scholarly journals Detection of SARS-CoV-2 in the tears and conjunctival secretions of Coronavirus disease 2019 patients

2020 ◽  
Vol 14 (09) ◽  
pp. 977-981 ◽  
Author(s):  
Hüseyin Kaya ◽  
Ahmet Çalışkan ◽  
Mehmet Okul ◽  
Tuğba Sarı ◽  
İsmail Hakkı Akbudak
Keyword(s):  
Case Series ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Ocular Manifestations ◽  
Case Series Study ◽  
Eye Symptoms ◽  
Polymerase Chain ◽  
Mean Time ◽  
Series Study

Introduction: Current studies suggest that tears and conjunctival secretions may be an important transmission route in coronavirus disease 2019 (COVID-19). The study aims to evaluate the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) virus in tears and conjunctival secretion of patients with COVID-19. Methodology: A prospective interventional case series study was performed, and 32 patients with COVID-19 were selected at the Pamukkale University Hospital from 15 to 22 May 2020. The tear and conjunctival samples were collected by a conjunctival swab. Each specimen was sent to the laboratory for reverse transcription-polymerase chain reaction (RT-PCR) analyses. To avoid cross-infection, gloves and personal protective equipment were changed after collecting each sample. Results: 32 patients (18 male, 14 female) with Covid-19 were included in this cross-sectional study. The average age of the patients was 52.81 ± 16.76 years. By the time of the first collection of conjunctival-tear samples, the mean time of the onset of complaints was 6.84 ± 6.81 (1-35) days. Tear-conjunctival samples from 5 patients (16%) without conjunctivitis yielded positive PCR results, 3 of whom had positive and 2 negative nasopharyngeal PCR results. Conclusions: Five of 32 patients (16 %) without conjunctivitis or any eye symptoms had viral RNA in their tear-conjunctival samples. The possibility of transmission via tears and conjunctival secretions should be recognized even in the absence of conjunctivitis or other ocular manifestations.

scholarly journals VIVAX MALARIA

2015 ◽  
Vol 22 (05) ◽  
pp. 559-564
Author(s):  
Ghulam Mustafa Mangrio ◽  
Mushtaq Ali Memon ◽  
Mumtaz Ali Shaikh ◽  
Hamid Nawaz Ali Memon ◽  
Suneel Arwani ◽  
...  
Keyword(s):  
Vivax Malaria ◽  
Case Series ◽  
University Hospital ◽  
Cross Sectional ◽  
Distribution Width ◽  
Male Predominance ◽  
Case Series Study ◽  
Combined Features ◽  
The Common ◽  
Series Study

Objective: To determine the frequency and severity of thrombocytopenia and toevaluate the variation of red cell distribution width (RDW) in patients with acute vivax malaria.Study Deign: Cross sectional descriptive case series study. Period: Six months. Setting:Liaquat University Hospital. Methods: All the patients with acute vivax malaria were evaluatedfor thrombocytopenia its severity and RDW. The data was analyzed in SPSS 10 and thefrequency and percentage was calculated. Results: Total 126 patients with acute vivax malariawere recruited, of which 88 were males and 38 were females. The mean age ±SD for male andfemale subjects was 44.76±6.83 and 40.83±7.42. The common features observed were fever31%, rigor 15% and combined features 14% (p=0.05). The thrombocytopenia was identified in86 patients of which 65 were males and 21 were females (p=0.04). The increased RDW wasobserved in 75 patients of which 57 were males and 18 were females (p=0.05). The bleedingwas detected in 56 and dyspnea and heart failure was found in 30 thrombocytopenic subjects(p=0.02). Regarding outcome 82 subjects were recovered while the 04 patients were expired(p=0.05). Regarding severity of thrombocytopenia majority 48.8% were in moderate categorywith male predominance (p=0.02). Conclusion: The thrombocytopenia and increased RDWwas observed in patients with acute vivax malaria.

scholarly journals Effects of the COVID-19 Epidemic on Hospital Admissions for Non-Communicable Diseases in a Large Italian University-Hospital: A Descriptive Case-Series Study

2021 ◽  
Vol 10 (4) ◽  
pp. 880
Author(s):  
Caterina Caminiti ◽  
Giuseppe Maglietta ◽  
Tiziana Meschi ◽  
Andrea Ticinesi ◽  
Mario Silva ◽  
...  
Keyword(s):  
Hospital Admissions ◽  
Case Series ◽  
Communicable Diseases ◽  
University Hospital ◽  
Negative Consequences ◽  
Non Communicable Diseases ◽  
Case Series Study ◽  
And Gender ◽  
Long Term Impact ◽  
Series Study

