Factors Influencing the Improvement of Activities of Daily Living during Inpatient Rehabilitation in Newly Diagnosed Patients with Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor. To identify the factors influencing the improvement of the activities of daily living (ADL) in newly diagnosed patients with GBM, we investigated the characteristics and variable factors and overall survival. A total of 105 patients with GBM were retrospectively analyzed and categorized into the following three groups according to the quartile of change of their Barthel index score from admission to discharge: deterioration (n = 25), no remarkable change (n = 55), and good recovery (n = 25). A statistical difference was observed in the pre-operative, intra-operative, post-operative, and rehabilitation-related factors between the deterioration and good recovery groups. Multiple regression analysis identified the following significant factors that may influence the improvement of ADL after surgery: the improvement of motor paralysis after surgery, mild fatigue during radio and chemotherapy, and length up to early walking training onset. The median overall survival was significantly different between the deterioration (10.6 months) and good recovery groups (18.9 months, p = 0.025). Our findings identified several factors that may be associated with post-operative functional improvement in patients with GBM. The inpatient rehabilitation during radio and chemotherapy may be encouraged without severe adverse events and can promote functional outcomes, which may contribute to the overall survival of newly diagnosed patients with GBM.

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Factors Influencing the Improvement of Activities of Daily Living During Inpatient Rehabilitation in Newly Diagnosed Patients with Glioblastoma

10.21203/rs.3.rs-764752/v1 ◽

2021 ◽

Author(s):

Keisuke Natsume ◽

Harutoshi Sakakima ◽

Kentaro Kawamura ◽

Akira Yoshida ◽

Shintaro Akihiro ◽

...

Keyword(s):

Overall Survival ◽

Activities Of Daily Living ◽

Daily Living ◽

Karnofsky Performance Status ◽

Performance Status ◽

Tumor Resection ◽

Inpatient Rehabilitation ◽

Newly Diagnosed ◽

Good Recovery ◽

Factors Influencing

Abstract Purpose To identify pre-, intra-, and postoperative factors influencing the improvement of the activities of daily living (ADL) in newly diagnosed patients with glioblastoma (GBM), we investigated the characteristics and variable factors and overall survival. Methods A total of 105 patients with GBM were retrospectively analyzed and categorized into three groups according to the quartile of change of Barthel index score from admission to discharge: deterioration (n = 25), no remarkable change (n = 55), and good recovery (n = 25). We compared with the characteristics, variable factors, and overall survival of patients with deterioration and good recovery after tumor resection. Results There was statistically different in the pre-, intra-, and post-operative factors between the groups. Multiple regression analysis identified four significant predictor variables that may influence the improvement of ADL after surgery: the improvement of motor paralysis after surgery, mild fatigue during chemoradiotherapy, poor Karnofsky performance status at admission, and length up to early walking training onset. The median overall survival was significantly different between the patients with deterioration (10.6 months, 95% CIs, 5.19–16.00) and good recovery (18.9 months, 95% CIs, 8.61–29.18) (p = 0.025). Conclusion This study identified four factors influencing the improvement of ADL after surgery. In addition, a structured inpatient rehabilitation programs can be performed safely and improve functional outcomes, which may contribute to the survival prognosis.

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Glioblastoma Multiforme from Diagnosis to Rehabilitation: a Prospective, Hospital- Based, Case Study of Inpatient Reported Symptoms, Physiotherapy and Functional Improvement

International Journal of Physiotherapy and Research ◽

10.16965/ijpr.2021.102 ◽

2021 ◽

Vol 9 (2) ◽

pp. 3785-3788

Author(s):

Parvez Inamdar ◽

◽

Sameer Shaikh ◽

Darshita Fatnani ◽

Sejal Sathe ◽

...

