scholarly journals Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study

2021 ◽  
Vol 7 (9) ◽  
pp. 185
Author(s):  
Giovanna Romanucci ◽  
Lisa Zantedeschi ◽  
Anna Ventriglia ◽  
Sara Mercogliano ◽  
Maria Vittoria Bisighin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Digital Breast Tomosynthesis ◽  
Matched Pairs ◽  
Breast Cancers ◽  
Test Results ◽  
Lobular Breast Cancer ◽  
Point Scale ◽  
Breast Tomosynthesis ◽  
Invasive Lobular Breast Cancer

Objectives: To compare the conspicuity of lobular breast cancers at digital breast tomosynthesis (DBT) versus synthesized 2D mammography (synt2D). Materials and methods: Seventy-six women (mean age 61.2 years, range 50–74 years) submitted to biopsy in our institution, from 2019 to 2021, with proven invasive lobular breast cancer (ILC) were enrolled in this retrospective study. The participants underwent DBT and synt2D. Five breast radiologists, with different years of experience in breast imaging, independently assigned a conspicuity score (ordinal 6-point scale) to DBT and synt2D. Lesion conspicuity was compared, for each reader, between the synt2D overall conspicuity interpretation and DBT overall conspicuity interpretation using a Wilcoxon matched pairs test. Results: A total of 50/78 (64%) cancers were detected on both synt2D and DBT by all the readers, while 28/78 (26%) cancers where not recognized by at least one reader on synt2D. For each reader, in comparison with synt2D, DBT increased significantly the conspicuity of ILC (p < 0.0001). The raw proportion of high versus low conspicuity by modality confirmed that cancers were more likely to have high conspicuity at DBT than synt2D. Conclusions: ILCs were more likely to have high conspicuity at DBT than at synt2D, increasing the chances of the detection of ILC breast cancer.

Comparison of Call-Back Rates between Digital Mammography and Digital Breast Tomosynthesis

2019 ◽  
Vol 85 (8) ◽  
pp. 855-857
Author(s):  
Anthony M. Scott ◽  
Madison G. Lashley ◽  
Nicholas B. Drury ◽  
Paul S. Dale
Keyword(s):  
Breast Cancer ◽  
Ultrasound Imaging ◽  
Digital Mammography ◽  
Breast Imaging ◽  
Digital Breast Tomosynthesis ◽  
Data System ◽  
Screening Tools ◽  
Radiographic Imaging ◽  
Breast Cancers ◽  
Breast Tomosynthesis

The effect of mammographic screening on the natural history and evolution of breast cancer treatment cannot be overstated; however, despite intensive and resource consuming screening, advanced breast cancer is still diagnosed frequently. The development of three-dimensional mammography or digital breast tomosynthesis (DBT) has already demonstrated greater sensitivity in the diagnosis of breast pathology and effectiveness in identifying early breast cancers. In addition to being a more sensitive screening tool, other studies indicate DBT has a lower call-back rate when compared with traditional DM. This study compares call-back rates between these two screening tools. A single institution, retrospective review was conducted of almost 20,000 patient records who underwent digital mammography or DBTin the years 2016 to 2018. These charts were analyzed for documentation of imaging type, Breast Imaging Reporting and Data System 0 status, call-back status, and type of further imaging that was required. Charts for 19,863 patients were reviewed, 17,899 digital mammography examinations were conducted compared with 11,331 DBT examinations resulting in 1,066 and 689 Breast Imaging Reporting and Data System 0 studies, respectively. Of the DM call-backs, 82.08 per cent were recommended for additional radiographic imaging and 17.82 per cent for ultrasound imaging. In the DBT group, only 39.77 per cent of callbacks were recommended for additional radiographic imaging and 60.09 per cent for ultrasound imaging. Our data suggest that DBT results in less call-back for additional mammographic images as compared with digital mammography. DBT may offer benefits over DM, including less imaging before biopsy, less time before biopsy, quicker diagnosis, and improved patient satisfaction.

