Association of ABO Blood Type with Bleeding Severity in Patients with Acute Gastroesophageal Variceal Bleeding

Background and Objectives: ABO blood types have been implicated as potential risk factors for various hemorrhagic diseases. No study has investigated the association between gastroesophageal variceal bleeding and ABO blood types. We aimed to evaluate the impact of ABO blood types on mortality and bleeding risk in acute gastroesophageal variceal bleeding. Materials and Methods: This is a retrospective observational study. Patients presenting with acute gastroesophageal varices bleeding diagnosed by endoscopy were enrolled, and were divided by blood type into a type O group and non-type O group. The outcomes were death within 30 days and the proportion of further bleeding. We used generalized linear mixed-effects models to analyze the outcomes. Results: A total of 327 patients and 648 records of emergency room visits were included. The 30-day mortality was 14.8% (21 of 142 patients) in the type O group, and 16.2% (30 of 185 patients) in the non-type O group (p = 0.532). Further bleeding within 30 days occurred in 34 cases (12.6%) in the type O group, and in 26 cases (6.9%) in the non-type O group (p = 0.539). Conclusions: There was no significant difference in blood transfusion volume in 24 h, recurrent bleeding rates, or mortality between patients with blood type O and those with non-type O.

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Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study

Diagnostics ◽

10.3390/diagnostics10100826 ◽

2020 ◽

Vol 10 (10) ◽

pp. 826

Author(s):

Daisuke Hasegawa ◽

Kazuki Nishida ◽

Takahiro Kawaji ◽

Yoshitaka Hara ◽

Yasuyo Shimomura ◽

...

Keyword(s):

Septic Shock ◽

Observational Study ◽

Odds Ratio ◽

Multivariate Logistic Regression Analysis ◽

Blood Type ◽

Retrospective Observational Study ◽

Blood Types ◽

Potential Risk Factors ◽

Sepsis And Septic Shock ◽

The Impact

ABO blood groups have been implicated as potential risk factors for various diseases. However, no study has investigated the association between sepsis mortality and ABO blood types. We aimed to evaluate the impact of these blood types on mortality in patients with sepsis and septic shock. This retrospective observational study was conducted at two general hospitals in Japan. Patients diagnosed with sepsis or septic shock were included and divided into four groups based on blood type (O, A, B, and AB). The association between type O vs. other types and 28- and 90-day mortalities was evaluated using multivariate logistic regression analysis adjusted for age, sex, and Sequential (Sepsis-related) Organ Failure Assessment score. This study included 415 patients, of whom 131 (31.6%), 171 (41.2%), 81 (19.5%), and 32 (7.7%) had type O, A, B, and AB, respectively. Blood type O was not associated with 28-day (odds ratio: 1.7 p = 0.08) or 90-day mortality (odds ratio: 1.53, p = 0.091). However, type O was significantly associated with higher 90-day mortality (odds ratio: 3.26, p = 0.009) in patients with septic shock. The role of ABO blood type in risk stratification for septic shock and the mechanisms that potentially affect the prognosis of sepsis patients need further investigation.

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The Impact of Blood Type O on Major Outcomes in Patients With Severe Burns

Journal of Burn Care & Research ◽

10.1093/jbcr/iraa059 ◽

2020 ◽

Vol 41 (5) ◽

pp. 1111-1117 ◽

Cited By ~ 1

Author(s):

Renqi Yao ◽

Wenjia Hou ◽

Tuo Shen ◽

Shuo Zhao ◽

Xingfeng He ◽

...

Keyword(s):

