scholarly journals Orofacial Cleft and Mandibular Prognathism—Human Genetics and Animal Models

2022 ◽  
Vol 23 (2) ◽  
pp. 953
Author(s):  
Anna Jaruga ◽  
Jakub Ksiazkiewicz ◽  
Krystian Kuzniarz ◽  
Przemko Tylzanowski
Keyword(s):  
Animal Models ◽  
Cleft Palate ◽  
Human Genetics ◽  
Current Knowledge ◽  
Craniofacial Development ◽  
Genetic Mutations ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Orofacial Clefts ◽  
Skeletal Class

Many complex molecular interactions are involved in the process of craniofacial development. Consequently, the network is sensitive to genetic mutations that may result in congenital malformations of varying severity. The most common birth anomalies within the head and neck are orofacial clefts (OFCs) and prognathism. Orofacial clefts are disorders with a range of phenotypes such as the cleft of the lip with or without cleft palate and isolated form of cleft palate with unilateral and bilateral variations. They may occur as an isolated abnormality (nonsyndromic—NSCLP) or coexist with syndromic disorders. Another cause of malformations, prognathism or skeletal class III malocclusion, is characterized by the disproportionate overgrowth of the mandible with or without the hypoplasia of maxilla. Both syndromes may be caused by the presence of environmental factors, but the majority of them are hereditary. Several mutations are linked to those phenotypes. In this review, we summarize the current knowledge regarding the genetics of those phenotypes and describe genotype–phenotype correlations. We then present the animal models used to study these defects.

scholarly journals A Comparative Assessment of Orthodontic Treatment Outcomes of Mild Skeletal Class III Malocclusion Between Facemask and Facemask in Combination with a Miniscrew For Anchorage in Growing Patients: A Single-center, Prospective Randomized Controlled trial

2019 ◽  
Vol 90 (1) ◽  
pp. 3-12 ◽  
Author(s):  
Masahiro Seiryu ◽  
Hiroto Ida ◽  
Atsushi Mayama ◽  
Satoshi Sasaki ◽  
Shutaro Sasaki ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Controlled Trial ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Skeletal Class ◽  
Randomized Controlled ◽  
Group 12 ◽  
Prospective Randomized Controlled Trial ◽  
Group A ◽  
Negative Side Effects

ABSTRACT Objectives To investigate the hypothesis that there is difference in the treatment outcomes of milder skeletal Class III malocclusion between facemask and facemask in combination with a miniscrew in growing patients. Materials and Methods Patients were randomly divided into two groups. In one group, the patients were treated with facemask therapy (FM group: 12 males, eight females, average age: 10 years, 5 months ± 1 year, 8 months). In the other group, patients were treated with facemask therapy along with a miniscrew (FM+MS group: 12 males, seven females, average age: 11 years, 1 month ± 1 year, 3 months). A lingual arch with hooks was fixed to the maxillary arch in both groups and a protractive force of 500 g was applied from the facemask to the hooks. The patients were instructed to use the facemask for 12 hours per day. In the FM+MS group, a miniscrew was inserted into the palate and fixed to the lingual arch. Results Mobility and loosening of the miniscrew were not observed during treatment. Lateral cephalometric analysis showed that SNA, SN-ANS, and ANB values were significantly increased in the FM+MS group compared with those for the FM group (SNA, 1.1° SN-ANS, 1.3° ANB, 0.8°). Increase in proclination of maxillary incisors was significantly greater in the FM group than in the FM+MS group (U1-SN, 5.0°). Conclusions During treatment of milder skeletal Class III malocclusion, facemask therapy along with a miniscrew exhibits fewer negative side effects and delivers orthopedic forces more efficiently to the maxillary complex than facemask therapy alone.

scholarly journals Skeletal Class III Malocclusion with Lateral Open Bite and Facial Asymmetry Treated with Asymmetric Lower Molar Extraction and Lingual Appliance: A Case Report

2021 ◽  
Vol 18 (10) ◽  
pp. 5381
Author(s):  
Vo Truong Nhu Ngoc ◽  
Nguyen Thi Thu Phuong ◽  
Nguyen Viet Anh
Keyword(s):  
Case Report ◽  
Open Bite ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Skeletal Class ◽  
Facial Esthetics ◽  
Lingual Appliance ◽  
Lower Incisors ◽  
Mandibular Incisors ◽  
Molar Extraction

A skeletal Class III malocclusion with open bite tendency is considered very difficult to treat orthodontically without surgery. This case report describes the lingual orthodontic treatment of an adult skeletal Class III patient with mandibular deviation to the left side, lateral open bite, unilateral posterior crossbite, zero overbite and negative overjet. The lower incisors were already retroclined to compensate with the skeletal discrepancy. The patient was treated by asymmetric molar extraction in the mandibular arch to retract the lower incisors and correct the dental midline, with the help of intermaxillary elastics. Lingual appliance was used with over-torqued lower anterior teeth’s brackets to control the torque of mandibular incisors. After a 30-month treatment, satisfactory smile and facial esthetics and good occlusion was achieved. A 12-month follow-up confirmed that the outcome was stable. Asymmetric molar extraction could be a viable option to retract mandibular incisors in Class III malocclusion with lower dental midline deviation.