Antecedents: A Half-Century of Imaging the Breast

2019 ◽  
Vol 1 (1) ◽  
pp. 2-8
Author(s):  
Daniel B Kopans
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance ◽  
Breast Imaging ◽  
Death Rate ◽  
Digital Breast Tomosynthesis ◽  
Breast Cancers ◽  
Breast Tomosynthesis ◽  
Half Century ◽  
X Ray ◽  
Detect Breast Cancer

Abstract The field of Breast Imaging evolved because a fairly small number of dedicated individuals realized the lifesaving potential of detecting breast cancer earlier. They persevered despite persistent efforts to curtail screening. From the first attempts to produce X-ray images of the breast to magnetic resonance and digital breast tomosynthesis, investigators have worked continuously to develop better ways to detect breast cancer at a time when cure is possible, while working continuously to preserve access for women to screening. Consequently, the death rate from breast cancer has declined by more than 40%. Therapy has improved, but therapy saves lives when breast cancers are treated early.

scholarly journals The value of mammography in women with focal breast complaints in addition to initial targeted ultrasound

2020 ◽  
Author(s):  
L. Appelman ◽  
P. T. M. Appelman ◽  
C. C. N. Siebers ◽  
P. Bult ◽  
H. L. S. Go ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Digital Breast Tomosynthesis ◽  
Breast Disease ◽  
Added Value ◽  
Breast Tomosynthesis ◽  
Targeted Ultrasound ◽  
Symptomatic Breast Cancer ◽  
Symptomatic Breast

Abstract Purpose To determine the added value of mammography in women with focal breast complaints and the utility of initial targeted ultrasound in this setting. Methods Women with symptomatic breast disease who were evaluated by breast imaging (mammography/digital breast tomosynthesis and ultrasound) between January 2016 and December 2016 in the Radboud University Medical Centre were included. We retrospectively collected the following data: date of birth, indication of imaging, visibility on mammography/ultrasound, whether biopsy was taken, additional findings, BI-RADS-classification, pathology and follow-up results. Results A total of 494 women were included (mean age 46.5, range 30 to 93). In 49 women (9.9%), symptomatic breast cancer was diagnosed, all visible during targeted ultrasound. The negative predictive value of targeted ultrasound was very high (99.8%). Additional findings on mammography were significantly more often malignant when the symptomatic lesion was also malignant (3.8% vs 70%, P < 0.05). In only one patient with symptoms caused by a benign finding, an incidental malignancy was detected on mammography outside the area of complaint (detection rate 2.2/1000 examinations). Conclusions The contribution of mammography for cancer detection in women with focal breast complaints is very low when targeted ultrasound is performed. Additional findings are most common in patients with symptomatic breast cancer. Our results suggest that initial targeted ultrasound is a more appropriate initial tool for the evaluation of focal breast complaints. Mammography could be performed on indication only.

scholarly journals Pros and cons for breast cancer screening with tomosynthesis – a review of the

2020 ◽  
Author(s):  
Julian Hans Kleinknecht ◽  
Anca Ileana Ciurea ◽  
Cristiana Augusta Ciortea
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Imaging ◽  
Digital Breast Tomosynthesis ◽  
Detection Rates ◽  
Breast Tomosynthesis ◽  
Screening Programs ◽  
Long Term Follow Up ◽  
Imaging Research

Breast cancer screening programs using mammography proved their value in detecting breast cancer at early stages and, consequently, reducing the mortality from this disease. Due to the technological progress, the screening programs have shifted from screen-film mammography to digital mammography and nowadays digital breast tomosynthesis became the focus of breast imaging research. Using tomosynthesis in screening increases cancer detection rates and decreases recall and false-positive rates, thus improving the effectiveness of breast cancer screening programs, with positive consequences on health care costs and on patient psychology. More long-term follow-up data must be collected for assessing absolute sensitivity and specificity of digital breast tomosynthesis, together with efforts for addressing the limitations of the method.

scholarly journals Comparison of Digital Breast Tomosynthesis and Digital Mammography for Detection of Breast Cancer in Kuwaiti Women

2018 ◽  
Vol 28 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Akram M. Asbeutah ◽  
Nouralhuda Karmani ◽  
AbdulAziz A. Asbeutah ◽  
Yasmin A. Echreshzadeh ◽  
Abdullah A. AlMajran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sensitivity And Specificity ◽  
Digital Mammography ◽  
Breast Imaging ◽  
Characteristic Curve ◽  
Digital Breast Tomosynthesis ◽  
Breast Lesions ◽  
Breast Tomosynthesis ◽  
Kappa Test ◽  
Significant Difference