Background: Concern is growing about the negative consequences that response measures to the COVID-19 epidemic may have on the management of other medical conditions. Methods: A retrospective descriptive case-series study conducted at a large University-hospital in northern Italy, an area severely hit by the epidemic. Results: Between 23 February and 14 May 2020, 4160 (52%) COVID-19 and 3778 (48%) non-COVID-19 patients were hospitalized. COVID-19 admissions peaked in the second half of March, a period characterized by an extremely high mortality rate (27.4%). The number of admissions in 2020 was similar to 2019, but COVID-19 patients gradually occupied all available beds. Comparison between COVID-19 and non-COVID-19 admissions in 2020 revealed significant differences concerning all age classes and gender. Specifically, COVID-19 patients were older, predominantly male, and exhibited more comorbidities. Overall, admissions for non-communicable diseases (NCDs) in 2020 vs. 2019 dropped by approximately one third. Statistically significant reductions were observed for acute myocardial infarction (−78, −33.9%), cerebrovascular disease (−235, −41.5%), and cancer (−368, −31.9%). While the first two appeared equally distributed between COVID-19 and non-COVID-19 patients, chronic NCDs were statistically significantly more frequent in the former, except cancer, which was less frequent in COVID-19 patients. Conclusions: Prevention of collateral damage to patients with other diseases should be an integral part of epidemic response plans. Prospective cohort studies are needed to understand the long-term impact.

Malaria among migrants in a university hospital in Colombia during 2018: A case series

2020 ◽  
pp. 004947552098130
Author(s):  
Fabián R Carreño-Almánzar ◽  
Adán Coronado-Galán ◽  
Sonia A Cala-Gómez ◽  
Agustín Vega-Vera
Keyword(s):  
Latin American ◽  
Previous History ◽  
Case Series ◽  
Cross Sectional Study ◽  
Imported Malaria ◽  
University Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Clinical Profiles

Imported malaria has increased in Colombia since 2015 and has been attributed to migrants coming from Venezuela. We present a series of malaria cases, nested in a retrospective cross-sectional study between 2017 and 2018, aimed at calculating the prevalence of medical diseases among immigrants in a University Hospital in Colombia. Among 154 immigrants admitted for medical causes between 2017 and 2018, 8 were diagnosed with malaria, all due to Plasmodium vivax. Of these, seven had uncomplicated malaria, five had a previous history of malaria, one was critically ill, but none died. We highlight that, similar to other case series of imported malaria, Latin American migrants were young, with similar clinical profiles, having a low proportion of severe cases, and P. vivax was the most frequent cause.

scholarly journals Who are dying and why? A case series study of maternal deaths in Nepal

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e042840
Author(s):  
Rajendra Karkee ◽  
Kirti Man Tumbahangphe ◽  
Nashna Maharjan ◽  
Bharat Budhathoki ◽  
Dharma Manandhar
Keyword(s):  
Case Series ◽  
Public Hospitals ◽  
Birth Preparedness ◽  
Framework Analysis ◽  
Cross Sectional ◽  
Maternal Deaths ◽  
Social Autopsy ◽  
Case Series Study ◽  
Referral Hospitals ◽  
Series Study

ObjectivesTo identify delays and associated factors for maternal deaths in Nepal.DesignA cross-sectional case series study of maternal deaths. An integrated verbal and social autopsy tool was used to collect quantitative and qualitative information regarding three delays. We recorded death accounts and conducted social autopsy by means of community Focus Group Discussions for each maternal death; and analysed data by framework analysis.SettingSixty-two maternal deaths in six districts in three provinces of Nepal.ResultsNearly half of the deceased women (45.2%) were primiparous and one-third had no formal education. About 40% were from Terai/Madhesi and 30.6% from lower caste. The most common place of death was private hospitals (41.9%), followed by public hospitals (29.1%). Nearly three-fourth cases were referred to higher health facilities and median time (IQR) of stay at the lower health facility was 120 (60–180) hours. Nearly half of deaths (43.5%) were attributable to more than one delay while first and third delay each contributed equally (25.8%). Lack of perceived need; perceived cost and low status; traditional beliefs and practices; physically inaccessible facilities and lack of service readiness and quality care were important factors in maternal deaths.ConclusionsThe first and third delays were the equal contributors of maternal deaths. Interventions related to birth preparedness, economic support and family planning need to be focused on poor and marginalised communities. Community management of quick transportation, early diagnosis of pregnancy risks, accommodation facilities near the referral hospitals and dedicated skilled manpower with adequate medicines, equipment and blood supplies in referral hospitals are needed for further reduction of maternal deaths in Nepal.

