scholarly journals Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4224
Author(s):  
Karolina Matulewicz ◽  
Łukasz Kaźmierski ◽  
Marek Wiśniewski ◽  
Szymon Roszkowski ◽  
Krzysztof Roszkowski ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Optimal Dose ◽  
Cell Death Pathway ◽  
Promising Strategy ◽  
Potential Applications ◽  
Cytotoxicity Effects ◽  
Drug Modification ◽  
Carbon Based Nanomaterials ◽  
Comprehensive Study ◽  
Carbon Based

Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.

Carbon-Based Nanomaterials for Drugs Sensing: A Review

2014 ◽  
Vol 807 ◽  
pp. 13-39
Author(s):  
Bavani Kasinathan ◽  
Ruzniza Mohd Zawawi
Keyword(s):  
Carbon Nanotubes ◽  
Graphene Oxide ◽  
Carbon Nanofibers ◽  
Chemical Vapour Deposition ◽  
Vapour Deposition ◽  
Chemical Vapour ◽  
Sensing Applications ◽  
Carbon Based Nanomaterials ◽  
Walled Carbon Nanotubes ◽  
Carbon Based

Carbon-based nanomaterials such as graphene, carbon nanotubes, carbon nanofibers and nanodiamonds have been fascinated considerable attention as promising materials for drug sensing. These materials have tremendous amount of attraction due to some extraordinary features such as excellent electrical and thermal conductivities as well as high mechanical strength. Hence, these nanomaterials have been used extensively in sensor technology in order to achieved desired sensitivities. To date, carbon based nanomaterials have been exploit in the development of various drug sensing due to their simple preparation methods, and cost effectiveness. The aim of this review is to focus upon carbon based nanomaterials predominantly on drugs sensing applications. This review has been written in summary form including properties, fabrication method, and analytical performances.Abbreviation:Au, Gold; CNFs, Carbon Nanofibers; CNTs, Carbon Nanotubes; CVD, Chemical Vapour Deposition; D-, Dextrorotatory enantiomer; D, Dimensional; DNase, deoxyribonuclease; ESD, Electrospinning deposition; GCE, Glassy Carbon Electrode; Gr, Graphene; GrO, Graphene Oxide; ILs, ionic liquids; L-, Levorotatory enantiomer; LOD, Limit of Detection; MTase, Methyltransferases; MW, Microwave; MWCNTs, Multi-walled Carbon nanotubes; NDs, Nanodiamonds; NPs, Nanoparticles; PECVD, Plasma Enhanced Chemical Vapour Deposition; RGO, Reduced Graphene Oxide; SPE, Screen-Printed Electrode; SPR, Surface Plasmon resonance; ssDNA, single-stranded DNA; SWCNTs, Single-walled Carbon nanotubes.

Light-controllable dispersion and recovery of graphenes and carbon nanotubes using a photo-switchable surfactant

Nanoscale ◽  
2016 ◽  
Vol 8 (13) ◽  
pp. 6969-6974 ◽  
Author(s):  
Thomas M. McCoy ◽  
Amelia C. Y. Liu ◽  
Rico F. Tabor
Keyword(s):  
Carbon Nanotubes ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Surfactant Molecule ◽  
Reduced Graphene ◽  
Carbon Based Nanomaterials ◽  
Aqueous Dispersibility ◽  
Carbon Based

The aqueous dispersibility of carbon-based nanomaterials, namely graphene oxide (GO), reduced graphene oxide (rGO) and carbon nanotubes (CNTs), can be controlled by light via the photoisomerisation of a photoswitchable surfactant molecule adsorbed to the surface of these materials.

scholarly journals Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

2021 ◽  
Vol 3 ◽  
Author(s):  
Sujit Kumar Debnath ◽  
Rohit Srivastava
Keyword(s):  
Drug Delivery ◽  
Informed Choice ◽  
Industrial Sector ◽  
Biological Interactions ◽  
Production Methods ◽  
Potential Applications ◽  
Carbon Based Nanomaterials ◽  
Human Health Effects ◽  
Carbon Based

