scholarly journals Age-Specific Breast Density Changes in Taiwanese Women: A Cross-Sectional Study

2020 ◽  
Vol 17 (9) ◽  
pp. 3186
Author(s):  
Yu-San Liao ◽  
Jia-Yu Zhang ◽  
Yuan-Chi Hsu ◽  
Min-Xuan Hong ◽  
Li-Wen Lee
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Breast Density ◽  
Breast Imaging ◽  
Cross Sectional Study ◽  
Dense Area ◽  
Cross Sectional ◽  
Women Subjects ◽  
Dense Breasts ◽  
Taiwanese Women

Breast density is a risk factor for breast cancer. This study explored distribution of mammographic density quantitatively and qualitatively in a wide age range of Taiwanese women. Subjects with negative and benign mammographic findings were included. According to the Breast Imaging Reporting and Data System, the proportion of extremely dense breasts declined from 58.0% in women < 30 years to 1.9% in women > 74 years. More than 80% of mammograms in women < 55 years old were classified as extremely or heterogeneously dense, while the proportion of dense breasts was still high in women aged 60–64 years (59.3%). The absolute dense area of the breast declined from 35.8% in women < 30 years to 18.5% in women > 74 years. The correlation between breast density and age was significant, with and without controlling for the effect of body composition (p < 0.001), implying that the relationship between breast density and age was not wholly related to body composition. In conclusion, the higher breast density in Taiwanese women aged 60–64 years was comparable to that of Western women aged 40–44 years in the literature. This suggests that breast cancer screening using mammography may be more challenging for Asian women than for Western women of the same age.

scholarly journals Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Asim Jamal Shaikh ◽  
Maeve Mullooly ◽  
Shahin Sayed ◽  
Rose Ndumia ◽  
Innocent Abayo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Analysis Of Covariance ◽  
Mammographic Breast Density ◽  
Breast Cancers ◽  
Obese Women ◽  
Dense Area ◽  
Cross Sectional

Introduction. Data examining mammographic breast density (MBD) among patients in Sub-Saharan Africa are sparse. We evaluated how MBD relates to breast cancer characteristics in Kenyan women undergoing diagnostic mammography. Methods. This cross-sectional study included women with pathologically confirmed breast cancers (n=123). Pretreatment mammograms of the unaffected breast were assessed to estimate absolute dense area (cm2), nondense area (cm2), and percent density (PD). Relationships between density measurements and clinical characteristics were evaluated using analysis of covariance. Results. Median PD and dense area were 24.9% and 85.3 cm2. Higher PD and dense area were observed in younger women (P<0.01). Higher dense and nondense areas were observed in obese women (P-trend < 0.01). Estrogen receptor (ER) positive patients (73%) had higher PD and dense area than ER-negative patients (P≤0.02). Triple negative breast cancer (TNBC) patients (17%) had lower PD and dense area (P≤0.01) compared with non-TNBCs. No associations were observed between MBD and tumor size and grade. Conclusions. Our findings show discordant relationships between MBD and molecular tumor subtypes to those previously observed in Western populations. The relatively low breast density observed at diagnosis may have important implications for cancer prevention initiatives in Kenya. Subsequent larger studies are needed to confirm these findings.

scholarly journals Menopausal Transition, Body Mass Index, and Prevalence of Mammographic Dense Breasts in Middle-Aged Women

2020 ◽  
Vol 9 (8) ◽  
pp. 2434
Author(s):  
Eun Young Kim ◽  
Yoosoo Chang ◽  
Jiin Ahn ◽  
Ji-Sup Yun ◽  
Yong Lai Park ◽  
...  
Keyword(s):  
Breast Density ◽  
Breast Imaging ◽  
Cross Sectional Study ◽  
Menopausal Transition ◽  
Mammographic Breast Density ◽  
Cross Sectional ◽  
Overweight Women ◽  
Dense Breasts ◽  
Excessive Adiposity ◽  
Prevalence Ratios

