scholarly journals Current State of “Omics” Biomarkers in Pancreatic Cancer

2021 ◽  
Vol 11 (2) ◽  
pp. 127 ◽  
Author(s):  
Beste Turanli ◽  
Esra Yildirim ◽  
Gizem Gulfidan ◽  
Kazim Yalcin Arga ◽  
Raghu Sinha
Keyword(s):  
Pancreatic Cancer ◽  
Personalized Medicine ◽  
Biomarker Discovery ◽  
Survival Rates ◽  
Postoperative Recurrence ◽  
Molecular Biomarkers ◽  
Background Information ◽  
Current State ◽  
Pancreatic Cancer Screening ◽  
The Future

Pancreatic cancer is one of the most fatal malignancies and the seventh leading cause of cancer-related deaths related to late diagnosis, poor survival rates, and high incidence of metastasis. Unfortunately, pancreatic cancer is predicted to become the third leading cause of cancer deaths in the future. Therefore, diagnosis at the early stages of pancreatic cancer for initial diagnosis or postoperative recurrence is a great challenge, as well as predicting prognosis precisely in the context of biomarker discovery. From the personalized medicine perspective, the lack of molecular biomarkers for patient selection confines tailored therapy options, including selecting drugs and their doses or even diet. Currently, there is no standardized pancreatic cancer screening strategy using molecular biomarkers, but CA19-9 is the most well known marker for the detection of pancreatic cancer. In contrast, recent innovations in high-throughput techniques have enabled the discovery of specific biomarkers of cancers using genomics, transcriptomics, proteomics, metabolomics, glycomics, and metagenomics. Panels combining CA19-9 with other novel biomarkers from different “omics” levels might represent an ideal strategy for the early detection of pancreatic cancer. The systems biology approach may shed a light on biomarker identification of pancreatic cancer by integrating multi-omics approaches. In this review, we provide background information on the current state of pancreatic cancer biomarkers from multi-omics stages. Furthermore, we conclude this review on how multi-omics data may reveal new biomarkers to be used for personalized medicine in the future.

scholarly journals Microbial Associations with Pancreatic Cancer: A New Frontier in Biomarkers

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3784
Author(s):  
Mark Stasiewicz ◽  
Marek Kwaśniewski ◽  
Tomasz M. Karpiński
Keyword(s):  
Pancreatic Cancer ◽  
Helicobacter Pylori ◽  
Survival Rates ◽  
Health Concern ◽  
Current State ◽  
Increased Risk ◽  
Microbial Biomarkers ◽  
New Frontier ◽  
Microbial Associations ◽  
Fungal Genus

Pancreatic cancer (PC) remains a global health concern with high mortality and is expected to increase as a proportion of overall cancer cases in the coming years. Most patients are diagnosed at a late stage of disease progression, which contributes to the extremely low 5-year survival rates. Presently, screening for PC remains costly and time consuming, precluding the use of widespread testing. Biomarkers have been explored as an option by which to ameliorate this situation. The authors conducted a search of available literature on PubMed to present the current state of understanding as it pertains to the use of microbial biomarkers and their associations with PC. Carriage of certain bacteria in the oral cavity (e.g., Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Streptococcus sp.), gut (e.g., Helicobacter pylori, Synergistetes, Proteobacteria), and pancreas (e.g., Fusobacterium sp., Enterobacteriaceae, Pseudomonadaceae) has been associated with an increased risk of developing PC. Additionally, the fungal genus Malassezia has likewise been associated with PC development. This review further outlines potential oncogenic mechanisms involved in the microbial-associated development of PC.

scholarly journals Age and Sex Effects across the Blood Proteome after Lonizing Radiation Exposure: Consequences for Biomarker Screening and Risk Assessment

2021 ◽  
Author(s):  
Britta Langen ◽  
Egor Vorontsov ◽  
Johan Spetz ◽  
John Swanpalmer ◽  
Carina Sihlbom ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Personalized Medicine ◽  
Biomarker Discovery ◽  
Molecular Biomarkers ◽  
Cancer Radiotherapy ◽  
Male And Female ◽  
Sex Effects ◽  
Proteomic Response ◽  
Age And Sex ◽  
Screening Approaches

