scholarly journals Investigation of the Compressibility and Compactibility of Titanate Nanotube-API Composites

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2582 ◽  
Author(s):  
Barbara Sipos ◽  
Klára Pintye-Hódi ◽  
Géza Regdon ◽  
Zoltán Kónya ◽  
Maryléne Viana ◽  
...  
Keyword(s):  
Elastic Recovery ◽  
Diclofenac Sodium ◽  
Drug Carriers ◽  
Titanate Nanotube ◽  
Pharmaceutical Ingredients ◽  
Ideal Plastic ◽  
Drug Manufacturing ◽  
Energetic Analysis ◽  
Tablet Compression ◽  
Tablet Hardness

The present work aims to reveal the pharma-industrial benefits of the use of hydrothermally synthesised titanate nanotube (TNT) carriers in the manufacturing of nano-sized active pharmaceutical ingredients (APIs). Based on this purpose, the compressibility and compactibility of various APIs (diltiazem hydrochloride, diclofenac sodium, atenolol and hydrochlorothiazide) and their 1:1 composites formed with TNTs were investigated in a comparative study, using a Lloyd 6000R uniaxial press instrumented with a force gauge and a linear variable differential transformer extensometer. The tablet compression was performed without the use of any excipients, thus providing the precise energetic characterisation of the materials’ behaviour under pressure. In addition to the powder functionality test, the post-compressional properties of the tablets were also determined and evaluated. The results of the energetic analysis demonstrated that the use of TNTs as drug carriers is beneficial in every step of the tabletting process: besides providing better flowability and more favourable particle rearrangement, it highly decreases the elastic recovery of the APIs and results in ideal plastic deformation. Moreover, the post-compressional properties of the TNT–API composites were found to be exceptional (e.g., great tablet hardness and tensile strength), affirming the above results and proving the potential in the use of TNT carriers for drug manufacturing.

scholarly journals Sulfanyl Porphyrazines with Morpholinylethyl Periphery—Synthesis, Electrochemistry, and Photocatalytic Studies after Deposition on Titanium(IV) Oxide P25 Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2280
Author(s):  
Tomasz Koczorowski ◽  
Wojciech Szczolko ◽  
Anna Teubert ◽  
Tomasz Goslinski
Keyword(s):  
Diclofenac Sodium ◽  
2D Nmr ◽  
Oxide Nanoparticles ◽  
Electrochemical Studies ◽  
Macrocyclic Compounds ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Vis Spectroscopy ◽  
Singlet Oxygen Quencher ◽  
Nmr Techniques

The syntheses, spectral UV–Vis, NMR, and electrochemical as well as photocatalytic properties of novel magnesium(II) and zinc(II) symmetrical sulfanyl porphyrazines with 2-(morpholin-4-yl)ethylsulfanyl peripheral substituents are presented. Both porphyrazine derivatives were synthesized in cyclotetramerization reactions and subsequently embedded on the surface of commercially available P25 titanium(IV) oxide nanoparticles. The obtained macrocyclic compounds were broadly characterized by ESI MS spectrometry, 1D and 2D NMR techniques, UV–Vis spectroscopy, and subjected to electrochemical studies. Both hybrid materials, consisting of porphyrazine derivatives embedded on the titanium(IV) oxide nanoparticles’ surface, were characterized in terms of particle size and distribution. Next, they were subjected to photocatalytic studies with 1,3-diphenylisobenzofuran, a known singlet oxygen quencher. The applicability of the obtained hybrid material consisting of titanium(IV) oxide P25 nanoparticles and magnesium(II) porphyrazine derivative was assessed in photocatalytic studies with selected active pharmaceutical ingredients, such as diclofenac sodium salt and ibuprofen.

scholarly journals DETERMINATION OF RADIOLOGICAL PARAMETERS OF SOME ACTIVE PHARMACEUTICAL INGREDIENTS USING WINXCOM SOFTWARE IN THE ENERGY RANGE 1KEV TO 100KEV

2021 ◽  
Vol 5 (5) ◽  
pp. 54-62
Author(s):  
Arome Aruwa ◽  
Philibus Musa Gyuk ◽  
Columbus Tobechukwu Eze ◽  
Suleiman Isah ◽  
Achor Mathias Ogwo ◽  
...  
Keyword(s):  
Energy Range ◽  
Electron Density ◽  
Attenuation Coefficient ◽  
Atomic Number ◽  
Diclofenac Sodium ◽  
Effective Atomic Number ◽  
Mass Attenuation Coefficient ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Mass Attenuation

The effective atomic number, electron density and mass attenuation coefficient of some selected active pharmaceutical ingredients such as Diclofenac Sodium, Femotidine, Alprazolam, Amiodar, Amiodarone, Ciprofloxacin, and Nimesulide have been calculated over the energy range from 1 keV to 100 GeV for total and partial photon interactions by using WinXCom. The obtained data shows that the change in mass attenuation coefficient and electron density varies with energy and chemical composition of the active pharmaceutical ingredients (API’s) in drugs. The results in the variation of photon interaction with energy and effective atomic number of the API’s in drug are shown in the logarithmic graphs.

