scholarly journals Comprehensive Evaluation of the Oral Health Status, Salivary Gland Function, and Oxidative Stress in the Saliva of Patients with Subacute Phase of Stroke: A Case-Control Study

2020 ◽  
Vol 9 (7) ◽  
pp. 2252 ◽  
Author(s):  
Piotr Gerreth ◽  
Mateusz Maciejczyk ◽  
Anna Zalewska ◽  
Karolina Gerreth ◽  
Katarzyna Hojan

This is the first study to assess, comprehensively, the oral health status; salivary glands’ function and enzymatic and non-enzymatic antioxidant defense; and oxidative damage to proteins and lipids in the non-stimulated (NWS) and stimulated (SWS) whole saliva of stroke patients. The study included 30 patients in the subacute phase of the stroke and an age and gender-matched control group. We showed that the activity of antioxidant enzymes (catalase and salivary peroxidase) was significantly higher in both NWS and SWS of stroke patients, similarly to uric acid concentration. However, in the study group, the reduced glutathione (GSH) concentration in SWS decreased. The contents of protein glycooxidation products (advanced glycation end products (AGE) and protein oxidation products (AOPP)) and lipid hydroperoxides were significantly higher in NWS and SWS of stroke patients. In the study group there was also a decrease in stimulated saliva secretion and total protein content. Interestingly, products of protein and lipid oxidation correlate negatively with SWS flow. The ROC analysis showed that salivary GSH with 100% specificity and 100% sensitivity differentiates the analyzed groups (AUC = 1.0). To sum up, in subacute stroke patients there are redox imbalances and oxidative damage to proteins and lipids in non-stimulated and stimulated saliva. Stroke patients also suffer from salivary gland dysfunction.

2019 ◽  
Vol 46 (12) ◽  
pp. 1170-1176 ◽  
Author(s):  
Michiyo Obana ◽  
Junichi Furuya ◽  
Chiaki Matsubara ◽  
Haruka Tohara ◽  
Motoki Inaji ◽  
...  

2019 ◽  
Vol 25 (3) ◽  
pp. 218-226
Author(s):  
Ji-Young Oh ◽  
Eun-Mi Noh ◽  
Hye-Young Park ◽  
Min-Kyung Lee ◽  
Hye-Jin Kim

2021 ◽  
Vol 12 (2) ◽  
pp. e0015
Author(s):  
Palanichamy Anjugam ◽  
◽  
Veerabadhran Mahesh Mathian ◽  
Murugesan Gawthaman ◽  
Selvaraj Vinod ◽  
...  

Background: The dental needs of cerebral palsy children are an area of study much in need of attention. The neglect of this aspect should be rectified, and simpler diagnostic methodologies should be established and used to serve this purpose. Aim: This study aimed to determine oral health status and salivary biomarkers (salivary flow rate, pH, buffering capacity) among children with cerebral palsy (CP), to compare their data with that of their healthy siblings, and to evaluate the relationship between salivary biomarkers and dental caries. Methods: A total of 30 CP children (study group) and 30 normal healthy siblings (controls) were selected between the ages of 5 and 12 years. Salivary biomarkers were assessed, and oral health status was examined. Statistical Analysis: Chi-square test was used for comparison of oral health status. “Unpaired t test was used to compare caries indexes (decay/filled teeth–primary dentition [dft] and decay/missing/filled teeth–permanent dentition [DMFT]) and salivary biomarkers between the groups. Pearson correlation was used to find the correlation between salivary biomarkers and caries. Results: The dft scores were significantly higher in the study group (P<0.05). The pH values and salivary flow rates were significantly lower in the study group (P<0.05 and P<0.001, respectively). There was a significant correlation between DMFT scores and salivary flow rate in the study group (P<0.05). Conclusion: Low pH and low salivary flow rate might be risk factors for dental caries in CP populations; moreover, the significant correlation between DMFT score and salivary flow rate suggests that salivary flow rate could be used as a screening tool for assessing at-risk subjects in such populations.


