Upscale Design, Process Development, and Economic Analysis of Industrial Plants for Nanomagnetic Particle Production for Environmental and Biomedical Use

Very few economical and process engineering studies have been made concerning the scale-up and implementation of nanomagnetic particle manufacturing into a full-scale plant, and determination of its viability. In this work we describe such a study for two types of industrial plants, one for manufacturing magnetic particles for applications in the environmental area, and the other for manufacturing nanomagnetic particles for applications in the biotechnology area; the two different applications are compared. The following methodology was followed: establish the manufacturing process for each application; determine the market demand of the product (magnetic nanoparticles) for both applications; determine the production capacity of each plant; engineer all the manufacturing process, determining all the process units and performing all the mass and energy balances for both plants; scale-up the main equipment; and determine the global economic impact and profitability. At the end both plants are found to be technologically and economically viable, the characteristics of the final products being, however, quite different, as well as the process engineering, economic analysis, and scale-up.

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Generic Modular Operations for Virtual Manufacturing Process Engineering

Volume 5: 17th Computers in Engineering Conference ◽

10.1115/detc97/cie-4309 ◽

1997 ◽

Author(s):

David E. Lee ◽

H. Thomas Hahn

Keyword(s):

Manufacturing Process ◽

Process Development ◽

Process Engineering ◽

Virtual Manufacturing ◽

Control Approach ◽

Computational Costs ◽

Direct Mechanism ◽

Novel Approach ◽

Operation Control ◽

Virtual Process

Abstract In order to address the computational costs of modeling and analyzing manufacturing processes, a novel approach to virtual manufacturing process engineering using generic modular operations is presented. Relying on a state based representation of operation control for a simplified virtual manufacturing workcell, the valid states for each sequence of generic modular operations are aggregated and both operation state and processing constraints applied to specify the subtasks required to complete each step in a product’s process plan. By adopting this state based control approach, virtual process engineering provides a direct mechanism to map virtual process representations onto actualized processes. Using these generic modular operations and their temporal and processing dependencies, the computationally complex elements of virtual manufacturing process simulation can be directly identified and an architecture for virtual process development specified. Examples from both machining and assembly processes are provided.

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Techno-Economic Analysis of an Alkali Catalyzed Biodiesel Production Using Waste Palm Oil

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.465-466.120 ◽

2013 ◽

Vol 465-466 ◽

pp. 120-124 ◽

Cited By ~ 1

Author(s):

Dipesh S. Patle ◽

Zainal Ahmad

Keyword(s):

Economic Analysis ◽

Palm Oil ◽

Fossil Fuels ◽

Renewable Energy Sources ◽

Scale Up ◽

Production Capacity ◽

Biodiesel Production ◽

Depth Analysis ◽

Process Simulator

In this contribution, we present an in-depth analysis of an alkali catalyzed biodiesel production using waste palm oil. In view of the limited availability of non-renewable energy sources and the environmental concerns due to the high polluting nature of fossil fuels, biodiesel is seen as a future fuel alternative. We consider a waste palm oil with 6 % free fatty acids as a feedstock, which makes this process economically attractive. A complete process including esterification and transesterification is simulated using the Aspen Plus process simulator. The quality of a produced biodiesel is compared against different standards. In the subsequent part, the effect free fatty acid in feed oil on the overall biodiesel production is tested. In the last section of this paper, a techno-economic analysis and the scale-up study is carried out to determine the dependence of the feasibility of process on production capacity. The results show that higher capacity is desirable.

