Ratio of IL-8 in CSF Versus Serum Is Elevated in Patients with Unruptured Brain Aneurysm

Only scarce data pertaining to interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human aneurysm can be found in the current literature. Therefore, the aim of this study was the evaluation of cerebrospinal fluid (CSF) and serum IL-8 and MCP-1 concentration in unruptured intracranial aneurysm (UIA) patients (n = 25) compared to the control group (n = 20). IL-8 and MCP-1 concentrations were measured with ELISA method. We demonstrated that CSF IL-8 concentration of UIA patients is significantly higher (p < 0.001) than that presented in the serum, which can indicate its local synthesis within central nervous system. CSF IL-8 concentration was also significantly related to aneurysm size, which may reflect the participation of IL-8 in the formation and development of brain aneurysms. IL-8 Quotient (CSF IL-8 divided by serum IL-8) in UIA patients was statistically higher compared to control individuals (p = 0.045). However, the diagnostic utility analysis did not equivocally indicate the diagnostic usefulness of the IL-8 Quotient evaluation in brain aneurysm patients. Nevertheless, this aspect requires further study.

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Same virus, different course: The relationship between monocyte chemoattractant protein-1 and surfactant protein-A levels and clinical course and prognosis of COVID-19

10.22541/au.160992372.26041095/v1 ◽

2021 ◽

Author(s):

Ferhan Kerget ◽

Buğra Kerget ◽

Sibel İba Yılmaz ◽

Ömer Karaşahin ◽

Ahmet Kızıltunç ◽

...

Keyword(s):

Real Time ◽

Real Time Pcr ◽

Clinical Course ◽

Protein A ◽

Surfactant Protein ◽

Surfactant Protein A ◽

Control Group ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein

Objective: To date, over 7 million people have been infected in the COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 which emerged in Wuhan, China in December 2019. This study examined the relationships between serum monocyte chemoattractant protein-1 (MCP-1) and surfactant protein-A (SP-A) levels and the clinical course and prognosis of COVID-19. Method: The study included a total of 108 subjects. Those in the patient group (n=88) were diagnosed with COVID-19 using real-time PCR analysis of nasopharyngeal swab samples and treated in the Atatürk University Pulmonary Diseases and the City Hospital Infectious Diseases department between March 24 and April 15. The control group (n=20) included asymptomatic healthcare workers whose real-time PCR results during routine COVID-19 screening in our hospital were negative. Results: The COVID-19 patient group had significantly higher MCP-1 and SP-A levels compared to the control group (p=0.001, p=0.001). Patients who developed macrophage activation syndrome had significantly higher MCP-1 and SP-A levels than those who did not both at admission (p=0.001, p=0.001) and on day 5 of treatment (p=0.05, p=0.04). Similarly, MCP-1 and SP-A levels were significantly higher in patients who developed acute respiratory distress syndrome compared to those who did not at both time points (p=0.001 for all). Both parameters were significantly higher in nonsurviving COVID-19 patients compared to survivors (p=0.001 for both). Conclusion: MCP-1 and SP-A are on opposing sides of the inflammatory balance, and SP-A may be a pneumoprotein of importance in the presentation, course, prognosis, and possibly the treatment of COVID-19 in the future.

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Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat

British Journal Of Nutrition ◽

10.1017/s0007114511002157 ◽

2011 ◽

Vol 106 (12) ◽

pp. 1810-1813 ◽

Cited By ~ 7

Author(s):

Jason K. Higa ◽

Wanyu Liu ◽

Marla J. Berry ◽

Jun Panee

Keyword(s):

Body Weight ◽

Visceral Fat ◽

High Fat Diet ◽

Water Extract ◽

Control Group ◽

Standard Diet ◽

High Fat ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein

Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine up-regulated in obese subjects, contributing to the development of type 2 diabetes. The present study investigated the inhibitory effect of an ethanol–water extract from bamboo (BEX,Phyllostachys edulis) on the blood concentration of MCP-1. C57BL/6J mice were fed a standard diet or a high-fat diet with or without the BEX supplement (11 g dry mass/17 000 kJ) for 6 months. A total of ten mice were used in each group. Body weight and food consumption were measured weekly. After euthanisation, the weight of visceral fat and circulating MCP-1 concentration were measured. In comparison with the standard control group, the high-fat control group had increased body weight, abdominal fat storage and serum MCP-1 concentration by 60 % (P < 0·001), 266 % (P < 0·001) and 180 % (P < 0·01), respectively. In comparison with the high-fat control group, the high-fat BEX group showed a 3 % decrease in body weight (P < 0·01), 24 % decrease in mesenteric fat depot (P < 0·01) and 49 % decrease in serum MCP-1 concentration (P < 0·05). The present study suggests that the BEX supplement in the high-fat diet ameliorates elevated MCP-1 concentrations in the blood, and whether this is related to modulated endocrine properties of the visceral fat is to be studied.