scholarly journals Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism

2021 ◽  
Author(s):  
Anjana Atteeri ◽  
Praveen Kumar Neela ◽  
Pavan Kumar Mamillapalli ◽  
Vasu M. Sesham ◽  
Sreekanth Keesara ◽  
...  
Keyword(s):  
Local Population ◽  
Research Work ◽  
Control Group ◽  
Study Group ◽  
Genome Wide Association Studies ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Mandibular Prognathism ◽  
Skeletal Class ◽  
Increased Risk

Abstract Background Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the causal genes and variants responsible for the deformity remained ambiguous. Aim This research work was aimed to study the association between polymorphism rs10850110 of the MYO1H gene and skeletal class-III malocclusion in our local population. Materials and Methods Thirty patients with skeletal class III due to mandibular prognathism in the study group and 30 patients with skeletal class I in the control group were selected for this study. These patients were from both sexes and above age 10 years. Based on the cephalometric values, patients were categorized into study and control groups. SNB (angle between sella, nasion and point B at nasion) greater than 82 degrees with an ANB (angle between point A, nasion and point B at nasion) of less than 0 degrees in the study group and ANB (angle between point A, nasion and point B at nasion) of 2 to 4 degrees in the control group were categorized. The polymorphism (rs10850110) of the MYO1H gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism. Associations were tested with SNP exact test using SNPstats software. Results The single-nucleotide polymorphism rs10850110 showed a statistically significant association with mandibular prognathism. The G allele of marker rs10850110 (5′ of myosin1H - MYO1H) was overrepresented when compared with the “A” allele in mandibular prognathism cases (p < 0.0001), and this was very significant. Conclusion These results suggest that the rs10850110 polymorphism of the MYO1H gene is associated with an increased risk for mandibular prognathism.

scholarly journals Analysis of Tongue Function from the Orthodontist’s Point of View: Not Only a Matter of Deglutition

2021 ◽  
Vol 11 (6) ◽  
pp. 2520
Author(s):  
Andrea Deregibus ◽  
Simone Parrini ◽  
Maria Chiara Domini ◽  
Jacopo Colombini ◽  
Tommaso Castroflorio
Keyword(s):  
Point Of View ◽  
Control Group ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Maxillary Hypoplasia ◽  
Skeletal Class ◽  
Posterior Crossbite ◽  
Rest Position ◽  
Functional Aspects ◽  
Angle Class Iii Malocclusion

Many studies report that maxillofacial growth is influenced by genetic and environmental elements and that incorrect breathing, chewing, sucking, and swallowing are promoting factors of malocclusion. This study aims to evaluate the function and the influence of the tongue positions in patients with Angle class III malocclusion, maxillary hypoplasia, and posterior crossbite. One hundred patients, aged between 6 and 12 years old, were enrolled for the study. In the first group, patients with a diagnosis of class III malocclusion, affected by maxillary hypoplasia, skeletal class III, and posterior dental crossbite were recruited. In the control group, not treated patients with no malocclusion, skeletal class I, and without posterior dental crossbite were selected. Regarding atypical deglutition, no statistical differences were reported between the two groups, and 14% of patients reported ankyloglossia. Statistical differences were found in tongue rest position and during the execution of “hold and pull” and “chuck” exercises. Results obtained in this observational study showed that the clinician (orthodontist or general dentist) should analyze the presence/absence of atypical swallowing, the anatomical and functional aspects, and the tongue behavior in the rest position.

scholarly journals Sexual dimorphism in the long-term stability (10 years) of skeletal Class III treatment

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Natalia Tejedor ◽  
Conchita Martín ◽  
José Antonio Alarcón ◽  
María Dolores Oteo-Calatayud ◽  
Juan Carlos Palma-Fernández
Keyword(s):  
Sexual Dimorphism ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Skeletal Class ◽  
Term Stability ◽  
Long Term Stability ◽  
Fixed Appliances ◽  
Males And Females ◽  
Class Iii Treatment

Abstract Background Class III malocclusion is associated with high sexual dimorphism, especially in individuals older than 13 years of age, with significant differences in growth between males and females during the pubertal and postpubertal stages, and in adulthood. The aim of this research was to examine differences between males and females in long-term stability (10 years) of treatment for skeletal Class III malocclusion. Methods Thirty patients (15 males and 15 females) with skeletal Class III malocclusion, who had been treated with rapid maxillary expansion (RME) combined with face mask protraction followed by fixed appliances, were selected sequentially. Thirty patients (15 males and 15 females) with skeletal Class I and mesofacial patterns treated only with fixed appliances for dental problems served as the control group. Differences between groups and sexes were evaluated using lateral cephalograms taken at the start of treatment (T0), immediately after the end of treatment (T1), and after 10 years (T2). The long-term treatment success rate was calculated. Results Ten years after Class III treatment, overjet and overbite relapse occurred similarly in females (− 0.68 ± 0.7 mm; − 0.38 ± 0.75 mm, respectively) and males (− 1.09 ± 1.47 mm; − 0.64 ± 0.9 mm, respectively); the ANB angle and Wits appraisal became significantly more negative in males (− 1.37 ± 1.06°; − 2.7 ± 2.53 mm) than in females (− 0.18 ± 1.26°; − 0.46 ± 1.94 mm). The success rate was 73.3% in males and 80% in females. Conclusions Significant differences in the long-term stability of Class III treatment outcomes have been found between males and females, with a larger skeletal Class III relapse and lower long-term success rates in males.

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