Can Anhedonia Be Considered a Suicide Risk Factor? A Review of the Literature

Background and Objectives: At present, data collected from the literature about suicide and anhedonia are controversial. Some studies have shown that low levels of anhedonia are associated with serious suicide attempts and death by suicide, while other studies have shown that high levels of anhedonia are associated with suicide. Materials and Methods: For this review, we searched PubMed, Medline, and ScienceDirect for clinical studies published from 1 January 1990 to 31 December 2018 with the following search terms used in the title or in the abstract: “anhedonia AND suicid*.” We obtained a total of 155 articles; 133 items were excluded using specific exclusion criteria, the remaining 22 articles included were divided into six groups based on the psychiatric diagnosis: mood disorders, schizophrenia spectrum disorders, post-traumatic stress disorder (PTSD), other diagnoses, attempted suicides, and others (healthy subjects). Results: The results of this review reveal inconsistencies. Some studies reported that high anhedonia scores were associated with suicidal behavior (regardless of the diagnosis), while other studies found that low anhedonia scores were associated with suicidal behavior, and a few studies reported no association. The most consistent association between anhedonia and suicidal behavior was found for affective disorders (7 of 7 studies reported a significant positive association) and for PTSD (3 of 3 studies reported a positive association). In the two studies of patients with schizophrenia, one found no association, and one found a negative association. For patients who attempted suicide (undiagnosed), one study found a positive association, one a positive association only for depressed attempters, and one a negative association. Conclusions: We found the most consistent positive association for patients with affective disorders and PTSD, indicating that the assessment of anhedonia may be useful in the evaluation of suicidal risk.

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Predictors of suicide attempts in 3.322 patients with affective disorders and schizophrenia spectrum disorders

Psychiatry Research ◽

10.1016/j.psychres.2015.05.024 ◽

2015 ◽

Vol 228 (3) ◽

pp. 791-796 ◽

Cited By ~ 13

Author(s):

Juan A. Gallego ◽

Vivekananda Rachamallu ◽

Eunice Y. Yuen ◽

Sabina Fink ◽

Laura M. Duque ◽

...

Keyword(s):

Affective Disorders ◽

Suicide Attempts ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Spectrum Disorders

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Perceived Overprotection and Its Association With Quality of Life in Dementia

GeroPsych ◽

10.1024/1662-9647/a000207 ◽

2019 ◽

Vol 32 (3) ◽

pp. 125-134

Author(s):

Mechthild Niemann-Mirmehdi ◽

Andreas Häusler ◽

Paul Gellert ◽

Johanna Nordheim

Keyword(s):

Quality Of Life ◽

Patient Autonomy ◽

Positive Association ◽

Well Being ◽

Negative Association ◽

Significant Positive Association ◽

Cross Sectional ◽

People With Dementia ◽

Mental Well Being

Abstract. To date, few studies have focused on perceived overprotection from the perspective of people with dementia (PwD). In the present examination, the association of perceived overprotection in PwD is examined as an autonomy-restricting factor and thus negative for their mental well-being. Cross-sectional data from the prospective DYADEM study of 82 patient/partner dyads (mean age = 74.26) were used to investigate the association between overprotection, perceived stress, depression, and quality of life (QoL). The analyses show that an overprotective contact style with PwD has a significant positive association with stress and depression, and has a negative association with QoL. The results emphasize the importance of avoiding an overprotective care style and supporting patient autonomy.

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GENETIC VARIATION AND SELECTION CRITERIA FOR SEED YIELD RELATED TRAITS IN RAPE SEED (Brassica napus L.)

Bangladesh Journal of Plant Breeding and Genetics ◽

10.3329/bjpbg.v26i2.23845 ◽

2015 ◽

Vol 26 (2) ◽

pp. 15-22

Author(s):

S. Parveen Parveen ◽

M. H. Rashid Rashid ◽

M. S. R. Bhuiyan

Keyword(s):

