scholarly journals Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART

2021 ◽  
Vol 10 (22) ◽  
pp. 5455
Author(s):  
Biagio Castaldi ◽  
Gloria Lanzoni ◽  
Osvalda Rampon ◽  
Daniele Donà ◽  
Angela Di Candia ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Young Adults ◽  
Cardiovascular Risk ◽  
Global Longitudinal Strain ◽  
Mean Value ◽  
Adolescents And Young Adults ◽  
Abdominal Aneurysm ◽  
Bilateral Carotid ◽  
Subclinical Cardiovascular Disease

Background: HIV infection and lifelong cART are responsible of an increase in cardiovascular risk. The aim of this study was to describe the subclinical cardiovascular disease and to identify early markers of cardiovascular damage in adolescents and young adults vertically infected with HIV on cART, through an innovative multi-parametric approach. Methods: We enrolled 52 patients vertically infected with HIV. Demographic records, traditional cardiovascular risk factors, laboratory findings and echocardiographic measurements were collected in a one-year routine follow up. The echocardiographic examination included measurements of the 2D and 3D ejection fraction (EF), E/A ratio, E/E′ ratio, carotid intima media thickness (cIMT), flow-mediated dilation (FMD) and global longitudinal strain (GLS). Results: At the time of enrolment, all the patients were on cART therapy. The viral load was suppressed in 95% of them. EF was normal in 94.2% of patients (66 ± 7.2%), and GLS (mean value: −20.0 ± 2.5%) was reduced in 29% of patients. The cIMT mean value was higher than the 95th centile for sex and age in 73%, and FMD was impaired in 45% of patients. Clinically evident disease was found in three patients: dilative cardiomyopathy in one, thoracic-abdominal aneurysm Crawford type II with a bilateral carotid dilation in one and carotid plaque with 30% of stenosis in a third patient. Conclusions: This study confirms the presence of clinical and subclinical cardiovascular disease in a very young population vertically infected with HIV, underlining the importance of an early, multi-parametric cardiovascular follow up.

scholarly journals The natural course of DSM-IV somatoform disorders and syndromes among adolescents and young adults: a prospective-longitudinal community study

2002 ◽  
Vol 17 (6) ◽  
pp. 321-331 ◽  
Author(s):  
Roselind Lieb ◽  
Petra Zimmermann ◽  
Robert H Friis ◽  
Michael Höfler ◽  
Sven Tholen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Young Adults ◽  
Somatoform Disorders ◽  
Epidemiologic Study ◽  
Natural Course ◽  
Adolescents And Young Adults ◽  
Prospective Longitudinal ◽  
Over Time

SummaryObjective.Although somatoform disorders are assumed to be chronic clinical conditions, epidemiological knowledge on their natural course based on representative samples is not available.Method.Data come from a prospective epidemiologic study of adolescents and young adults in Munich, Germany. Respondents’ diagnoses (N = 2548) at baseline and follow-up on average 42 months later are considered. The follow-up incidence, stability as well as selected baseline risk factors (sociodemographics, psychopathology, trauma exposure) for the incidence and stability of somatoform disorders and syndromes are prospectively examined. Diagnostic information was assessed by using the standardized Munich-Composite International Diagnostic Interview (M-CIDI).Results.Over the follow-up period, incidence rate for any of the covered somatoform diagnoses was 25.7%. Stability for the overall group of any somatoform disorder/syndrome was 48%. Female gender, lower social class, the experience of any substance use, anxiety and affective disorder as well as the experience of traumatic sexual and physical threat events predicted new onsets of somatoform conditions, while stability was predicted by being female, prior existing substance use, affective and eating disorders as well as the experience of a serious accident.Conclusions.At least for a substantial proportion of individuals, the overall picture of somatization seems to be relatively stable, but with fluctuation in the symptom picture over time. Being female, the experience of substance use as well as anxiety disorder seem to constitute risk factors for the onset of new somatoform conditions as well as for a stable course over time.

scholarly journals Examining the Association and Directionality between Mental Health Disorders and Substance Use among Adolescents and Young Adults in the U.S. and Canada—A Systematic Review and Meta-Analysis

2018 ◽  
Vol 7 (12) ◽  
pp. 543 ◽  
Author(s):  
Sarvenaz Esmaeelzadeh ◽  
John Moraros ◽  
Lilian Thorpe ◽  
Yelena Bird
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Substance Use ◽  
Young Adults ◽  
Meta Analysis ◽  
Mental Health Disorders ◽  
Adolescents And Young Adults ◽  
Health Disorders ◽  
The U.S

Background: The purpose of this systematic review was to examine the association and directionality between mental health disorders and substance use among adolescents and young adults in the U.S. and Canada. Methods: The following databases were used: Medline, PubMed, Embase, PsycINFO, and Cochrane Library. Meta-analysis used odds ratios as the pooled measure of effect. Results: A total of 3656 studies were screened and 36 were selected. Pooled results showed a positive association between depression and use of alcohol (odds ratio (OR) = 1.50, 95% confidence interval (CI): 1.24–1.83), cannabis (OR = 1.29, 95% CI: 1.10–1.51), and tobacco (OR = 1.65, 95% CI: 1.43–1.92). Significant associations were also found between anxiety and use of alcohol (OR = 1.54, 95% CI: 1.19–2.00), cannabis (OR = 1.36, 95% CI: 1.02–1.81), and tobacco (OR = 2.21, 95% CI: 1.54–3.17). A bidirectional relationship was observed with tobacco use at baseline leading to depression at follow-up (OR = 1.87, CI = 1.23–2.85) and depression at baseline leading to tobacco use at follow-up (OR = 1.22, CI = 1.09–1.37). A unidirectional relationship was also observed with cannabis use leading to depression (OR = 1.33, CI = 1.19–1.49). Conclusion: This study offers insights into the association and directionality between mental health disorders and substance use among adolescents and young adults. Our findings can help guide key stakeholders in making recommendations for interventions, policy and programming.

