scholarly journals The 9th Santorini Conference: Systems Medicine, Personalised Health and Therapy. “The Odyssey from Hope to Practice”, Santorini, Greece, 30 September–3 October 2018

2018 ◽  
Vol 8 (4) ◽  
pp. 43
Author(s):  
Sophie Visvikis-Siest ◽  
Vesna Gorenjak ◽  
Maria Stathopoulou ◽  
Alexandros Petrelis ◽  
Georges Weryha ◽  
...  
Keyword(s):  
Big Data ◽  
Clinical Practice ◽  
Metabolic Diseases ◽  
Personalised Medicine ◽  
Modern Medicine ◽  
Greek Mythology ◽  
Scientific Program ◽  
Systems Medicine ◽  
Gene Environment ◽  
Personalised Therapy

The 9th traditional biannual conference on Systems Medicine, Personalised Health & Therapy—“The Odyssey from Hope to Practice”, inspired by the Greek mythology, was a call to search for practical solutions in cardio-metabolic diseases and cancer, to resolve and overcome the obstacles in modern medicine by creating more interactions among disciplines, as well as between academic and industrial research, directed towards an effective ‘roadmap’ for personalised health and therapy. The 9th Santorini Conference, under the Presidency of Sofia Siest, the director of the INSERM U1122; IGE-PCV (www.u1122.inserm.fr), University of Lorraine, France, offered a rich and innovative scientific program. It gathered 34 worldwide distinguished speakers, who shared their passion for personalised medicine with 160 attendees in nine specific sessions on the following topics: First day: The Odyssey from hope to practice: Personalised medicine—landmarks and challenges Second day: Diseases to therapeutics—genotype to phenotype an “-OMICS” approach: focus on personalised therapy and precision medicine Third day: Gene-environment interactions and pharmacovigilance: a pharmacogenetics approach for deciphering disease “bench to clinic to reality” Fourth day: Pharmacogenomics to drug discovery: a big data approach and focus on clinical data and clinical practice. In this article we present the topics shared among the participants of the conference and we highlight the key messages.

scholarly journals Personalized medicine into health national services: barriers and potentialities

2018 ◽  
Vol 33 (4) ◽  
pp. 159-163 ◽  
Author(s):  
Ana E. Rodríguez Vicente ◽  
Maria José Herrero Cervera ◽  
María Luisa Bernal ◽  
Luis Rojas ◽  
Ana M. Peiró
Keyword(s):  
Big Data ◽  
Clinical Practice ◽  
Personalized Medicine ◽  
New Paradigm ◽  
Policy Makers ◽  
Research And Innovation ◽  
Wide Range ◽  
The Relationship ◽  
Personalised Therapy ◽  
Guided Therapy

Abstract Research and innovation in personalized medicine (PM) are extensive and expanding, with several pharmacogenetic/pharmacogenomic (PGx) testing options currently available for a wide range of health problems. However, PGx-guided therapy faces many barriers to full integration into clinical practice and acceptance by practitioner/patient: utilization and uptake by payers in real-world practice are being discussed, and the criteria to guide clinicians and policy makers in PGx test selection are not fully incorporated. This review focuses on the advances of pharmacogenomics to individualize treatments, the relationship between pharmacogenetics and pharmacometabolomics, the new paradigm of the Big Data, the needs and barriers facing PGx clinical application and the situation of PGx testing in health national services. It is based on lectures presented by speakers of the European Society of Pharmacogenomics and Personalised Therapy (ESPT) Fourth Conference, held in Catania, October 4th, 2017.

scholarly journals Leviathan, or the Rudder of Public Health

2017 ◽  
Vol 2 (Suppl. 1) ◽  
pp. 1-8
Author(s):  
Denis Horgan ◽  
Walter Ricciardi
Keyword(s):  
Public Health ◽  
Big Data ◽  
New Technologies ◽  
Personalised Medicine ◽  
Member States ◽  
Reform Agenda ◽  
The World ◽  
The Face ◽  
The Eu ◽  
Do So