Keyword(s):

Quality Of Life ◽

Glioblastoma Multiforme ◽

Activities Of Daily Living ◽

Physical Function ◽

Cancer Diagnosis ◽

Daily Living ◽

Survival Rates ◽

Functional Improvement ◽

Patients With Cancer

A physiotherapist treats patients with Glioblastoma multiforme. Glioblastoma multiforme treatment includes chemotherapy, radiotherapy, and surgery, which are being continuously developed and thus increase the survival of patients with a cancer diagnosis. More specifically, 5-year survival rates increase with a cancer diagnosis. Patients with Glioblastoma multiforme have many problems including muscle weakness, pulmonary dysfunction, fatigue, and pain. In the end, patients with cancer tend to have a decline in activities of daily living (ADL) and quality of life (QOL). Additionally, patients often have progressive disease, depression, and anxiety. Physiotherapy often helps patients regain strength and physical function and improve their QOL and independence of daily living that they may have lost due to its treatment. Physiotherapy has an important role in increasing the physical function of Glioblastoma multiforme patients. In the future, physiotherapy may be progressively needed for the management of Glioblastoma multiforme patients. KEYWORDS: Glioblastoma multiforme, Activities of daily living, Quality of Life, Physiotherapy.

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Analysis of Medication Adherence and Its Influencing Factors in Patients with Schizophrenia in the Chinese Institutional Environment

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094746 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4746

Author(s):

Wei Yu ◽

Jie Tong ◽

Xirong Sun ◽

Fazhan Chen ◽

Jie Zhang ◽

...

Keyword(s):

Quality Of Life ◽

Medication Adherence ◽

Activities Of Daily Living ◽

Influencing Factors ◽

Self Efficacy ◽

Daily Living ◽

Institutional Environment ◽

Factors Influencing ◽

Quality Of Life Scale

Background: Factors related to medication adherence in patients with schizophrenia have always been key to the treatment and rehabilitation of these patients. However, the treatment modes in different countries are not the same, and there is no research on the factors influencing medication adherence under different mental health service modes. Objectives: The purpose of this study was to explore medication adherence and its influencing factors in patients with schizophrenia in the Chinese institutional environment. Methods: We conducted a cross-sectional study of hospitalized persons living with schizophrenia from November 2018 to January 2019. A systematic sampling method was used to select 217 hospitalized persons living with schizophrenia. The Medication Adherence Rating Scale (MARS), Positive and Negative Syndrome Scale (PANSS), General Self-Efficacy Scale (GSES), Schizophrenia Quality of Life Scale (SQLS), and Scale of Social Skills for Psychiatric Inpatients (SSPI) were used to explore medication compliance and its influencing factors in the Chinese institutional environment. Results: The descriptive analysis and ANOVA showed that there were no significant differences in medication adherence when assessed by demographic characteristics such as sex, marital status, and education level (p > 0.05). A correlation analysis showed that there was no significant correlation between medication adherence and mental symptoms (p > 0.05) but that there was a positive correlation with self-efficacy, quality of life, and activities of daily living (p < 0.01). The linear regression analysis showed that self-efficacy, psychosocial factors, symptoms/side effects, and activities of daily living had significant effects on medication adherence (F = 30.210, p < 0.001). Conclusions: Our findings show that the self-efficacy, quality of life, and social function of patients with schizophrenia are important self-factors influencing medication adherence in the Chinese institutional environment.

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Abstract WP138: Effect of Duration Between Stroke Onset and Admission to Inpatient Rehabilitation Facilities on Improvement in Activities of Daily Living During Hospitalization

Stroke ◽

10.1161/str.49.suppl_1.wp138 ◽

2018 ◽

Vol 49 (Suppl_1) ◽

Author(s):

Shiraishi Nariaki ◽

Daisuke Matsumoto ◽

Yusuke Suzuki ◽

Seungwon Jeong ◽

Motoya Sugiyama ◽

...

