scholarly journals Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment

2021 ◽  
Vol 11 (6) ◽  
pp. 571
Author(s):  
Md Abdus Subhan ◽  
Satya Siva Kishan Yalamarty ◽  
Nina Filipczak ◽  
Farzana Parveen ◽  
Vladimir P. Torchilin
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
World Wide ◽  
Lymphatic Drainage ◽  
Epr Effect ◽  
Endothelial Junctions ◽  
Tumor Selectivity ◽  
Major Shortcoming ◽  
High Level ◽  
Over Time

Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent in most of anticancer drugs is their lack of tumor selectivity. Nanodrugs for cancer therapy administered intravenously escape renal clearance, are unable to penetrate through tight endothelial junctions of normal blood vessels and remain at a high level in plasma. Over time, the concentration of nanodrugs builds up in tumors due to the EPR effect, reaching several times higher than that of plasma due to the lack of lymphatic drainage. This review will address in detail the progress and prospects of tumor-targeting via EPR effect for cancer therapy.

scholarly journals RECENT PROGRESS OF DENDRIMERS IN DRUG DELIVERY FOR CANCER THERAPY

2018 ◽  
Vol 10 (5) ◽  
pp. 34 ◽  
Author(s):  
P. Anitha ◽  
J. Bhargavi ◽  
G. Sravani ◽  
B. Aruna ◽  
Ramkanth S.
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Targeting ◽  
Therapeutic Agent ◽  
Conventional Chemotherapy ◽  
Passive Targeting ◽  
Recent Advances ◽  
Anti Cancer ◽  
Diagnostic Applications ◽  
High Level

With the recent advances of nanotechnology, dendrimers are emerging as a highly attractive class of drug delivery vectors for cancer therapy. Dendrimers are multifunctional smart Nanocarriers to deliver one or more therapeutic agent safely and selectively to cancer cells. The high level of control over the synthesis of dendritic architecture makes dendrimers a nearly perfect (spherical) nanocarrier for site-specific drug delivery. The presence of functional groups in the dendrimers exterior also permits the addition of other moieties that can actively target certain diseases which are now widely used as tumor targeting strategies. Drug encapsulation, solubilization and passive targeting also equally contribute to the therapeutic use of dendrimers. Dendrimers are ideal carrier vehicles on cytotoxicity, blood plasma retention time, biodistribution and tumor uptake. In this review we highlight the advantages of dendrimers over conventional chemotherapy, toxicity and its management, following anti-cancer drugs delivered by using dendrimers and recent advances in drug delivery by various types of dendrimers as well as its diagnostic applications.

scholarly journals Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 838
Author(s):  
Katharina A. Sterenczak ◽  
Nadine Stache ◽  
Sebastian Bohn ◽  
Stephan Allgeier ◽  
Bernd Köhler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dendritic Cells ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Laser Scanning Microscopy ◽  
Sensory Nerves ◽  
Confocal Laser ◽  
Corneal Nerves ◽  
Over Time

During breast cancer therapy, paclitaxel and trastuzumab are both associated with adverse effects such as chemotherapy-induced peripheral neuropathy and other systemic side effects including ocular complications. Corneal nerves are considered part of the peripheral nervous system and can be imaged non-invasively by confocal laser scanning microscopy (CLSM) on the cellular level. Thus, in vivo CLSM imaging of structures of the corneal subbasal nerve plexus (SNP) such as sensory nerves or dendritic cells (DCs) can be a powerful tool for the assessment of corneal complications during cancer treatment. During the present study, the SNP of a breast cancer patient was analyzed over time by using large-scale in vivo CLSM in the course of paclitaxel and trastuzumab therapy. The same corneal regions could be re-identified over time. While the subbasal nerve morphology did not alter significantly, a change in dendritic cell density and an additional local burst within the first 11 weeks of therapy was detected, indicating treatment-mediated corneal inflammatory processes. Ocular structures such as nerves and dendritic cells could represent useful biomarkers for the assessment of ocular adverse effects during cancer therapy and their management, leading to a better visual prognosis.

Guideline-recommended incorporation of biomarker testing results in metastatic colorectal cancer therapy

2020 ◽  
Vol 17 (3) ◽  
pp. 185-194
Author(s):  
Jared Freml ◽  
Thomas Delate ◽  
Jesus Hermosillo-Rodriguez
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Cancer Therapy ◽  
Metastatic Colorectal Cancer ◽  
Small Proportion ◽  
Biomarker Testing ◽  
Over Time

Aim: To describe pharmacogenomic tumor testing among patients with metastatic colorectal cancer. Methods: This was a retrospective study of patients with metastatic colorectal cancer diagnosed between 1 January 2014 and 30 June 2018. Patients were assessed for pharmacogenomic testing and appropriateness of chemotherapy use. Results: Overall, 112/167 (67.1%) patients had at least one of the three recommended pharmacogenomic tests and 41/167 (24.6%) had all tests. Twenty-four patients were treated with cetuximab with 8/167 (4.7%) identified as being treated with a RAS variant (n = 3) or incomplete testing (n = 5); thus, not in accordance with guidelines. Conclusion: Uptake of testing was variable but increased over time; however, a small proportion of patients received cetuximab with a variant or not all recommended tests being performed.

