scholarly journals Candida parapsilosis as a Causative Agent of Onychomycosis in Patient with Cirrhosis of the Liver

2020 ◽  
Vol 6 (4) ◽  
pp. 313
Author(s):  
Yelena Kukhar ◽  
Ainura Smagulova ◽  
Ainash Daniyarova ◽  
Aliya Baiduissenova ◽  
Vladimir Kiyan
Keyword(s):  
Causative Agent ◽  
Urease Activity ◽  
Antifungal Agents ◽  
Candida Parapsilosis ◽  
Biological Properties ◽  
Cirrhosis Of The Liver ◽  
Yeast Cells ◽  
Yeast Form ◽  
Light Yellow ◽  
First Case

We report the first case of non-dermatophytic onychomycosis of the toenail described in Kazakhstan caused by Candida parapsilosis. The biological properties of the strain were studied. C. parapsilosis forms white creamy colonies, smooth with focal wrinkles, and the reversum is light-yellow. The culture of C. parapsilosis is represented by a yeast form, characterized by the presence of round or cylindrical yeast cells with active budding. The strain has a high saccharolytic and urease activity and is indifferent to the sucrose and maltose. The C. parapsilosis strain was sensitive to polyene and azole antifungal agents. The highest sensitivity was found to ketoconazole, itraconazole and nystatin.

scholarly journals Candida parapsilosis as a Causative Agent of Onychomycosis in Patient with Cirrhosis of the Liver

2021 ◽  
Author(s):  
Yelena Kukhar ◽  
Ainura Smagulova ◽  
Ainash Daniyarova ◽  
Aliya Baiduissenova ◽  
Vladimir Kiyan
Keyword(s):  
Causative Agent ◽  
Candida Parapsilosis ◽  
Cirrhosis Of The Liver

The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus

2017 ◽  
Vol 68 (7) ◽  
pp. 1598-1601 ◽  
Author(s):  
Anisia Iuliana Alexa ◽  
Roxana Ciuntu ◽  
Alina Cantemir ◽  
Nicoleta Anton ◽  
Ciprian Danielescu ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
Fungal Infections ◽  
Prolonged Treatment ◽  
Endogenous Endophthalmitis ◽  
Pressure Therapy ◽  
First Case ◽  
Severe Infections ◽  
Pars Plana ◽  
Delay In Treatment ◽  
Vitreous Biopsy

Severe infections with C. albicans should be treated promptly with antifungal agents, any delay in treatment increases the risk of endophthalmitis. The systemic Amphotericin B therapy is the gold standard in the treatment of endophthalmitis, but in the case of fungal infections it has not yet been determined. Numerous studies have shown that the use of Fluconazole is effective in the treatment of fungal endophthalmitis. In this paper, we report two cases (3 eyes) that have been presented for the same accusations of significant decrease of AV (visual acuity), ocular pain and blepharospasm suddenly installed, both of which required urgent antibiotic and intravenous antifungal treatment. Both are diagnosed with endogenous endophthalmitis and vitreous biopsy + VPP (pars plana vitrectomy) are performed, with a negative result of the vitreous culture. In both situations the treatment was with antibiotic and systemic antifungals. Postoperatively, evolution was favorable in the first case and less favorable in the second one. The prognosis depends on the virulence of the microorganisms and the time elapsed until initiation of the treatment. Also, the presence of risk factors such as diabetes, sepsis, recent abdominal surgery (C. Albicans is part of the comesary flora of the digestive tract) have influenced the prognosis decisively. Severe infections with C. albicans should be promptly treated with antifungal agents, any delay in treatment increases the risk of endophthalmitis. Even when prolonged treatment of candidemia is instituted, 3% of patients can develop endogenous endophthalmitis, so ocular evaluation is particularly important for patients immobilized in anesthesia and intensive care units.

scholarly journals Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species

2017 ◽  
Vol 61 (11) ◽  
Author(s):  
Wiley A. Schell ◽  
A. M. Jones ◽  
Katyna Borroto-Esoda ◽  
Barbara D. Alexander
Keyword(s):  
Candida Glabrata ◽  
Antifungal Agents ◽  
Candida Parapsilosis ◽  
Candida Krusei ◽  
Wild Type ◽  
Content Type ◽  
Clinical Resistance ◽  
Excellent Activity ◽  
Candida Lusitaniae

ABSTRACT SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida lusitaniae, and Candida parapsilosis, including 44 Candida isolates with known genotypic (FKS1 or FKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species.

