scholarly journals Risk Factors for Perioperative Hemodynamic Instability in Pheochromocytoma: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (19) ◽  
pp. 4531
Author(s):  
Fumihiko Urabe ◽  
Shoji Kimura ◽  
Kosuke Iwatani ◽  
Kazuhiro Takahashi ◽  
Kagenori Ito ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Confidence Interval ◽  
Systematic Reviews ◽  
Tumor Size ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Hemodynamic Instability ◽  
Cochrane Library ◽  
The Cochrane Library

Objective: To evaluate the risk factors of perioperative hemodynamic instability in pheochromocytoma, we conducted a systematic search of the literature using the Preferred Reporting Items for Systematic Reviews and Meta-analysis. Methods: In April 2021, we systematically searched PubMed, the Cochrane library, and Scopus for relevant studies on the risk factors of perioperative hemodynamic instability of adrenalectomy in patients with pheochromocytoma, and we subjected the findings from those studies to formal meta-analysis. Results: Our systematic review identified 14 studies involving 1725 patients, of which nine studies with 967 patients were eligible for meta-analysis. The results of meta-analysis showed that tumor size (odds ratio (OR): 1.14 for each increased cm, 95% confidence interval (CI) 1.03–1.26, z = 2.57) and urinary norepinephrine (OR, 1.51: 95% CI 1.26–1.81; z = 4.50) were most closely associated with the occurrence of perioperative hemodynamic instability. Conclusion: These findings suggest that tumor size and urinary norepinephrine are important predictors and risk factors for perioperative hemodynamic instability in adrenalectomy for pheochromocytoma. Such findings may be of value to surgeons and anesthesiologists when considering or preparing for this procedure.

scholarly journals Risk factors for new ischaemic cerebral lesions after carotid artery stenting: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030025 ◽  
Author(s):  
Yao Feng ◽  
Long Li ◽  
Xuesong Bai ◽  
Tao Wang ◽  
Yanfei Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Carotid Artery ◽  
Systematic Reviews ◽  
Carotid Artery Stenting ◽  
Meta Analysis ◽  
Primary Data ◽  
Occurrence Rate ◽  
Cochrane Library ◽  
Cerebral Lesions

IntroductionNew ischaemic cerebral lesions (NICL) detected by diffusion-weighted imaging MRI are common after carotid artery stenting (CAS), with an occurrence rate ranging from 18% to 57%. Many studies reported occurrence of NICL could increase risk of future cerebrovascular events and cognitive impairment. However, controversies about determinants for occurrence of NICL after CAS exist among studies, and one risk factor embodied in an article may not be in another. Aim of this study is to introduce a protocol for a systematic review and meta-analysis to identify risk factors associated with occurrence of NICL after CAS.Methods and analysisAll relevant literature referring to risk factors for occurrence of NICL after CAS will be searched on the major databases, such as PubMed, Embase, Web of Science and the Cochrane Library until 31 December 2018. Literature, which must be randomised controlled trials, case–control studies or cohort studies, will be included in accordance with the prespecified eligibility criteria. The risk of bias will be assessed using the Cochrane Collaboration criteria and the quality of evidence will be assessed with the corresponding scale. Data will be extracted with a form prepared before and analysed using RevMan V.5.3 analyses software. Heterogeneity will be assessed using I2statistic. Our systematic review will be performed according to the guidance from the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.Ethics and disseminationThere is no need for ethical approval because primary data will not be attained. The systematic review will be presented at international conferences and published in peer-reviewed journals.PROSPERO registration numberCRD42019121129

scholarly journals Incidence of injuries and illness and related risk factors in mountain biking events: A systematic review protocol

2020 ◽  
Author(s):  
Kim Buchholtz ◽  
Mike Lambert ◽  
Theresa Burgess
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Narrative Analysis ◽  
Meta Analysis ◽  
Sports Injury ◽  
Cochrane Library ◽  
Mountain Biking ◽  
True Incidence ◽  
Related Risk ◽  
The Cochrane Library