With growing interest, a large number of researches have been conducted on carbon-based nanomaterials (CBNs). However, their uses are limited due to comprehensive potential environmental and human health effects. It is often confusing for researchers to make an informed choice regarding the versatile carbon-based nanocarrier system and its potential applications. This review has highlighted emerging applications and cutting-edge progress of CBNs in drug delivery. Some critical factors like enzymatic degradation, surface modification, biological interactions, and bio-corona have been discussed here. These factors will help to fabricate CBNs for effective drug delivery. This review also addresses recent advancements in carbon-based target specific and release controlled drug delivery to improve disease treatment. The scientific community has turned their research efforts into the development of novel production methods of CBNs to make their production more attractive to the industrial sector. Due to the nanosize and diversified physical properties, these CBNs have demonstrated distinct biological interaction. Thus long-term preclinical toxicity study is recommended before finally translating to clinical application.

scholarly journals Carbon-Based Nanomaterials for Plasmonic Sensors: A Review

Sensors ◽  
2019 ◽  
Vol 19 (16) ◽  
pp. 3536 ◽  
Author(s):  
Banshi D. Gupta ◽  
Anisha Pathak ◽  
Vivek Semwal
Keyword(s):  
Graphene Oxide ◽  
Surface Area ◽  
Sensitivity Enhancement ◽  
Large Surface Area ◽  
Plasmonic Sensors ◽  
Spr Sensor ◽  
Reduced Graphene ◽  
Dna Antibodies ◽  
Carbon Based Nanomaterials ◽  
Carbon Based

The surface plasmon resonance (SPR) technique is a remarkable tool, with applications in almost every area of science and technology. Sensing is the foremost and majorly explored application of SPR technique. The last few decades have seen a surge in SPR sensor research related to sensitivity enhancement and innovative target materials for specificity. Nanotechnological advances have augmented the SPR sensor research tremendously by employing nanomaterials in the design of SPR-based sensors, owing to their manifold properties. Carbon-based nanomaterials, like graphene and its derivatives (graphene oxide (GO)), (reduced graphene oxide (rGO)), carbon nanotubes (CNTs), and their nanocomposites, have revolutionized the field of sensing due to their extraordinary properties, such as large surface area, easy synthesis, tunable optical properties, and strong compatible adsorption of biomolecules. In SPR based sensors carbon-based nanomaterials have been used to act as a plasmonic layer, as the sensitivity enhancement material, and to provide the large surface area and compatibility for immobilizing various biomolecules, such as enzymes, DNA, antibodies, and antigens, in the design of the sensing layer. In this review, we report the role of carbon-based nanomaterials in SPR-based sensors, their current developments, and challenges.

scholarly journals The Biogenic Synthesis of Reduced Graphene Oxide using Hibiscus sabdariffa L. as Natural Precursor

2021 ◽  
Author(s):  
Emmellie Laura Albert ◽  
Eddie Khay Ming Tan ◽  
Huey Fang Teh ◽  
Theresa Ng Lee Mei ◽  
Che Azurahanim Che Abdullah
Keyword(s):  
Graphene Oxide ◽  
Green Synthesis ◽  
Reduced Graphene Oxide ◽  
Cost Effective ◽  
Hibiscus Sabdariffa ◽  
One Pot ◽  
Cost Effective Method ◽  
Reduced Graphene ◽  
Carbon Based Nanomaterials ◽  
Carbon Based

Owing to their extraordinary properties, carbon-based nanomaterials are gaining traction in biomedicine. Green synthesis is the cost-effective method for fabricating carbon-based nanomaterials due to its rapidity, renewable nature, and sustainability. This study emphasis on the graphene oxide (GO) reduction using a simple one-pot technique that does not require the use of toxic reducing agents. This article reports the green synthesis of reduced graphene oxide (RGO) using Hibiscus sabdariffa L. calyxes extract as the natural reducing agent. Additionally, this article also provides analysis RGO using X-ray diffraction (XRD), UV-Visible spectroscopy (UV-Vis), and Raman spectroscopy. XRD result showed that the GO peak at 11o diminished, and a new hump appear at 22o indicating that the GO is fully reduced when it is refluxed for 6 hours, at 100oC with 1:3 ratio of GO:PE. The UV-Vis data indicated absorption peak of GO (237 nm) and RGO (265 nm) at distinct locations. This finding shed new light on the enormous potential of Hibiscus sabdariffa L. calyxes extract for green GO reduction. As a result, this environmentally friendly method can help reduce dependence on chemical materials.

scholarly journals Extraordinary thermal behavior of graphene oxide in air for electrode applications