scholarly journals 3D Printing for Drug Manufacturing: A Perspective on the Future of Pharmaceuticals

2017 ◽  
Vol 4 (1) ◽  
pp. 119 ◽  
Author(s):  
Eric Lepowsky ◽  
Savas Tasoglu
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Selective Laser Sintering ◽  
Drug Carriers ◽  
Patient Specific ◽  
Drug Products ◽  
Fused Deposition ◽  
The Future ◽  
Drug Manufacturing ◽  
3D Printed

Since a three-dimensional (3D) printed drug was first approved by the Food and Drug Administration in 2015, there has been a growing interest in 3D printing for drug manufacturing. There are multiple 3D printing methods – including selective laser sintering, binder deposition, stereolithography, inkjet printing, extrusion-based printing, and fused deposition modeling – which are compatible with printing drug products, in addition to both polymer filaments and hydrogels as materials for drug carriers. We see the adaptability of 3D printing as a revolutionary force in the pharmaceutical industry. Release characteristics of drugs may be controlled by complex 3D printed geometries and architectures. Precise and unique doses can be engineered and fabricated via 3D printing according to individual prescriptions. On-demand printing of drug products can be implemented for drugs with limited shelf life or for patient-specific medications, offering an alternative to traditional compounding pharmacies. For these reasons, 3D printing for drug manufacturing is the future of pharmaceuticals, making personalized medicine possible while also transforming pharmacies.

scholarly journals Development of liposomal drug formulations: quality attributes and methods for quality control

2018 ◽  
pp. 33-39
Author(s):  
E.V. Melnikova ◽  
D.V. Goryachev ◽  
A.A. Chaplenko ◽  
M.A. Vodyakova ◽  
A.R. Sayfutdinova ◽  
...  
Keyword(s):  
Quality Control ◽  
Gel Filtration ◽  
Chemical Properties ◽  
Drug Carriers ◽  
Quality Attributes ◽  
Scanning Calorimetry ◽  
Liposomal Drug ◽  
Wide Range ◽  
Drug Manufacturing ◽  
Major Trend

The use of nanostructured components in drug manufacturing and, more specifically, targeted drug delivery has recently become a major trend in the pharmaceutical industry. Nanodrugs encompass a wide range of pharmaceutical agents containing dendrimers, nanocrystals, micelles, liposomes, and polymer nanoparticles. Liposomes are the most well-studied nanoparticles and effective drug carriers. However, the more complex their structure is, the more process controls are needed and the more quality attributes have to be monitored, including the chemical properties of the liposomal fraction such as the shape, size and charge of the nanoparticle, conjugation efficacy, and distribution of the active ingredient. We believe that quality control of key liposome characteristics should rely on dynamic and laser light scattering coupled with electrophoresis, differential scanning calorimetry, cryo-electron microscopy, nuclear magnetic resonance, laser diffraction analysis, and gel filtration chromatography.

scholarly journals Performance Evaluation of a High-Precision Low-Dose Powder Feeder

2020 ◽  
Vol 21 (8) ◽  
Author(s):  
Sara Fathollahi ◽  
Stephan Sacher ◽  
M. Sebastian Escotet-Espinoza ◽  
James DiNunzio ◽  
Johannes G. Khinast
Keyword(s):  
Test Performance ◽  
Feed Rate ◽  
Low Dose ◽  
Elastic Recovery ◽  
Density Variation ◽  
Feeding Performance ◽  
Dose Rates ◽  
Pharmaceutical Ingredients ◽  
Feeding Process ◽  
Bed Expansion

Abstract Highly potent active pharmaceutical ingredients (APIs) and low-dose excipients, or excipients with very low density, are notoriously hard to feed with currently available commercial technology. The micro-feeder system presented in this work is capable of feeding low-dose rates of powders with different particle sizes and flow properties. Two different grades of lactose, di-calcium phosphate, croscarmellose sodium, silicon dioxide, a spray-dried intermediate, and an active ingredient were studied to vary material properties to test performance of the system. The current micro-feeder system is a volumetric feeder combined with a weighing balance at the outlet that measures feeder output rates. Feeding results are shown as a so-called “displacement-feed factor” curve for each material. Since the powder mass and volume are known in the micro-feeder system, in this work, we characterized an observed density variation during processing via a “displacement-feed factor” profile for each of the fed powders. This curve can be later used for calibrating the system to ensure an accurate, constant feed rate and in addition predicting feeding performance for that material at any feed rate. There is a relation between powder properties and feeding performance. Powders with finer particles and higher compressibility show densification during their feeding process. However, powders with larger particles and lower compressibility show both “densification” and “powder bed expansion,” which is the manifestation of dilation and elastic recovery of particles during the micro-feeding process. Through the application of the displacement-feed factor, it is possible to provide precise feeding accuracy of low-dose materials. Graphical abstract

scholarly journals Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 697
Author(s):  
Hidetoshi Arima
Keyword(s):  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Pamam Dendrimer ◽  
Pamam Dendrimers ◽  
Active Targeting ◽  
Low Molecular Weight ◽  
The Novel ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
New Type