Abstract Background Cycling is a popular sport and method of transportation globally but is a significant contributor to sports injury admissions in hospital emergency units. Mountain biking events present additional challenges with remote venues, and isolated courses. Most mountain biking events will provide on-site medical care for both injury and illness occurring during races. These data are essential to understand the true incidence of injury and illness in mountain biking events as national health data may not represent these unique events specifically. Methods This review will follow the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. Search engines PubMed, Scopus, SPORTDiscus (EBSCOhost), PEDro and the Cochrane Library will be systematically searched. Gray literature searches of Google Scholar and manual searching of reference lists and congress abstracts from cycling specific congresses will be conducted. Journal articles documenting illness and injury in adults participating in mountain bike cross-country marathon events will be included. A narrative analysis of the types, severity and area of injuries; and illness type and severity will be performed. A quantitative analysis may be performed should there be sufficient studies reported in the same format. Discussion This protocol outlines a systematic review on injury and illness in mountain biking events. Data from hospital records may not adequately represent the burden of injury and illness at events held in remote venues, especially if those treated on site do not require further hospital based treatment. This review will assist with the development of further research in this area, and in preparation of clinicians working in these types of events. Systematic review registration: This protocol has been registered with PROSPERO International prospective register of systematic reviews (No: CRD42019134586).

scholarly journals Efficacy of Transparent vs. Pressure Dressing in Prevention of Post-Cardiac Catheterization Pain, Discomfort and Hematoma: A Systematic Review and Meta-analysis of RCTs

2021 ◽  
Vol 10 (2) ◽  
pp. 103-110
Author(s):  
Suresh K Sharma ◽  
Kalpana Thakur ◽  
Shiv K Mudgal ◽  
Barun Kumar
Keyword(s):  
Systematic Review ◽  
Confidence Interval ◽  
Cardiac Catheterization ◽  
Odds Ratio ◽  
English Language ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Significant Difference ◽  
Pressure Dressing

ABSTRACT Introduction: There is lack consensus on superiority of transparent vs. pressure dressing for prevention of post-cardiac catheterization pain, discomfort and hematoma. Therefore, we conducted this systematic review and meta-analysis of available RCTs on this subject. Methods: We performed a systematic search of RCTs published between in 2000-2019 in English language using databases including PubMed Medline, EMBASE, CINAHL, Cochrane Library, ERMED Journals, Clinical trials database, DELNET, Google Scholar and Discovery Search. Studies conducted on adult patients with femoral dressing after cardiac catheterization measuring pain, discomfort, hematoma as intended outcomes have been included. Data extraction, critical appraisal, assessment of risk bias was done and decisions on quality were made on mutual consensus. Mantel-Haenszel (MH) and odds ratio for dichotomous variables was calculated by Review Manager 5.3 software. Results: Out of all identified studies, only 5 studies comprising 664 patients fulfilled the inclusion criteria and met the quality assessment. Incidence of discomfort (25, 333) were significantly less in transparent dressing group as compared to pressure dressing group (149, 331); odds ratio 0.10, 95% confidence interval [CI] 0.06-0.15; I2 = 0%, P= 0.00. Four studies reported significantly lower number of pain cases in transparent dressing (17, 203) as compared to pressure dressing (57, 201); odds ratio 0.13, 95% confidence interval [CI] 0.03-0.59; I2 = 47%, P= 0.01). However, incidence of hematoma did not reveal any significant difference between two groups. Conclusion: Transparent dressing is a better option in patients with femoral/groin dressing after cardiac catheterization as it is more effective in prevention of pain and discomfort.

scholarly journals Accuracy of Ultrasound in Diagnosis of Pneumothorax: A Comparison between Neonates and Adults—A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Hamid Dahmarde ◽  
Fateme Parooie ◽  
Morteza Salarzaei
Keyword(s):  
Systematic Review ◽  
Confidence Interval ◽  
Odds Ratio ◽  
English Language ◽  
Meta Analysis ◽  
Diagnostic Odds Ratio ◽  
World Health ◽  
Cochrane Library ◽  
Chest Ultrasonography ◽  
Link Type