The interrelationship between menopausal stage, excessive adiposity and dense breasts remains unclear. We aimed to investigate the relationship between menopausal stage and dense-breast prevalence in midlife women while considering a possible effect modification of being overweight. The present cross-sectional study comprised 82,677 Korean women, aged 35–65 years, who attended a screening exam. Menopausal stages were categorized based on the Stages of Reproductive Aging Workshop (STRAW + 10) criteria. Mammographic breast density was categorized according to Breast Imaging Reporting and Data System (BI-RADS). Dense breasts were defined as BI-RADS Breast Density category D (extremely dense). The prevalence of dense breasts decreased as menopausal stage increased (p-trend < 0.001), and this pattern was pronounced in overweight women than non-overweight women (p-interaction = 0.016). Compared with pre-menopause, the multivariable-adjusted prevalence ratios (and 95% confidence intervals) for dense breasts were 0.98 (0.96–1.00) in early transition, 0.89 (0.86–0.92) in late transition, and 0.55 (0.52–0.59) in post-menopause, among non-overweight women, while corresponding prevalence ratios were 0.92 (0.87–0.98), 0.83 (0.77–0.90) and 0.36 (0.31–0.41) among overweight women. The prevalence of dense breasts was inversely associated with increasing menopausal stages and significantly decreased from the late menopausal transition, with stronger declines among overweight women.

scholarly journals A cross-sectional study exploring the justification of opportunistic breast cancer screening in Thailand

2021 ◽  
Author(s):  
Bhoowit Lerttiendamrong ◽  
Lertpong Satapongpeera ◽  
Mawin Vongsaisuwon
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Density ◽  
Screening Method ◽  
Cross Sectional Study ◽  
Screening Mammography ◽  
Breast Ultrasonography ◽  
Cross Sectional ◽  
Dense Breasts

Objective: Breast cancer is currently the most common malignant disease in Thailand. The present study aims to evaluate the most beneficial method of breast cancer screening in different breast densities by analyzing the benefits of screening mammography with additional breast ultrasonography classified by breast density. Method: 49 middle-aged and elderly Bangkokian women who had undergone both mammography and ultrasonography were picked at random for analysis. BI-RADS scores were assigned based on mammography results alone and based on combined mammography and ultrasonography results. Concordance/discordance rates between the 2 radiographic techniques were compared in women stratified based on their breast densities. Results: All of our participants were given a score between BIRADS 1 and 3, while over 40% of participants are in the BIRADS 2 category. 60% of subjects with extremely dense breasts benefit from screening mammography with additional breast ultrasonography, while only 50% of samples with heterogeneous density and 34.21% samples with heterogeneous fibroglandular breasts benefit from the extra intervention. Conclusion: Our study concludes that women with higher breast density are more likely to benefit from screening using ultrasonography in addition to mammography as opposed to mammography screening alone. We recommend both mammography and ultrasonography for initial breast cancer screening. For follow-up visits, we suggest the screening method in accordance with breast density, using ultrasonography alone for women with high breast densities and mammography for women with heterogeneously dense breasts.

scholarly journals Mammography in asymptomatic women aged 40-49 years

2014 ◽  
Vol 48 (6) ◽  
pp. 931-939 ◽  
Author(s):  
Flávio Xavier Silva ◽  
Leila Katz ◽  
Alex Sandro Rolland Souza ◽  
Melania Maria Ramos Amorim
Keyword(s):  
Breast Cancer ◽  
Mammography Screening ◽  
Breast Imaging ◽  
Ductal Carcinoma ◽  
Cross Sectional Study ◽  
Northeastern Brazil ◽  
Cross Sectional ◽  
Increased Risk ◽  
Grade Ii ◽  
Asymptomatic Women

OBJECTIVE To assess findings of mammography of and interventions resulting from breast cancer screening in women aged 40-49 years with no increased risk (typical risk) of breast cancer. METHODS This cross-sectional study evaluated women aged 40-49 years who underwent mammography screening in a mastology reference center in Recife, PE, Northeastern Brazil, between January 2010 and October 2011. Women with breast-related complaints, positive findings in the physical examination, or high risk of breast cancer were excluded. RESULTS The 1,000 mammograms performed were classified into the following Breast Imaging-Reporting and Data System (BI-RADS) categories BI-RADS 0, 232; BI-RADS 1, 294; BI-RADS 2, 294; BI-RADS 3, 16; BI-RADS 4A, 2; BI-RADS 5, 1. There was one case of grade II invasive ductal carcinoma and various interventions, including 469 ultrasound scans, 53 referrals to mastologists, 11 cytological examinations, and 8 biopsies. CONCLUSIONS Mammography screening in women aged 40-49 years with typical risk of breast cancer led to the performance of other interventions. However, it also resulted in increased costs without demonstrable efficacy in decreasing mortality.

scholarly journals Comparing Visually Assessed BI-RADS Breast Density and Automated Volumetric Breast Density Software: A Cross-Sectional Study in a Breast Cancer Screening Setting

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0136667 ◽  
Author(s):  
Daniëlle van der Waal ◽  
Gerard J. den Heeten ◽  
Ruud M. Pijnappel ◽  
Klaas H. Schuur ◽  
Johanna M. H. Timmers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Density ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Is Mammographic Breast Density an Endophenotype for Breast Cancer?

