scholarly journals Menopausal Transition, Body Mass Index, and Prevalence of Mammographic Dense Breasts in Middle-Aged Women

2020 ◽  
Vol 9 (8) ◽  
pp. 2434
Author(s):  
Eun Young Kim ◽  
Yoosoo Chang ◽  
Jiin Ahn ◽  
Ji-Sup Yun ◽  
Yong Lai Park ◽  
...  
Keyword(s):  
Breast Density ◽  
Breast Imaging ◽  
Cross Sectional Study ◽  
Menopausal Transition ◽  
Mammographic Breast Density ◽  
Cross Sectional ◽  
Overweight Women ◽  
Dense Breasts ◽  
Excessive Adiposity ◽  
Prevalence Ratios

The interrelationship between menopausal stage, excessive adiposity and dense breasts remains unclear. We aimed to investigate the relationship between menopausal stage and dense-breast prevalence in midlife women while considering a possible effect modification of being overweight. The present cross-sectional study comprised 82,677 Korean women, aged 35–65 years, who attended a screening exam. Menopausal stages were categorized based on the Stages of Reproductive Aging Workshop (STRAW + 10) criteria. Mammographic breast density was categorized according to Breast Imaging Reporting and Data System (BI-RADS). Dense breasts were defined as BI-RADS Breast Density category D (extremely dense). The prevalence of dense breasts decreased as menopausal stage increased (p-trend < 0.001), and this pattern was pronounced in overweight women than non-overweight women (p-interaction = 0.016). Compared with pre-menopause, the multivariable-adjusted prevalence ratios (and 95% confidence intervals) for dense breasts were 0.98 (0.96–1.00) in early transition, 0.89 (0.86–0.92) in late transition, and 0.55 (0.52–0.59) in post-menopause, among non-overweight women, while corresponding prevalence ratios were 0.92 (0.87–0.98), 0.83 (0.77–0.90) and 0.36 (0.31–0.41) among overweight women. The prevalence of dense breasts was inversely associated with increasing menopausal stages and significantly decreased from the late menopausal transition, with stronger declines among overweight women.

scholarly journals Age-Specific Breast Density Changes in Taiwanese Women: A Cross-Sectional Study

2020 ◽  
Vol 17 (9) ◽  
pp. 3186
Author(s):  
Yu-San Liao ◽  
Jia-Yu Zhang ◽  
Yuan-Chi Hsu ◽  
Min-Xuan Hong ◽  
Li-Wen Lee
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Breast Density ◽  
Breast Imaging ◽  
Cross Sectional Study ◽  
Dense Area ◽  
Cross Sectional ◽  
Women Subjects ◽  
Dense Breasts ◽  
Taiwanese Women

Breast density is a risk factor for breast cancer. This study explored distribution of mammographic density quantitatively and qualitatively in a wide age range of Taiwanese women. Subjects with negative and benign mammographic findings were included. According to the Breast Imaging Reporting and Data System, the proportion of extremely dense breasts declined from 58.0% in women < 30 years to 1.9% in women > 74 years. More than 80% of mammograms in women < 55 years old were classified as extremely or heterogeneously dense, while the proportion of dense breasts was still high in women aged 60–64 years (59.3%). The absolute dense area of the breast declined from 35.8% in women < 30 years to 18.5% in women > 74 years. The correlation between breast density and age was significant, with and without controlling for the effect of body composition (p < 0.001), implying that the relationship between breast density and age was not wholly related to body composition. In conclusion, the higher breast density in Taiwanese women aged 60–64 years was comparable to that of Western women aged 40–44 years in the literature. This suggests that breast cancer screening using mammography may be more challenging for Asian women than for Western women of the same age.

scholarly journals Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Asim Jamal Shaikh ◽  
Maeve Mullooly ◽  
Shahin Sayed ◽  
Rose Ndumia ◽  
Innocent Abayo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Analysis Of Covariance ◽  
Mammographic Breast Density ◽  
Breast Cancers ◽  
Obese Women ◽  
Dense Area ◽  
Cross Sectional