In the world of modern health, despite the fact that we've been blessed with amazing advances of late - the advent of personalised medicine is just one example - “change” for most citizens seems slow. There are clear discrepancies in availability of the best care for all, the divisions in access from country to country, wealthy to poor, are large. There are even discrepancies between regions of the larger countries, where access often varies alarmingly. Too many Member States (with their competence for healthcare) appear to be clinging stubbornly to the concept of “one-size-fits-all” in healthcare and often stifle advances possible through personalised medicine. Meanwhile, the legislative arena encompassing health has grown big and unwieldy in many respects. And bigger is not always better. The health advances spoken of above, an increased knowledge on the part of patients, the emergence of Big Data and more, are quickly changing the face of healthcare in Europe. But healthcare thinking across the EU isn't changing fast enough. The new technologies will certainly speak for themselves, but only if allowed to do so. Acknowledging that, this article highlights a positive reform agenda, while explaining that new avenues need to be explored.

scholarly journals A Healthy Sense of Trust

2017 ◽  
Vol 2 (Suppl. 1) ◽  
pp. 1-10
Author(s):  
Denis Horgan
Keyword(s):  
European Union ◽  
Clinical Trials ◽  
Big Data ◽  
Data Protection ◽  
Fast Moving ◽  
Ethical Issues ◽  
Personalised Medicine ◽  
Drug Pricing ◽  
The Right ◽  
The Eu

In the fast-moving arena of modern healthcare with its cutting-edge science it is already, and will become more, vital that stakeholders collaborate openly and effectively. Transparency, especially on drug pricing, is of paramount importance. There is also a need to ensure that regulations and legislation covering, for example the new, smaller clinical trials required to make personalised medicine work effectively, and the huge practical and ethical issues surrounding Big Data and data protection, are common, understood and enforced across the EU. With more integration, collaboration, dialogue and increased trust among each and every one in the field, stakeholders can help mould the right frameworks, in the right place, at the right time. Once achieved, this will allow us all to work more quickly and more effectively towards creating a healthier - and thus wealthier - European Union.

scholarly journals Research on Gene–Environment Interplay in the Era of “Big Data”

2016 ◽  
Vol 77 (5) ◽  
pp. 681-683 ◽  
Author(s):  
Andrew C. Heath ◽  
Christina N. Lessov-Schlaggar ◽  
Min Lian ◽  
Ruth Miller ◽  
Alexis E. Duncan ◽  
...  
Keyword(s):  
Big Data ◽  
Gene Environment

scholarly journals The Birth of Endowiki, An Italian Online Platform for Continuous Medical Education In Endocrinology

2018 ◽  
Vol 1 (1) ◽  
pp. 10-13
Author(s):  
Roberto Attanasio ◽  
Luca Gualano ◽  
Irene Misischi ◽  
Silvia Caprioli ◽  
Enrico Papini ◽  
...  
Keyword(s):  
Medical Education ◽  
Clinical Practice ◽  
Metabolic Diseases ◽  
Task Force ◽  
Continuous Medical Education ◽  
Clinical Approach ◽  
Educational Tool ◽  
Clinical Context ◽  
Online Tools ◽  
Online Availability

Background Conventional tools for medical education are burdened by many drawbacks. Textbooks become rapidly outdated, meeting attendance is expensive, and results reported in journals are not easily suitable for clinical practice. Uptodate and Endotext are excellent online tools, but they have been developed for a clinical context far different from that of our country. Methodology Italian Association of Clinical Endocrinologists (AME) charged a task force aiming to develop an educational tool specifically tailored for Italian clinical endocrinologists. Required characteristics were clinical approach, modularity, continuous updating, full online availability (even by mobile devices), open sections and sections for registered members only, opportunity for individualization, indexing and search engine to facilitate browsing. Starting from an open-source platform, Joomla, several changes were implemented. Results Three editors, 2 central editorial secretaries, 30 section coordinators and over 350 authors have been involved in the writing of 21 different sections covering all fields of endocrine and metabolic diseases. The access to Endowiki is free for AME members and is fully open in sections for patients. All readers are requested to serve as referee, pointing to mistakes and need for revision. The system is attended daily by a mean of 250 individuals. Conclusions Endowiki stands alone as an opportunity for medical education in Italy. The big challenges will be the continuous updating and the link to the national certified system for CME.