Tuberculosis allergy

1937 ◽  
Vol 33 (10) ◽  
pp. 1237-1244
Author(s):  
N. N. Sirotinin
Keyword(s):  
Infectious Diseases ◽  
Causative Agent ◽  
Biological Properties ◽  
The State ◽  
Exceptional Value

The doctrine of allergy in general and tuberculosis in particular appeared during the heyday of bacteriology and immunology. This was the time when in the etiology of infectious diseases the causative agent was attributed to an exceptional value, while the state of the microorganism was interested mainly in terms of its immuno-biological properties.

scholarly journals Differential Activities of Newer Antifungal Agents against Candida albicans and Candida parapsilosis Biofilms

2007 ◽  
Vol 52 (1) ◽  
pp. 357-360 ◽  
Author(s):  
Αspasia Katragkou ◽  
Athanasios Chatzimoschou ◽  
Maria Simitsopoulou ◽  
Maria Dalakiouridou ◽  
Eudoxia Diza-Mataftsi ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Agents ◽  
Candida Parapsilosis ◽  
Planktonic Cells

ABSTRACT The activities of voriconazole, posaconazole, caspofungin, and anidulafungin against Candida albicans and Candida parapsilosis biofilms were evaluated. In contrast to planktonic cells, the MICs for voriconazole and posaconazole for the biofilms of the two species were high (≥256 and >64 mg/liter, respectively) but relatively low for the echinocandins caspofungin and anidulafungin (≤1 and ≤2 mg/liter, respectively).

scholarly journals Candida Parapsilosis Endocarditis in a Very Low Birth Weight Premature Infant Successfully Treated with the Association of Caspofungin and Voriconazole

2008 ◽  
Vol 1 ◽  
pp. IDRT.S895
Author(s):  
Vanessa A. Aguiare Lopes ◽  
Alexandre Ordones Lopes ◽  
Orlei Ribeiro De Araújo ◽  
Valeska A. Schauer Aguiare
Keyword(s):  
Premature Infant ◽  
Antifungal Agents ◽  
Candida Parapsilosis ◽  
Very Low Birth Weight ◽  
Prolonged Mechanical Ventilation ◽  
Superior Vena ◽  
Combined Therapy ◽  
Vena Cava ◽  
Surgical Removal

Objectives To report a case in where a mural endocarditis caused by Candida parapsilosis was successfully treated with the combination of 2 antifungal agents, caspofungin and voriconazole, in an extremely premature infant. Description A female infant born at 30.7 weeks with weight 925 g. The infant had a pneumothorax and respiratory distress syndrome, requiring prolonged mechanical ventilation, 1 venous umbilical and 3 central catheters, and broad-spectrum antibiotics. At 51 days of life, an echocardiogram showed an image compatible with fungal vegetation on the junction of the superior vena cava to the right atrium. Blood cultures grew Candida parapsilosis in various sequential samples, despite treatment with fluconazole and amphotericin-B and in vitro sensitivity to these drugs. A treatment of combined voriconazole and caspofungin was initiated resulting in clinical improvement and no need for surgical removal of vegetation. Comments Combined therapy with newer antifungal agents can be life-saving in premature infants with Candida parapsilosis complicated sepsis.

scholarly journals Novel Characteristics of the Biological Properties of the YeastSaccharomyces cerevisiaeEukaryotic Initiation Factor 2A