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PROCESS DEVELOPMENT, OPTIMIZATION AND VALIDATION OF MANUFACTURING PROCESS OF ALLOPURINOL

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2021v13i2.41548 ◽

2021 ◽

pp. 58-60

Author(s):

SAYYED MOHSINA CHISHTI ◽

NIMITA MANOCHA

Keyword(s):

Manufacturing Process ◽

Process Development ◽

Scale Up ◽

Research Work ◽

Batch Size ◽

Critical Parameters ◽

Ideal Condition ◽

Process Operation ◽

Machine Speed ◽

Control Limits

Objective: The objective of the present research work is to identify the critical parameters in the process that affect the quality of the finished product. The processs validation of the manufacturing process for Allopurinol tablet USP, 300 mg to be manufactured with change in manufacturing site and with increased batch size. Methods: Prior to Scaling up to production, pilot batches were manufactured. Three consecutive commercial batches are to be produced using similar test equipment and in full compliance with cGMP and existing SOPs. Critical process parameters of the machine was set within operating range and was not exceeded upper and lower control limits during process operation. Equipment were operated within its assigned control limits, which shows upon scale up into new site, the specification for hardness did not meet requirements that had been set during development. There was no significant effect observed on thickness, friability, disintegration, dissolution, uniformity of dosage and were found within specification. Pre process batch was challenged by manufacturing product at upper and lower processing limits and circumstances which pose the greatest chance of process or product failure compared to ideal condition. Results: Based on the data obtained from pre-process validation batch, operating ranges for compression force and machine speed had been established. Collected data shows robustness around these parameters and there is increased confidence that the process can be successfully scaled up under target conditions for these parameters. Conclusion: From this study, it was concluded that process was optimized and gave a reproducible product that meet predetermined quality requirements and do so consistently and reliably.

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Respect for the Environment is Part of Competitiveness - Best Available Technology Applied to an Old Pulp Mill at Kaskinen

Water Science & Technology ◽

10.2166/wst.1999.0713 ◽

1999 ◽

Vol 40 (11-12) ◽

pp. 201-206

Author(s):

I. Reilama ◽

N. Ilomäki

Keyword(s):

Process Development ◽

Continuous Production ◽

Production Capacity ◽

Pulp Mill ◽

Process Technology ◽

Line Production ◽

Nutrient Emissions ◽

Best Available Technology ◽

Available Technology ◽

Process Solutions

Oy Metsä-Botnia Ab's Kaskinen mill produces ECF and TCF bleached softwood and hardwood pulp on a single continuous production line. Production capacity has been raised from 250,000 tonnes to 420,000 tonnes a year after the commission in 1977. The basic process solutions date mainly from the 1970s. However, process technology has been gradually modernised. With systematic and well-timed process development investments the mill has remained competitive and among frontrunners in terms of environmental protection. Today, Kaskinen represent the best available technology (BAT) applicable to old mills. Effluent loading in general and nutrient emissions in particular has diminished during the development projects of the mill. Comparison to other mills shows that as far as effluent emissions are concerned, Kaskinen is one of the best pulp mills in Finland and Scandinavia. In this presentation, Kaskinen is also compared to Metsä-Rauma, the first greenfield TCF mill in the world, which was started up in 1996. Kaskinen's pioneering work on TCF technology was used as a basis for process solutions in the Rauma greenfield project.

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Xylo-Oligosaccharide Process Development, Composition, and Techno-Economic Analysis. Cooperative Research and Development Final Report, CRADA Number CRD-12-483

10.2172/1233147 ◽

2015 ◽

Author(s):

Joe Shekiro ◽

Richard Elander

Keyword(s):

Economic Analysis ◽

Research And Development ◽

Process Development ◽

Final Report ◽

Cooperative Research ◽

Cooperative Research And Development

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Scaling-up production of plant endophytes in bioreactors: concepts, challenges and perspectives

Bioresources and Bioprocessing ◽

10.1186/s40643-021-00417-y ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Seedhabadee Ganeshan ◽

Seon Hwa Kim ◽

Vladimir Vujanovic

Keyword(s):

