Effects of the COVID-19 Epidemic on Hospital Admissions for Non-Communicable Diseases in a Large Italian University-Hospital: A Descriptive Case-Series Study

Background: Concern is growing about the negative consequences that response measures to the COVID-19 epidemic may have on the management of other medical conditions. Methods: A retrospective descriptive case-series study conducted at a large University-hospital in northern Italy, an area severely hit by the epidemic. Results: Between 23 February and 14 May 2020, 4160 (52%) COVID-19 and 3778 (48%) non-COVID-19 patients were hospitalized. COVID-19 admissions peaked in the second half of March, a period characterized by an extremely high mortality rate (27.4%). The number of admissions in 2020 was similar to 2019, but COVID-19 patients gradually occupied all available beds. Comparison between COVID-19 and non-COVID-19 admissions in 2020 revealed significant differences concerning all age classes and gender. Specifically, COVID-19 patients were older, predominantly male, and exhibited more comorbidities. Overall, admissions for non-communicable diseases (NCDs) in 2020 vs. 2019 dropped by approximately one third. Statistically significant reductions were observed for acute myocardial infarction (−78, −33.9%), cerebrovascular disease (−235, −41.5%), and cancer (−368, −31.9%). While the first two appeared equally distributed between COVID-19 and non-COVID-19 patients, chronic NCDs were statistically significantly more frequent in the former, except cancer, which was less frequent in COVID-19 patients. Conclusions: Prevention of collateral damage to patients with other diseases should be an integral part of epidemic response plans. Prospective cohort studies are needed to understand the long-term impact.

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Endoscopic Harmonic Midline Partial Glossectomy in Obstructive Sleep Apnea

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i130800 ◽

2021 ◽

pp. 98-104

Author(s):

A. I. Elkawa ◽

Y. I. Aglan ◽

M. A. Hagras

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Case Series ◽

University Hospital ◽

Obstructive Sleep ◽

Case Series Study ◽

Prospective Case Series ◽

Series Study ◽

Partial Glossectomy ◽

Posterior Midline

Aim: Our study was done to evaluate the role of Endoscopic posterior midline partial glossectomy as a surgical modality for the hypopharyngeal collapse in obstructive sleep apnea patients. Study design: Prospective case series study. Place and Duration of Study: Tanta university hospital, otolaryngology department, from October 2017 till March 2019. Methodology: This was a prospective case series study, conducted on 10 patients from 2017 -2019 with tongue base collapse and normal craniofacial angles, the patients were evaluated preoperative and 6 months postoperative subjectively by Epworth sleepiness scale (ESS) and objectively by polysomnography and lateral cephalometry. Results: Our study included 10 patients with age (mean ± SD48.70±4.08), BMI( mean ±SD24.45±1.56), 5 patients showed a significant reduction in AHI with a success rate of 50% with a significant change in ESS and the non-significant changes in cephalometric parameters. Conclusion: Transoral endoscopic posterior midline partial glossectomy can improve the surgical outcomes of obstructive sleep apnea patients.

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Frequency of Mortality in Patients with Post-Partum Eclampsia-A Study at Liaquat University Hospital, Hyderabad, Sindh, India

International Journal of Multidisciplinary and Current Research ◽

10.14741/ijmcr/v.7.3.16 ◽

2019 ◽

Vol 7 (03) ◽

Author(s):

Almas Almas ◽

Naushaba Rizwan ◽

Syed Farhan Uddin

Keyword(s):

Post Partum ◽

Case Series ◽

University Hospital ◽

Study Patient ◽

Inclusion Criteria ◽

Risks And Benefits ◽

Number Of Patients ◽

Case Series Study ◽

Patient Will ◽

Series Study

Postpartum preeclampsia is the occurrence of hypertension and proteinuria after delivery. Preeclampsia plus seizures after delivery is defined as postpartum eclampsia. Objective: To determine the frequency of mortality in patients with post-partum eclampsia; To determine the obstetrical factors leading to maternal mortality in patient with postpartum eclampsia. Methodology: The descriptive case series study was carried out in the department of Department of obstetrics and gynecology LUMHS Hospital Hyderabad from 1st January 2018 to 30 June 2018. All patients who fulfilled the inclusion criteria were included in the study. Informed consent was taken after explaining the procedure, risks and benefits of the study. All patients of postpartum eclampsia with increase blood pressure and proteinuria admitted through out-patient department or emergency within 48 hours of delivery will be included in the study. Patient will be followed for 10 days. All the collected data were entered into the proforma attached at the end. Results: Mean ± SD of age was 27.88±7.77 with C.I (27.02…….28.74) years. Mean ± SD of systolic B.P and urine protein was 161.46±22.09 mmhg and 1432.59±967.33 mg respectively. Out of 369 was occurred mortality in 190 (60%) women. Conclusion: It is to be concluded that mortality is most in eclampctic women followed by patients with Pre-eclampsia. However a study design comprising multiple centers, and a higher number of patients over a longer period of time will be more representative.