2005 ◽  
Vol 280 (16) ◽  
pp. 15601-15611 ◽  
Author(s):  
Anton A. Komar ◽  
Stephane R. Gross ◽  
Diane Barth-Baus ◽  
Ryan Strachan ◽  
Jack O. Hensold ◽  
...  
Keyword(s):  
Translational Control ◽  
Internal Ribosome Entry Site ◽  
Biological Properties ◽  
Yeast Cells ◽  
Initiation Factor ◽  
Dependent Manner ◽  
Entry Site ◽  
Regulation Of Expression ◽  
Internal Ribosome Entry ◽  
Expression Of Genes

Eukaryotic initiation factor 2A (eIF2A) has been shown to direct binding of the initiator methionyl-tRNA (Met-tRNAi) to 40 S ribosomal subunits in a codon-dependent manner, in contrast to eIF2, which requires GTP but not the AUG codon to bind initiator tRNA to 40 S subunits. We show here that yeast eIF2A genetically interacts with initiation factor eIF4E, suggesting that both proteins function in the same pathway. The doubleeIF2A/eIF4E-tsmutant strain displays a severe slow growth phenotype, which correlated with the accumulation of 85% of the double mutant cells arrested at the G2/M border. These cells also exhibited a disorganized actin cytoskeleton and elevated actin levels, suggesting that eIF2A might be involved in controlling the expression of genes involved in morphogenic processes. Further insights into eIF2A function were gained from the studies of eIF2A distribution in ribosomal fractions obtained from either aneIF5BΔ (fun12Δ) strain or aeIF3b-ts(prt1-1) strain. It was found that the binding of eIF2A to 40 and 80 S ribosomes was not impaired in either strain. We also found that eIF2A functions as a suppressor of Ure2p internal ribosome entry site-mediated translation in yeast cells. The regulation of expression from theURE2internal ribosome entry site appears to be through the levels of eIF2A protein, which has been found to be inherently unstable with a half-life of ∼17 min. It was hypothesized that this instability allows for translational control through the level of eIF2A protein in yeast cells.

scholarly journals Multiechinocandin- and Multiazole-Resistant Candida parapsilosis Isolates Serially Obtained during Therapy for Prosthetic Valve Endocarditis

2005 ◽  
Vol 49 (2) ◽  
pp. 767-769 ◽  
Author(s):  
Varsha Moudgal ◽  
Tania Little ◽  
Dina Boikov ◽  
Jose A. Vazquez
Keyword(s):  
Case Report ◽  
Prosthetic Valve ◽  
Candida Parapsilosis ◽  
Prosthetic Valve Endocarditis ◽  
First Case

ABSTRACT Echinocandins are approved for the treatment of candidal infections. In vitro they have been shown to be less potent against strains of Candida parapsilosis than against other Candida spp. This is the first case report describing the development of a secondary multidrug (echinocandin-azole)-resistant Candida strain during therapy.

scholarly journals Profiling of the effects of antifungal agents on yeast cells based on morphometric analysis

2015 ◽  
Vol 15 (5) ◽  
pp. fov040 ◽  
Author(s):  
Abraham Abera Gebre ◽  
Hiroki Okada ◽  
Cholgwang Kim ◽  
Karen Kubo ◽  
Shinsuke Ohnuki ◽  
...  
Keyword(s):  
Morphometric Analysis ◽  
Antifungal Agents ◽  
Yeast Cells

scholarly journals Zika fever: clinical, epidemiological, laboratory, and diagnostic aspects

2017 ◽  
Vol 95 (2) ◽  
pp. 112-117
Author(s):  
K. V. Zhdanov ◽  
S. M. Zakharenko ◽  
Aleksandr N. Kovalenko ◽  
A. V. Semenov ◽  
S. S. Kozlov ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Causative Agent ◽  
Clinical Symptoms ◽  
Biological Properties ◽  
Laboratory Diagnostics ◽  
Diagnostic Aspects ◽  
And Control ◽  
Zika Fever

The authors overview data on the prevalence of Zika fever with reference to biological properties of the causative agent, epidemiological process, pathogenesis, and clinical symptoms of the disease. Special attention is given to the identification of the virus in pregnant women, microcephaly in the babies born by Zika-infected women, algorithm of laboratory diagnostics, and measures needed to prevent and control mosquitoes that spread viruses.

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