Effects of Secondhand Smoke Exposure and Noise Exposure on Tinnitus Occurrence in College Students and Adolescents

2019 ◽  
Author(s):  
Laurel Elise Money ◽  
Ishara Ramkissoon
Keyword(s):  
Risk Factors ◽  
College Students ◽  
Young Adults ◽  
Secondhand Smoke ◽  
Noise Exposure ◽  
Adolescents And Young Adults ◽  
Chi Square ◽  
Main Effect ◽  
Shs Exposure

Background: Recent research indicated that young adults and adolescents reported tinnitus in highernumbers than previously. Thus, it is important to fully investigate risk factors for tinnitus in adolescentsand young adults.<br />Purpose: The current study examined the influence of two environmental risk factors, secondhandsmoke (SHS) exposure and noise exposure on tinnitus occurrence as self-reported by U.S. adolescentsand young adults.<br />Research Design: A nonexperimental, cross-sectional design was used for this survey study.<br />Study Sample: Of 265 surveys received, 43 were excluded due to ineligibility. The remaining 222 surveysconstituted the study sample. Participant respondents included 80 high school students (ages14–17) and 142 college students (ages 18–30). The sample was primarily female (n = 160).<br />Data Collection and Analysis: Three (3) yes/no survey questions regarding SHS exposure, noise exposure,and tinnitus occurrence were analyzed. Statistical analyses included logistic regression, chisquarefollow-up tests, and Pearson bivariate correlation analysis.<br />Results: Results revealed that 40 percent of young adults and adolescents surveyed reported that they experiencedtinnitus. Regression analysis revealed significant main effects for noise (p = 0.004), gender (p =0.017), and the interaction of SHS and noise (p = 0.001). There was no main effect of SHS exposurenor age on tinnitus occurrence. Follow-up chi-square analysis conducted to probe the gender effectrevealed that females (45.1 percent) were more likely to experience tinnitus than males (27.7 percent). Chi-squaretesting to examine the significant interaction effect revealed statistical significance (p = 0.001) for individualswith reported noise exposure but not for individuals without noise exposure. In the noise-exposedgroup, individuals who also reported SHS exposure had a lower occurrence of tinnitus (23.6 percent). In contrast,the noise-exposed individuals without SHS exposure had a higher prevalence of tinnitus (57.9 percent).An additional chi-square follow-up analysis to examine the main effect of noise revealed no significance(p = 0.199). However, there was a significant (p < 0.01) negative correlation (r = –0.244) of noise exposurewith age.<br />Conclusion: The current study results suggest there is a higher than expected report of tinnitus incidencein adolescents and young adults. The relationship between tinnitus occurrence and a combinedexposure to noise and secondhand smoke revealed a unique effect in adolescents and young adults.<br />

69. A Quality Improvement Project to Increase Larc Follow-Up for Adolescents and Young Adults

2020 ◽  
Vol 66 (2) ◽  
pp. S36
Author(s):  
Sarah Pitts ◽  
Carly Milliren ◽  
Grace Berg ◽  
Danielle McPeak ◽  
Amy DiVasta
Keyword(s):  
Young Adults ◽  
Quality Improvement ◽  
Quality Improvement Project ◽  
Adolescents And Young Adults ◽  
Improvement Project

scholarly journals HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Monika Hunjadi ◽  
Claudia Lamina ◽  
Patrick Kahler ◽  
Tamara Bernscherer ◽  
Jorma Viikari ◽  
...  
Keyword(s):  
Young Adults ◽  
Cardiovascular Risk ◽  
Cholesterol Efflux ◽  
Subclinical Atherosclerosis ◽  
Structure And Function ◽  
Risk Markers ◽  
Arterial Structure ◽  
And Function ◽  
Young Finns Study

Abstract The atherogenic process begins already in childhood and progresses to symptomatic condition with age. We investigated the association of cholesterol efflux capacity (CEC) and vascular markers of subclinical atherosclerosis in healthy, young adults. CEC was determined in 2282 participants of the Young Finns study using cAMP treated 3H-cholesterol-labeled J774 cells. The CEC was correlated to baseline and 6-year follow-up data of cardiovascular risk factors and ultrasound measurements of arterial structure and function. CEC was higher in women, correlated with total cholesterol, HDL-C, and apolipoprotein A-I, but not with LDL-C or apolipoprotein B. Compared to the lowest CEC quartile, the highest CEC quartile was significantly associated with high CRP levels and inversely associated with adiponectin. At baseline, high CEC was associated with decreased flow-mediated dilation (FMD) and carotid artery distensibility, as well as an increased Young's modulus of elasticity, indicating adverse changes in arterial structure, and function. The association reversed with follow-up FMD data, indicating the interaction of preclinical parameters over time. A higher CEC was directly associated with a lower risk of subclinical atherosclerosis at follow-up. In young and healthy subjects, CEC was associated with important lipid risk parameters at baseline, as in older patients and CAD patients, but inversely with early risk markers for subclinical atherosclerosis.

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