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3916
Author(s):  
Ellie Darcey ◽  
Nina McCarthy ◽  
Eric K. Moses ◽  
Christobel Saunders ◽  
Gemma Cadby ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Density ◽  
Disease Risk ◽  
Health Study ◽  
Mammographic Breast Density ◽  
Dense Area ◽  
Cross Sectional ◽  
Meta Analyses

Mammographic breast density (MBD) is a strong and highly heritable predictor of breast cancer risk and a biomarker for the disease. This study systematically assesses MBD as an endophenotype for breast cancer—a quantitative trait that is heritable and genetically correlated with disease risk. Using data from the family-based kConFab Study and the 1994/1995 cross-sectional Busselton Health Study, participants were divided into three status groups—cases, relatives of cases and controls. Participant’s mammograms were used to measure absolute dense area (DA) and percentage dense area (PDA). To address each endophenotype criterion, linear mixed models and heritability analysis were conducted. Both measures of MBD were significantly associated with breast cancer risk in two independent samples. These measures were also highly heritable. Meta-analyses of both studies showed that MBD measures were higher in cases compared to relatives (β = 0.48, 95% CI = 0.10, 0.86 and β = 0.41, 95% CI = 0.06, 0.78 for DA and PDA, respectively) and in relatives compared to controls (β = 0.16, 95% CI = −0.24, 0.56 and β = 0.16, 95% CI = −0.21, 0.53 for DA and PDA, respectively). This study formally demonstrates, for the first time, that MBD is an endophenotype for breast cancer.

scholarly journals Comparison of Automated Breast Ultrasound and Hand-Held Breast Ultrasound in the Screening of Dense Breasts

2021 ◽  
Vol 43 (03) ◽  
pp. 190-199
Author(s):  
Fernanda Philadelpho ◽  
Maria Julia Gregorio Calas ◽  
Gracy de Almeida Coutinho Carneiro ◽  
Isabela Cunha Silveira ◽  
Andréia Brandão Ribeiro Vaz ◽  
...  
Keyword(s):  
Breast Imaging ◽  
Statistical Significance ◽  
Lobular Carcinoma ◽  
Cross Sectional Study ◽  
Breast Ultrasound ◽  
Cross Sectional ◽  
Dense Breasts ◽  
Time Required ◽  
Automated Breast Ultrasound

Abstract Objective To compare hand-held breast ultrasound (HHBUS) and automated breast ultrasound (ABUS) as screening tool for cancer. Methods A cross-sectional study in patients with mammographically dense breasts was conducted, and both HHBUS and ABUS were performed. Hand-held breast ultrasound was acquired by radiologists and ABUS by mammography technicians and analyzed by breast radiologists. We evaluated the Breast Imaging Reporting and Data System (BI-RADS) classification of the exam and of the lesion, as well as the amount of time required to perform and read each exam. The statistical analysis employed was measures of central tendency and dispersion, frequencies, Student t test, and a univariate logistic regression, through the odds ratio and its respective 95% confidence interval, and with p < 0.05 considered of statistical significance. Results A total of 440 patients were evaluated. Regarding lesions, HHBUS detected 15 (7.7%) BI-RADS 2, 175 (89.3%) BI-RADS 3, and 6 (3%) BI-RADS 4, with 3 being confirmed by biopsy as invasive ductal carcinomas (IDCs), and 3 false-positives. Automated breast ultrasound identified 12 (12.9%) BI-RADS 2, 75 (80.7%) BI-RADS 3, and 6 (6.4%) BI-RADS 4, including 3 lesions detected by HHBUS and confirmed as IDCs, in addition to 1 invasive lobular carcinoma and 2 high-risk lesions not detected by HHBUS. The amount of time required for the radiologist to read the ABUS was statistically inferior compared with the time required to read the HHBUS (p < 0.001). The overall concordance was 80.9%. A total of 219 lesions were detected, from those 70 lesions by both methods, 126 only by HHBUS (84.9% not suspicious by ABUS) and 23 only by ABUS. Conclusion Compared with HHBUS, ABUS allowed adequate sonographic study in supplemental screening for breast cancer in heterogeneously dense and extremely dense breasts.

