Preparation and Characterization of a Hybrid Complex of Cyclodextrin-Based Metal–Organic Frameworks-1 and Ascorbic Acid Derivatives

Cyclodextrin-based metal–organic frameworks-1 (CD-MOF-1) prepared using potassium hydroxide, ethanol, and γ-cyclodextrin (γ-CD) has been reported as a new type of MOF for the development of pharmaceutical formulations. The present study aimed to investigate the physicochemical properties of ascorbic acid derivatives (L-ascorbyl 6-palmitate (ASCP); L-ascorbyl 2,6-palmitate (ASCDP)) complexed with CD-MOF-1 by a solvent evaporation method. Powder X-ray diffraction revealed that the crystal diffraction pattern of CD-MOF-1 changed from α-type to β-type when prepared by a solvent evaporation method. For ASCP/CD-MOF-1 = 1/2 and ASCDP/CD-MOF-1 = 1/4 evaporated samples, the crystal diffraction peaks derived from ASCP and ASCDP disappeared, indicating a β-like behavior. Differential scanning calorimetry results revealed that the endothermic peaks of evaporated samples (ASCP/CD-MOF-1 = 1/2 and ASCDP/CD-MOF-1 = 1/4) were not detected due to melting. Furthermore, intermolecular interactions were observed in the hydrogen bonds between the CH groups of the side chains of ASCP and ASCDP and the OH group of CD-MOF-1 in (ASCP/CD-MOF-1 = 1/2) and EVP (ASCDP/CD-MOF-1 = 1/4), based on the near-infrared absorption spectroscopy analysis. CD-MOF-1 did not form inclusion complexes with the lactone rings of ASCP and ASCDP, but with the lipophilic side chains. These results suggested that CD-MOF-1 may be useful in preparing novel drug carriers for ASCP and ASCDP.

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Cocrystallization of Mefenamin Acid and Ascorbic Acid by the Solvent Evaporation Method

The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019) ◽

10.2991/ahsr.k.200523.014 ◽

2020 ◽

Author(s):

Indra ◽

Physca Fathiyatul Azhariyah ◽

Ratih Aryani

Keyword(s):

Ascorbic Acid ◽

Solvent Evaporation ◽

Solvent Evaporation Method ◽

Evaporation Method

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Synthesize Glibenclamide-Ascorbic Acid Cocrystal Using Solvent Evaporation Method to Increase Solubility and Dissolution Rate of Glibenclamide

Research Journal of Pharmacy and Technology ◽

10.5958/0974-360x.2019.01005.9 ◽

2019 ◽

Vol 12 (12) ◽

pp. 5805

Author(s):

Arif Budiman ◽

Sandra Megantara ◽

Putri Saraswati

Keyword(s):

Ascorbic Acid ◽

Dissolution Rate ◽

Solvent Evaporation ◽

Solvent Evaporation Method ◽

Evaporation Method

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Glibenclamide-Nicotinamide Cocrystals Synthesized by The Solvent Evaporation Method to Enhance Solubility and Dissolution Rate of Glibenclamide

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.9.1.4 ◽

2019 ◽

Vol 9 (01) ◽

pp. 21-26

Author(s):

Arif Budiman ◽

Ayu Apriliani ◽

Tazyinul Qoriah ◽

Sandra Megantara

Keyword(s):

Solvent Evaporation ◽

Physical Mixture ◽

Dissolution Profile ◽

Solvent Evaporation Method ◽

X Ray Diffraction ◽

Scanning Calorimetry ◽

Evaporation Method ◽

Dissolution Properties ◽

Mixture Characterization

Purpose: To develop glibenclamide-nicotinamide cocrystals with the solvent evaporation method and evaluate their solubility and dissolution properties. Methods: Cocrystals of glibenclamide-nicotinamide (1:2) were prepared with the solvent evaporation method. The prediction of interactive cocrystals was observed using in silico method. The solubility and dissolution were performed as evaluation of cocrystals. The cocrystals also were characterized by differential scanning calorimetry (DSC), infrared spectrophotometry, and powder X-ray diffraction (PXRD). Result: The solubility and dissolution profile of glibenclamide-nicotinamide cocrystal (1:2) increased significantly compared to pure glibenclamide as well as its physical mixture. Characterization of cocrystal glibenclamide-nicotinamide (1:2) including infrared Fourier transform, DSC, and PXRD, indicated the formation of a new solid crystal phase differing from glibenclamide and nicotinamide. Conclusion: The confirmation of cocrystal glibenclamide-nicotinamide (1:2) indicated the formation of new solid crystalline phases that differ from pure glibenclamide and its physical mixture

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Preparation and Evaluation of Glipizide Tablets Containing both Enhanced and Sustained Release Solid Dispersions