2021 ◽  
Vol 11 (3) ◽  
pp. 338
Author(s):  
Piotr Gerreth ◽  
Karolina Gerreth ◽  
Mateusz Maciejczyk ◽  
Anna Zalewska ◽  
Katarzyna Hojan

The study’s aim was a clinical observation concerning the influence of oral health on functional status in stroke patients undergoing neurorehabilitation. This pilot cross-sectional clinical study was performed in 60 subacute phase stroke patients during 12 weeks of treatment. The program was patient-specific and consisted of neurodevelopmental treatment by a comprehensive rehabilitation team. The functional assessment was performed using the Barthel index (BI), Berg balance scale (BBS), functional independence measure (FIM), and Addenbrooke’s cognitive examination III (ACE III) scales. Oral health was assessed according to World Health Organization (WHO) criteria, and it was presented using DMFT, DMFS, gingival index (GI), and plaque index (PlI). Significant improvement in many functional scales was noticed. However, important differences in most dental parameters without relevant changes in GI and PlI after the study were not observed. Reverse interdependence (p < 0.05) was shown between physical functioning (BI, FIM, or BBS) with GI and PlI results, and most dental parameters correlated with ACE III. Using multivariate regression analysis, we showed that ACE III and BI are predictive variables for DMFT, just as FIM is for DS (p < 0.05). The present research revealed that poor oral health status in patients after stroke might be associated with inpatient rehabilitation results.


Author(s):  
Anisha Keshan ◽  
Manju R. ◽  
Amitha M. Hegde

Background: Chronic arsenic exposure, especially via the consumption of contaminated ground water has far reaching consequences on human health. Thus, the aim of this study was to assess the effect of arsenic on oral health status of children.Methods: 100 children selected from Sanduru, Bellary district, North Karnataka (ground water is not contaminated with arsenic) were categorized as control group and 100 children of age 10 to 14 years from Hutti, Raichur district, North Karnataka (ground water contaminated with arsenic) were categorized as the study group. Water samples were analysed for arsenic and fluoride levels. Chronic arsenic exposure in children was determined by measuring the arsenic levels in their hair and nail samples. Enamel defects, oral mucosal lesions and tooth eruption timing were recorded in both the groups using the modified WHO oral health assessment form, 2013.Results: There was a significant increase in the arsenic content in the hair and nail samples of children in study group. Prevalence of enamel defects were significantly higher and a marked delay in eruption of permanent was seen among the study population.Conclusions: Chronic arsenic exposure could be a possible cause for the enamel defects and the eruption delay seen in children residing in Hutti, Raichur district, North Karnataka. 


2018 ◽  
Vol 11 (4) ◽  
pp. 2085-2089
Author(s):  
Ali Hadi Fahad ◽  
Raed Faisal Al-Huwaizi ◽  
Yamama A. Al-Rubbaey ◽  
Abbas F. Alhuwaizi

Differences in susceptibility to dental caries occurs even under the similar, controlled conditions because of genetic variations, certain environmental factors are potentially more cariogenic for some individuals than for others. Salivary constituents differences may cause variation in caries susceptibility. This study was conducted to assess the salivary pH, flow rate and streptococcus mutans count in relation to oral health status among colored eyes adolescents. The study group included all 85 colored eyes adolescents from 6 secondary schools, while control group contained 85 brown eyes adolescents selected randomly from the same schools (12-15 for both groups, only males). Decayed, missing and filled teeth (DMFT), plaque (PlI), Gingival (GI) and calculus (CI) indices were used to measure oral health status for both groups. Salivary samples collection was done in the morning at least one hour after breakfast, then normal saline was added to have tenfold dilutions, to assess the total colony counting of the caries related microorganisms (streptococcus mutans), after that inoculation was done in the special selective media (Mitis-Salivarius-Bacitracin agar). Counting of bacterial colonies were estimated by the aid of dissection microscope. Salivary pH and flow rate were measured directly. The data of present study was analyzed using SPSS version 21. The median and mean rank values for DMFT, PlI, GI and CI indices were higher in study group than control group with high significant differences with regard to DMFT and PlI. A strong positive correlation was recorded between DMFT and PlI, GI, CI in both groups. Salivary pH and flow rate were lower in study compared to the control group (statistically significant difference with salivary flow rate). Higher mean value of salivary streptococcus mutans count among study group compared to control group with statistical significant difference. Dental caries experience and streptococcus mutans count were higher in colored eyes adolescents than brown eyes adolescents. Oral hygiene and salivary flow rate were lower in study group than control group.


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