Recently, the number of gene and oligonucleotide drugs are increasing. Of various drug delivery systems (DDSs) for gene and oligonucleotide drugs, few examples of the clinical application of polymer as drug carriers are known, despite development of the novel polymers has been progressing. Cyclodextrin (CD) conjugates with starburst polyamidoamine (PAMAM) dendrimer (CDEs), as a new type of polymer-based carriers, were first published in 2001. After that, galactose-, lactose-, mannose-, fucose-, folate-, and polyethyleneglycol (PEG)-appended CDEs have been prepared for passive and active targeting for gene, oligonucleotide, and low-molecular-weight drugs. PEG-appended CDE formed polypsuedorotaxanes with α-CD and γ-CD, which are useful for a sustained release system of gene and oligonucleotide drugs. Interestingly, CDEs were found to have anti-inflammatory effects and anti-amyloid effects themselves, which have potential as active pharmaceutical ingredients. Most recently, CDE is reported to be a useful Cas9-RNA ribonucleoproteins (Cas9 RNP) carrier that induces genome editing in the neuron and brain. In this review, the history and progression of CDEs are overviewed.

scholarly journals AN EVALUATION OF FIXED DOSE COMBINATIONS (FDCs) USED FOR TREATMENT OF DIABETES IN INDIAN MARKET

2018 ◽  
pp. 6-9
Author(s):  
Supreet Kamni ◽  
Akram A Naikwadi ◽  
Anant Khot
Keyword(s):  
Analytical Study ◽  
Study Data ◽  
Essential Medicines ◽  
Fixed Dose ◽  
Pharmacokinetic Parameters ◽  
Indian Market ◽  
Pharmaceutical Ingredients ◽  
Drug Manufacturing ◽  
Treatment Of Diabetes ◽  
Medical Specialities

Objective: To analyse the rationality of various FDCs used in the treatment Diabetes Mellitus and to find out the irrational FDCs existing in Indian market. Material and Methods: Study Design: Analytical study. Data on FDC's available in the Indian market was collected from Current Index of Medical Specialities (CIMS) and Monthly Index of Medical Specialities (MIMS) and their rationality was analysed using a pretested tool based on FDCs listed in WHO essential list of medicines and National List of Essential Medicines (NLEM), others based on their pharmacodynamic activity, Pharmacokinetic parameters and significant drug interactions occurring due to API (Active pharmaceutical ingredients) contained within the product Result: A total of 18 combinations were analysed, among those 11 combinations were irrational. Conclusion: Predominantly irrational FDCs are being circulated in the Indian market hence through analyses by prescribers is needed before prescribing to patients in order to avoid ADR. This calls for a close scrutiny of marketed FDC's and educating prescribers to use them with great care and caution also indicates a serious review of regulatory framework for drug manufacturing and marketing. KEYWORDS: Fixed Dose Combinations; Antidiabetics; Irrational.

scholarly journals The state of cognitive functions after angioreconstructive operations on the carotid arteries

2019 ◽  
pp. 65-71
Author(s):  
M.M. Tanashyan ◽  
R.B. Medvedev ◽  
O.V. Lagoda ◽  
E.S. Berdnikovich ◽  
S.I. Skrylev ◽  
...  
Keyword(s):  
Gel Filtration ◽  
Chemical Properties ◽  
Drug Carriers ◽  
Scanning Calorimetry ◽  
Wide Range ◽  
Drug Manufacturing ◽  
Major Trend ◽  
Pharmaceutical Agents ◽  
Process Controls ◽  
Resonance Laser

The use of nanostructured components in drug manufacturing and, more specifically, targeted drug delivery has recently become a major trend in the pharmaceutical industry. Nanodrugs encompass a wide range of pharmaceutical agents containing dendrimers, nanocrystals, micelles, liposomes, and polymer nanoparticles. Liposomes are the most well-studied nanoparticles and effective drug carriers. However, the more complex their structure is, the more process controls are needed and the more quality attributes have to be monitored, including the chemical properties of the liposomal fraction such as the shape, size and charge of the nanoparticle, conjugation efficacy, and distribution of the active ingredient. We believe that quality control of key liposome characteristics should rely on dynamic and laser light scattering coupled with electrophoresis, differential scanning calorimetry, cryo-electron microscopy, nuclear magnetic resonance, laser diffraction analysis, and gel filtration chromatography.

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