scholarly journals THE MEDICAL PHYSICIST - SCIENTIST BEHIND THE CURTAIN

2021 ◽  
Vol 10 (4) ◽  
pp. 3212-3213
Author(s):  
Anurag A. Luharia
Keyword(s):  
Quality Assurance ◽  
Clinical Practice ◽  
Radiation Protection ◽  
Medical Physics ◽  
Analytical Techniques ◽  
Modern Medicine ◽  
Quality Assurance Program ◽  
Medical Physicist ◽  
Accurate Treatment ◽  
Medical Physicists

Ionizing radiation has validated its existence and effectiveness in modern medicine for both diagnostic and therapeutic use. For the last decade rapid growth in medical radiation application has witnessed in India towards the betterment of mankind, for safe and quality clinical practice, radiation protection and quality assurance. At the end of the 19th century Physics brought paradigm shift in the field of radiation-based medical diagnosis and treatment and giving rise to the modern medical physicist profession and revolutionized the practice of medicine. Medical Physicists are the scientists with Post graduation / PhD degrees, and certified from A.E.R.B as Radiological Safety Officer, deals with utilization of Physics knowledge in developing not only lifesaving tools & technology but also diagnosis and treatments of various medical conditions that help humans live longer and healthier. Medical Physicists are responsible to carry out the commissioning, establishment of entire Radiation facility and get the clearance of statutory compliances form authorities in order to start the clinical practice are also responsible for research, developing and evaluating new analytical techniques, planning and ensuring safe and accurate treatment of patients also provide advice about radiation protection, training and updating healthcare, scientific and technical staff , managing radiotherapy quality assurance program, mathematical modeling ,maintaining equipment ,writing reports, teaching ,laboratory management and administration. Now it’s a time to raise the curtain from the Medical Physics profession and utilize their services up to maximum extent in the field of scientific research, academic, teaching, diagnosis, treatment and safety.

scholarly journals Role of Herbal Plants on Autophagy

2020 ◽  
Vol 9 (2) ◽  
pp. 179
Author(s):  
Susanti Husen ◽  
Ronny Lesmana ◽  
Hanna Goenawan ◽  
Setiawan Setiawan
Keyword(s):  
Anticancer Agents ◽  
Defense Mechanisms ◽  
Metabolic Diseases ◽  
Herbal Medicines ◽  
Modern Medicine ◽  
Herbal Plants ◽  
Physiological Approach ◽  
New Treatment ◽  
Biomolecular System