Objective. The present systematic review and meta-analysis were conducted to investigate the accuracy of ultrasound in the diagnosis of pneumothorax in neonates and adults. Method. The searches were conducted by two independent researchers (MS and HD) to find the relevant studies published from 01/01/2009 until the end of 01/01/2019. We searched for published literature in the English language in MEDLINE via PubMed, Embase™ via ovid, the Cochrane Library, and Trip database. For literature published in other languages, we searched national databases (Magiran and SID), KoreaMed, and LILACS, and we searched OpenGrey (http://www.opengrey.eu/) and the World Health Organization Clinical Trials Registry (http://who.int/ictrp) for unpublished literature and ongoing studies. The keywords used in the search strategy were pneumothorax or ultrasound or chest ultrasonography or neonate or adult or aerothorax or sensitivity or specificity or diagnostic accuracy. The list of previous study resources and systematic reviews was also searched for identifying the published studies (MS and HD). Analyses were performed using Meta-Disc 1.4. Results. In total, 1,565 patients (255 neonates, 1212 adults, and 101 pediatrics suspected of pneumothorax) were investigated in 10 studies. The overall specificity of chest ultrasound in the diagnosis of pneumothorax in both populations of adults and neonates was 85.1% at the confidence interval of 95 percent (95% CI 81.1%–88.5%). At the confidence interval of 95 percent, the sensitivity was 98.6% (95% CI 97.7%–99.2%). The diagnostic odds ratio was 387.72 (95% CI 76.204–1972.7). For the diagnosis of pneumothorax in neonates, the ultrasound sensitivity was 96.7% at the confidence interval of 95 percent (95% CI 88.3%–99.6%). At the confidence interval of 95 percent, the specificity was 100% (95% CI 97.7%–100%). For the diagnosis of pneumothorax in adults, the ultrasound sensitivity was 82.9% at the confidence interval of 95 percent (95% CI 78.3–86.9%). At the confidence interval of 95 percent, the specificity was 98.2% (95% CI 97.0%–99.0%). The diagnostic odds ratio was 423.13 (95% CI 45.222–3959.1). Analyzing studies indicated that the sensitivity of “absence lung sliding” sign for the diagnosis of pneumothorax was 87.2% (95% CI 77.7–93.7), and specificity was 99.4% (95% CI 96.5%–100%). DOR was 556.74 (95% CI 100.03–3098.7). The sensitivity of “lung point” sign for the diagnosis of pneumothorax was 82.1% (95% CI 71.7%–89.8%), and the specificity was 100% (at the confidence interval of 95% CI 97.6%–100%). DOR was 298.0 (95% CI 58.893–1507.8). Conclusion. The diagnosis of pneumothorax using ultrasound is accurate and reliable; additionally, it can result in timely diagnoses specifically in neonatal pneumothorax. Using this method facilitates the therapy process; lack of ionizing radiation and easy operation are benefits of this imaging technique.

scholarly journals Incidence of injuries and illness and related risk factors in mountain biking events: A systematic review protocol

2020 ◽  
Author(s):  
Kim Buchholtz ◽  
Mike Lambert ◽  
Theresa Burgess
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Narrative Analysis ◽  
Meta Analysis ◽  
Sports Injury ◽  
Cochrane Library ◽  
Mountain Biking ◽  
True Incidence ◽  
Related Risk ◽  
The Cochrane Library

Abstract Background Cycling is a popular sport and method of transportation globally but is a significant contributor to sports injury admissions in hospital emergency units. Mountain biking events present additional challenges with remote venues, and isolated courses. Most mountain biking events will provide on-site medical care for both injury and illness occurring during races. These data are essential to understand the true incidence of injury and illness in mountain biking events as national health data may not represent these events specifically. Methods This review will follow the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. Search engines PubMed, Scopus, CINAHL (EBSCOhost), PEDro and the Cochrane Library will be systematically searched. Gray literature searches of Google Scholar and manual searching of reference lists and congress abstracts from cycling specific congresses will be conducted. Journal articles documenting illness and injury in adults participating in mountain bike cross-country marathon events will be included. A narrative analysis of the types, severity and area of injuries; and illness type and severity will be performed. A quantitative analysis will be performed should there be sufficient studies reported in the same format. Discussion This protocol outlines a systematic review on injury and illness in mountain biking events. Data from hospital records may not adequately represent the burden of injury and illness at events held in remote venues, especially if those treated on site do not require further hospital based treatment. This review will assist with the development of further research in this area, and in preparation of clinicians working in these types of events. Systematic review registration: This protocol has been registered with PROSPERO International prospective register of systematic reviews (No: CRD42019134584).

scholarly journals Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Kiarash Tanha ◽  
Azadeh Mottaghi ◽  
Marzieh Nojomi ◽  
Marzieh Moradi ◽  
Rezvan Rajabzadeh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Ovarian Cancer ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Uterine Cancer ◽  
Cochrane Library ◽  
P Value ◽  
Prevention Measures ◽  
Coffee Intake