Hospital Mortality ◽

Clinical Outcomes ◽

Poor Prognosis ◽

Kidney Injury ◽

Blood Type ◽

Blood Types ◽

Severe Burns ◽

Icu Length Of Stay ◽

Abo Blood Type ◽

The Impact

Abstract ABO blood type has been reported to be a predictor of poor prognosis in critically ill patients. Here, we aim to correlate different blood types with clinical outcomes in patients with severe burns. We conducted a single-center retrospective cohort study by enrolling patients with severe burn injuries (≥40% TBSA) between January 2012 and December 2017. Baseline characteristics and clinical outcomes were compared between disparate ABO blood types (type O vs non-O type). Multivariate logistic and linear regression analyses were performed to identify an association between ABO blood type and clinical outcomes, including in-hospital mortality, the development of acute kidney injury (AKI), and hospital or ICU length of stay. A total of 141 patients were finally enrolled in the current study. Mortality was significantly higher in patients with type O blood compared with those of other blood types. The development of AKI was significantly higher in patients with blood type O vs non-O blood type (P = .001). Multivariate analysis demonstrated that blood type O was independently associated with in-hospital mortality and AKI occurrence after adjusting for other potential confounders. Our findings indicated the blood type O was an independent risk factor of both increased mortality and the development of AKI postburn. More prudent and specific treatments are required in treating these patients to avoid poor prognosis.

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Association of ABO Blood Types and Clinicopathological Features of Prostate Cancer

Disease Markers ◽

10.1155/2017/9237481 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Fang-Ming Wang ◽

Yan Zhang ◽

Gui-Ming Zhang ◽

Ya-Nan Liu ◽

Li-Jiang Sun ◽

...

Keyword(s):

Prostate Cancer ◽

Regression Analysis ◽

High Risk ◽

Gleason Score ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

High Risk Group ◽

Blood Type ◽

Blood Types ◽

Significant Difference

Purpose. To investigate the association between ABO blood types and clinicopathological characteristics in patients with prostate cancer (PC). Methods. A total of 237 pathologically diagnosed PC patients were enrolled. All patients were classified as low–middle or high-risk group. The correlation of ABO blood types with high-risk PC was determined by univariate and multivariate regression analysis. Results. Data indicated 144 (85.7%) patients were stratified as high risk in the non-O group, while 50 (72.5%) patients in the O group (p=0.025). However, there was no significant difference regarding PSA, Gleason score, stage, or metastasis between O and non-O group (p>0.05). Univariate logistic regression analyses revealed PSA, Gleason score, and blood type non-O were all correlated with high-risk PC (OR = 1.139, p<0.001; OR = 9.465, p<0.001; OR = 2.280, p=0.018, resp.). In the stepwise multivariate regression analysis, the association between blood type non-O and high-risk PC remained significant (OR = 33.066, 95% CI 2.391–457.323, and p=0.009) after adjusting for confounding factors as well as PSA and Gleason score. Conclusion. The present study firstly demonstrated that non-O blood type was at higher risk of aggressive PC compared with O type, suggesting that PC patients with non-O blood type should receive more attention in clinical practice.

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Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

10.21203/rs.3.rs-34071/v1 ◽

2020 ◽

Author(s):

Yajun Liu ◽

Junzhi Sun ◽

Yun Xia ◽

Michael R. Lyaker ◽

Jianshe Yu

Keyword(s):

Blood Transfusion ◽

Digestive Tract ◽

Blood Group ◽

Radical Resection ◽

Foxp3 Expression ◽

Blood Type ◽

Foxp3 Mrna ◽

Blood Types ◽

Significant Difference ◽

Group A

Abstract Background Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3 + CD4 + CD25 + FOXP3 + T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes. The effect of blood transfusion on immune function in patients with different ABO blood types is variable. This study investigates the effect of intraoperative blood transfusion on the number of Tregs and the expression of FOXP3 in the blood of patients with different ABO blood types and digestive tract malignancies. Methods Patients with digestive tract malignancies who underwent radical resection and received intraoperative blood transfusion were divided into four groups according to their blood types:blood group A, B, O and AB (n=20 ). Blood was collected before surgery, immediately after transfusion, 1 day after transfusion, and 5 days after transfusion. The number of Tregs was measured by flow cytometry. The expression of FOXP3 was detected by real time reverse transcription polymerase chain reaction (RT-PCR). Results There was no significant difference in the number of Tregs or expression of FOXP3 mRNA among patients with different blood types before surgery. However, the number of Tregs and the expression of FOXP3 increased after blood transfusion in all blood type groups. This increase was especially evident and statistically significant on the first day after blood transfusion when compared with measures obtained before the surgery. Measures returned to the preoperative level five days after surgery. There were significant differences in the increase of Tregs and expression of FOXP3 among patients with different blood types. The greatest increase was seen in patients with blood group B and the least in blood group A. Conclusions Intraoperative blood transfusion can lead to an increase in blood Tregs and FOXP3 expression in patients with digestive tract malignancies. Increases were greatest on the first day after surgery and differed among patients with different blood types. Increases were greatest in blood type B and least in blood type A.