Objective: To investigate the sensitivity and specificity of digital mammography (DM) and digital breast tomosynthesis (DBT) for the detection of breast cancer in comparison to histopathology findings. Subjects and Methods: We included 65 breast lesions in 58 women, each detected by two diagnostic mammography techniques – DM and DBT using Senographe Essential (GE Healthcare, Buc, France) – and subsequently confirmed by histopathology. The Breast Imaging Reporting and Data System was used for characterizing the lesions. Results: The average age of women was 48.3 years (range 26–81 years). There were 34 malignant and 31 benign breast lesions. The sensitivity of DM and DBT was 73.5 and 100%, respectively, while the specificity was 67.7 and 94%, respectively. Receiver operating characteristic curve analysis showed an overall diagnostic advantage of DBT over DM, with a significant difference between DBT and DM (p < 0.001). By performing Cohen’s kappa test, we found that there was a strong level of agreement according to Altman guidelines between DBT and histopathology findings (0.97), but a weak agreement between DM and histopathology findings (0.47). Conclusion: DBT improves the clinical accuracy of mammography by increasing both sensitivity and specificity. We believe that this improvement is due to improved image visibility and quality. These results could be of interest to health care institutions as they may impact their decision on whether to upgrade to DBT not only for diagnosis, but also for screening.

scholarly journals The Adjunctive Digital Breast Tomosynthesis in Diagnosis of Breast Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Tsung-Lung Yang ◽  
Huei-Lung Liang ◽  
Chen-Pin Chou ◽  
Jer-Shyung Huang ◽  
Huay-Ben Pan
Keyword(s):  
Breast Cancer ◽  
Diagnostic Performance ◽  
Digital Breast Tomosynthesis ◽  
Subjective Assessment ◽  
Architectural Distortion ◽  
Breast Cancers ◽  
Chi Square ◽  
Breast Tomosynthesis ◽  
Chi Square Test ◽  
Mass Lesions

Purpose. To compare the diagnostic performance of digital breast tomosynthesis (DBT) and digital mammography (DM) for breast cancers.Materials and Methods. Fifty-seven female patients with pathologically proved breast cancer were enrolled. Three readers gave a subjective assessment superiority of the index lesions (mass, focal asymmetry, architectural distortion, or calcifications) and a forced BIRADS score, based on DM reading alone and with additional DBT information. The relevance between BIRADS category and index lesions of breast cancer was compared by chi-square test.Result. A total of 59 breast cancers were reviewed, including 17 (28.8%) mass lesions, 12 (20.3%) focal asymmetry/density, 6 (10.2%) architecture distortion, 23 (39.0%) calcifications, and 1 (1.7%) intracystic tumor. Combo DBT was perceived to be more informative in 58.8% mass lesions, 83.3% density, 94.4% architecture distortion, and only 11.6% calcifications. As to the forced BIRADS score, 84.4% BIRADS 0 on DM was upgraded to BIRADS 4 or 5 on DBT, whereas only 27.3% BIRADS 4A on DM was upgraded on DBT, as BIRADS 4A lesions were mostly calcifications. A significantPvalue (<0.001) between the BIRADS category and index lesions was noted.Conclusion. Adjunctive DBT gives exquisite information for mass lesion, focal asymmetry, and/or architecture distortion to improve the diagnostic performance in mammography.

Supplemental Screening for Women with Dense Breasts: What Do Practicing Radiologists Recommend?