A Low Dose of Hydrous Icaritin Nano-Formulation with Remarkable Efficacy and Tumor Targeting in Cancer Therapy

2021 ◽  
Vol 17 (10) ◽  
pp. 2003-2013
Author(s):  
Jingxin Fu ◽  
Yian Wang ◽  
Haowen Li ◽  
Likang Lu ◽  
Hui Ao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Low Dose ◽  
Drug Loading ◽  
Tumor Therapy ◽  
High Dose ◽  
Inhibition Rate ◽  
Tumor Inhibition ◽  
Nano Formulation ◽  
Tumor Inhibition Rate

Background: The use of chemotherapeutic drugs is restricted in the tumor-therapy because of the severely toxic and side effects among most important factors. The active herbal extracts are always used as a high dose while in the tumortherapy to achieve good anti-tumor effects. Hydrous icaritin has a high activity while there are few existing dosage forms as a result of low solubility in water and poor bioavailability. Results: The prepared hydrous icaritin nanorods (DP-HICT NRs) using mPEG2000-DSPE as a stabilizer, presented a narrow distribution of particle size with of 217 nm and a properly high drug-loading content of approximately 65.3±1.5%. A low dose of hydrous icaritin nano-formulation shows remarkable efficacy in cancer therapy (tumor inhibition rate: 61.36±10.80%) compared with the same dose of Paclitaxel injection (tumor inhibition rate: 66.80±4.43%), which approved as medicaments. Not only that, DP-HICT NRs can escape the clearance of the immune system and enhance targeting ability to the tumor site with only one excipient and such a low dose. Conclusions: This kind of nanoparticles contain a low dose of HICT used mPEG2000-DSPE as a stabilizer, while can achieve good tumor targeting as some active targeting agents and an anti-tumor effect as the PTX injection. There are broad prospects in drug safety, anti-tumor efficacy and even prognosis.

scholarly journals Enhancing main fermentation velocities in beer by the use of a membrane bioreactor – approach and preliminary results (membrane bioreactor beer)

2018 ◽  
Vol 14 (s1) ◽  
pp. 121-131 ◽  
Author(s):  
Lisa Stumpf ◽  
Stefan Schildbach
Keyword(s):  
Membrane Bioreactor ◽  
Membrane Technology ◽  
Gas Jet ◽  
Fermentation Processes ◽  
Preliminary Results ◽  
Module Design ◽  
Continuous Basis ◽  
Membrane Flux ◽  
High Level ◽  
Over Time

The potential of the most recent membrane technology is still unaccounted for in many respects. Combining fermentation with up-to-date membrane technology building a membrane bioreactor allows the adjustment of the cell count on a high level, increasing yield per volume and time. Applied to beer manufacturing, main fermentation times of less than 20 h seem possible, avoiding the disadvantages of already known accelerated fermentation processes operated on a continuous basis. Although module design was adapted and backwash procedure altered to gas-jet, maintaining a sufficient membrane flux over time still poses a major problem. Nevertheless, preliminary results in respect of beer quality look promising.

scholarly journals Co-occurrence of Hyperacusis Accelerates With Tinnitus Burden Over Time and Requires Medical Care

2021 ◽  
Vol 12 ◽  
Author(s):  
Fatma Refat ◽  
Jakob Wertz ◽  
Pauline Hinrichs ◽  
Uwe Klose ◽  
Hesham Samy ◽  
...  
Keyword(s):  
Medical Care ◽  
Global Burden ◽  
Neural Correlate ◽  
Hearing Thresholds ◽  
Causal Therapy ◽  
Advanced Therapies ◽  
High Level ◽  
Neural Gain ◽  
Over Time