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Adverse drug reactions in SARS-CoV-2 hospitalised patients: a case-series with a focus on drug–drug interactions

Internal and Emergency Medicine ◽

10.1007/s11739-020-02586-8 ◽

2020 ◽

Author(s):

Giada Crescioli ◽

Valentina Brilli ◽

Cecilia Lanzi ◽

Andrea Burgalassi ◽

Alessandra Ieri ◽

...

Keyword(s):

Adverse Drug Reactions ◽

Case Series ◽

University Hospital ◽

Drug Reactions ◽

Case Evaluation ◽

Hospitalised Patients ◽

Number Of Patients ◽

Case Series Study ◽

Caucasian Patients ◽

Series Study

AbstractDue to the need of early and emergency effective treatments for COVID-19, less attention may have been paid to their safety during the global emergency. In addition, characteristics of drug–drug interaction (DDI)-related adverse drug reactions (ADRs) in COVID-19 patients have not yet been studied in depth. The aim of the present case-series study is to describe clinical and pharmacological characteristics of SARS-CoV-2 hospitalised patients, focusing on ADRs, particularly those related to DDIs. We evaluated all reports of COVID-19 medication-related ADRs collected within the COVID-19 Units of Careggi University Hospital, Florence (Italy), between January 1st and 31st May 2020. Information regarding COVID-19 medications, patients’ demographic and clinical characteristics, concomitant drugs, ADRs description and outcome, were collected. Each case was evaluated for the causality assessment and to identify the presence of DDIs. During the study period, 23 Caucasian patients (56.5% males, mean age 76.1 years) experienced one or more ADRs. The majority of them were exposed to polypharmacy and 17.4% presented comorbidities. ADRs were referred to cardiovascular, psychiatric and gastrointestinal disorders. The most frequently reported preferred term was QT prolongation (mean QT interval 496.1 ms). ADRs improved or resolved completely in 60.8% of cases. For all patients, a case-by-case evaluation revealed the presence of one or more DDIs, especially those related to pharmacokinetic interactions. Despite the small number of patients, our evidence underline the clinical burden of DDIs in SARS-CoV-2 hospitalised patients and the risk of unexpected and uncommon psychiatric ADRs.

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Combined endophthalmitis and orbital cellulitis in patients with corona virus disease (COVID-19)

Journal of Ophthalmic Inflammation and Infection ◽

10.1186/s12348-021-00258-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mohamed Farouk Sayed Othman Abdelkader ◽

Ahmed Mohamed Kamal Elshafei ◽

Mahmoud Mamdouh Nassar ◽

Mostafa A. Abu Elela ◽

Raafat Mohyeldeen Abdelrahman Abdallah

Keyword(s):

Visual Loss ◽

Clinical Laboratory ◽

Virus Disease ◽

Systemic Disease ◽

Case Series ◽

Orbital Cellulitis ◽

University Hospital ◽

Case Series Study ◽

Work Up ◽

Series Study

Abstract Purpose To document the presentation of unilateral combined endophthalmitis and orbital cellulitis in patients with COVID-19 infection and study their prognosis. Patients and methods This interventional case series study included 9 patients referred to the Ophthalmology Department, Minia University Hospital with unilateral combined endophthalmitis and orbital cellulitis between April 2020 and March 2021. In addition to the COVID-19 work-up, all patients were subjected to full ophthalmological evaluation and managed according to their ophthalmic and systemic disease. Results The patients were 5 females and 4 males. They had clinical, laboratory and imaging findings that confirmed COVID-19 infection. All patients had unilateral endophthalmitis with orbital cellulitis and profound visual loss in the affected eye. Three patients died due to respiratory failure, while 6 patients recovered systemically. The survived patients developed atrophia bulbi in 4 patients and in 2 patients, the globe retained normal size but with complete visual loss. Conclusion Combined endophthalmitis and orbital cellulitis can be one of the early presentations of patients with COVID-19 infection with poor visual prognosis. Trial registration Clinical registration: clinicaltrials.gov identifier: NCT04456556.

