scholarly journals Automatic Diagnosis of Neurodegenerative Diseases: An Evolutionary Approach for Facing the Interpretability Problem

Information ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 30 ◽  
Author(s):  
Rosa Senatore ◽  
Antonio Della Cioppa ◽  
Angelo Marcelli
Keyword(s):  
State Of The Art ◽  
Black Box ◽  
Intervention Strategies ◽  
Classification Model ◽  
Automatic Identification ◽  
Healthy Controls ◽  
Classification Rules ◽  
Explicit Model ◽  
Cartesian Genetic Programming ◽  
Testing Protocols

Background: The use of Artificial Intelligence (AI) systems for automatic diagnoses is increasingly in the clinical field, being a useful support for the identification of several diseases. Nonetheless, the acceptance of AI-based diagnoses by the physicians is hampered by the black-box approach implemented by most performing systems, which do not clearly state the classification rules adopted. Methods: In this framework we propose a classification method based on a Cartesian Genetic Programming (CGP) approach, which allows for the automatic identification of the presence of the disease, and concurrently, provides the explicit classification model used by the system. Results: The proposed approach has been evaluated on the publicly available HandPD dataset, which contains handwriting samples drawn by Parkinson’s disease patients and healthy controls. We show that our approach compares favorably with state-of-the-art methods, and more importantly, allows the physician to identify an explicit model relevant for the diagnosis based on the most informative subset of features. Conclusion: The obtained results suggest that the proposed approach is particularly appealing in that, starting from the explicit model, it allows the physicians to derive a set of guidelines for defining novel testing protocols and intervention strategies.

scholarly journals Efficient Black-Box Planning Using Macro-Actions with Focused Effects

2021 ◽  
Author(s):  
Cameron Allen ◽  
Michael Katz ◽  
Tim Klinger ◽  
George Konidaris ◽  
Matthew Riemer ◽  
...  
Keyword(s):  
State Of The Art ◽  
Search Tree ◽  
Black Box ◽  
Domain Model ◽  
State Variables ◽  
Explicit Model ◽  
Wide Range ◽  
Full Domain

The difficulty of deterministic planning increases exponentially with search-tree depth. Black-box planning presents an even greater challenge, since planners must operate without an explicit model of the domain. Heuristics can make search more efficient, but goal-aware heuristics for black-box planning usually rely on goal counting, which is often quite uninformative. In this work, we show how to overcome this limitation by discovering macro-actions that make the goal-count heuristic more accurate. Our approach searches for macro-actions with focused effects (i.e. macros that modify only a small number of state variables), which align well with the assumptions made by the goal-count heuristic. Focused macros dramatically improve black-box planning efficiency across a wide range of planning domains, sometimes beating even state-of-the-art planners with access to a full domain model.

Review of the Applications of Deep Learning in Bioinformatics

2021 ◽  
Vol 15 (8) ◽  
pp. 898-911
Author(s):  
Yongqing Zhang ◽  
Jianrong Yan ◽  
Siyu Chen ◽  
Meiqin Gong ◽  
Dongrui Gao ◽  
...  
Keyword(s):  
Deep Learning ◽  
Drug Discovery ◽  
Biomedical Imaging ◽  
State Of The Art ◽  
Black Box ◽  
Medical Data ◽  
Biological Data ◽  
High Dimensional ◽  
Biological Research ◽  
Process Data

Rapid advances in biological research over recent years have significantly enriched biological and medical data resources. Deep learning-based techniques have been successfully utilized to process data in this field, and they have exhibited state-of-the-art performances even on high-dimensional, nonstructural, and black-box biological data. The aim of the current study is to provide an overview of the deep learning-based techniques used in biology and medicine and their state-of-the-art applications. In particular, we introduce the fundamentals of deep learning and then review the success of applying such methods to bioinformatics, biomedical imaging, biomedicine, and drug discovery. We also discuss the challenges and limitations of this field, and outline possible directions for further research.

scholarly journals CoCoX: Generating Conceptual and Counterfactual Explanations via Fault-Lines

2020 ◽  
Vol 34 (03) ◽  
pp. 2594-2601
Author(s):  
Arjun Akula ◽  
Shuai Wang ◽  
Song-Chun Zhu
Keyword(s):  
Neural Network ◽  
State Of The Art ◽  
Input Image ◽  
Classification Model ◽  
Learning Models ◽  
Fault Line ◽  
Semantic Level ◽  
Explainable Ai ◽  
Fault Lines ◽  
Classification Category

