scholarly journals Four New Chromones from the Endophytic Fungus Phomopsis asparagi DHS-48 Isolated from the Chinese Mangrove Plant Rhizophora mangle

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 348
Author(s):  
Chengwen Wei ◽  
Chunxiao Sun ◽  
Zhao Feng ◽  
Xuexia Zhang ◽  
Jing Xu
Keyword(s):  
Endophytic Fungus ◽  
Spectroscopic Analysis ◽  
B Lymphocyte ◽  
Rhizophora Mangle ◽  
Immunosuppressive Activity ◽  
Mangrove Plant ◽  
Natural Sources ◽  
Basic Hydrolysis ◽  
Phomopsis Asparagi ◽  
Modified Mosher’S Method

Four new chromones, phomochromenones D–G (1–4), along with four known analogues, diaporchromone A (5), diaporchromanone C (6), diaporchromanone D (7), and phomochromenone C (8), were isolated from the culture of Phomopsis asparagi DHS-48 from Chinese mangrove Rhizophora mangle. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. The absolute configurations of 1 and 4 were assigned on the basis of experimental and calculated electronic circular dichroism (ECD) data, and those of enantiomers 2 and 3 were determined by a modified Mosher’s method and basic hydrolysis. To the best of our knowledge, phomochromenones D–F (1–4) possessing a 3-substituted-chroman-4-one skeleton are rarely found in natural sources. Diaporchromone A (5) showed moderate to weak immunosuppressive activity against T and/or B lymphocyte cells with IC50 of 34 μM and 117 μM.

scholarly journals Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale

2020 ◽  
Vol 16 ◽  
pp. 2100-2107
Author(s):  
Ken-ichi Nakashima ◽  
Junko Tomida ◽  
Tomoe Tsuboi ◽  
Yoshiaki Kawamura ◽  
Makoto Inoue
Keyword(s):  
Antibacterial Activity ◽  
Endophytic Fungus ◽  
Spectroscopic Analysis ◽  
Gram Positive ◽  
Electronic Circular Dichroism ◽  
Gram Positive Bacteria ◽  
Circular Dichroism Data ◽  
Circular Dichroïsm ◽  
Weak Antibacterial Activity ◽  
Modified Mosher’S Method

Two new azaphilones, namely muyocopronones A (1) and B (2), were isolated from the cultures of an endophytic fungus Muyocopron laterale ECN279. Their structures were elucidated by extensive spectroscopic analysis. Their absolute configurations were determined using the modified Mosher’s method and through comparisons of experimental and calculated electronic circular dichroism data. In addition, muyocopronone B (2) was found to exhibit a weak antibacterial activity against some Gram-positive bacteria.

scholarly journals Secondary metabolites from the endophytic fungus Pestalotiopsis virgatula isolated from the mangrove plant Sonneratia caseolaris

2013 ◽  
Vol 54 (25) ◽  
pp. 3256-3259 ◽  
Author(s):  
David Rönsberg ◽  
Abdessamad Debbab ◽  
Attila Mándi ◽  
Victor Wray ◽  
Haofu Dai ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Endophytic Fungus ◽  
Mangrove Plant ◽  
Sonneratia Caseolaris

scholarly journals Two new α-Methoxy-γ-Pyrones From the Mangrove Sediment-Derived Streptomyces psammoticus SCSIO NS126

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110414
Author(s):  
Kunlong Li ◽  
Mengdie Zhou ◽  
Ziqi Su ◽  
Xiliang Yang ◽  
Xuefeng Zhou ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Spectroscopic Analysis ◽  
Mangrove Sediment ◽  
Natural Sources ◽  
Fermentation Conditions ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Actinomycete Strain

Two new α-methoxy- γ-pyrone analogs, 2-methoxy-3-methyl-5,6-diethyl- γ-pyrone (2) and 2-methoxy-3,5-dimethyl-6-propyl- γ-pyrone (3), together with 2-methoxy-3,5-dimethyl-6-ethyl- γ-pyrone (1), firstly isolated from natural sources, were obtained from the EtOAc-solube extract of the mangrove sediment-derived actinomycete strain Streptomyces psammoticus SCSIO NS126, under the optimized fermentation conditions. Their structures were elucidated by detailed spectroscopic analysis and by comparison of their spectroscopic data with those reported in the literature. Those α-methoxy-γ-pyrones were evaluated for their acetylcholinesterase inhibitory activity; however, none of them exhibited obvious activity. Moreover, their biosynthetic relationship with piericidins was also discussed.