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TIPS vs. endoscopic treatment for prevention of recurrent variceal bleeding: a long-term follow-up of 126 patients

Radiology and Oncology ◽

10.2478/raon-2021-0006 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Spela Korsic ◽

Borut Stabuc ◽

Pavel Skok ◽

Peter Popovic

Keyword(s):

Variceal Bleeding ◽

Endoscopic Treatment ◽

Observation Time ◽

Recurrent Bleeding ◽

Gastroesophageal Varices ◽

Cumulative Survival ◽

Long Term Follow Up ◽

Life Threatening

Abstract Background Recurrent bleeding from gastroesophageal varices is the most common life-threatening complication of portal hypertension. According to guidelines, transjugular intrahepatic portosystemic shunt (TIPS) should not be used as a first-line treatment and should be limited to those bleedings which are refractory to pharmacologic and endoscopic treatment (ET). To our knowledge, long-term studies evaluating the role of elective TIPS in comparison to ET in patients with recurrent variceal bleeding episodes are rare. Patients and methods This study was designed as a retrospective single-institution analysis of 70 patients treated with TIPS and 56 with ET. Patients were followed-up from inclusion in the study until death, liver transplantation, the last follow-up observation or until the end of our study. Results Recurrent variceal bleeding was significantly more frequent in ET group compared to patients TIPS group (66.1% vs. 21.4%, p < 0.001; χ2-test). The incidence of death secondary to recurrent bleeding was higher in the ET group (28.6% vs. 10%). Cumulative survival after 1 year, 2 years and 5 years in TIPS group compared to ET group was 85% vs. 83%, 73% vs. 67% and 41% vs. 35%, respectively. The main cause of death in patients with cumulative survival more than 2 years was liver failure. Median observation time was 47 months (range; 2–194 months) in the TIPS group and 40 months (range; 1–168 months) in the ET group. Conclusions In present study TIPS was more effective in the prevention of recurrent variceal bleeding and had lower mortality due to recurrent variceal bleeding compared to ET.

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AB0 BLOOD TYPES AND MALIGNANT COLORECTAL NEOPLASMS OF DIFFERENT LOCATION: A RETROSPECTIVE ANALYSIS OF 1570 CASES

Annals of the Russian academy of medical sciences ◽

10.15690/vramn884 ◽

2017 ◽

Vol 72 (6) ◽

pp. 458-465

Author(s):

R. A. Kerimov ◽

B. D. Seksenbayev ◽

O. V. Galimov ◽

B. K. Nurmashev ◽

M. E. Znanteyev

Keyword(s):

Colorectal Cancer ◽

Logistic Regression ◽

Retrospective Analysis ◽

Odds Ratio ◽

Malignant Tumors ◽

Multinomial Logistic Regression ◽

Statistical Significance ◽

Blood Type ◽

Blood Types ◽

Significant Difference

Background: AB0 blood type antigens are unequally expressed in different portions of the colon resulting in so-called proximal-distal gradient. In most research studies considering the link between blood types and colorectal cancer, this gradient has not been taken into account. In the present context the findings of such studies are not convincing, no evidence-based results are reflected in literature. Valid studies of this association require antigenic distribution of the colon and malignant tumor location to be taken into account.Aim: To assess the possible relation between AB0 blood type antigens and malignant tumors located in different parts of the large intestine.Materials and methods: We performed a case-control study with retrospective analysis of medical records on patients with the presented disease (cases) and patients who did not suffer from it (controls). Required data was obtained from regional oncological centers of South Kazakhstan, Karaganda, East Kazakhstan, and Mangystau regions. Every third case of colorectal cancer registered in 2011−2016 years was included in the survey. The studied association was estimated by means of a chi-square test. A multinomial logistic regression was used to calculate the odds ratio (OR) with confounding risk factors to be taken into account. Shares of the samples were compared by means of Student’s t-test. A critical level of statistical significance (p-value) was considered to be 0.05.Results: Each group included 1570 patients. Gender, age, and ethnic distribution did not differ statistically in cases and controls (p0.4 for all comparisons). When blood type distributions were compared between groups regardless of tumor locations, any significant difference was not revealed (p=0.141). When similar calculations were applied to specific parts of the large intestine, the association between 0 blood type and malignancies of distal portions of the colon was demonstrated (p=0.0002). When we calculate the odds ratio for the disease development in the colon parts (using a multinomial logistic regression), the following results were obtained: 1.518 (p=0.004) for 0, 0.781 (p=0.099) for A, 0.785 (p=0.143) for B, and 0.965 (p=0.884) for AB blood types.Conclusions: The results of the present study revealed a statistical correlation between the 0 blood type and malignant tumors located in the distal portions of the colon.