Keyword(s):

Activities Of Daily Living ◽

Daily Living ◽

Inpatient Rehabilitation ◽

Stroke Onset ◽

Rehabilitation Facilities

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Comprehensive geriatric assessment is correlated to overall survival among gynaecologic oncology patients

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyz178 ◽

2019 ◽

Vol 50 (3) ◽

pp. 276-281

Author(s):

Nadav Michaan ◽

Sang Yoon Park ◽

Myong Cheol Lim

Keyword(s):

Overall Survival ◽

Multivariate Analysis ◽

Activities Of Daily Living ◽

Geriatric Assessment ◽

Comprehensive Geriatric Assessment ◽

Daily Living ◽

Nutritional Assessment ◽

Mini Nutritional Assessment ◽

Cancer Type ◽

Oncology Patients

Abstract Objective To investigate the correlation of comprehensive geriatric assessment to overall survival among older gynaecologic oncology patients. Methods Between 2011 and 2017, patients >70 years had geriatric assessment before treatment. Geriatric assessment included the following tests: Old American resource and services, instrumental activities of daily living, modified Barthels index, mini-mental state examination, geriatric depression scale, mini-nutritional assessment, risk of falling and medication use. Overall survival was calculated for patients’ groups below and above median tests scores. Univariate as well as multivariate analysis was done to evaluate the association between each variable and survival. Results About 120 patients had geriatric assessment. Mean patients’ age was 76.4 ± 5. A total of 78 Patients had ovarian cancer, 16 uterine cancer, 17 cervical cancer and 9 had other gynaecologic malignancies. No correlation was found between age, BMI (body mass index) and cancer type to overall survival. Patients with scores below cut-off values of modified Barthels index, instrumental activities of daily living, mini-nutritional assessment and mini-nutritional assessment had significantly shorter overall survival (P = 0.004, 0.031, 0.046 and 0.004, respectively). This remained significant in both univariate and multivariate analysis. Conclusions Gynaecologic oncology patients with lower geriatric assessment scores have significantly lower overall survival, irrespective of cancer type. Geriatric assessment tests allow objective assessment of older patients with worst prognosis before treatment planning.

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Factors influencing recovery of activities of daily living in stroke patients

Nosotchu ◽

10.3995/jstroke.8.407 ◽

1986 ◽

Vol 8 (5) ◽

pp. 407-411

Author(s):

Kazuo Kitagawa ◽

Kenichi Tanaka ◽

Motonobu Miyai ◽

Tadaastu Nukada ◽

Setsuo Hakata

Keyword(s):

Activities Of Daily Living ◽

Daily Living ◽

Stroke Patients ◽

Factors Influencing

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Effects of depression, dementia and delirium on activities of daily living in elderly patients after discharge

BMC Geriatrics ◽

10.1186/s12877-019-1294-9 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 6

Author(s):

Ching-Fu Weng ◽

Kun-Pei Lin ◽

Feng-Ping Lu ◽

Jen-Hau Chen ◽

Chiung-Jung Wen ◽

...

Keyword(s):

Activities Of Daily Living ◽

Functional Status ◽

Daily Living ◽

Short Form ◽

Medical Center ◽

Functional Decline ◽

Depression Scale ◽

Assessment Method ◽

Functional Improvement ◽

The Impact

Abstract Background The three geriatric conditions, depression, dementia and delirium (3D’s), are common among hospitalized older patients and often lead to impairments of activities of daily living. The aim of this study is to explore the impact of depression, dementia and delirium on activities of daily living (ADLs) during and after hospitalization. Methods A prospective cohort study was conducted between 2012 and 2013 in a tertiary medical center in Taiwan. Patients who aged over 65 years and admitted to the geriatric ward were invited to this study. Geriatric Depression Scale Short Form, Mini-Mental State and Confusion Assessment Method were used to identify patients with depression, dementia and delirium on admission, respectively. Barthel Index (BI) was used to evaluate patients’ functional status on admission, at discharge, 30-day, 90-day and 180-day after discharge. Generalized Estimating Equation (GEE) was used to calculate the associations between 3 D’s and BI. Results One-hundred-and-forty-nine patients were included in this study. Twenty-seven patients (18.1%) had depression, 37 (24.8%) had dementia, and 85 (57.0%) had delirium. The study demonstrated that all the geriatric patients with functional decline presented gradual improvements of physical function up to 180 days after discharge. Whether depression exists did not substantially affect functional recovery after discharge, whilst either dementia or delirium could impede elder people functional status. The recovery of functional improvement in delirium or dementia was relatively irreversible when comparing with depression. Once delirium or dementia was diagnosed, poorer functional restore was expected. In brief, intensive work and strategies on modifying delirium or dementia should be put more effort as early as possible. Conclusions Old hospitalized patients with depression can recover well after adequate intervention. We emphasize that early detection of dementia and delirium is imperative in subsequent functional outcome, even if at or before admission. Comprehensive plan must be implemented timely.