scholarly journals Two New Cyclic Depsipeptides from the Endophytic Fungus Fusarium sp

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Fang Lv ◽  
Georgios Daletos ◽  
Wenhan Lin ◽  
Peter Proksch
Keyword(s):  
Endophytic Fungus ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Moderate Activity ◽  
Amino Acid Residues ◽  
Human Ovarian Cancer Cell ◽  
Mangrove Plant ◽  
Fusarium Sp ◽  
New Compounds

Two new cyclic depsipeptides, W493 C (1) and D (2), along with two known derivatives W493 A (3) and B (4) were obtained from the endophytic fungus Fusarium sp. isolated from the Mangrove plant Ceriops tagal. The structures of the new compounds were determined on the basis of one- and two dimensional NMR and high-resolution mass spectroscopic data. The absolute configurations of the amino acid residues of 1 and 2 were confirmed by application of Marfey's method. W493 A (3) and B (4) exhibited moderate activity against the fungus Cladosporium cladosporiodes and weak antitumor activity against the human ovarian cancer cell line A2780.

Two new diterpenoids from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum

2016 ◽  
Vol 27 (6) ◽  
pp. 957-960 ◽  
Author(s):  
Min Zhang ◽  
Ji-Mei Liu ◽  
Jin-Lian Zhao ◽  
Ning Li ◽  
Ri-Dao Chen ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Mangrove Plant ◽  
Xylocarpus Granatum ◽  
Trichoderma Sp

scholarly journals Chemoreversal Metabolites from the Endophytic Fungus Penicillium citrinum Isolated from a Mangrove Avicennia marina

2015 ◽  
Vol 10 (7) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Jin Liu ◽  
Meng Xu ◽  
Ming-Yi Zhu ◽  
Yun Feng
Keyword(s):  
Endophytic Fungus ◽  
Spectroscopic Analysis ◽  
Efflux Pump ◽  
Quinic Acid ◽  
Avicennia Marina ◽  
Penicillium Citrinum ◽  
Pump Function ◽  
P Glycoprotein ◽  
New Compounds

Two new compounds, named ( Z)-7,4′-dimethoxy-6-hydroxyaurone-4- O-β-glucopyranoside (1) and (-)-4- O-(4- O-β-D-glucopyranosylcaffeoyl)quinic acid (2), were isolated from the endophytic fungus Penicillium citrinum of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 2 exhibited potent chemoreversal activity, mainly by inhibiting P-glycoprotein efflux pump function.

Aspernolides L and M, new butyrolactones from the endophytic fungus Aspergillus versicolor

2017 ◽  
Vol 72 (5-6) ◽  
pp. 155-160 ◽  
Author(s):  
Sabrin R.M. Ibrahim ◽  
Gamal A. Mohamed ◽  
Samir A. Ross
Keyword(s):  
Endophytic Fungi ◽  
Endophytic Fungus ◽  
Spectroscopic Analysis ◽  
2D Nmr ◽  
Systematic Search ◽  
Aspergillus Versicolor ◽  
Active Compounds ◽  
Etoac Extract ◽  
First Time

Abstract During the systematic search of active compounds from endophytic fungi, two new butyrolactones, namely aspernolides L (2) and M (4), together with four known compounds: 1-O-acetylglycerol (1), butyrolactone I (3), butyrolactone VI (5), and (+) alantrypinone (6) were characterized from the EtOAc extract of the endophytic fungus Aspergillus versicolor isolated from the roots of Pulicaria crispa (Asteraceae). Extensive spectroscopic analysis, including 1D, 2D NMR, and HRESIMS, was used to elucidate their structures. Compounds 1, 5, and 6 are reported for the first time from this fungus.

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