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The Diagnostic Value of Monocyte Chemoattractant Protein-1, Compared with Procalcitonin, C-reactive Protein, and Lactate in Bacteremia Estimation for Patients with Febrile Neutropenia

Revista Romana de Medicina de Laborator ◽

10.2478/rrlm-2020-0036 ◽

2020 ◽

Vol 28 (4) ◽

pp. 419-426

Author(s):

İlker Ödemiş ◽

Şükran Köse ◽

Süheyla Serin Senger ◽

İlkay Akbulut ◽

Didem Çelik

Keyword(s):

Blood Culture ◽

Febrile Neutropenia ◽

Diagnostic Value ◽

Control Group ◽

P Value ◽

C Reactive Protein ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Reactive Protein ◽

Monocyte Chemoattractant Protein

AbstractBacteremia in the febrile neutropenic patients significantly increases the mortality. It takes a long time to complete the blood culture for the diagnosis of bacteremia. Therefore, quick and specific markers are needed for the prediction of bacteremia. The purpose of this study are to compare the diagnostic value of lactate, procalcitonin, C-reactive protein (CRP) and monocyte chemoattractant protein-1 (MCP-1) levels in a patient with febrile neutropenia, and to evaluate its usefulness in predicting bacteremia. This study was designed to be prospective case-control study. Forty-eight patients and forty control cases aged 18 years or older who were monitored between May 2016 and May 2017 were included in the study. P-value as <0.05 was accepted to be significant. Significantly increased values were determined by the level of inflammatory markers of patients compared to the control group. The highest diagnostic odds ratio were found to be in MCP-1. For patients with febrile neutropenia, CRP (83.3%), and MCP-1 (81.2%) were the most sensitive markers while lactate (85.0%), MCP-1 (75%), and procalcitonin (75%) were the most specific markers. CRP was the only beneficial biomarker in the estimation of bacteremia. No significant results were observed for any biomarker for the prediction of the gram positive/negative discrimination of bacteria in the blood culture. We believe that CRP, MCP-1, and lactate levels can be taken into consideration for diagnosis, and CRP can be beneficial in the estimation of bacteremia.

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Serum malondialdehyde, monocyte chemoattractant protein-1, and vitamin C levels in wet type age-related macular degeneration patients

Therapeutic Advances in Ophthalmology ◽

10.1177/2515841420951682 ◽

2020 ◽

Vol 12 ◽

pp. 251584142095168

Author(s):

Ramazan Kürşad Zor ◽

Serpil Erşan ◽

Erkut Küçük ◽

Gamze Yıldırım ◽

İsmail Sarı

Keyword(s):

Oxidative Stress ◽

Vitamin C ◽

Serum Vitamin ◽

Serum Levels ◽

Age Related Macular Degeneration ◽

Control Group ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein ◽

Age Related

Purpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Methods: Thirty patients with wAMD were included in the study and serum levels of MDA, MCP-1, and vitamin C were compared with healthy participants ( n = 30). Serum vitamin C and MDA levels were measured using a spectrophotometric method. Serum MCP-1 levels were determined by the ELISA method. Results: MCP-1 and MDA levels were higher in patients with wAMD compared with the control group ( p < 0.05). Serum vitamin C levels were lower in patients with wAMD compared with the control group ( p < 0.05). Conclusions: The increase in the MCP-1 levels in patients with wAMD may be associated with increased inflammation in wAMD. Decreased serum vitamin C and elevated MDA levels in patients with wAMD suggest increased oxidative stress in wAMD patients. These results indicate that the increased oxidative stress and inflammation can play a role in the pathogenesis of wAMD.

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Cotinine Levels Influence the Risk of Rupture of Brain Aneurysms

10.21203/rs.3.rs-1064733/v1 ◽

2021 ◽

Author(s):

Paolo Missori ◽

Angela Ambrosone ◽

Antonio Currà ◽

Sergio Paolini ◽

Giorgio Incarbone ◽

...