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Asymptomatic Esophageal Varices Should Be Endoscopically Treated

Canadian Journal of Gastroenterology ◽

10.1155/1998/854293 ◽

1998 ◽

Vol 12 (5) ◽

pp. 347-350 ◽

Cited By ~ 1

Author(s):

Nib Soehendra

Keyword(s):

Esophageal Varices ◽

Variceal Bleeding ◽

Bleeding Risk ◽

Recurrent Bleeding ◽

Randomized Controlled ◽

Asymptomatic Patients ◽

Elective Treatment ◽

Prophylactic Sclerotherapy ◽

Endoscopic Methods

Endoscopic treatment has generally been accepted in the management of bleeding esophageal varices. Both the control of acute variceal bleeding and elective variceal eradication to prevent recurrent bleeding can be achieved via endoscopic methods. In contrast to acute and elective treatment, the role of endoscopic therapy in asymptomatic patients who have never had variceal bleeding remains controversial because of the rather disappointing results obtained from prophylactic sclerotherapy. Most published randomized controlled trials showed that prophylactic sclerotherapy had no effect on survival. In some studies, neither survival rate nor bleeding risk was improved. In this article, the author champions the view that asymptomatic esophageal varices should be endoscopically treated.

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Impact of Thrombocytopenia on Postoperative Bleeding Incidence in Patients Receiving Aspirin Following Coronary Artery Bypass Grafting

Journal of Pharmacy Practice ◽

10.1177/0897190020966193 ◽

2020 ◽

pp. 089719002096619

Author(s):

Anne M. Rodino ◽

James B. Henderson ◽

Kelsey F. Dobbins ◽

Deanna T. Rubin ◽

Ian B. Hollis

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass ◽

Major Bleeding ◽

Artery Bypass ◽

Bypass Graft ◽

Postoperative Bleeding ◽

Bleeding Risk ◽

Cabg Surgery ◽

Significant Difference ◽

The Impact

Background: Early postoperative aspirin following coronary artery bypass graft (CABG) surgery has been shown to maintain bypass graft patency, reduce mortality, and prevent adverse cardiovascular events. Despite this known benefit, aspirin may be delayed due to thrombocytopenia and perceived higher bleeding risk. The purpose of this study was to assess the impact of postoperative platelet count on bleeding in patients receiving aspirin after CABG. Methods: A retrospective analysis included all patients who underwent CABG surgery at our institution from April 2014 to June 2018 and received aspirin within 24 hours. The primary outcome was International Society on Thrombosis and Hemostasis (ISTH) major bleeding within 7 days (or up to discharge) following CABG surgery compared between patients with and without postoperative thrombocytopenia. Results: This study included 280 patients. Major bleeding occurred in 24.6% of the population, with no difference when stratified by the presence or absence of postoperative thrombocytopenia (27.3% versus 23.8%, p = 0.571). There was no significant difference in hemoglobin fall (13.6% versus 14%, p = 0.948), transfusion requirement (6.1% versus 4.2%, p = 0.531), or critical site bleeding (12.1% versus 7.9%, p = 0.298). Conclusion: In this single-center analysis of patients who received aspirin within 24 hours of CABG, postoperative thrombocytopenia was not associated with an increase in bleeding.