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Development of a Frailty Score for Older Patients with Myelodysplastic Syndromes and Acute Myeloid Leukemia.

Blood ◽

10.1182/blood.v114.22.1775.1775 ◽

2009 ◽

Vol 114 (22) ◽

pp. 1775-1775

Author(s):

Barbara Deschler ◽

Gabriele Ihorst ◽

Uwe Platzbecker ◽

Ulrich Germing ◽

Michael Lübbert

Keyword(s):

Risk Factors ◽

Overall Survival ◽

Stem Cell ◽

Stem Cell Transplantation ◽

Activities Of Daily Living ◽

Cell Transplantation ◽

Daily Living ◽

Older Patients ◽

Treatment Allocation ◽

Frailty Score

Abstract Abstract 1775 Poster Board I-801 Introduction Treatment options in older patients (pts) with MDS/AML range from best supportive care (BSC) to intensive chemotherapy/hematopoietic stem cell transplantation (IC/HCT), with low-dose chemotherapy or novel non-intensive agents (e.g. hypomethylating agents; HA) as alternatives. Due to frequent age-related physical and/or mental impairments, intensive treatment is not always feasible. As the basis for treatment decision-making is not well defined, the generation of comprehensive assessments of age-specific functional and quality of life (QOL)-aspects in addition to disease-specific risk factor definition therefore is urgently needed. Geriatric Assessment (GA) is expected to offer rational support in this process. Patients and Methods Since January 2004, we have prospectively evaluated the prognostic impact of GA on overall survival (OS) in 195 consecutive pts ≥60 years (yrs) with AML (n=132) or MDS (n=63) in three participating centers, receiving either BSC or HA+BSC or IC/HCT. Of the pts receiving non-intensive treatment, 50% had MDS. GA included eight instruments evaluating QOL, activities of daily living, depression, mental functioning, mobility, comorbidities and performance status (PS). In addition, disease- and patient-specific laboratory parameters were obtained. Results Median age of pts was 71 yrs (range: 60-87 yrs). The primary treatment allocation was BSC in 47 pts (median age: 75 yrs); HA+BSC in 66 pts (74 yrs); IC/HCT in 75 pts (68 yrs). 62% of IC/HCT pts received a matched related/unrelated stem cell transplantation. Application of age-specific tests at the different study centers was readily feasible. The initial multidimensional GA was associated with treatment allocation, age, hematological and functional parameters and treatment outcome. Multivariate analyses revealed impairments in activities of daily living (ADL: Barthel Test, HR: 2.22) and fatigue (measured by EORTC QLQ-C30; HR: 1.68) as significant prognostic parameters for overall survival. Both risk factors were combined to construct a simple risk score for survival. Conducting a Cox regression model with established risk factors, a high risk frailty score in the entire pt population was associated with an elevated HR of 4.17 (p<0.0001), while adverse cytogenetics (AML), blasts >20% and comorbidities >1 proved to be independently associated with HRs of 2.491 (p=0.0001), 2.756 (p=0.0005) and 1.495 (p=0.1281). When this score was applied to pts receiving sole BSC or HA+BSC, highly significant differences in OS could be demonstrated, with p=0.0035 and p<0.0001, respectively. Conclusions Our data demonstrate that GA is a useful and objective tool in the in-depth evaluation process prior to treatment allocation in elderly patients with MDS/AML. A simple prognostic score based solely on ADL and fatigue to predict outcome of patients treated non-intensively has been established. Validation in independent cohorts appears warranted. Disclosures No relevant conflicts of interest to declare.

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