Coefficient Of Variation ◽

Seed Weight ◽

Positive Association ◽

Negative Association ◽

Genetic Advance ◽

Rape Seed ◽

Significant Positive Association ◽

Days To Maturity ◽

Additive Gene ◽

High Heritability

The field experiment was conducted to estimate the genetic variability and correlation between yield contributing traits using 15 rape seed genotypes. The results indicated that the phenotypic variance for all the characters was considerably higher than the genotypic variance denoting little influence of environmental factors on their expression. Characters like 1000-seed weight (12.39, 14.10), days to 50% flowering (18.36, 18.77) and days to maturity (4.63, 5.06) showed low genotypic and phenotypic coefficient of variation. Moderate genotypic and phenotypic coefficient of variation was observed in number of primary branches per plant (20.22, 22.16), length of siliqua (20.84, 20.97), number of seeds per siliqua (30.90, 33.06), number of siliquae per plant (49.34, 49.81) and yield per plant (34.36, 39.98) and high genotypic (67.00) and phenotypic coefficient of variation (68.57) was observed for number of secondary branches per plant. Plant height (85.98%, 30.89), 1000 seed weight (77.14%, 22.41), days to 50% flowering (95.66%, 20.35) and days to maturity (83.85%, 7.82) showed high heritability with low genetic advance which indicated the possibility of non-additive gene action. Number of primary branches per plant (83.22%, 37.99, 636.02), length of siliqua (98.83%, 42.68, 1084.42), number of seeds per siliqua (87.40%, 59.52, 424.22), number of siliqua per plant (98.15%, 100.71, 178.83) and yield per plant (73.87%, 60.84, 4539.97) showed high heritability with high genetic advance and high genetic advance in percentage of mean revealed the possibility of predominance of additive gene effects. Number of primary branches per plant had showed highly significant positive association with number of secondary branches per plant (rg=0.597, rp= 0.537) and yield per plant (rg=0.43). Days to 50% flowering showed significant positive association with seeds per siliqua (rg=0.492; rp=0.436), 1000 seed weight (rg=0.486; rp=0.472) and yield per plant (rg=0.438; rp=0.379). Length of siliqua manifested highly significant positive association with siliqua per plant (rg=0.571; rp=0.514) and significant negative association with yield per plant (-0.471) at genotypic level. Siliqua per plant had highly significant negative association at both genotypic and phenotypic level with yield per plant (-0.697; -0.525) but 1000 seed weight had highly significant positive association with yield per plant both genotypic and phenotypic level (0.893; 0.814). The results of the path analysis revealed that 1000 seed weight (0.766) had the maximum direct effect and the maximum negative direct effect was observed in seeds per siliqua (0.305). In summary, the results suggested that there were some yield related traits such as 1000 seed weight and days to 50% flowering could be selected and used in breeding program for increasing the grain yield of rapeseed.

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Oat β-glucans: An evaluation of eastern Canadian cultivars and unregistered lines

Canadian Journal of Plant Science ◽

10.4141/cjps93-062 ◽

1993 ◽

Vol 73 (2) ◽

pp. 429-436 ◽

Cited By ~ 16

Author(s):

S. S. Miller ◽

R. G. Fulcher ◽

D. J. Vincent ◽

J. Weisz

Keyword(s):

Content Analysis ◽

Environmental Factors ◽

Avena Sativa ◽

Rank Order ◽

Positive Association ◽

Kernel Weight ◽

Negative Association ◽

Significant Positive Association ◽

Factors Influencing ◽

Oat Cultivars

The (1-3), (1-4)-β-D-glucan (β-glucan) content of a number of domestic Canadian oat cultivars and selected unregistered lines was determined to establish the range of β-glucan content in eastern Canadian oat varieties. Seed samples were taken from oats grown at five locations over 3 years in an attempt to assess the effect of environment on variation in β-glucan content. Analysis of variance indicated that the greater source of variation in β-glucan content was due to genetic rather than environmental factors. The highest β-glucan cultivar (Marion) was about 30% higher than the lowest cultivars (OA516-2 and Donald). Differences in β-glucan content among the intermediate cultivars were generally smaller, and in some cases not significant, although the rank order of the cultivars among environments was consistent. A low, but significant, negative association between β-glucan content and precipitation, and a low, but significant, positive association between β-glucan content and temperature was found, but these were not dominant factors influencing β-glucan levels in oats. There was no consistent association between β-glucan content and protein, oil, thousand kernel weight or grain yield (kg/hectare). Key words: Oat, Avena sativa, β-glucan, variation

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Unwanted pregnancy as a risk factor for offspring schizophrenia-spectrum and affective disorders in adulthood: a prospective high-risk study

Psychological Medicine ◽

10.1017/s0033291708004479 ◽

2008 ◽

Vol 39 (6) ◽

pp. 957-965 ◽

Cited By ~ 15

Author(s):

T. F. McNeil ◽

E. W. Schubert ◽

E. Cantor-Graae ◽

M. Brossner ◽

P. Schubert ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Mental Disorders ◽

Genetic Risk ◽

Affective Disorders ◽

Early Life ◽

Unwanted Pregnancy ◽

Psychosocial Factor ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum

BackgroundThis study investigated whether ‘unwanted pregnancy’ (i.e. a negative or ambivalent attitude towards the pregnancy/reproduction) is associated with schizophrenia-spectrum and affective disorders in the offspring in adulthood, and if so, whether other pregnancy, perinatal, childhood or genetic-risk factors account for this association.MethodIn a prospective study beginning during pregnancy, unwanted pregnancy (in combination with other early life risk factors) was studied in relation to adult mental disorders in 75 genetic high-risk (HR) and 91 normal-risk (NR) offspring, defined through maternal psychosis history. Early life risk factors were studied through personal interviews, observations and medical records, and offspring mental disorders were independently diagnosed through follow-up examination at about 22 years of age.ResultsUnwanted pregnancy by itself was significantly related to adult offspring schizophrenia-spectrum disorders in both the total sample and the HR subgroup, but the effect was found to be limited to the HR group and occurred in interaction with genetic risk. Other co-temporaneous pregnancy stressors and later perinatal complications, malformations and early childhood environmental stressors could not explain this relationship. Unwanted pregnancy also interacted with genetic-risk status in relating to affective disorders in the offspring.ConclusionsUnwanted pregnancy, when occurring together with genetic risk for psychosis, was found to be related to both adult schizophrenia-spectrum and affective mental disorders in the offspring. Although the effect of unwanted pregnancy could be mediated by other yet-unidentified factors, unwanted pregnancy might be a functional, discrete environmental psychosocial factor with its own deleterious impact on offspring mental development, when co-occurring with genetic risk.

