scholarly journals Androgen and Anti-Mullerian Hormone Concentrations at Term in Newborns and Their Mothers with and without Polycystic Ovary Syndrome

2019 ◽  
Vol 8 (11) ◽  
pp. 1817
Author(s):  
Martina Kollmann ◽  
Barbara Obermayer-Pietsch ◽  
Elisabeth Lerchbaum ◽  
Uwe Lang ◽  
Sereina A. Herzog ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Animal Studies ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Female Offspring ◽  
Cross Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Hormone Levels ◽  
Androgen Levels

Objectives: The aetiology of polycystic ovary syndrome (PCOS) is not particularly mapped; however, a complex interaction of various factors, such as genetic, environmental and intrauterine factors, can be assumed. Experimental animal studies and clinical observations support the hypothesis that developmental programming by excess intrauterine steroid is relevant. The aim of the study was to investigate whether mothers with and without PCOS exhibit different androgen and anti-Mullerian hormone (AMH) levels at the end of pregnancy and how maternal hormone levels are reflected in their offspring. Methods: Between March 2013 and December 2015, we performed a prospective cross-sectional study at the Medical University of Graz. We included 79 women with PCOS according to the ESHRE/ASRM 2003 definition and 354 women without PCOS, both with an ongoing pregnancy ≥37 + 0 weeks of gestation, who gave birth in our institution. Primary outcome parameters were the levels of maternal and neonatal androgens (testosterone, free testosterone, androstenedione) and AMH at delivery. Results: Androgen levels in female offspring of PCOS and non-PCOS women at birth did not differ, while maternal hormone levels differed significantly. Androgen levels in PCOS boys were significantly higher when compared to levels in PCOS girls. Discussion: Our findings do not support the hypothesis that maternal androgen excess contributes to elevated androgen concentrations in the female offspring. Nevertheless, the effects of the increased androgen concentrations in mothers on their offspring have to be investigated in future studies.

scholarly journals Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome

2014 ◽  
Vol 170 (3) ◽  
pp. 401-409 ◽  
Author(s):  
Flavia Tosi ◽  
Daniela Di Sarra ◽  
Cecilia Bonin ◽  
Francesca Zambotti ◽  
Marlene Dall'Alda ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Equilibrium Dialysis ◽  
Free Testosterone ◽  
Cross Sectional Study ◽  
Pentraxin 3 ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Glucose Clamp Technique ◽  
Serum Crp

ObjectivePentraxin-3 (PTX3), like C-reactive protein (CRP), is an acute-phase protein that belongs to the pentraxin superfamily. Moreover, it is expressed in the cumulus oophorus and appears to be involved in female fertility. The aim of the present study was to assess whether PTX3 levels are altered in polycystic ovary syndrome (PCOS) women and whether they show any relationship with the main features of these subjects.DesignA cross-sectional study was conducted at the outpatient clinic of an academic centre.MethodsA total of 66 women affected with PCOS and 51 healthy controls were studied. Plasma PTX3 and serum CRP were measured by ELISA. Androgens were measured by liquid chromatography–mass spectrometry and free testosterone was measured by equilibrium dialysis. In PCOS women, insulin sensitivity was assessed by the glucose clamp technique.ResultsAdjusting for age and BMI, plasma PTX3 was reduced in PCOS women (P=0.036), in contrast with serum CRP, which was increased (P=0.004). In multiple regression analysis, serum androgens and other endocrine and ovarian features of PCOS were predictors of PTX3 levels, whereas body fat was the main independent predictor of CRP concentrations.ConclusionsPlasma PTX3 levels were reduced in PCOS women and independently associated with hyperandrogenism and other endocrine and ovarian features of PCOS.

scholarly journals Prevalence of Self-reported Polycystic Ovary Syndrome and Profiles of Health Among Women of Different Generations: A Cross Sectional Study

2019 ◽  
Vol 01 (03) ◽  
pp. 141-147
Author(s):  
Jodie C. Avery ◽  
Lisa J. Moran ◽  
Vivienne Moore ◽  
Renae C. Fernandez ◽  
Melissa Whitrow ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Age Groups ◽  
South Australia ◽  
Cross Sectional Study ◽  
Age Group ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Younger Women

Objective: Although polycystic ovary syndrome (PCOS) is considered a lifelong disorder, very little is understood about the diagnosis and impact of this condition in women outside of the peak reproductive years. We examined the frequency of diagnosed PCOS and concurrent health conditions in women across the lifespan. Methods: Data were analysed from 1509 women aged 15–95 years participating in a cross-sectional, face-to-face population survey in South Australia, 2015. We assessed the prevalence of PCOS in 10-year age groups and the frequency of comorbidities in women with and without PCOS subgrouped by age (< 45, [Formula: see text] 45 years). The main outcome measures were Diagnosed PCOS and other chronic conditions; lifestyle factors. Logistic regression analyses determined the risk of comorbidities in women with PCOS adjusting for age and BMI. Results: Overall prevalence of PCOS was 5.6% (95% confidence interval (CI) 4.6–6.9%), peaking in the 35–44 year age group (9.1%), and lowest in those aged 15–24 (4.1%) or [Formula: see text] 65 (3.7%) years. Women with PCOS and aged <45 years were more likely to report diabetes (16.7% vs. 3.8%), cardiovascular disease (15.5% vs. 7.2%) and arthritis (15.5% vs. 7.2%) than their peers; these differences were diminished in the [Formula: see text] 45 year age group. The odds of diabetes and cardiovascular disease were more than doubled among women with PCOS (adjOR 2.23, 95% CI 1.49–4.31; adjOR 3.18, 95% CI 1.31–7.68). Conclusion: PCOS is underdiagnosed in young and post-menopausal women. Diabetes and cardiovascular disease are key comorbidities requiring greater attention in younger women with PCOS.