Abstract Molecular biomarkers of ionizing radiation (IR) exposure are a promising new tool in various disciplines: they can give necessary information for adaptive treatment planning in cancer radiotherapy, enable risk projection for radiation-induced survivorship diseases, or facilitate triage and intervention in radiation hazard events. However, radiation biomarker discovery has not yet resolved the most basic features of personalized medicine: age and sex. To overcome this critical bias in biomarker identification, we quantitated age and sex effects and assessed their relevance in the radiation response across the blood proteome. We used high-throughput mass spectrometry on blood plasma collected 24 hours after 0.5 Gy total body irradiation (15 MV nominal photon energy) from male and female C57BL/6N mice at juvenile (7-weeks-old) or adult (18-weeks-old) age. We also assessed sex and strain effects using juvenile male and female BALB/c nude mice. We showed that age and sex created significant effects in the proteomic response regarding both extent and functional quality of IR-induced responses. Furthermore, we found that age and sex effects appeared non-linear and were often end-point specific. Overall, age contributed more to differences in the proteomic response than sex, most notably in immune responses, oxidative stress, and apoptotic cell death. Interestingly, sex effects were pronounced for DNA damage & repair pathways and associated cellular outcome (pro-survival vs. pro-apoptotic). Only one protein (AHSP) was identified as a potential general biomarker candidate across age and sex, while GMNN, REG3B, and SNCA indicated some response similarity across age. This low yield advocated that unisex or uniage biomarker screening approaches are not feasible. In conclusion, age- and sex-specific screening approaches should be implemented as standard protocol to ensure robustness and diagnostic power of biomarker candidates. Bias-free molecular biomarkers are a necessary progression towards personalized medicine and integral for advanced adaptive cancer radiotherapy and risk assessment.

scholarly journals BIOBANKS ARE AN ESSENTIAL TOOL FOR TRANSPLANTATION. HISTORY, CURRENT STATE, PERSPECTIVES

2017 ◽  
Vol 18 (4) ◽  
pp. 123-132 ◽  
Author(s):  
O. N. Reznik ◽  
D. O. Kuzmin ◽  
A. E. Skvortsov ◽  
A. O. Reznik
Keyword(s):  
Personalized Medicine ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Survival Rates ◽  
New Drugs ◽  
Patient Specific ◽  
Organ Shortage ◽  
Therapy Targets ◽  
Current State ◽  
New Biomarkers

Organ shortage remains to be a crucial issue in transplantation. However, it’s not the only challenge that modern transplantation is facing. There are critical issues to be solved, such as, choosing optimal patient-specific immunosuppressive regimen, preventing or coping effectively with graft rejection and improving graft and patient survival rates. There are still a number of ongoing studies on ischemia-reperfusion injury mechanisms. It is also unknown what the true limitations of organ viability are and what mechanisms actually regulate it. The upcoming era of personalized medicine dictates the necessity for individualized approach to these issues. The creation of transplant biobanks followed by different studies on their base may be the key option to resolve problems of modern transplantation. Biobanks are an essential basis of personalized medicine, which allows largescale population studies, discovery of new biomarkers and therapy targets as well as new drugs development. The importance of this relatively new fi eld has increased over last decades making its way from small collections of samples to large national and international biorepositories. There are biobanks of different types and purposes. In this article a systematic review is given covering historical reference, term definition, and classifi cation variants. Furthermore, the current state of the industry is highlighted along with current issues and perspectives with respect to transplantation.

scholarly journals Air defense of the Baltic states. Looking toward the future

2021 ◽  
Vol 7 (2) ◽  
pp. 12-21
Author(s):  
Eugeniusz CIEŚLAK
Keyword(s):  
Early Years ◽  
Background Information ◽  
Capability Development ◽  
Baltic States ◽  
Air Defense ◽  
Security Environment ◽  
Current State ◽  
Starting Point ◽  
The Future ◽  
The Baltic