Although tinnitus represents a major global burden, no causal therapy has yet been established. Ongoing controversies about the neuronal pathophysiology of tinnitus hamper efforts in developing advanced therapies. Hypothesizing that the unnoticed co-occurrence of hyperacusis and differences in the duration of tinnitus may possibly differentially influence the neural correlate of tinnitus, we analyzed 33 tinnitus patients without (T-group) and 20 tinnitus patients with hyperacusis (TH-group). We found crucial differences between the T-group and the TH-group in the increase of annoyance, complaints, tinnitus loudness, and central neural gain as a function of tinnitus duration. Hearing thresholds did not differ between T-group and TH-group. In the TH-group, the tinnitus complaints (total tinnitus score) were significantly greater from early on and the tinnitus intensity distinctly increased over time from ca. 12 to 17 dB when tinnitus persisted more than 5 years, while annoyance responses to normal sound remained nearly constant. In contrast, in the T-group tinnitus complaints remained constant, although the tinnitus intensity declined over time from ca. 27 down to 15 dB beyond 5 years of tinnitus persistence. This was explained through a gradually increased annoyance to normal sound over time, shown by a hyperacusis questionnaire. Parallel a shift from a mainly unilateral (only 17% bilateral) to a completely bilateral (100%) tinnitus percept occurred in the T-group, while bilateral tinnitus dominated in the TH-group from the start (75%). Over time in the T-group, ABR wave V amplitudes (and V/I ratios) remained reduced and delayed. By contrast, in the TH-group especially the ABR wave III and V (and III/I ratio) continued to be enhanced and shortened in response to high-level sound stimuli. Interestingly, in line with signs of an increased co-occurrence of hyperacusis in the T-group over time, ABR wave III also slightly increased in the T-group. The findings disclose an undiagnosed co-occurrence of hyperacusis in tinnitus patients as a main cause of distress and the cause of complaints about tinnitus over time. To achieve urgently needed and personalized therapies, possibly using the objective tools offered here, a systematic sub-classification of tinnitus and the co-occurrence of hyperacusis is recommended.

scholarly journals Sequence Braiding: Visual Overviews of Temporal Event Sequences and Attributes

2020 ◽  
Author(s):  
Sara Di Bartolomeo ◽  
Yixuan Zhang ◽  
Fangfang Sheng ◽  
Cody Dunne
Keyword(s):  
Completion Time ◽  
Source Code ◽  
Good Evidence ◽  
Task Completion ◽  
Event Sequences ◽  
Sentinel Events ◽  
Temporal Events ◽  
High Level ◽  
Over Time ◽  
Temporal Event Sequences

Temporal event sequence alignment has been used in many domains to visualize nuanced changes and interactions over time. Existing approaches align one or two sentinel events. Overview tasks require examining all alignments of interest using interaction and time or juxtaposition of many visualizations. Furthermore, any event attribute overviews are not closely tied to sequence visualizations. We present SEQUENCE BRAIDING, a novel overview visualization for temporal event sequences and attributes using a layered directed acyclic network.SEQUENCE BRAIDING visually aligns many temporal events and attribute groups simultaneously and supports arbitrary ordering, absence, and duplication of events. In a controlled experiment we compare SEQUENCE BRAIDING and IDMVis on user task completion time, correctness, error, and confidence. Our results provide good evidence that users of SEQUENCE BRAIDING can understand high-level patterns and trends faster and with similar error. A full version of this paper with all appendices;the evaluation stimuli, data, and analysis code; and source code are available at osf.io/s92bu.

Corruption control and prevention in the Korean government

2018 ◽  
Vol 7 (3) ◽  
pp. 303-314 ◽  
Author(s):  
Jin-Wook Choi
Keyword(s):  
South Korea ◽  
Qualitative Analysis ◽  
Design Methodology ◽  
Institution Building ◽  
Content Type ◽  
Korean Government ◽  
Policies And Measures ◽  
Control And Prevention ◽  
High Level ◽  
Over Time

Purpose The purpose of this paper is to examine how corruption has changed over time in South Korea and to explore how the corruption control and prevention efforts of the Korean government have been successful and failed. Design/methodology/approach This paper draws on institutional theory to formulate a qualitative analysis to assess the effectiveness of anti-corruption policies and measures, and to identify the strengths and weaknesses of anti-corruption reform efforts in South Korea. Findings This paper argues that while the Korean government has been quite successful in building anti-corruption institutions to control low-level petty corruption, it has failed to institutionalize anti-corruption institutions to curb high-level grand corruption. Originality/value While many studies have attempted to identify the successful factors of fighting corruption, this paper draws a theoretical distinction between institution-building vs institutionalization to examine the success and failure of corruption control and prevention efforts in South Korea.

Prior Audit Experience and CFO Financial Reporting Aggressiveness

2021 ◽  
Author(s):  
Eric R. Condie ◽  
Kara M. Obermire ◽  
Timothy A. Seidel ◽  
Michael S. Wilkins
Keyword(s):  
Financial Reporting ◽  
Audit Fees ◽  
Chief Financial Officers ◽  
Public Accounting ◽  
Reporting Behavior ◽  
High Level ◽  
Time Away ◽  
Over Time

In this study, we investigate the financial reporting behavior of chief financial officers (CFOs) with significant prior audit experience. Our tests indicate that, on average, CFOs who were former audit managers or partners report less aggressively than CFOs without prior audit experience. Thus, the mindset that auditors develop during their time in public accounting – which should value objective, transparent, and conservative financial reporting – appears to persist when auditors take high-level positions in industry. However, we also find that the reporting behavior of prior-auditor CFOs becomes more aggressive over time as the salience of their audit experience decays. Further, we find that audit fees are lower for clients with prior-auditor CFOs but increase as the CFOs’ time away from auditing increases. Overall, our study offers important insights regarding how audit experience is associated with the financial reporting behavior of CFOs.

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