scholarly journals Periodontal Bifunctional Biomaterials: Progress and Perspectives

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7588
Author(s):  
Qiuxia Huang ◽  
Xin Huang ◽  
Lisha Gu
Keyword(s):  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Drug Delivery Systems ◽  
Tooth Loss ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Tissue Engineering Scaffolds ◽  
Periodontal Tissues ◽  
Bioactive Agents ◽  
Composite Biomaterials

Periodontitis is a chronic infectious disease that destroys periodontal supportive tissues and eventually causes tooth loss. It is attributed to microbial and immune factors. The goal of periodontal therapy is to achieve complete alveolar bone regeneration while keeping inflammation well-controlled. To reach this goal, many single or composite biomaterials that produce antibacterial and osteogenic effects on periodontal tissues have been developed, which are called bifunctional biomaterials. In this review, we summarize recent progress in periodontal bifunctional biomaterials including bioactive agents, guided tissue regeneration/guided bone regeneration (GTR/GBR) membranes, tissue engineering scaffolds and drug delivery systems and provide novel perspectives. In conclusion, composite biomaterials have been greatly developed and they should be chosen with care due to the risk of selection bias and the lack of evaluation of the validity of the included studies.

scholarly journals Periodontal Bone-Ligament-Cementum Regeneration via Scaffolds and Stem Cells

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 537 ◽  
Author(s):  
Jin Liu ◽  
Jianping Ruan ◽  
Michael D. Weir ◽  
Ke Ren ◽  
Abraham Schneider ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Tooth Loss ◽  
Soft Tissues ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Periodontal Tissues ◽  
Oral And Maxillofacial Region ◽  
And Function ◽  
Bone Remains

Periodontitis is a prevalent infectious disease worldwide, causing the damage of periodontal support tissues, which can eventually lead to tooth loss. The goal of periodontal treatment is to control the infections and reconstruct the structure and function of periodontal tissues including cementum, periodontal ligament (PDL) fibers, and bone. The regeneration of these three types of tissues, including the re-formation of the oriented PDL fibers to be attached firmly to the new cementum and alveolar bone, remains a major challenge. This article represents the first systematic review on the cutting-edge researches on the regeneration of all three types of periodontal tissues and the simultaneous regeneration of the entire bone-PDL-cementum complex, via stem cells, bio-printing, gene therapy, and layered bio-mimetic technologies. This article primarily includes bone regeneration; PDL regeneration; cementum regeneration; endogenous cell-homing and host-mobilized stem cells; 3D bio-printing and generation of the oriented PDL fibers; gene therapy-based approaches for periodontal regeneration; regenerating the bone-PDL-cementum complex via layered materials and cells. These novel developments in stem cell technology and bioactive and bio-mimetic scaffolds are highly promising to substantially enhance the periodontal regeneration including both hard and soft tissues, with applicability to other therapies in the oral and maxillofacial region.

scholarly journals Local Injection of Allogeneic Stem Cells from Apical Papilla Enhanced Periodontal Tissue Regeneration in Minipig Model of Periodontitis

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Guoqing Li ◽  
Nannan Han ◽  
Xiuli Zhang ◽  
Haoqing Yang ◽  
Yangyang Cao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Local Injection ◽  
Swine Model ◽  
Periodontal Tissue ◽  
Clinical Assessments ◽  
Periodontal Tissues ◽  
Periodontal Tissue Regeneration ◽  
Apical Papilla

Background. Discovering suitable seeding cells and simple application technique will be beneficial for MSC-mediated treatment of periodontitis. Stem cells from apical papilla (SCAPs) might be the candidate seeding cell for the periodontal tissues regeneration based on their origin and characters. In this research, we investigated the effect of SCAPs on periodontal tissue regeneration in swine by local injection. Methods. We established experimental periodontitis model in miniature pigs and then treated them with SCAPs by local injection. Clinical assessments, computed tomography (CT) scanning, histologic examination, and quantitative measurements were used to evaluate the effect of periodontal tissues regeneration. Results. At 12 weeks after injection, clinical assessments showed that probing depth, gingival recession, and attachment loss values were 5.44±0.77 mm versus 7.33±1.0 mm (p<0.01), 2.33±0.33 mm versus 2.11±0.69 mm (p>0.05), and 7.78±0.84 mm versus 9.44±1.07 mm (p<0.01) in SCAPs group and 0.9% NaCl group, respectively. CT scan results showed a significant increase of 12.86 mm3 alveolar bone regeneration in SCAPs group compared with 0.9% NaCl group. In addition, histopathology results demonstrated remarkable regeneration in SCAPs group, whereas regeneration of periodontal tissue was hardly found in 0.9% NaCl group. Conclusion. Local injection of SCAPs could effectively restore tissue defects brought about by periodontitis in the swine model. Thus, SCAPs, as an easily accessible dental-deriving stem cell, may serve as an alternative application for periodontitis treatment.