scholarly journals The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study

2010 ◽  
Vol 8 (1) ◽  
pp. 151 ◽  
Author(s):  
Dimitrios Panidis ◽  
Konstantinos Tziomalos ◽  
Ekaterini Koiou ◽  
Eleni A Kandaraki ◽  
Elena Tsourdi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Lipocalin 2 ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional

scholarly journals Changes in clinical and biochemical characteristics of polycystic ovary syndrome with advancing age

2020 ◽  
Vol 9 (2) ◽  
pp. 74-89 ◽  
Author(s):  
Sebastião Freitas de Medeiros ◽  
Márcia Marly Winck Yamamoto ◽  
Matheus Antônio Souto de Medeiros ◽  
Bruna Barcelo Barbosa ◽  
José Maria Soares ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Total Cholesterol ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Reproductive Period ◽  
University Hospital ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Biochemical Characteristics ◽  
Age Stratification

Objective To verify whether aging can modify the clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Material and methods This observational cross-sectional study was conducted at the reproductive endocrinology clinics of Julio Muller University Hospital and Tropical Institute of Reproductive Medicine in Cuiabá, MT, Brazil, between 2003 and 2017. Both, 796 PCOS and 444 non-PCOS normal cycling women underwent the same examination. PCOS was diagnosed using the Rotterdam criteria as recommended for adolescent and adult subjects. Anthropometric, metabolic, and endocrinological modifications with aging were initially examined in the two groups: control and PCOS. Further analyses were performed after a 5-year age stratification of data throughout the reproductive period. All participants signed a consent form approved by the local ethical committee. Results Biomarkers of adiposity were more remarkable in African descendant PCOS women. Body weight, waist/hip ratio, fat mass, and BMI were higher in PCOS women and tended to increase at all 5 age-strata, between ≤19 and 35 years of age. Serum androgen levels decreased with aging, markedly in PCOS subjects (P < 0.01 for all age-strata comparisons), but remained elevated when compared with the levels found in controls. Carbohydrate markers, triglycerides, and total cholesterol tended to increase over time in PCOS (P < 0.01 for all age-strata comparisons). Total cholesterol also tended to increase with age in non-PCOS women (P = 0.041). Conclusion The present study has shown that the advancing age influences many features of PCOS women. Biochemical hyperandrogenism, the core criterion recommended in the current systems to define the syndrome, showed statistically significant tendencies to decrease with aging progression but did not normalize. The use of age-adjusted features for the diagnosis of PCOS are recommended.

scholarly journals Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study

2020 ◽  
Author(s):  
Akramsadat Dehghani Firoozabadi ◽  
Razieh Dehghani Firouzabadi ◽  
Maryam Eftekhar ◽  
Afsar Sadat Tabatabaei Bafghi ◽  
Farimah Shamsi
Keyword(s):  
Gestational Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Pregnant Women ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Neonatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Induced Hypertension

Background: Pregnancy is a process associated with various metabolic and hormonal changes, and polycystic ovary syndrome (PCOS) can affect this process. Objective: This study aimed to evaluate and compare the maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes. Materials and Methods: In this cross-sectional study, 200 pregnant women with PCOS according to the 2003 ESHRE/ASRM criteria were categorized into four phenotype groups (A-D). The maternal outcomes include gestational diabetes mellitus, pregnancy-induced hypertension, premature rupture of membranes, preterm labor, small-for-gestational age birth, intrauterine growth restriction, intrauterine mortality, preeclampsia, abortion, amniotic fluid disorders, delivery method, and cause of cesarean section were studied between groups. Additionally, neonatal outcomes such as neonatal weight, neonatal recovery, 5-min Apgar score, neonatal icter, the need for NICU admission, the cause of hospitalization, and infant mortality rate were investigated and compared among the groups. Results: According to the results, phenotype D (37%) was the most common phenotype among the participants. The risk of gestational diabetes was more common in phenotype A than in the other phenotypes, whereas pregnancy-induced hypertension was most common in phenotype B. No significant differences were observed in the neonatal complications among the PCOS phenotypes. Conclusion: Considering the higher risk of gestational diabetes mellitus and pregnancy-induced hypertension in PCOS phenotypes A and B, women with these phenotypes need more precise prenatal care. Key words: Pregnancy outcome, Polycystic ovary syndrome, Phenotype, Pregnancy.

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