A Retrospective, Multicenter, Cross-Sectional Case Series Study Evaluating Outcomes of CAD/CAM Abutments on Implants from Four Manufacturers: 4-Year Mean Follow-up

2021 ◽  
Vol 36 (5) ◽  
pp. 966-976
Author(s):  
Christopher Barwacz ◽  
Kumar Shah ◽  
Nurit Bittner ◽  
William Parker ◽  
Toni Neumeier ◽  
...  
Keyword(s):  
Case Series ◽  
Cross Sectional ◽  
Case Series Study ◽  
Cad Cam ◽  
Series Study

scholarly journals Endoscopic Harmonic Midline Partial Glossectomy in Obstructive Sleep Apnea

2021 ◽  
pp. 98-104
Author(s):  
A. I. Elkawa ◽  
Y. I. Aglan ◽  
M. A. Hagras
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Case Series ◽  
University Hospital ◽  
Obstructive Sleep ◽  
Case Series Study ◽  
Prospective Case Series ◽  
Series Study ◽  
Partial Glossectomy ◽  
Posterior Midline

Aim: Our study was done to evaluate the role of Endoscopic posterior midline partial glossectomy as a surgical modality for the hypopharyngeal collapse in obstructive sleep apnea patients. Study design: Prospective case series study. Place and Duration of Study: Tanta university hospital, otolaryngology department, from October 2017 till March 2019. Methodology: This was a prospective case series study, conducted on 10 patients from 2017 -2019 with tongue base collapse and normal craniofacial angles, the patients were evaluated preoperative and 6 months postoperative subjectively by Epworth sleepiness scale (ESS) and objectively by polysomnography and lateral cephalometry. Results: Our study included 10 patients with age (mean ± SD48.70±4.08), BMI( mean ±SD24.45±1.56), 5 patients showed a significant reduction in AHI with a success rate of 50% with a significant change in ESS and the non-significant changes in cephalometric parameters. Conclusion: Transoral endoscopic posterior midline partial glossectomy can improve the surgical outcomes of obstructive sleep apnea patients.

scholarly journals Frequency of Mortality in Patients with Post-Partum Eclampsia-A Study at Liaquat University Hospital, Hyderabad, Sindh, India

2019 ◽  
Vol 7 (03) ◽  
Author(s):  
Almas Almas ◽  
Naushaba Rizwan ◽  
Syed Farhan Uddin
Keyword(s):  
Post Partum ◽  
Case Series ◽  
University Hospital ◽  
Study Patient ◽  
Inclusion Criteria ◽  
Risks And Benefits ◽  
Number Of Patients ◽  
Case Series Study ◽  
Patient Will ◽  
Series Study

Postpartum preeclampsia is the occurrence of hypertension and proteinuria after delivery. Preeclampsia plus seizures after delivery is defined as postpartum eclampsia. Objective: To determine the frequency of mortality in patients with post-partum eclampsia; To determine the obstetrical factors leading to maternal mortality in patient with postpartum eclampsia. Methodology: The descriptive case series study was carried out in the department of Department of obstetrics and gynecology LUMHS Hospital Hyderabad from 1st January 2018 to 30 June 2018. All patients who fulfilled the inclusion criteria were included in the study. Informed consent was taken after explaining the procedure, risks and benefits of the study. All patients of postpartum eclampsia with increase blood pressure and proteinuria admitted through out-patient department or emergency within 48 hours of delivery will be included in the study. Patient will be followed for 10 days. All the collected data were entered into the proforma attached at the end. Results: Mean ± SD of age was 27.88±7.77 with C.I (27.02…….28.74) years. Mean ± SD of systolic B.P and urine protein was 161.46±22.09 mmhg and 1432.59±967.33 mg respectively. Out of 369 was occurred mortality in 190 (60%) women. Conclusion: It is to be concluded that mortality is most in eclampctic women followed by patients with Pre-eclampsia. However a study design comprising multiple centers, and a higher number of patients over a longer period of time will be more representative.