2021 ◽  
Author(s):  
Joong Tark Han ◽  
Joon Young Cho ◽  
Jeong Hoon Kim
Keyword(s):  
Thermal Stability ◽  
Graphene Oxide ◽  
Physical Properties ◽  
Thermal Behavior ◽  
Stability Of Solution ◽  
Exfoliated Graphene ◽  
Potential Applications ◽  
Thermal Stability Of

The thermal stability of solution-exfoliated graphene oxide (GO) in air is one of the most important physical properties influencing its potential applications. To date, majority of the GO prepared by...

scholarly journals Lerf–Klinowski-type models of graphene oxide and reduced graphene oxide are robust in analyzing non-covalent functionalization with porphyrins

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra Siklitskaya ◽  
Ewelina Gacka ◽  
Daria Larowska ◽  
Marta Mazurkiewicz-Pawlicka ◽  
Artur Malolepszy ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Excited States ◽  
Reduced Graphene ◽  
Simulation Protocol ◽  
Potential Applications ◽  
H 26 ◽  
High Level ◽  
Experimental And Theoretical Studies ◽  
Low Solubility

AbstractGraphene-based nanohybrids are good candidates for various applications. However, graphene exhibits some unwanted features such as low solubility in an aqueous solution or tendency to aggregate, limiting its potential applications. On the contrary, its derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), have excellent properties and can be easily produced in large quantities. GO/RGO nanohybrids with porphyrins were shown to possess great potential in the field of photocatalytic hydrogen production, pollutant photodegradation, optical sensing, or drug delivery. Despite the rapid progress in experimental research on the porphyrin-graphene hybrids some fundamental questions about the structures and the interaction between components in these systems still remain open. In this work, we combine detailed experimental and theoretical studies to investigate the nature of the interaction between the GO/RGO and two metal-free porphyrins 5,10,15,20-tetrakis(4-aminophenyl) porphyrin (TAPP) and 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (TPPH)]. The two porphyrins form stable nanohybrids with GO/RGO support, although both porphyrins exhibited a slightly higher affinity to RGO. We validated finite, Lerf–Klinowski-type (Lerf et al. in J Phys Chem B 102:4477, 1998) structural models of GO ($$\hbox {C}_{59}\hbox {O}_{26}\hbox {H}_{26}$$ C 59 O 26 H 26 ) and RGO ($$\hbox {C}_{59}\hbox {O}_{17}\hbox {H}_{26}$$ C 59 O 17 H 26 ) and successfully used them in ab initio absorption spectra simulations to track back the origin of experimentally observed spectral features. We also investigated the nature of low-lying excited states with high-level wavefunction-based methods and shown that states’ density becomes denser upon nanohybrid formation. The studied nanohybrids are non-emissive, and our study suggests that this is due to excited states that gain significant charge-transfer character. The presented efficient simulation protocol may ease the properties screening of new GO/RGO-nanohybrids.

scholarly journals The Structure–Properties–Cytotoxicity Interplay: A Crucial Pathway to Determining Graphene Oxide Biocompatibility

2021 ◽  
Vol 22 (10) ◽  
pp. 5401
Author(s):  
Marta Dziewięcka ◽  
Mirosława Pawlyta ◽  
Łukasz Majchrzycki ◽  
Katarzyna Balin ◽  
Sylwia Barteczko ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Defense Mechanisms ◽  
Physicochemical Analysis ◽  
Experimental Models ◽  
Acheta Domesticus ◽  
Synthesis Process ◽  
Synthesis Methods ◽  
Toxicity Potential ◽  
Potential Applications

Interest in graphene oxide nature and potential applications (especially nanocarriers) has resulted in numerous studies, but the results do not lead to clear conclusions. In this paper, graphene oxide is obtained by multiple synthesis methods and generally characterized. The mechanism of GO interaction with the organism is hard to summarize due to its high chemical activity and variability during the synthesis process and in biological buffers’ environments. When assessing the biocompatibility of GO, it is necessary to take into account many factors derived from nanoparticles (structure, morphology, chemical composition) and the organism (species, defense mechanisms, adaptation). This research aims to determine and compare the in vivo toxicity potential of GO samples from various manufacturers. Each GO sample is analyzed in two concentrations and applied with food. The physiological reactions of an easy model Acheta domesticus (cell viability, apoptosis, oxidative defense, DNA damage) during ten-day lasting exposure were observed. This study emphasizes the variability of the GO nature and complements the biocompatibility aspect, especially in the context of various GO-based experimental models. Changes in the cell biomarkers are discussed in light of detailed physicochemical analysis.

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