scholarly journals Diagnostic accuracy of ultrasound in detection of pregnancy associated breast cancer

2021 ◽  
Vol 4 (1) ◽  
pp. 3-8
Author(s):  
Zainab Mehmood ◽  
Rafia Shahzad ◽  
Ismat Fatima ◽  
Abubaker Shahid
Keyword(s):  
Breast Cancer ◽  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Gold Standard ◽  
Breast Imaging ◽  
Ductal Carcinoma ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Linear Probe

Introduction: Some unique physiological changes occur in breast volume and water content during pregnancy which makes the radiological evaluation of the breast difficult.  As a result, diagnosis of Pregnancy Associated Breast Cancer.  is often delayed. Objective: To find out the diagnostic accuracy of ultrasonography in detection of pregnancy associated breast cancer taking histopathology as gold standard. Methodology: Present Cross-sectional study was carried out at INMOL Hospital, Lahore. Ultrasound of 200 women was performed. The patient was laid supine and then turned slightly in oblique position to scan the breast with high frequency linear probe (7.5-10 MHz). The contra-lateral breast and both axillae were also scanned in the same way. Findings were categorized on the basis of Breast Imaging Reporting and Data System (BI-RADS) assessment categories. Subsequently the breast tissue was sent to histopathology laboratory for tissue diagnosis. The pathologist was blinded of the results of ultrasonography. Results: Mean age was 34 ± 11.36 years. Twenty-eight percent patients were primi-para while 72% patients were multi-para. Diagnostic accuracy of ultrasonography taking histopathology as gold standard was analyzed and ultrasonography had sensitivity 84.78%, specificity 98.05%, positive predictive value 92.85%, negative predictive value 95.56% and diagnostic accuracy was 95%. Invasive ductal carcinoma was most commonly observed (P<0.001) malignant histopathology. On the other hand, significantly high (P = 0.033) number of benign lesions were Fibroadenomas. Conclusion: The high sensitivity and specificity along with easy availability, and non-invasive nature makes ultrasonography a very useful technique for the diagnosis of Pregnancy Associated Breast Cancer.

scholarly journals The Importance of Physical Exercise in Cardiovascular Fitness in Breast Cancer Survivors. A Cross-sectional Study: Women in Motion 2.0.”

2021 ◽  
Author(s):  
Lucía Gil Herrero ◽  
Marina Pollán Santamaría ◽  
Miguel Martín Jimenez ◽  
Sara López Tarruella ◽  
Mónica Castellanos Montealegre ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Physical Exercise ◽  
Breast Cancer Survivors ◽  
Previous History ◽  
Cross Sectional Study ◽  
Cardiovascular Fitness ◽  
Sectional Study ◽  
Cross Sectional ◽  
Bonferroni Test

Abstract PurposeTo compare the cardiovascular fitness of breast cancer (BC) survivors with an active lifestyle to those with a sedentary lifestyle. MethodsA cross-sectional study was conducted. Participants were classified into four different groups: sedentary with BC (Sed-BCW), active with BC (Act-BCW), sedentary without BC (Sed-HW) and active without BC (Act-HW). VO2max was estimated by the 6-minute walking test (6MWT); speed was measured by the 35-meter test; isometric strength was measured by dynamometry tests; lower body maximum strength was measured by the squat test; explosive strength was measured by the Sargent Jump Test; balance was measured by the 30-second balance test; and body composition was measured by bioimpedance. ANOVA was used to analyze group differences and post hoc comparisons were developed with the Bonferroni test. ResultsA total of 92 women were recruited. Significant differences were found in VO2max between the Act-BCW and Sed-BCW groups (MeanDif=5.86, p<0.001). No differences in VO2max were observed between the active groups (MeanDif= 0.42, p= 0.753). Related body composition and fat mass levels were significantly lower in the Act-BCW group than in the sedentary groups (Sed-BCW MeanDif= -6.78; p= 0.012 and Sed-HW MeanDif= -12.07; p<0.001) ConclusionsWomen who are Act-BCW can achieve similar values in physical condition as women who are Act-HW and have better values than women in who are sedentary. Moreover, physical exercise might be a stronger determinant of body composition than a previous history of BC.

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