2019 ◽  
Vol 1 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Tisha Singer ◽  
Ana P Lourenco ◽  
Grayson L Baird ◽  
Martha B Mainiero
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Breast Imaging ◽  
Digital Breast Tomosynthesis ◽  
Risk Groups ◽  
High Rate ◽  
Breast Tomosynthesis ◽  
Dense Breasts ◽  
Additional Imaging ◽  
Magnetic Resonance Imaging Mri

Abstract Objective To evaluate radiologists’ supplemental screening recommendations for women with dense breasts, at average, intermediate, or high risk of breast cancer, and to determine if there are differences between their recommendations for their patients, their friends and family, and themselves. Methods This is an anonymous survey of Society of Breast Imaging (SBI) members. Demographics, knowledge of breast density as a risk factor, and recommendations for screening with digital breast tomosynthesis (DBT), ultrasound (US), and magnetic resonance imaging (MRI) in women with dense breasts, at average, intermediate, or high- risk of breast cancer were assessed. The likelihood of their recommending the screening test for their patients, their family and friends, and themselves was assessed on a Likert scale from 0 to 4 (0 = “not at all likely” to 4 = “extremely likely”). Results There were 295 responses: 67% were women, and breast imaging comprised 95% of their practice. Among participants, 53% correctly answered the question on relative risk of breast cancer when comparing extremely dense versus fatty breasts, and 57% when comparing heterogeneously dense versus scattered breasts. US is recommended at a relatively low rate (1.0–1.4 on the 0–4 scale), regardless of risk. DBT is recommended at a relatively high rate (2.5–3.0 on the 0–4 scale), regardless of risk status. MR is recommended mainly for those at high risk (3.6 on the 0–4 scale). Radiologists were more likely to recommend additional imaging for themselves than for their patients and their family and friends. Conclusion For women with dense breasts, radiologists are “somewhat likely” to recommend US and “likely” to “very likely” to recommend DBT regardless of risk group. They are “very likely” to recommend MRI for high-risk groups.

A Survey on Female Breast Cancer

2019 ◽  
pp. 209-226
Author(s):  
Kalaivani Anbarasan ◽  
Ramya S.
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Research Work ◽  
Three Dimensional ◽  
Digital Breast Tomosynthesis ◽  
Female Breast Cancer ◽  
Breast Tomosynthesis ◽  
Imaging Model ◽  
Image Set ◽  
Aided Diagnosis

The mortality rate of breast cancer can be effectively reduced by early diagnosis. Imaging modalities are used to diagnose through computer for women breast cancer. Digital mammography is the best imaging model for breast cancer screening technique and diagnosis. Digital breast tomosynthesis (DBT), a three-dimensional (3-D) mammography, is an advanced form of breast imaging where multiple images of the breast from different angles are captured and reconstructed (synthesized) into a three-dimensional image set. This chapter discusses the research work carried out on the computer diagnosis of women breast cancer through digital breast tomosynthesis and concludes with further improvement in the computer-aided diagnosis.

scholarly journals Utility of Digital Breast Tomosynthesis with Two-Dimensional Synthesized Mammography Images: A Pictorial Essay

2021 ◽  
Author(s):  
Pradipta C. Hande ◽  
Sabita S. Desai ◽  
Sarabjeet K. Arneja ◽  
Sreedevi Sathian
Keyword(s):  
High Resolution ◽  
Breast Imaging ◽  
Digital Breast Tomosynthesis ◽  
Two Dimensional ◽  
Breast Cancers ◽  
Data Set ◽  
Breast Tomosynthesis ◽  
Full Field ◽  
Full Field Digital Mammography ◽  
Pictorial Essay

Abstract Background Mammography has been established as the key modality in the detection and diagnosis of breast cancers. Digital breast tomosynthesis (DBT) has emerged as a mammographic technique which allows improved visualization of abnormalities by reducing the effect of overlapping breast tissue. Purpose This article is a pictorial essay which highlights the advantages of DBT with two-dimensional (2D) synthesized mammography (2DSM) images, its clinical applications, and its role in breast imaging. Materials and Methods Selenia Dimensions HD mammography machine performs DBT which acquires a series of low-dose digital mammographic images of the compressed breast followed by full-field digital mammography. Software using specialized algorithms helps to create a 2DSM image reconstructed from the DBT data set. The images are interpreted on a dedicated work station on high-resolution monitors by the radiologist. American College of Radiology Breast Imaging-Reporting and Data System (BI-RADS) lexicon is used for reporting. High-resolution breast ultrasound which includes evaluation of the axilla is done for all cases. Conclusion DBT improves detection and better characterization of lesions which thereby increases confidence of interpretation of mammograms and assigning BI-RADS categories for further management.

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