Histologic Analysis of Alveolar Bone Following Guided Bone Regeneration

2004 ◽  
Vol 75 (5) ◽  
pp. 750-756 ◽  
Author(s):  
S. Ersanli ◽  
V. Olgac ◽  
B. Leblebicioglu
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Histologic Analysis

scholarly journals Guided Bone Regeneration- A Comprehensive Review

2021 ◽  
Author(s):  
Vineetha Venugopalan ◽  
Anegundi Raghavendra Vamsi ◽  
Santhosh Shenoy ◽  
Karishma Ashok ◽  
Biju Thomas
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Primary Stability ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Bony Defect ◽  
Graft Material ◽  
Bone Augmentation ◽  
Wide Range ◽  
Space Maintenance

Successful implant treatment requires prosthetically driven placement of an implant, primary stability at placement, and careful living bone management. The resorptive changes of alveolar bone are an inevitable process following tooth loss, periodontal disease or trauma which causes bone defects. This results in various aesthetic and functional complications such as soft tissue recession, infection and inflammation. Various methods have been tried and advocated for augmenting these bone deficiencies. Guided Bone Regeneration (GBR) is a successful modality for bone augmentation with a wide range of indications and helps restore the alveolar ridge dimensions. It utilises the principle of Guided Tissue Regeneration (GTR) for space maintenance within a bony defect. Different types of barrier membranes are being utilised along with various bone grafts in GBR. Thorough knowledge regarding the biology of bone is required before the initiation of any bone augmentation procedure. A combination of Collagen Membrane (CM) and graft material was found successful for GBR. Hence, this review focuses on presentation of best available evidence for various aspects of GBR.

scholarly journals Double-layered microsphere based dual growth factor delivery system for guided bone regeneration

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16503-16512 ◽  
Author(s):  
Chun Xu ◽  
Jia Xu ◽  
Lan Xiao ◽  
Zhihao Li ◽  
Yin Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Guided Bone Regeneration ◽  
Delivery Systems ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery

Microsphere based drug delivery systems show great advantages for tissue engineering.

scholarly journals Guided bone regeneration with subperiosteal implants of PTFE and hydroxyapatite physical barriers in rats

2003 ◽  
Vol 14 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Nelson Luiz de Macedo ◽  
Luís Guilherme Scavone de Macedo ◽  
Fábio da Silva Matuda ◽  
Suzana Martins Ouchi ◽  
Adriana Socorro Ferreira Monteiro ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
Physical Barrier ◽  
Group Iii ◽  
Group I ◽  
Membrane Technique ◽  
Physical Barriers ◽  
Membrane Design

Regeneration of periodontal and alveolar ridge defects utilizing membranes is a well-established procedure in reconstructive surgery. Biomaterial characteristics and membrane design employed in guided tissue regeneration (GTR) techniques play an important role in good results. The purpose of this histologic experimental study in rats was to compare the use of two physical barriers in the osteopromotion by using GTR principles in bone defects created in tibias. Fifteen animals divided into 3groups were used: group I (non-porous polytetrafluoroethylene (PTFE) barrier), group II (coral hydroxyapatite (HA) blocks), and group III (defects that received no physical barrier). Histological examination showed varied amounts of newly formed bone beneath both types of barriers. The non-porous PTFE barrier showed better results than the HA group. The results of this study suggest that bone regeneration can be successfully enhanced by a submerged membrane technique.

Management of Membrane Exposure Utilizing Concentrated Growth Factor (CFG) in Guided Bone Regeneration: A Clinical Report

2020 ◽  
Vol 14 (1) ◽  
pp. 763-768
Author(s):  
Muhammad Syafiq Alauddin ◽  
Haslinda Ramli
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Healthy Woman ◽  
Guided Bone Regeneration ◽  
Gingival Tissue ◽  
Clinical Report ◽  
Bone Segment ◽  
Alternative Material ◽  
Membrane Exposure

Introduction: This is a clinical case of a healthy woman with a missing upper right central incisor (#8) who requested a permanent prosthetic replacement due to endodontic failure. Clinically, she was presented with thin edentulous ridges and fibrous gingival tissue and minimal or compromised alveolar bone segment on the buccal profile as detected on cone-beam computed tomography (CBCT). Case Report: The conventional treatment approach is to add pink porcelain; however, rarely does the prosthetic gingiva substitute blend well with the existing oral profile. Therefore,Guided Bone Regeneration (GBR) was done instead on #8 using the allograft [RegenOss, Neobiotech] and PTFE membrane. Upon examination, membrane exposure was detected, and the size was found to be increased in follow-up visits. The membrane was replaced with a Concentrated Growth Factor [CGF] and sutured at the site of the defect. After 12 months, a vertical and horizontal bone with adequate soft tissue emergence profile was achieved clinically, radiographically, and digitally. The delayed removal of the exposed membrane provided more time for initial bone regeneration in GBR. The replacement barrier of an exposed membrane using CGF is considered an innovative procedure with the cellular content providing vascularization and regeneration. Conclusion: This case concludes that CGF can be a viable alternative material to enhance GBR outcome in replacing exposed membranes.

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