scholarly journals Evaluation of Children with COVİD-19 in the First Month of the Outbreak in Turkey; Initial Pediatric Data from a Tertiary Hospital

2021 ◽  
Author(s):  
Aybüke Akaslan Kara ◽  
Elif Kıymet ◽  
Elif Böncüoğlu ◽  
Şahika Şahinkaya ◽  
Ela Cem ◽  
...  
Keyword(s):  
Medical Records ◽  
Age Groups ◽  
Case Series ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Republic Of China ◽  
Training And Research ◽  
Polymerase Chain ◽  
The City

Objective: SARS-CoV-2, emerged in December 2019 in the city of Wuhan in the People’s Republic of China affects children as well as all age groups. The aim of the study was to evaluate the clinical features and outcomes of pediatric cases with COVID-19 in the first month of the epidemic in Turkey. Method: This single center cross-sectional study was conducted in University of Health Sciences Dr Behçet Uz Child Diseases and Pediatric Surgery Training and Research Hospital during the period of March 11 – April 20, 2020. Demographic, epidemiological and clinical data were collected from medical records. All patients were confirmed by real time reverse transcription- polymerase chain reaction. Chidren were classified as asymptomatic, mild, moderate, severe, and critically ill patients. Results: In this study, we reported the clinical characteristics of a case series involving 30 chilren with COVID-19 aged from 23 days to 16 years. Twenty-nine (96.7%) patients had confirmed contact with family members for COVİD-19. The majority of patients were asymptomatic (50%) or had mild symptoms (26.7%). Fever (46.6%) and cough (33.3%) were the most common symptoms. Conclusion: Our study indicated that COVID 19 in children exhibited less severe symptoms and had better outcomes

scholarly journals Adverse drug reactions in SARS-CoV-2 hospitalised patients: a case-series with a focus on drug–drug interactions

2020 ◽  
Author(s):  
Giada Crescioli ◽  
Valentina Brilli ◽  
Cecilia Lanzi ◽  
Andrea Burgalassi ◽  
Alessandra Ieri ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Case Series ◽  
University Hospital ◽  
Drug Reactions ◽  
Case Evaluation ◽  
Hospitalised Patients ◽  
Number Of Patients ◽  
Case Series Study ◽  
Caucasian Patients ◽  
Series Study

AbstractDue to the need of early and emergency effective treatments for COVID-19, less attention may have been paid to their safety during the global emergency. In addition, characteristics of drug–drug interaction (DDI)-related adverse drug reactions (ADRs) in COVID-19 patients have not yet been studied in depth. The aim of the present case-series study is to describe clinical and pharmacological characteristics of SARS-CoV-2 hospitalised patients, focusing on ADRs, particularly those related to DDIs. We evaluated all reports of COVID-19 medication-related ADRs collected within the COVID-19 Units of Careggi University Hospital, Florence (Italy), between January 1st and 31st May 2020. Information regarding COVID-19 medications, patients’ demographic and clinical characteristics, concomitant drugs, ADRs description and outcome, were collected. Each case was evaluated for the causality assessment and to identify the presence of DDIs. During the study period, 23 Caucasian patients (56.5% males, mean age 76.1 years) experienced one or more ADRs. The majority of them were exposed to polypharmacy and 17.4% presented comorbidities. ADRs were referred to cardiovascular, psychiatric and gastrointestinal disorders. The most frequently reported preferred term was QT prolongation (mean QT interval 496.1 ms). ADRs improved or resolved completely in 60.8% of cases. For all patients, a case-by-case evaluation revealed the presence of one or more DDIs, especially those related to pharmacokinetic interactions. Despite the small number of patients, our evidence underline the clinical burden of DDIs in SARS-CoV-2 hospitalised patients and the risk of unexpected and uncommon psychiatric ADRs.

scholarly journals FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study

2011 ◽  
Vol 1 (1) ◽  
pp. 21 ◽  
Author(s):  
MaryAnn Zhang ◽  
Raymond Hsu ◽  
Chi-yuan Hsu ◽  
Kristina Kordesch ◽  
Erica Nicasio ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Case Series ◽  
Kidney Injury ◽  
Cross Sectional ◽  
Case Series Study ◽  
Fgf 23 ◽  
Series Study
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