Introduction. Data examining mammographic breast density (MBD) among patients in Sub-Saharan Africa are sparse. We evaluated how MBD relates to breast cancer characteristics in Kenyan women undergoing diagnostic mammography. Methods. This cross-sectional study included women with pathologically confirmed breast cancers (n=123). Pretreatment mammograms of the unaffected breast were assessed to estimate absolute dense area (cm2), nondense area (cm2), and percent density (PD). Relationships between density measurements and clinical characteristics were evaluated using analysis of covariance. Results. Median PD and dense area were 24.9% and 85.3 cm2. Higher PD and dense area were observed in younger women (P<0.01). Higher dense and nondense areas were observed in obese women (P-trend < 0.01). Estrogen receptor (ER) positive patients (73%) had higher PD and dense area than ER-negative patients (P≤0.02). Triple negative breast cancer (TNBC) patients (17%) had lower PD and dense area (P≤0.01) compared with non-TNBCs. No associations were observed between MBD and tumor size and grade. Conclusions. Our findings show discordant relationships between MBD and molecular tumor subtypes to those previously observed in Western populations. The relatively low breast density observed at diagnosis may have important implications for cancer prevention initiatives in Kenya. Subsequent larger studies are needed to confirm these findings.

scholarly journals Comparison of Automated Breast Ultrasound and Hand-Held Breast Ultrasound in the Screening of Dense Breasts

2021 ◽  
Vol 43 (03) ◽  
pp. 190-199
Author(s):  
Fernanda Philadelpho ◽  
Maria Julia Gregorio Calas ◽  
Gracy de Almeida Coutinho Carneiro ◽  
Isabela Cunha Silveira ◽  
Andréia Brandão Ribeiro Vaz ◽  
...  
Keyword(s):  
Breast Imaging ◽  
Statistical Significance ◽  
Lobular Carcinoma ◽  
Cross Sectional Study ◽  
Breast Ultrasound ◽  
Cross Sectional ◽  
Dense Breasts ◽  
Time Required ◽  
Automated Breast Ultrasound

Abstract Objective To compare hand-held breast ultrasound (HHBUS) and automated breast ultrasound (ABUS) as screening tool for cancer. Methods A cross-sectional study in patients with mammographically dense breasts was conducted, and both HHBUS and ABUS were performed. Hand-held breast ultrasound was acquired by radiologists and ABUS by mammography technicians and analyzed by breast radiologists. We evaluated the Breast Imaging Reporting and Data System (BI-RADS) classification of the exam and of the lesion, as well as the amount of time required to perform and read each exam. The statistical analysis employed was measures of central tendency and dispersion, frequencies, Student t test, and a univariate logistic regression, through the odds ratio and its respective 95% confidence interval, and with p < 0.05 considered of statistical significance. Results A total of 440 patients were evaluated. Regarding lesions, HHBUS detected 15 (7.7%) BI-RADS 2, 175 (89.3%) BI-RADS 3, and 6 (3%) BI-RADS 4, with 3 being confirmed by biopsy as invasive ductal carcinomas (IDCs), and 3 false-positives. Automated breast ultrasound identified 12 (12.9%) BI-RADS 2, 75 (80.7%) BI-RADS 3, and 6 (6.4%) BI-RADS 4, including 3 lesions detected by HHBUS and confirmed as IDCs, in addition to 1 invasive lobular carcinoma and 2 high-risk lesions not detected by HHBUS. The amount of time required for the radiologist to read the ABUS was statistically inferior compared with the time required to read the HHBUS (p < 0.001). The overall concordance was 80.9%. A total of 219 lesions were detected, from those 70 lesions by both methods, 126 only by HHBUS (84.9% not suspicious by ABUS) and 23 only by ABUS. Conclusion Compared with HHBUS, ABUS allowed adequate sonographic study in supplemental screening for breast cancer in heterogeneously dense and extremely dense breasts.

scholarly journals A cross-sectional study exploring the justification of opportunistic breast cancer screening in Thailand

2021 ◽  
Author(s):  
Bhoowit Lerttiendamrong ◽  
Lertpong Satapongpeera ◽  
Mawin Vongsaisuwon
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Density ◽  
Screening Method ◽  
Cross Sectional Study ◽  
Screening Mammography ◽  
Breast Ultrasonography ◽  
Cross Sectional ◽  
Dense Breasts

Objective: Breast cancer is currently the most common malignant disease in Thailand. The present study aims to evaluate the most beneficial method of breast cancer screening in different breast densities by analyzing the benefits of screening mammography with additional breast ultrasonography classified by breast density. Method: 49 middle-aged and elderly Bangkokian women who had undergone both mammography and ultrasonography were picked at random for analysis. BI-RADS scores were assigned based on mammography results alone and based on combined mammography and ultrasonography results. Concordance/discordance rates between the 2 radiographic techniques were compared in women stratified based on their breast densities. Results: All of our participants were given a score between BIRADS 1 and 3, while over 40% of participants are in the BIRADS 2 category. 60% of subjects with extremely dense breasts benefit from screening mammography with additional breast ultrasonography, while only 50% of samples with heterogeneous density and 34.21% samples with heterogeneous fibroglandular breasts benefit from the extra intervention. Conclusion: Our study concludes that women with higher breast density are more likely to benefit from screening using ultrasonography in addition to mammography as opposed to mammography screening alone. We recommend both mammography and ultrasonography for initial breast cancer screening. For follow-up visits, we suggest the screening method in accordance with breast density, using ultrasonography alone for women with high breast densities and mammography for women with heterogeneously dense breasts.