The article offers the discussion of the origins, current state and the future of air defence of the Baltic states. It tries to relate developments in the field of air defense to changes in security environment, and defence polices of the Baltic states. The article starts with a retrospection on origins and developments of air defence of the Baltic states before they joined NATO. Then it focuses on early years of integration with NATO Integrated Air Defense System and implications for air defence of the Baltic states related to changes in the security of the Euro-Atlantic region stemming from Russian aggressive actions. An assessment of current posture of air defence of the Baltic states serves as a starting point for the discussion on requirements for future developments, and predicting possible outcomes. The research uses unclassified, publicly available documents and analytical reports to provide background information for the discussion on the future of air defense of the Baltic states. The Baltic states are aware of the limitations of their air defense, and try to develop this capability within available resources. Changes to security environment after 2014 gave new impetus to the development of air defense of the Baltic states, both for the efforts undertaken by NATO and for national capability development.

Remedies for Breach of Contract: The Future Development of Scots Law in its European and International Context

1997 ◽  
Vol 1 (2) ◽  
pp. 200-226 ◽  
Author(s):  
Hector L MacQueen
Keyword(s):  
Future Development ◽  
European Contract ◽  
Breach Of Contract ◽  
International Context ◽  
The United Kingdom ◽  
Current State ◽  
The Future ◽  
University Of Edinburgh ◽  
International Conventions ◽  
Law Commission

This paper,first presented on 21 October 1995 at ajoint seminar ofthe Scottish Law Commission and the Faculty of Law, University of Edinburgh, on the subject of breach of contract, considers the future development of the law in this area, first by considering its history and current state in comparative terms and drawing the conclusion that it is characterised by a mixture of Civilian and Common Law elements; second, by comparing Scots law with the provisions on breach contained in recently published proposals for a harmonised law of contract (the UNIDROIT Principles of International Commercial Contracts, the Principles of European Contract Law prepared by the Lando Commission, and the draft “code”for the United Kingdom prepared on behalf of the English Law Commission by Harvey McGregor in the late 1960s) and in international conventions on the sale of goods. Although Scots law emerges reasonably wellfrom this exercise, there are a number of points to be taken on board in any future reform, as well as some insights into important underlying principles.

Artistic Challenges within Control Societies: Big Data and Democratic Resistance

MedienJournal ◽  
2017 ◽  
Vol 38 (4) ◽  
pp. 50-61 ◽  
Author(s):  
Jan Jagodzinski
Keyword(s):  
Big Data ◽  
Gilles Deleuze ◽  
Data Archive ◽  
Current State ◽  
The Future ◽  
The Way

This paper will first briefly map out the shift from disciplinary to control societies (what I call designer capitalism, the idea of control comes from Gilles Deleuze) in relation to surveillance and mediation of life through screen cultures. The paper then shifts to the issues of digitalization in relation to big data that have the danger of continuing to close off life as zoë, that is life that is creative rather than captured via attention technologies through marketing techniques and surveillance. The last part of this paper then develops the way artists are able to resist the big data archive by turning the data in on itself to offer viewers and participants a glimpse of the current state of manipulating desire and maintaining copy right in order to keep the future closed rather than being potentially open.

日本における抑うつ症状に対する心理学的介入を目的とした スマートフォン用アプリケーション・プログラムのレビュー

2020 ◽  
Author(s):  
Hikari Takashina ◽  
Kengo Yokomitsu
Keyword(s):  
Depressive Symptoms ◽  
Daily Life ◽  
Behavioral Therapy ◽  
Mobile Apps ◽  
Evaluation Model ◽  
Ease Of Use ◽  
Background Information ◽  
Evidence Based ◽  
Privacy And Security ◽  
Current State

There are thousands of mobile apps delivering information and offering support and intervention in situations of daily life. The aim of this study was to identify the current state of apps for depressive symptoms or prevention of depression within the official Android and iOS app stores in Japan. The 47 apps for depression available for download from the app stores were evaluated by the App Evaluation Model regarding background information, risk/ privacy and security, evidence, ease of use, and interoperability. Also, we evaluated their primary purpose, technology components, and cognitive-behavioral therapy components. The results suggest that in general few apps have been developed that are evidence-based, secure, and provide the services that users expect. In the future, it will be necessary to develop a framework for developing and disseminating more effective apps. This study is the first review of apps for depression available in Japan and seeks to help create a framework for such apps.

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