Autophagy is a biomolecular system known to play an important role in cell growth, development as well as defense mechanisms, and is also a physiological approach towards homeostasis maintenance. This phenomenon is an intermediary pathway in the pathogenesis and therapy of various disease types, and is currently a new treatment route in the medical world. Hence, it is necessary to deeply understand the regulations, to prepare a treatment strategy in the future. Conversely, there is a high utilization of drugs, in line with the numerous disease cases in the community. Some limited chemical forms have large but necessary side effects, including anticancer agents. The high incidence of resistance and polypharmacy has been implicated in adverse drug interactions, and exorbitant costs, thus the initiative to return back to natural means. Furthermore, herbal medicines have been used in treatments for thousands of years, prior to the discovery of modern medicine. The various types previously studied have been highly beneficial in various disease cases. This review on researches within the last 5 years identified some herbal research articles in the aspect of autophagy, which was then summarized in a table form. Meanwhile, autophagy has been used for cancer therapy, and many plants have the potential to be therapeutic for various diseases through this pathway. Hence, improving related knowledge adds a new dimension to herbal medicine application in the pharmaceutical industry.Keywords: Autophagy, herbal, cancer, metabolic diseases, liver injury, neurological disorderPeran Berbagai Tanaman Herbal pada AutofagiAbstrakAutofagi adalah sistem biomolekuler sel yang berperan penting dalam pertumbuhan sel, perkembangan dan mekanisme pertahanan, dan merupakan sebuah cara fisiologis untuk mempertahankan homeostasis. Autofagi digunakan sebagai jalur perantara untuk patogenesis dan terapi berbagai jenis penyakit, dan saat ini autofagi telah menjadi jalan pengobatan baru di dunia medis sehingga regulasi jalur autofagi harus dipelajari lebih dalam untuk mempersiapkan strategi pengobatan di masa depan. Di sisi lain, tingginya pemanfaatan obat-obatan sejalan dengan banyaknya kasus penyakit yang muncul di masyarakat. Beberapa obat kimia memiliki efek samping yang besar tetapi jumlahnya terbatas, misalnya pada obat antikanker. Selain itu, tingginya kasus resistensi obat dan polifarmasi menyebabkan interaksi obat yang merugikan dan biaya obat yang tinggi. Oleh karena itu, pengobatan kini telah kembali ke alam. Herbal telah digunakan sebagai pengobatan selama ribuan tahun sebelum pengobatan modern ditemukan. Berbagai jenis herbal telah dipelajari dan memiliki manfaat yang baik dalam berbagai kasus penyakit di masyarakat. Pada artikel review ini, ditelaah artikel-artikel penelitian herbal yang mengambil jalur autofagi dan hasilnya dirangkum dalam bentuk tabel. Studi yang dilakukan dalam kurun waktu 5 tahun terakhir dimasukkan dalam review ini. Sampai sekarang, autofagi telah lebih banyak digunakan untuk terapi kanker dibandingkan yang tanpa kanker. Banyak tanaman herbal yang memiliki potensi untuk menjadi terapi berbagai jenis penyakit melalui jalur autofagi. Pengetahuan tentang autofagi menambah dimensi baru pada pengobatan herbal dan dapat diterapkan dalam industri farmasi.Kata kunci: Autofagi, gangguan metabolisme, gangguan saraf, herbal, kanker, kerusakan hati

scholarly journals Can Big Data Simplify the Complexity of Modern Medicine?

2016 ◽  
Vol 4 (9) ◽  
pp. 722-725 ◽  
Author(s):  
Tariq Ahmad ◽  
Jeffrey M. Testani ◽  
Nihar R. Desai
Keyword(s):  
Big Data ◽  
Modern Medicine

The Acquisition and Management of Healthcare Data, Within a Hospital Infrastructure

2020 ◽  
Author(s):  
James Darby-Taylor ◽  
Fernando Luís-Ferreira ◽  
João Sarraipa ◽  
Ricardo Jardim-Goncalves
Keyword(s):  
Big Data ◽  
Clinical Practice ◽  
Big Data Analysis ◽  
Data Handling ◽  
Healthcare Data ◽  
Health And Wellbeing ◽  
Clinical Procedures ◽  
Legal Constraints ◽  
Hospital Practices

Abstract The quality of care provided to citizens by professionals and institutions depends on the quality and availability of information. Early commencement of treatment and medication, and the decisions on how to proceed, depend a lot on patients’ data in the different modalities available. It is also important to notice that large pools of data help inform health and wellbeing parameters for the largest possible community. To make that possible it is necessary both to have the best hospital practices but also to get consent and collaboration from patients. In order to accomplish such a goal, it is necessary to use practices, which adhere to legal constraints and are transparent while handling data and also to transmit those practices and protocols to professionals and patients. The present document aims to provide a framework envisaging the seamless application of the clinical procedures, following legal guidance and making the process known, secure and trustworthy. It aims to contribute to clinical practice, and clinical research, thereby contributing to big data analysis by ensuring trust and best clinical data handling.

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