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2009.2.4.5 ◽

1970 ◽

Vol 2 (4) ◽

pp. 714-725

Author(s):

Adel M. Aly ◽

Ahmed S. Ali

Keyword(s):

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Solid Dispersions ◽

Solvent Evaporation ◽

In Vivo Studies ◽

Solvent Evaporation Method ◽

Evaporation Method ◽

Tablet Formulations

: Glipizide (GZ) is an oral blood-glucose-lowering drug of the sulfonylurea class characterized by its poor aqueous solubility. Aiming for the production of GZ tablets with rapid onset of action followed by prolonged effect; GZ-Polyethylene glycol (PEG 4000 and 6000) solid dispersions with different ratios, (using melting and solvent evaporation method), as well as, coprecipitate containing GZ with polymethyl-methacrylate (PMMA) were prepared. Four tablet formulations were prepared containing; a) GZ alone, b) GZ: PEG6000, 1:10, c) GZ:PMMA 1:3, and, d)both GZ:PEG6000 1:10 and GZ:PMMA 1:3. The solvent evaporation method showed more enhancement of GZ solubility than the melting one, and this solubilizing effect increased with PEG increment. Generally, PEG6000 showed more enhancement of dissolution than PEG4000 especially at 1:10 drug: polymer ratio (the most enhancing formula). Also, the prepared tablet formulations showed acceptable physical properties according to USP/NF requirements. The dissolution results revealed that tablets containing PEG6000 (1:10) have the most rapid release rate, followed by the formula containing both PEG6000 and PMMA, while that including PMMA alone showed the slowest dissolution rate. Moreover, In-vivo studies for each of the above four formulations, were performed using four mice groups. The most effective formula in decreasing the blood glucose level, through the first 6 hours, was that containing GZ and PEG6000, 1:10. However, formula containing the combination of enhanced and sustained GZ was the most effective in decreasing the blood glucose level through 16 hours. Successful in-vitro in-vivo correlations could be detected between the percent released and the percent decreasing of blood glucose level after 0.5 hours.

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Formulation Design and Optimization of Repaglinide Solid Dispersions by Central Composite Design

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2018.11.6.7 ◽

2018 ◽

Vol 11 (6) ◽

pp. 4337-4348

Author(s):

Bhikshapathi D. V. R. N. ◽

Srinivas I

Keyword(s):

Central Composite Design ◽

Dissolution Rate ◽

Solid Dispersion ◽

Solid Dispersions ◽

Solvent Evaporation ◽

Release Mechanism ◽

Solvent Evaporation Method ◽

Onset Of Action ◽

Evaporation Method ◽

Central Composite

Repaglinide is a pharmaceutical drug used for the treatment of type II diabetes mellitus, it is characterized with poor solubility which limits its absorption and dissolution rate and delays onset of action. In the present study, immediate release solid dispersion of repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by solvent evaporation method. A 3-factor, 3-level central composite design employed to study the effect of each independent variable on dependent variables. FTIR studies revealed that no drug excipient interaction takes place. From powder X-ray diffraction (p-XRD) and by scanning electron microscopy (SEM) studies it was evident that polymorphic form of repaglinide has been converted into an amorphous form from crystalline within the solid dispersion formulation. The correlation coefficient showed that the release profile followed Higuchi model anomalous behavior and hence release mechanism was indicative of diffusion. The obtained results suggested that developed solid dispersion by solvent evaporation method might be an efficacious approach for enhancing the solubility and dissolution rate of repaglinide.

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Preparation and in vitro evaluation of polystyrene-coated diltiazem-resin complex by oil-in-water emulsion solvent evaporation method

AAPS PharmSciTech ◽

10.1208/pt070246 ◽

2006 ◽

Vol 7 (2) ◽

pp. E105-E112 ◽

Cited By ~ 15

Author(s):

Arindam Halder ◽

Biswanath Sa

Keyword(s):

Solvent Evaporation ◽

Solvent Evaporation Method ◽

Water Emulsion ◽

In Vitro Evaluation ◽

Evaporation Method ◽

Oil In Water ◽

Oil In Water Emulsion

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A simple and high efficient composite based on g-C3N4 for super rapid removal multiple organic dyes in water under sunlight

Catalysis Science & Technology ◽

10.1039/d1cy01689j ◽

2022 ◽

Author(s):

Siwei Yang ◽

Qiang Sun ◽

Weihang Han ◽

Yuanfang Shen ◽

Zhigang Ni ◽

...

Keyword(s):

Organic Dyes ◽

Solvent Evaporation ◽

Solvent Evaporation Method ◽

Evaporation Method ◽

High Efficient ◽

Rapid Removal ◽

Porous Composites

A simple and high efficient porous composites via the solvent evaporation method using g-C3N4 and NiSO4 was developed. It can super rapidly remove multiple organic dyes in water including rhodamine...

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