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POSTPARTUM HAEMORRHAGE;

The Professional Medical Journal ◽

10.29309/tpmj/2017.24.07.1031 ◽

2017 ◽

Vol 24 (07) ◽

pp. 1016-1019

Author(s):

Raheela Rani Junejo ◽

Rabail Rani Junejo ◽

Shahla Baloch ◽

Raheel Sikandar ◽

Mehrunnisa Khaskheli

Keyword(s):

Blood Loss ◽

Postpartum Haemorrhage ◽

Case Series ◽

University Hospital ◽

Age Group ◽

Chi Square ◽

Case Series Study ◽

Increased Risk ◽

Maternal Risks ◽

Series Study

Objectives: To determine the frequency of postpartum haemorrhage in obeseprimigravid women. Study Design: Case series study. Period: Six months was conductedfrom 1st October 2014 to 30 March 2015. Setting: Department of gynecology and obstetricsat Liaquat University Hospital Jamshoro. Patients and Methods: All the primigravid obese(≥30kg/m2) ladies 18 to 35 years of age with 37-42 weeks of gestational age were evaluate forthe occurrence of PPH by estimating blood loss of greater than 500 ml of blood following vaginaldelivery or 1000 ml of blood loss following caesarean section. All data was entered and analyzedthrough statistical package SPSS version 17, the chi-square statistical test was applied and thep-value ≤0.05 was considered as statistical significant. Results: Total 203 primigravid obeseladies were studies, the age group was analyzed which shows that in age group between 18-25years were 105(52.00%) women, in age group of 26-30 years were 62(30.69%) women and agegroup of 30 years and above were 35 (17.31%) women. The modes of delivery were evaluatedwhich shows that 66.5% women underwent C-section and 33.4% women had normal vaginaldelivery. The PPH was observed in 34.97% patients (70.4% with C-Section and 29.6 with NVD).Conclusion: Obesity carries a significant increased risk of complications during pregnancyand maternal risks during labour are PPH and more frequent C-section and nulliparous obesewomen have twofold high risk for PPH

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Detection of SARS-CoV-2 in the tears and conjunctival secretions of Coronavirus disease 2019 patients

The Journal of Infection in Developing Countries ◽

10.3855/jidc.13224 ◽

2020 ◽

Vol 14 (09) ◽

pp. 977-981 ◽

Cited By ~ 1

Author(s):

Hüseyin Kaya ◽

Ahmet Çalışkan ◽

Mehmet Okul ◽

Tuğba Sarı ◽

İsmail Hakkı Akbudak

Keyword(s):

Case Series ◽

Cross Sectional Study ◽

University Hospital ◽

Cross Sectional ◽

Ocular Manifestations ◽

Case Series Study ◽

Eye Symptoms ◽

Polymerase Chain ◽

Mean Time ◽

Series Study

Introduction: Current studies suggest that tears and conjunctival secretions may be an important transmission route in coronavirus disease 2019 (COVID-19). The study aims to evaluate the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) virus in tears and conjunctival secretion of patients with COVID-19. Methodology: A prospective interventional case series study was performed, and 32 patients with COVID-19 were selected at the Pamukkale University Hospital from 15 to 22 May 2020. The tear and conjunctival samples were collected by a conjunctival swab. Each specimen was sent to the laboratory for reverse transcription-polymerase chain reaction (RT-PCR) analyses. To avoid cross-infection, gloves and personal protective equipment were changed after collecting each sample. Results: 32 patients (18 male, 14 female) with Covid-19 were included in this cross-sectional study. The average age of the patients was 52.81 ± 16.76 years. By the time of the first collection of conjunctival-tear samples, the mean time of the onset of complaints was 6.84 ± 6.81 (1-35) days. Tear-conjunctival samples from 5 patients (16%) without conjunctivitis yielded positive PCR results, 3 of whom had positive and 2 negative nasopharyngeal PCR results. Conclusions: Five of 32 patients (16 %) without conjunctivitis or any eye symptoms had viral RNA in their tear-conjunctival samples. The possibility of transmission via tears and conjunctival secretions should be recognized even in the absence of conjunctivitis or other ocular manifestations.

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PORTO-SYSTEMIC ENCEPHALOPATHY (PSE);

The Professional Medical Journal ◽

10.29309/tpmj/2012.19.05.2336 ◽

2012 ◽

Vol 19 (05) ◽

pp. 672-678

Author(s):

ATIF SITWAT HAYAT ◽

MOHAMMAD ADNAN BAWANY ◽

FURRUKH NAZ SILAWAT ◽

Mohammad Akber Memon

Keyword(s):