Keyword(s):

Cerebral Aneurysms ◽

Aneurysm Rupture ◽

Ruptured Aneurysm ◽

Control Group ◽

Rupture Risk ◽

Brain Aneurysm ◽

Cotinine Level ◽

Risk Of Rupture ◽

Brain Aneurysms ◽

The Relationship

Abstract The relationship between nicotine levels in smokers and brain aneurysm has never been determined. To assess the levels of cotinine in smoker patients with ruptured and unruptured brain aneurysm and the risk of aneurysm rupture we quantified cotinine levels in smoker patients with ruptured or unruptured brain aneurysms. We identified a control group of smokers and nonsmokers without brain aneurysm. Out of 182 participants cerebral aneurysms were statistically significantly associated with smoking (P<0.001) and female sex (P=0.006). Cotinine levels were significantly correlated with both the presence (P=0.009) and the rupture (P=0.002) of brain aneurysms. Compared with nonsmokers, smokers had a 5-fold higher risk of having a brain aneurysm (OR, 5.72; 95% CI, 2.96–11.07; P<0.001). The risk of rupture of brain aneurysms increased by 50% with each cotinine unit and was 4-fold higher with cotinine levels between 4 and 6 (OR, 3.75; 95% CI, 1.48–9.53; P=0.005). With increasing age, the cotinine level decreased (P <0.001, rho= –0.28), declining by 2% with each year of age. In the whole population, the probability of a ruptured aneurysm in patients with cotinine levels between 4 and 6 was higher than in those with levels between 0 and 3 (OR, 5.55; 95% CI, 1.08–28.5; P=0.040). Our results suggest that high cotinine levels in smokers with brain aneurysm, rather than size, are significantly associated with high rupture risk. Cotinine levels decrease with age, possibly reducing the risk of formation and rupture of a brain aneurysm.

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Monocyte chemoattractant protein-1 in patients with peripheral arterial disease

Mediators of Inflammation ◽

10.1080/09629350410001664752 ◽

2004 ◽

Vol 13 (1) ◽

pp. 39-43 ◽

Cited By ~ 14

Author(s):

Jana Petrkova ◽

Jaroslava Szotkowska ◽

Zuzana Hermanova ◽

Jan Lukl ◽

Martin Petrek

Keyword(s):

Peripheral Arterial Disease ◽

Density Lipoprotein ◽

Arterial Disease ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein ◽

Potential Marker ◽

Peripheral Arterial

Background:Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study therefore investigated MCP-1 in patients with PAD.Methods:Serum MCP-1 was determined by enzyme-linked immunosorbent assay in 36 healthy, control subjects and in 19 patients with PAD. Statistical analysis utilised the Mann-Whitney test and Spearman correlation(p<0.05).Results:MCP-1 (pg/ml) was increased in patients compared with in controls (mean±standard error of the mean: PAD group, 748±60; control group, 459±27; p=0.0001). MCP-1 levels tended to decrease with progressing disease. From atherosclerosis risk factors, diabetes inclined to increase MCP-1 levels; hypertension had no effect. Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but not high-density lipoprotein.Conclusion:Elevation of MCP-1 in the circulation of PAD patients shown in the present pilot study implicates this CC chemokine ligand 2 in inflammatory processes contributing to PAD clinical symptomatology. Further investigations are necessary to evaluate whether MCP-1 can be used as a potential marker of peripheral arterial disease follow-up and/or prognosis.

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MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) CONCENTRATIONS IN CARRAGEENAN-INDUCED GASTROENTEROCOLITIS

Health and Ecology Issues ◽

10.51523/2708-6011.2017-14-2-14 ◽

2017 ◽

pp. 64-67

Author(s):

A. S. Tkachenko ◽

O. A. Nakonechnaya ◽

T. V. Gorbach ◽

A. I. Onischenko ◽

T. N. Chubukova

Keyword(s):

Oxidative Stress ◽

Blood Serum ◽

Proinflammatory Cytokine ◽

Food Additive ◽

Control Group ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein ◽

Tnf Α

Aim: to study MCP-1 concentrations in chronic carrageenan-induced gastroenterocolitis and the role of this protein in the development and progression of the disease. Material and methods . Thirty female WAG rats were divided into three groups (each group consisted of ten individuals): 1) introduction of 1% carrageenan solution for 14 days; 2) introduction of 1 % carrageenan solution for 28 days; 3) the control group. The animals of the first two groups were developing gastroenterocolitis. The MCP-1 and TNF-α concentrations were measured in the blood serum by ELISA. Results. Development of carrageenan-induced gastroenterocolitis was accompanied by increased levels of both MCP-1 and TNF-α in the blood serum. The level of the increase of both the parameters was more evident after four-week oral taking of the food additive carrageenan. Conclusion. The increased MCP-1 production in carrageenan-induced gastroenterocolitis may be directly due to the toxic effect of carrageenan on the macrophages of the gastrointestinal tract, development of oxidative stress, as well as due to the stimulating effect of the proinflammatory cytokine TNF-α.

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