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

2021 ◽  
Author(s):  
Ashraf Moini ◽  
Elnaz Salari ◽  
Hadi Rashidi ◽  
Khadije Maajani ◽  
Mahboubeh Abedi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Cross Sectional Study ◽  
Influential Factors ◽  
Mammographic Breast Density ◽  
P Value ◽  
Inverse Association ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of

Abstract Background Endometriosis is a common benign but painful gynecologic condition. Studies suggest that the risk of some types of malignancies such as breast cancer is higher in women with endometriosis. Mammographic breast density (MBD) is known as an important predictor for breast cancer. The present study aimed to investigate the potential relationship between endometriosis and MBD. Methods This cross-sectional study was conducted on 370 women over 40 years of age. Laparoscopic surgery was carried out for the diagnosis of endometriosis. MBD was classified into four categories according to the ACR BI-RADS classification. Statistical analysis was performed using SPSS software to evaluate the potential association between variables. Results The mean age of all participants was 47.2±6.4 years, and most participants (76.8 %) were premenopausal. Multivariate analysis of the potential predictors of MBD, including age, body mass index, oral contraceptive consumption, progesterone consumption, family history of breast cancer and endometriosis showed that age (P-value=0.002), history of progesterone consumption (P-value=0.004) and endometriosis (P-value=0.006) were the independent factors for MBD. Conclusion This study indicated that endometriosis had an inverse association with MBD. Age and history of progesterone use were also independent influential factors for MBD. This finding shows that the positive association between breast cancer and endometriosis is not mediated through MBD.

scholarly journals Prevalence of anxiety in patients admitted to a university hospital in southern Brazil and associated factors

2013 ◽  
Vol 16 (3) ◽  
pp. 644-657 ◽  
Author(s):  
Inês Gullich ◽  
Andrews Barcellos Ramos ◽  
Tiago Rafael Anschau Zan ◽  
Cíntia Scherer ◽  
Raúl Andrés Mendoza-Sassi
Keyword(s):  
Health Care ◽  
Associated Factors ◽  
Depression Scale ◽  
Female Gender ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Clinical Ward ◽  
Long Time ◽  
Prevalence Ratios

Objective: To identify the prevalence of anxiety in adults hospitalized in the clinical ward of a university hospital and to analyze the possible associated factors. Method: A cross-sectional study was performed in a university hospital. All interviewees answered a specific questionnaire and the Hospital Anxiety and Depression Scale. A Poisson regression was used to calculate prevalence ratios with 95% confidence intervals. Results: 282 patients were enrolled. The prevalence of anxiety was 33.7% (95%CI 28.2 - 39.3). Characteristics associated with the outcome were female gender (RP 2.44), age ≥ 60 years (PR 0.65), consultation in primary health care (PR 2.37), estimated time of contact between patient and student > 30 min (RP 1.36), high blood pressure (PR 1.57), diabetes mellitus (PR 1.43), and obesity (RP 1.43). Conclusion: This study found prevalence of high anxiety. It may be associated with certain characteristics of the patients (gender, age, chronic diseases); the medical appointment in primary care and time (estimated by the patient) that the student remained with this patient. The need for a focused approach to mental health care within the hospital has been discussed for a long time. The particularity of this study refers to the environment of a university hospital and to what extent the environment and the patient's relationship with the student are associated with higher prevalence of anxiety.

scholarly journals Edentulism, Severe Tooth Loss and Lack of Functional Dentition in Elders: A Study in Southern Brazil

2016 ◽  
Vol 27 (3) ◽  
pp. 345-352 ◽  
Author(s):  
Camila Garcez Ribeiro ◽  
Andreia Morales Cascaes ◽  
Alexandre Emídio Ribeiro Silva ◽  
Lenise Menezes Seerig ◽  
Gustavo Giacomelli Nascimento ◽  
...  
Keyword(s):  
Tooth Loss ◽  
Population Based ◽  
Cross Sectional Study ◽  
Older Individuals ◽  
Prosthetic Rehabilitation ◽  
Cross Sectional ◽  
High Prevalence ◽  
Functional Dentition ◽  
Prevalence Ratios ◽  
Degrees Of Severity