AbstractFollowing cervical and uterine cancer, ovarian cancer (OC) has the third rank in gynecologic cancers. It often remains non-diagnosed until it spreads throughout the pelvis and abdomen. Identification of the most effective risk factors can help take prevention measures concerning OC. Therefore, the presented review aims to summarize the available studies on OC risk factors. A comprehensive systematic literature search was performed to identify all published systematic reviews and meta-analysis on associated factors with ovarian cancer. Web of Science, Cochrane Library databases, and Google Scholar were searched up to 17th January 2020. This study was performed according to Smith et al. methodology for conducting a systematic review of systematic reviews. Twenty-eight thousand sixty-two papers were initially retrieved from the electronic databases, among which 20,104 studies were screened. Two hundred seventy-seven articles met our inclusion criteria, 226 of which included in the meta-analysis. Most commonly reported genetic factors were MTHFR C677T (OR=1.077; 95 % CI (1.032, 1.124); P-value<0.001), BSML rs1544410 (OR=1.078; 95 %CI (1.024, 1.153); P-value=0.004), and Fokl rs2228570 (OR=1.123; 95 % CI (1.089, 1.157); P-value<0.001), which were significantly associated with increasing risk of ovarian cancer. Among the other factors, coffee intake (OR=1.106; 95 % CI (1.009, 1.211); P-value=0.030), hormone therapy (RR=1.057; 95 % CI (1.030, 1.400); P-value<0.001), hysterectomy (OR=0.863; 95 % CI (0.745, 0.999); P-value=0.049), and breast feeding (OR=0.719, 95 % CI (0.679, 0.762) and P-value<0.001) were mostly reported in studies. Among nutritional factors, coffee, egg, and fat intake significantly increase the risk of ovarian cancer. Estrogen, estrogen-progesterone, and overall hormone therapies also are related to the higher incidence of ovarian cancer. Some diseases, such as diabetes, endometriosis, and polycystic ovarian syndrome, as well as several genetic polymorphisms, cause a significant increase in ovarian cancer occurrence. Moreover, other factors, for instance, obesity, overweight, smoking, and perineal talc use, significantly increase the risk of ovarian cancer.

scholarly journals Risk Factors for Tumor Size Increase During Active Surveillance of Papillary Thyroid Cancer: Meta-Analysis and Systematic Review

2021 ◽  
Vol 64 (12) ◽  
pp. 914-921
Author(s):  
Doh Young Lee ◽  
Pilkeun Jang
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Active Surveillance ◽  
Tumor Size ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Size Increase ◽  
Papillary Thyroid

Background and Objectives The purpose of this study was to systematically review literatures on active surveillance for low-risk differentiated thyroid cancer, and to evaluate risk factors for tumor size increase during active surveillance.Subjects and Method We conducted a systematic review and a meta-analysis of studies reporting on tumor growth during active surveillance of papillary thyroid cancer. Using the MEDLINE and EMBASE databases, we searched studies published from the inception of database to December 2020. Studies were included if reported on at least one clinical risk parameter in addition to reporting on the change in tumor size during active surveillance.Results Out of 33 studies screened, seven were included in the meta-analysis. The odds ratio of a temporal size increase of more than 3 mm in papillary thyroid cancer was 0.011 person-years (95% confidence interval [CI]: 0.009 to 0.013). The odds ratio of lymph node metastasis was 0.002 person-years (95% CI: 0.001 to 0.003). Younger age was a significant risk factor for tumor growth during active surveillance, with a standardized median difference of -0.63 (95% CI: -1.00 to -0.27). In the three studies that evaluated the association of thyroid-stimulating hormone levels and tumor size, the results were contradictory.Conclusion Active surveillance may be used more cautiously for younger patients.

Warming Acupuncture in the Treatment of Cervical Spondylotic Radiculopathy: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Wang Zuqing ◽  
Li Yan
Keyword(s):  
Systematic Review ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Effective Rate ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Vas Score ◽  
Cervical Spondylotic Radiculopathy ◽  
The Cochrane Library

Background: Warming acupuncture (WA) is widely used in the management of Cervical spondylotic radiculopathy (CSR)in China and obtains desirable efficacy. Therefore, the aim of this study is to systematically assess the efficacy and safety whether using WA alone or combined with traditional Chinese medicine (TCM) therapy for the treatment of CSR. <br><br> Methods: PubMed, EMBASE, Sinomed, the Cochrane Library, CNKI, VIP and Wangfang databases were searched from their inception through 30 September 2020. All the retrieved records were screened or excluded based on the criteria that were pre-established, and the results that meet the criteria were assessed by the Cochrane risk of bias tool and Meta-analysis was conducted by using RevMan5.3 software. <br><br> Results: Fourteen RCTs (1021patients) were included in the meta-analysis. The effective rate of WA alone or combination with TCM therapy was analyzed in comparison with the treatment of regular therapy. The results indicated that compared with regular therapy, WA alone or in combination with TCM therapy increased clinical effective rate (Odds ratio (OR)=4.43,95%CI 2.85 to 6.90, P<0.01). Additionally decreased VAS score (mean difference (MD)=-1.21,95%CI -1.68 to -0.73, P<0.01), PPI (MD=-1.34, 95% CI -2.08 to -0.61) and PRI (MD=-0.55,95% CI -0.72 to -0.37, P<0.001). However, adverse events of WA were not specially reported in all studies. <br> Conclusions: WA as the main treatment for CSR can improve the clinical effective rate and reduce the level of VAS score, PPI and PRI. Further research is needed to determine the effectiveness of WA for CSR treatment, rigorously and unambiguously.

