnel ◽  
Ranse Solver ◽  
Insight Into ◽  
Numerical Approaches

In the present paper an experimental and numerical analysis of an unconventional CLT propeller is carried out. Two different numerical approaches, a potential panel method and an RANSE solver, are employed. Cavitation tunnel experiments are carried out in order to measure, as usual, thrust, torque, and cavity extension for different propeller working points. Moreover, LDV measurements are performed to have a deep insight into the complex wake behind the propeller and to analyze the dynamics of generated tip vortexes. The numerical/experimental analysis and comparison of results highlight the peculiarities of this kind of propellers, the possibility to increase efficiency and reduce cavitation risk, in order to exploit the design approaches already well proven for conventional propellers also in the case of these unconventional geometries.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

Thousands of human sequences provide deep insight into single genomes

Nature ◽  
2020 ◽  
Vol 581 (7809) ◽  
pp. 385-386
Author(s):  
Deanna M. Church
Keyword(s):  
Deep Insight ◽  
Insight Into

Mobile-Friendly Dashboards to Display Associations Between Cited-by and Similar Journals on Mobile Health Research: A Bibliometric Study (Preprint)

2018 ◽  
Author(s):  
Tsair-Wei Chien ◽  
Hsien-Yi Wang ◽  
Yang Shao ◽  
Willy Chou
Keyword(s):  
Social Network ◽  
Mobile Health ◽  
Health Research ◽  
Similarity Criteria ◽  
Network Density ◽  
Deep Insight ◽  
Density Indices ◽  
The Subject ◽  
The Given ◽  
Insight Into

BACKGROUND Researchers often spend a great deal of time and effort retrieving related journals for their studies and submissions. Authors often designate one article and then retrieve other articles that are related to the given one using PubMed’s service for finding cited-by or similar articles. However, to date, none present the association between cited-by and similar journals related to a given journal. Authors need one effective and efficient way to find related journals on the topic of mobile health research. OBJECTIVE This study aims (1) to show the related journals for a given journal by both cited-by and similarity criteria; (2) to present the association between cited-by and similarity journals related to a given journal; (3) to inspect the patterns of network density indices among clusters classified by social network analysis (SNA); (4) to investigate the feature of Kendall's coefficient(W) of concordance. METHODS We obtained 676 abstracts since 2013 from Medline based on the keywords of ("JMIR mHealth and uHealth"[Journal]) on June 30, 2018, and plotted the clusters of related journals on Google Maps by using MS Excel modules. The features of network density indices were examined. The Kendall coefficient (W) was used to assess the concordance of clusters across indices. RESULTS This study found that (1) the journals related to JMIR mHealth and uHealth are easily presented on dashboards; (2) a mild association(=0.14) exists between cited-by and similar journals related to JMIR mHealth and uHealth; (3) the median Impact Factor were 3.37 and 2.183 based on the representatives of top ten clusters grouped by the cited-by and similar journals, respectively; (4) all Kendall’s coefficients(i.e., 0.82, 0.89, 0.92, and 0.75) for the four sets of density centrality have a statistically significant concordance (p < 0.05). CONCLUSIONS SNA provides deep insight into the relationships of related journals to a given journal. The results of this research can provide readers with a knowledge and concept diagram to use with future submissions to a given journal in the subject category of Mobile Health Research. CLINICALTRIAL Not available

Deep insight into the charge transfer interactions in 1,2,4,5-tetracyanobenzene-phenazine cocrystal

2021 ◽  
Author(s):  
Hongnan Wu ◽  
Yajing Sun ◽  
Lingjie Sun ◽  
Liwei Wang ◽  
Xiaotao Zhang ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Deep Insight ◽  
Insight Into

scholarly journals First Insight into Nutraceutical Properties of Local Salento Cichorium intybus Varieties: NMR-Based Metabolomic Approach

2021 ◽  
Vol 18 (8) ◽  
pp. 4057
Author(s):  
Chiara Roberta Girelli ◽  
Francesca Serio ◽  
Rita Accogli ◽  
Federica Angilè ◽  
Antonella De Donno ◽  
...  
Keyword(s):  
1H Nmr ◽  
Cichorium Intybus ◽  
Resonance Spectroscopy ◽  
Metabolic Profiles ◽  
Whole Plant ◽  
Different Content ◽  
Insight Into ◽  
Nutraceutical Properties ◽  
Metabolomic Approach

Background: Plants of genus Cichorium are known for their therapeutic and nutraceutical properties determined by a wealth of phytochemical substances contained in the whole plant. The aim of this paper was to characterize the metabolic profiles of local Salento chicory (Cichorium intybus L.) varieties (“Bianca”, “Galatina”, “Leccese”, and “Otranto”) in order to describe their metabolites composition together with possible bioactivity and health beneficial properties. Methods: The investigation was performed by 1H-NMR spectroscopy and Multivariate Analysis (MVA), by which the metabolic profiles of the samples were easily obtained and compared. Results: The supervised Partial Least Squares Discriminant Analysis (PLS-DA) analysis showed as “Bianca” and “Galatina” samples grouped together separated by “Leccese” and “Otranto” varieties. A different content of free amino acids and organic acids was observed among the varieties. In particular a high content of cichoric and monocaffeoyl tartaric acid was observed for the “Leccese” variety. The presence of secondary metabolites adds significant interest in the investigation of Cichorium inthybus, as this vegetable may benefit human health when incorporated into the diet. Conclusions: The 1H-NMR (Nuclear Magnetic Resonance Spectroscopy) based characterization of Salento chicory varieties allowed us to determine the potential usefulness and nutraceutical properties of the product, also providing a method to guarantee its authenticity on a molecular scale.

scholarly journals Surface contact behavior of functionally graded thermoelectric materials indented by a conducting punch

2021 ◽  
Author(s):  
Xiaojuan Tian ◽  
Yueting Zhou ◽  
Lihua Wang ◽  
Shenghu Ding
Keyword(s):  
Thermoelectric Materials ◽  
Singular Integral Equations ◽  
Damage Mechanism ◽  
Functionally Graded ◽  
Deep Insight ◽  
Displacement Fields ◽  
Thermoelectric Effects ◽  
Homogeneous Solutions ◽  
The Fourier Transform ◽  
Insight Into

AbstractThe contact problem for thermoelectric materials with functionally graded properties is considered. The material properties, such as the electric conductivity, the thermal conductivity, the shear modulus, and the thermal expansion coefficient, vary in an exponential function. Using the Fourier transform technique, the electro-thermo-elastic problems are transformed into three sets of singular integral equations which are solved numerically in terms of the unknown normal electric current density, the normal energy flux, and the contact pressure. Meanwhile, the complex homogeneous solutions of the displacement fields caused by the gradient parameters are simplified with the help of Euler’s formula. After addressing the non-linearity excited by thermoelectric effects, the particular solutions of the displacement fields can be assessed. The effects of various combinations of material gradient parameters and thermoelectric loads on the contact behaviors of thermoelectric materials are presented. The results give a deep insight into the contact damage mechanism of functionally graded thermoelectric materials (FGTEMs).

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