Abstract The aim of this study was to estimate self-reported prevalence of edentulism, severe tooth loss and lack of functional dentition in elders, and to identify potential associated factors. A population based cross-sectional study was carried out with 1,451 elders (≥60 years), in Pelotas, RS, Brazil. Crude and adjusted prevalence ratios were estimated using Poisson regressions. The prevalence of edentulism, severe tooth loss and lack of functional dentition was 39.3%, 60.9% and 82.7%, respectively. The factors positively associated with tooth loss in the three-degree severity were sex (females), older individuals, low familial income, low level of schooling and having the last dental visit longer than 24 months ago. The high prevalence of tooth loss in its different degrees of severity and the association with preventable factors highlight the need of programs focused on elders, emphasizing the prevention of tooth loss and need for prosthetic rehabilitation.

scholarly journals Breast imaging hindered during covid-19 pandemic, in Brazil

2021 ◽  
Vol 55 ◽  
pp. 8
Author(s):  
Jordana de Faria Bessa
Keyword(s):  
Breast Imaging ◽  
Detection Rate ◽  
Cross Sectional Study ◽  
Federal State ◽  
Private Institutions ◽  
Sectional Study ◽  
Public Health Services ◽  
Cross Sectional ◽  
Entire Country ◽  
Open Access Database

OBJECTIVE: To report the decrease in breast imaging after covid-19 pandemic, obtaining the number of mammograms performed in 2019 and 2020. Additionally, to investigate if there was an increase in the proportion of women undergoing mammography for diagnostic purposes, with palpable lesions. METHOD: This is a cross-sectional study, based on the number of mammograms performed by the Brazilian public health services, provided by DATASUS, an open access database. Mammograms from private institutions were not included. This study compares the number of mammograms performed in 2019 and 2020, in women aged 50–69 years, stratified by month, in each federal state, and the presence of palpable lumps (physician-reported). RESULTS: In total, 1,948,471 mammograms were performed in 2019 and 1,126,688 in 2020, for the population studied. These values represent a 42% decline. Monthly, a significant decreased is observed after April 2020. The results varied slightly according to federal state; yet the entire country was affected. Rondônia was the most affected state, with 67% decline. The proportion of women presenting palpable lumps increased from 7.06% on average in 2019 to 7.94% in 2020 (OR = 1.135, 95%CI 1.125–1.145, p = 0,001). DISCUSSION: The number of mammograms performed in 2020 declined considerably. Out of the women who presented for mammogram, the proportion of palpable lumps was significantly higher in 2020. Considering the detection rate of digital mammography, the loss of 800,000 exams means 4,000 undiagnosed breast cancer cases, by the end of 2020.

scholarly journals Metabolic Syndrome in Patients of a Psychosocial Care Center in Brazil: A Cross-Sectional Study

2021 ◽  
Author(s):  
Dandara Almeida Reis da Almeida Reis da Silva ◽  
Ludmila Santana de Almeida ◽  
Livia Lugarinho Correa ◽  
Rodrigo Fernandes Weyll Pimentel ◽  
Antonio Marcos Tosoli Gomes ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Care Center ◽  
Psychosocial Care ◽  
Cross Sectional Study ◽  
Descriptive Statistics ◽  
Adult Treatment Panel ◽  
Sectional Study ◽  
Cross Sectional ◽  
The City ◽  
Prevalence Ratios

Background: Metabolic syndrome (MS) is associated with a greater risk of morbimortality. Ob-jective: To estimate the prevalence of Metabolic Syndrome (MS) and associated factors in patients of a Psychosocial Care Center (CAPS) in the city of Salvador, state of Bahia, Brazil. Method: Cross-sectional study set at CAPS in the city of Salvador-Bahia, between August 2019 and February 2020. MS was evaluated according to the National Cholesterol Education Program's Adult Treatment Panel III. In addition to descriptive statistics, gross and adjusted prevalence ratios were described. Results: MS was found in 100 (35.2%) individuals, 116 (40.9%) were obese and 165 (58.1%) had increased waist circumference. Polypharmacy was identified in 63 (22.3%) patients and 243 (85.9%) used antipsychotics. In the gross evaluation, the female (PR = 1.88; 95% CI: 1.35-2.63) and the use of antidepressants (PR = 1.41; 95%CI: 1.05-1.88) were associated with MS. After logistic re-gression, depression (PR = 1.86; 95%CI: 1.38-2.51), acanthosis (PR = 1.50; 95%CI: 1.18 - 1.90), use of antipsychotics (PR = 1.88; 95%CI: 1.13 - 2.75) and the hypertriglyceremic waist (PR = 3.33; 95%CI: 2.48- 4.46) were associated with MS. Conclusion: The prevalence of MS alerts to multimorbidity among individuals with mental disorders and the need for clinical screening.

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