scholarly journals Efficacy of Acupuncture and Related Techniques on Delirium: Protocol of a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Sulan Tan ◽  
Yu Zhang ◽  
Yiping Bai ◽  
Shuting Yang ◽  
Liming Luan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Guideline Development ◽  
Meta Analysis ◽  
Length Of Hospital Stay ◽  
Cochrane Library ◽  
Major Surgery ◽  
Cochrane Central Register ◽  
Statistical Heterogeneity ◽  
The Cochrane Library

Abstract Background: Delirium, contributing to subsequent increased morbidity and mortality, is common in hospitalized patients, especially in patients undergoing major surgery. Published systematic reviews suggest that certain medications for delirium management may decrease pain scores and analgesic requirements, at the expense of troublesome side effects. People are urgently seeking non-medication strategies for delirium. Acupuncture and related techniques (ART) are increasingly used to provide medical care and have potential to prevent delirium, however, the efficacy of ART on delirium remains controversial.Methods: In accordance with the PRISMA-P guidelines, we will search PubMed, Embase, the Cochrane Library (Cochrane Central Register of Controlled Trials (CENTRAL)), Web of Science, Medline and the Cochrane Library for clinical trials on ART use in people, without language restrictions. The incidence of delirium will be defined our primary outcome. Additional outcomes will be the incidence of adverse events, pain score, consumption of analgesics, number of cumulative delirious days, hemodynamics, length of hospital stay. Two researchers independently complete further review work and data abstraction based on pre-specified inclusion and exclusion criteria. Any discrepancy will be solved by negotiation or a third investigators. Cochrane Risk of Bias tool will be used to assess the methodological quality of all the studies that are finally included. Statistical heterogeneity was assessed by forest plots, confidence intervals (CI) and I² statistic. If feasible, a meta-analysis of included results will be performed.Conclusions: This protocol will be favorable to bridge the gap between non-medication strategies and clinical diseases, and potential to help future guideline development in management of preventing delirium.Systematic review registration: The protocol was prospectively registered on the homepage of the International Prospective Register of Systematic Reviews (PROSPERO): https://www.crd.york.ac.uk/PROSPERO.

Serological biomarkers as risk factors of SLE-associated pulmonary arterial hypertension: a systematic review and meta-analysis

Lupus ◽  
2017 ◽  
Vol 26 (13) ◽  
pp. 1390-1400 ◽  
Author(s):  
J Wang ◽  
J Qian ◽  
Y Wang ◽  
J Zhao ◽  
Q Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Pulmonary Arterial Hypertension ◽  
Confidence Interval ◽  
Arterial Hypertension ◽  
Early Recognition ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Pulmonary Arterial ◽  
Serological Biomarkers

Objective This article aims to determine the serological biomarkers which can be considered as risk factors of systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension by a systematic review and meta-analysis. Methods This study was conducted in accordance with the PRISMA statement. The search database included MEDLINE, EMBASE, Cochrane Library and Scopus. The Newcastle–Ottawa scale was used for the quality assessment. The odds ratio was the primary measure of effect of the risk factors. Results Twelve studies were included in this meta-analysis. The results identified the anti-RNP antibody and anti-Sm antibody as risk factors for SLE-associated pulmonary arterial hypertension with the pooled odds ratios 3.68 (95% confidence interval 2.04–6.63, P < 0.0001) and 1.71 (95% confidence interval 1.06–2.76, P = 0.03), respectively. Conclusion Pulmonary arterial hypertension is a serious complication of SLE with a worse prognosis than SLE patients without pulmonary arterial hypertension. The early recognition of pulmonary arterial hypertension with transthoracic echocardiography routinely performed in SLE patients with risk factors is necessary, especially in Asian patients.

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