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Effect of intraoperative blood transfusion on Treg and FOXP3 in patients with digestive tract malignancies and different ABO blood types

BMC Anesthesiology ◽

10.1186/s12871-021-01330-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yajun Liu ◽

Junzhi Sun ◽

Yun Xia ◽

Michael R. Lyaker ◽

Jianshe Yu

Keyword(s):

Blood Transfusion ◽

Digestive Tract ◽

Blood Group ◽

Foxp3 Expression ◽

Blood Type ◽

Foxp3 Mrna ◽

Blood Types ◽

Significant Difference ◽

Group A ◽

Group B

Abstract Background Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3+CD4+CD25+FOXP3+ T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes. The effect of blood transfusion on immune function in patients with different ABO blood types is variable. This study investigates the effect of intraoperative blood transfusion on the number of Tregs and the expression of FOXP3 in the blood of patients with different ABO blood types and digestive tract malignancies. Methods Patients with digestive tract malignancies who underwent radical resection and received intraoperative blood transfusion were divided into four groups according to their blood types:blood group A, blood group B, blood group O and blood group AB (n = 20 for each group). Blood was collected from all patients before surgery, immediately after transfusion, 1 day after transfusion, and 5 days after transfusion. The number of Tregs was measured by flow cytometry. The expression of FOXP3 was detected by real time reverse transcription polymerase chain reaction (RT-PCR). Results There was no significant difference in the number of Tregs or expression of FOXP3 mRNA among patients with different blood types before surgery. However, the number of Tregs and the expression of FOXP3 increased after blood transfusion in all blood type groups. This increase was especially evident and statistically significant on the first day after blood transfusion when compared with measures obtained before the surgery. Measures returned to the preoperative level five days after surgery. There were significant differences in the increase of Tregs and expression of FOXP3 among patients with different blood types. The greatest increase was seen in patients with blood group B and the least in blood group A. Conclusions Intraoperative blood transfusion can lead to an increase in blood Tregs and FOXP3 expression in patients with digestive tract malignancies. Increases were greatest on the first day after surgery and differed among patients with different blood types. Increases were greatest in blood type B and least in blood type A.

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Geographic Distance From Transplant Center Does Not Impact Pediatric Heart Transplant Outcomes

Progress in Transplantation ◽

10.1177/1526924818765811 ◽

2018 ◽

Vol 28 (2) ◽

pp. 170-173

Author(s):

Meghann McKane ◽

Debra A. Dodd ◽

Bret A. Mettler ◽

Kari A. Wujcik ◽

Justin Godown

Keyword(s):

Heart Transplantation ◽

Heart Transplant ◽

Blood Type ◽

Transplant Recipients ◽

Transplant Outcomes ◽

Transplant Center ◽

Significant Difference ◽

Heart Transplant Recipients ◽

The Impact ◽

Pediatric Heart Transplant

Background: Many pediatric heart transplant recipients live a significant distance from their transplant center. This results in families either traveling long distances or relying on outside physicians to assume aspects of their care. Distance has been implicated to play a role in congenital heart disease outcomes, but its impact on heart transplantation has not been reported. The aim of this study was to assess the impact of distance on pediatric heart transplant outcomes. Methods: The Scientific Registry of Transplant Recipients database was queried for all pediatric heart transplant recipients from large US children’s hospitals (1987-2014). Patients were stratified into 4 groups (<20, 20-50, 50-100, and >100 miles) based on distance. Survival curves were generated and compared using the log-rank test. Cox proportional hazards regression was performed to adjust for differences between groups. Results: A total of 4768 patients were included in the analysis, of which 1435 (30.1%) were <20 miles, 940 (19.7%) were 20 to 50 miles, 806 (16.9%) were 50 to 100 miles, and 1587 (33.3%) were >100 miles from their transplant center. There was no difference in posttransplant survival based on distance after adjusting for patient age, gender, ethnicity, blood type, diagnosis, listing status, and the need for pretransplant ventricular assist device, extracorporeal membrane oxygenation, or ventilator support. Conclusion: There is no significant difference in graft survival after pediatric heart transplantation based on patient distance from their transplant center. Our data suggest the current strategy of transitioning some aspects of transplant care to local physicians or management from a distance does not increase posttransplant mortality risk.

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