We present CoCoX (short for Conceptual and Counterfactual Explanations), a model for explaining decisions made by a deep convolutional neural network (CNN). In Cognitive Psychology, the factors (or semantic-level features) that humans zoom in on when they imagine an alternative to a model prediction are often referred to as fault-lines. Motivated by this, our CoCoX model explains decisions made by a CNN using fault-lines. Specifically, given an input image I for which a CNN classification model M predicts class cpred, our fault-line based explanation identifies the minimal semantic-level features (e.g., stripes on zebra, pointed ears of dog), referred to as explainable concepts, that need to be added to or deleted from I in order to alter the classification category of I by M to another specified class calt. We argue that, due to the conceptual and counterfactual nature of fault-lines, our CoCoX explanations are practical and more natural for both expert and non-expert users to understand the internal workings of complex deep learning models. Extensive quantitative and qualitative experiments verify our hypotheses, showing that CoCoX significantly outperforms the state-of-the-art explainable AI models. Our implementation is available at https://github.com/arjunakula/CoCoX

BiLabel-Specific Features for Multi-Label Classification

2021 ◽  
Vol 16 (1) ◽  
pp. 1-23
Author(s):  
Min-Ling Zhang ◽  
Jun-Peng Fang ◽  
Yi-Bo Wang
Keyword(s):  
Predictive Models ◽  
Comparative Studies ◽  
State Of The Art ◽  
Classification Model ◽  
Generation Process ◽  
Prototype Selection ◽  
Class Label ◽  
Benchmark Datasets ◽  
Label Correlations ◽  
Class Labels

In multi-label classification, the task is to induce predictive models which can assign a set of relevant labels for the unseen instance. The strategy of label-specific features has been widely employed in learning from multi-label examples, where the classification model for predicting the relevancy of each class label is induced based on its tailored features rather than the original features. Existing approaches work by generating a group of tailored features for each class label independently, where label correlations are not fully considered in the label-specific features generation process. In this article, we extend existing strategy by proposing a simple yet effective approach based on BiLabel-specific features. Specifically, a group of tailored features is generated for a pair of class labels with heuristic prototype selection and embedding. Thereafter, predictions of classifiers induced by BiLabel-specific features are ensembled to determine the relevancy of each class label for unseen instance. To thoroughly evaluate the BiLabel-specific features strategy, extensive experiments are conducted over a total of 35 benchmark datasets. Comparative studies against state-of-the-art label-specific features techniques clearly validate the superiority of utilizing BiLabel-specific features to yield stronger generalization performance for multi-label classification.

Learning emotional word embeddings for sentiment analysis

2021 ◽  
pp. 1-13
Author(s):  
Qingtian Zeng ◽  
Xishi Zhao ◽  
Xiaohui Hu ◽  
Hua Duan ◽  
Zhongying Zhao ◽  
...  
Keyword(s):  
Sentiment Analysis ◽  
Language Processing ◽  
State Of The Art ◽  
Research Problem ◽  
Emotional Word ◽  
Classification Model ◽  
Data Sets ◽  
Word Embeddings ◽  
Real World Data ◽  
Text Documents

Word embeddings have been successfully applied in many natural language processing tasks due to its their effectiveness. However, the state-of-the-art algorithms for learning word representations from large amounts of text documents ignore emotional information, which is a significant research problem that must be addressed. To solve the above problem, we propose an emotional word embedding (EWE) model for sentiment analysis in this paper. This method first applies pre-trained word vectors to represent document features using two different linear weighting methods. Then, the resulting document vectors are input to a classification model and used to train a text sentiment classifier, which is based on a neural network. In this way, the emotional polarity of the text is propagated into the word vectors. The experimental results on three kinds of real-world data sets demonstrate that the proposed EWE model achieves superior performances on text sentiment prediction, text similarity calculation, and word emotional expression tasks compared to other state-of-the-art models.