Crop Production ◽

Process Development ◽

Hazard Analysis ◽

Scale Up ◽

Process Technology ◽

Lack Of Information ◽

Agriculture Industry ◽

Start Up ◽

Plant Growth Promoting ◽

Agriculture And Food

AbstractThe benefit of microorganisms to humans, animals, insects and plants is increasingly recognized, with intensified microbial endophytes research indicative of this realization. In the agriculture industry, the benefits are tremendous to move towards sustainable crop production and minimize or circumvent the use of chemical fertilizers and pesticides. The research leading to the identification of potential plant endophytes is long and arduous and for many researchers the challenge is ultimately in scale-up production. While many of the larger agriculture and food industries have their own scale-up and manufacturing facilities, for many in academia and start-up companies the next steps towards production have been a stumbling block due to lack of information and understanding of the processes involved in scale-up fermentation. This review provides an overview of the fermentation process from shake flask cultures to scale-up and the manufacturing steps involved such as process development optimization (PDO), process hazard analysis (PHA), pre-, in- and post-production (PIP) challenges and finally the preparation of a technology transfer package (TTP) to transition the PDO to manufacturing. The focus is on submerged liquid fermentation (SLF) and plant endophytes production by providing original examples of fungal and bacterial endophytes, plant growth promoting Penicillium sp. and Streptomyces sp. bioinoculants, respectively. We also discuss the concepts, challenges and future perspectives of the scale-up microbial endophyte process technology based on the industrial and biosafety research platform for advancing a massive production of next-generation biologicals in bioreactors.

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Catholyte-free electroreduction of CO2 for sustainable production of CO: Concept, process development, techno-economic analysis, and CO2 reduction assessment

Green Chemistry ◽

10.1039/d0gc02969f ◽

2021 ◽

Author(s):

Jaeseo Lee ◽

Wonhee Lee ◽

Kyung Hwan Ryu ◽

Joungho Park ◽

Hyo-Jin Lee ◽

...

Keyword(s):

Economic Analysis ◽

Process Development ◽

Co2 Reduction ◽

Sustainable Production ◽

Carbon Neutrality ◽

The Future

Electrochemical CO2 reduction (ECO2R) is considered as one of economically viable means to convert CO2 into useful products, for achieving carbon neutrality in the future. Many studies have been conducted...

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Is Scale-Up Worth It? Challenges in Economic Analysis of Diagnostic Tests for Tuberculosis

PLoS Medicine ◽

10.1371/journal.pmed.1001063 ◽

2011 ◽

Vol 8 (7) ◽

pp. e1001063 ◽

Cited By ~ 42

Author(s):

David W. Dowdy ◽

Adithya Cattamanchi ◽

Karen R. Steingart ◽

Madhukar Pai

Keyword(s):

Economic Analysis ◽

Diagnostic Tests ◽

Scale Up

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Innovationen multi-perspektiv entwickeln*/Multi-perspective development of innovations - Holistic view of innovation processes for the derivation of manufacturing strategic decision areas

wt Werkstattstechnik online ◽

10.37544/1436-4980-2017-03-85 ◽

2017 ◽

Vol 107 (03) ◽

pp. 189-193

Author(s):

M. Röhm ◽

T. Prof. Bauernhansl ◽

T. Schrodi

Keyword(s):

Process Development ◽

Innovation Process ◽

Strategic Decision ◽

Maturity Model ◽

Market Demand ◽

Critical Fields ◽

Holistic View ◽

Development Processes ◽

Technology Market ◽

Innovation Processes

Für eine marktgerechte Produktentwicklung gibt es in Anlehnung an das Technologie-Reifegradmodell eine Vielzahl von Ansätzen, die den Entwicklungsstand von Technologie und Markt bewerten. Um im Innovationsprozess produktionsstrategische Lücken rechtzeitig aufzuzeigen, müssen Entwicklungsprozesse von Technologie, Markt und Produktion jedoch ganzheitlich betrachtet werden. Hierfür werden unterschiedliche Reifegradmodelle gegenübergestellt, Korrelationen aufgezeigt und erfolgsentscheidende Entwicklungsstufen abgeleitet.   Based on the technology maturity model, there is a variety of approaches describing the maturity of market demand and technology in order to combine technology push and market pull perspectives. However, to be able to show strategic gaps during the innovation process, development processes of technology, market and manufacturing skills have to be viewed holistically. For this purpose, the authors present different degrees of maturity models, show correlations and derive critical fields of action.

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