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Do risk factors for suicidal behavior differ by affective disorder polarity?

Psychological Medicine ◽

10.1017/s0033291708004078 ◽

2008 ◽

Vol 39 (5) ◽

pp. 763-771 ◽

Cited By ~ 25

Author(s):

J. G. Fiedorowicz ◽

A. C. Leon ◽

M. B. Keller ◽

D. A. Solomon ◽

J. P. Rice ◽

...

Keyword(s):

Risk Factors ◽

Substance Abuse ◽

Affective Disorder ◽

Suicidal Behavior ◽

Active Substance ◽

Affective Disorders ◽

Suicide Risk ◽

Suicide Attempts ◽

Age Of Onset ◽

Suicide Risk Factors

BackgroundSuicide is a leading cause of death and has been strongly associated with affective disorders. The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort.MethodParticipants with major affective disorders in the National Institute of Mental Health (NIMH) Collaborative Depression Study (CDS) were followed prospectively for up to 25 years. A total of 909 participants meeting prospective diagnostic criteria for major depressive and bipolar disorders were followed through 4204 mood cycles. Suicidal behavior was defined as suicide attempts or completions. Mixed-effects, grouped-time survival analysis assessed risk of suicidal behavior and differential effects of risk factors for suicidal behavior by polarity. In addition to polarity, the main effects of age, gender, hopelessness, married status, prior suicide attempts and active substance abuse were modeled, with mood cycle as the unit of analysis.ResultsAfter controlling for age of onset, there were no differences in prior suicide attempts by polarity although bipolar participants had more prior severe attempts. During follow-up, 40 cycles ended in suicide and 384 cycles contained at least one suicide attempt. Age, hopelessness and active substance abuse but not polarity predicted suicidal behavior. The effects of risk factors did not differ by polarity.ConclusionsBipolarity does not independently influence risk of suicidal behavior or alter the influence of well-established suicide risk factors within affective disorders. Suicide risk assessment strategies may continue to appraise these common risk factors without regard to mood polarity.

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Clustering of lifestyle risk factors among Algerian adolescents: Comparison between urban and rural area

10.29117/quarfe.2021.0140 ◽

2021 ◽

Author(s):

Fatima alzahra Hasan Yakti ◽

Hissa Al-Mannai ◽

Dana Saad ◽

Abdelhamid Kerkadi ◽

Grace Attieh ◽

...

Keyword(s):

Risk Factors ◽

Urban Area ◽

Rural Area ◽

Physical Inactivity ◽

Fruits And Vegetables ◽

Positive Association ◽

Negative Association ◽

Design Data ◽

Significant Positive Association ◽

Cross Sectional

Background: Lifestyle behavior risk factors (LBRs) such as sedentary behavior, physical inactivity, smoking, unhealthy eating patterns and being overweight/obese play a major role in the development or prevention of NCDs. Objective: Compare the clustering of LBRs between urban and rural Algerian adolescents. We expect differences in LBRs between urban and rural area. Design: Data of this cross-sectional study was derived from GSHS. Self-administered, anonymous questionnaire was filled out by 4532 adolescents (11–16 years), which addressed LBRs of NCDs. LBRs clustering was measured by the ratios of observed (O) and expected (E) prevalence of one or more simultaneously occurring LBRs for urban and rural area separately. Multivariate logistic regression was performed to examine the association of LBRs as dependent variable with demographic variables (location, age, gender). Results: The most common LBR was physical inactivity (84.6%: 50.9% for urban and 49.1% for rural). Adolescents in urban area had a higher prevalence of two (56.8% vs. 43.2%) and three and more (61.3 vs. 38.7%) LBRs than rural. In urban area, a significant positive association was found between: (low fruits and vegetables + physical inactivity) [2.06 (1.61-2.64)] and (high SB + smoking) [2.10 (1.54-2.76)], while (physical inactivity + high SB) [0.70 (0.54-0.91)] showed a significant negative association. In rural area, (high SB + overweight/obesity) [1.49 (1.09-2.04)] had a significant positive association. While, (low fruits and vegetables + high SB) [0.75 (0.60-0.94)], (physical inactivity + high SB) [0.65 (0.49-0.86)] and (physical inactivity + smoking) [0.70 (0.49-0.99)] had a negative association. Conclusions: Several socio-demographic factors have been identified to play a role in LBRs clustering among Algerian adolescents. Results of the study suggest the development of intervention aiming to tackle different LBRs rather than focusing on a single LBR.

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