Spanish Version of the Mini-Linguistic State Examination for the Diagnosis of Primary Progressive Aphasia

2021 ◽  
pp. 1-8
Author(s):  
Jordi A. Matias-Guiu ◽  
Vanesa Pytel ◽  
Laura Hernández-Lorenzo ◽  
Nikil Patel ◽  
Katie A. Peterson ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Spanish Version ◽  
Classification Model ◽  
Healthy Controls ◽  
Language Test ◽  
Cross Sectional ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Clinical Variants ◽  
State Examination

Background: Primary progressive aphasia (PPA) is a neurodegenerative syndrome with three main clinical variants: non-fluent, semantic, and logopenic. Clinical diagnosis and accurate classification are challenging and often time-consuming. The Mini-Linguistic State Examination (MLSE) has been recently developed as a short language test to specifically assess language in neurodegenerative disorders. Objective: Our aim was to adapt and validate the Spanish version of MLSE for PPA diagnosis. Methods: Cross-sectional study involving 70 patients with PPA and 42 healthy controls evaluated with the MLSE. Patients were independently diagnosed and classified according to comprehensive cognitive evaluation and advanced neuroimaging. Results: Internal consistency was 0.758. The influence of age and education was very low. The area under the curve for discriminating PPA patients and healthy controls was 0.99. Effect sizes were moderate-large for the discrimination between PPA and healthy controls. Motor speech, phonology, and semantic subscores discriminated between the three clinical variants. A random forest classification model obtained an F1-score of 81%for the three PPA variants. Conclusion: Our study provides a brief and useful language test for PPA diagnosis, with excellent properties for both clinical routine assessment and research purposes.

scholarly journals Image Classification for the Automatic Feature Extraction in Human Worn Fashion Data

Mathematics ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 624
Author(s):  
Stefan Rohrmanstorfer ◽  
Mikhail Komarov ◽  
Felix Mödritscher
Keyword(s):  
Neural Networks ◽  
Feature Extraction ◽  
Image Classification ◽  
Convolutional Neural Networks ◽  
Data Augmentation ◽  
State Of The Art ◽  
Image Data ◽  
Classification Model ◽  
Upper Body ◽  
Automatic Feature Extraction

With the always increasing amount of image data, it has become a necessity to automatically look for and process information in these images. As fashion is captured in images, the fashion sector provides the perfect foundation to be supported by the integration of a service or application that is built on an image classification model. In this article, the state of the art for image classification is analyzed and discussed. Based on the elaborated knowledge, four different approaches will be implemented to successfully extract features out of fashion data. For this purpose, a human-worn fashion dataset with 2567 images was created, but it was significantly enlarged by the performed image operations. The results show that convolutional neural networks are the undisputed standard for classifying images, and that TensorFlow is the best library to build them. Moreover, through the introduction of dropout layers, data augmentation and transfer learning, model overfitting was successfully prevented, and it was possible to incrementally improve the validation accuracy of the created dataset from an initial 69% to a final validation accuracy of 84%. More distinct apparel like trousers, shoes and hats were better classified than other upper body clothes.

scholarly journals Automatic Identification of Harmful, Aggressive, Abusive, and Offensive Language on the Web: A Survey of Technical Biases Informed by Psychology Literature

2021 ◽  
Vol 4 (3) ◽  
pp. 1-56
Author(s):  
Agathe Balayn ◽  
Jie Yang ◽  
Zoltan Szlavik ◽  
Alessandro Bozzon
Keyword(s):  
Computer Science ◽  
State Of The Art ◽  
Automatic Detection ◽  
Automatic Identification ◽  
Machine Learning Classification ◽  
Detection Systems ◽  
Science Community ◽  
Psychology Literature ◽  
Offensive Language ◽  
The Web

The automatic detection of conflictual languages (harmful, aggressive, abusive, and offensive languages) is essential to provide a healthy conversation environment on the Web. To design and develop detection systems that are capable of achieving satisfactory performance, a thorough understanding of the nature and properties of the targeted type of conflictual language is of great importance. The scientific communities investigating human psychology and social behavior have studied these languages in details, but their insights have only partially reached the computer science community. In this survey, we aim both at systematically characterizing the conceptual properties of online conflictual languages, and at investigating the extent to which they are reflected in state-of-the-art automatic detection systems. Through an analysis of psychology literature, we provide a reconciled taxonomy that denotes the ensemble of conflictual languages typically studied in computer science. We then characterize the conceptual mismatches that can be observed in the main semantic and contextual properties of these languages and their treatment in computer science works; and systematically uncover resulting technical biases in the design of machine learning classification models and the dataset created for their training. Finally, we discuss diverse research opportunities for the computer science community and reflect on broader technical and structural issues.

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