Renal Impairment ◽

Tertiary Care ◽

Case Series ◽

University Hospital ◽

Medical Emergency ◽

Precipitating Factors ◽

Case Series Study ◽

Statistical Program ◽

Series Study ◽

Study Setting

Background: Porto-systemic encephalopathy (PSE) is a common medical emergency at our settings due to increasedprevalence of chronic liver disease. Objective: To determine frequency of common precipitating factors in patients having porto-systemicencephalopathy (PSE) at tertiary care settings in Hyderabad. Study design: Descriptive case series study. Setting: Department of MedicineIsra University Hospital Hyderabad. Period: 1st April 2011 to 31st December 2011. Methods: A total 100 patients manifesting clinical featuresof PSE were included in this study by non-probability convenience sampling. The data was evaluated in statistical program SPSS version 16.Results: As 100 patients with PSE were enrolled in the current study, out of these 96 patients have precipitating factors involved while only 4patients have no such factors. Out of these 96 patients, 36 patients have only single risk factor found while in 64 cases multiple factors wereimplicated. Constipation, infections (except SBP) and renal impairment were noted in 36%, 24% and 22% respectively. Conclusions:Constipation, infections (except SBP) and renal impairment were the most common precipitating factors of porto-systemic encephalopathy inour study. Hence priority should be given to them in terms of hospital funds, medicines and human efforts.

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Efficacy of Hayman Suture in the Treatment of Atonic Postpartum Hemorrhage

Journal of Scientific Research in Medical and Biological Sciences ◽

10.47631/jsrmbs.v2i4.330 ◽

2021 ◽

Vol 2 (4) ◽

pp. 38-43

Author(s):

Ahmed M. Abdul Hameed ◽

Haney A. Farouk ◽

Mohamed S. Fahmy

Keyword(s):

Postpartum Hemorrhage ◽

Medical Management ◽

Case Series ◽

University Hospital ◽

Obstetrics And Gynecology ◽

Case Series Study ◽

Fertility Sparing ◽

Series Study

Purpose: The study aims to investigate the effectiveness of Hayman’s suture in the management of Atonic postpartum hemorrhage. Subjects and Method: The study includes 37 patients who developed severe atonic PPH not responsive to pharmacological measures at the Department of Obstetrics and Gynecology at Aswan University hospital, in the period between Mars 2018 and December 2019. This is a case series study of 37 patients upon whom Hayman suture is applied when failed to respond to medical management, step-wise devascularization of the uterus is attempted when the suture cannot control the bleeding alone, reserving hysterectomy as a last resort when all measures are failed. Results: Results of the research None of the 37 patients of our study required hysterectomy to control the bleeding, Hayman suture succeeded solely to arrest the hemorrhage in 30 patients (81.1%), while 7 patients(18.9%) required step-wise devascularization of the uterus with Hayman suture to stop the bleeding. It is not uncommon for complications to be described with the use of uterine compression sutures. In our study, we did not report any complications. Conclusion: The application of Hayman’s suture is a fast, efficient, non-complex, lifesaving and fertility-sparing technique to control atonic postpartum hemorrhage.

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VIVAX MALARIA

The Professional Medical Journal ◽

10.29309/tpmj/2015.22.05.1267 ◽

2015 ◽

Vol 22 (05) ◽

pp. 559-564

Author(s):

Ghulam Mustafa Mangrio ◽

Mushtaq Ali Memon ◽

Mumtaz Ali Shaikh ◽

Hamid Nawaz Ali Memon ◽

Suneel Arwani ◽

...

Keyword(s):

Vivax Malaria ◽

Case Series ◽

University Hospital ◽

Cross Sectional ◽

Distribution Width ◽

Male Predominance ◽

Case Series Study ◽

Combined Features ◽

The Common ◽

Series Study

Objective: To determine the frequency and severity of thrombocytopenia and toevaluate the variation of red cell distribution width (RDW) in patients with acute vivax malaria.Study Deign: Cross sectional descriptive case series study. Period: Six months. Setting:Liaquat University Hospital. Methods: All the patients with acute vivax malaria were evaluatedfor thrombocytopenia its severity and RDW. The data was analyzed in SPSS 10 and thefrequency and percentage was calculated. Results: Total 126 patients with acute vivax malariawere recruited, of which 88 were males and 38 were females. The mean age ±SD for male andfemale subjects was 44.76±6.83 and 40.83±7.42. The common features observed were fever31%, rigor 15% and combined features 14% (p=0.05). The thrombocytopenia was identified in86 patients of which 65 were males and 21 were females (p=0.04). The increased RDW wasobserved in 75 patients of which 57 were males and 18 were females (p=0.05). The bleedingwas detected in 56 and dyspnea and heart failure was found in 30 thrombocytopenic subjects(p=0.02). Regarding outcome 82 subjects were recovered while the 04 patients were expired(p=0.05). Regarding severity of thrombocytopenia majority 48.8% were in moderate categorywith male predominance (p=0.02). Conclusion: The thrombocytopenia and increased RDWwas observed in patients with acute vivax malaria.

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