scholarly journals AB0 BLOOD TYPES AND MALIGNANT COLORECTAL NEOPLASMS OF DIFFERENT LOCATION: A RETROSPECTIVE ANALYSIS OF 1570 CASES

2017 ◽  
Vol 72 (6) ◽  
pp. 458-465
Author(s):  
R. A. Kerimov ◽  
B. D. Seksenbayev ◽  
O. V. Galimov ◽  
B. K. Nurmashev ◽  
M. E. Znanteyev
Keyword(s):  
Colorectal Cancer ◽  
Logistic Regression ◽  
Retrospective Analysis ◽  
Odds Ratio ◽  
Malignant Tumors ◽  
Multinomial Logistic Regression ◽  
Statistical Significance ◽  
Blood Type ◽  
Blood Types ◽  
Significant Difference

Background: AB0 blood type antigens are unequally expressed in different portions of the colon resulting in so-called proximal-distal gradient. In most research studies considering the link between blood types and colorectal cancer, this gradient has not been taken into account. In the present context the findings of such studies are not convincing, no evidence-based results are reflected in literature. Valid studies of this association require antigenic distribution of the colon and malignant tumor location to be taken into account.Aim: To assess the possible relation between AB0 blood type antigens and malignant tumors located in different parts of the large intestine.Materials and methods: We performed a case-control study with retrospective analysis of medical records on patients with the presented disease (cases) and patients who did not suffer from it (controls). Required data was obtained from regional oncological centers of South Kazakhstan, Karaganda, East Kazakhstan, and Mangystau regions. Every third case of colorectal cancer registered in 2011−2016 years was included in the survey. The studied association was estimated by means of a chi-square test. A multinomial logistic regression was used to calculate the odds ratio (OR) with confounding risk factors to be taken into account. Shares of the samples were compared by means of Student’s t-test. A critical level of statistical significance (p-value) was considered to be 0.05.Results: Each group included 1570 patients. Gender, age, and ethnic distribution did not differ statistically in cases and controls (p0.4 for all comparisons). When blood type distributions were compared between groups regardless of tumor locations, any significant difference was not revealed (p=0.141). When similar calculations were applied to specific parts of the large intestine, the association between 0 blood type and malignancies of distal portions of the colon was demonstrated (p=0.0002). When we calculate the odds ratio for the disease development in the colon parts (using a multinomial logistic regression), the following results were obtained: 1.518 (p=0.004) for 0, 0.781 (p=0.099) for A, 0.785 (p=0.143) for B, and 0.965 (p=0.884) for AB blood types.Conclusions: The results of the present study revealed a statistical correlation between the 0 blood type and malignant tumors located in the distal portions of the colon.

scholarly journals The yield of colorectal cancer among fast track patients with normocytic and microcytic anaemia

2014 ◽  
Vol 96 (4) ◽  
pp. 289-293 ◽  
Author(s):  
IG Panagiotopoulou ◽  
D Fitzrol ◽  
RA Parker ◽  
J Kuzhively ◽  
N Luscombe ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Logistic Regression ◽  
Odds Ratio ◽  
Fast Track ◽  
Microcytic Anaemia ◽  
Exact Test ◽  
Fisher's Exact Test ◽  
Significant Difference ◽  
Fisher’S Exact Test ◽  
Normocytic Anaemia

Introduction We receive fast track referrals on the basis of iron deficiency anaemia (IDA) for patients with normocytic anaemia or for patients with no iron studies. This study examined the yield of colorectal cancer (CRC) among fast track patients to ascertain whether awaiting confirmation of IDA is necessary prior to performing bowel investigations. Methods A review was undertaken of 321 and 930 consecutive fast track referrals from Centre A and Centre B respectively. Contingency tables were analysed using Fisher’s exact test. Logistic regression analyses were performed to investigate significant predictors of CRC. Results Overall, 229 patients were included from Centre A and 689 from Centre B. The odds ratio for microcytic anaemia versus normocytic anaemia in the outcome of CRC was 1.3 (95% confidence interval [CI]: 0.5–3.9) for Centre A and 1.6 (95% CI: 0.8–3.3) for Centre B. In a logistic regression analysis (Centre B only), no significant difference in CRC rates was seen between microcytic and normocytic anaemia (adjusted odds ratio: 1.9, 95% CI: 0.9–3.9). There was no statistically significant difference in the yield of CRC between microcytic and normocytic anaemia (p=0.515, Fisher’s exact test) in patients with anaemia only and no colorectal symptoms. Finally, CRC cases were seen in both microcytic and normocytic groups with or without low ferritin. Conclusions There is no significant difference in the yield of CRC between fast track patients with microcytic and normocytic anaemia. This study provides insufficient evidence to support awaiting confirmation of IDA in fast track patients with normocytic anaemia prior to requesting bowel investigations.

Predictive value of ABO blood type with Carcinoembryonic antigen in a Nigerians population with preoperative Colorectal Cancer

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S90-S90
Author(s):  
C N Nwadike ◽  
J Nnodim ◽  
M K Anyagwa ◽  
U Edward ◽  
D K Ogbuokiri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Medical Center ◽  
Type A ◽  
Short Chain Fatty Acids ◽  
Blood Type ◽  
Blood Types ◽  
Significant Difference ◽  
Abo Blood Type ◽  
The Mean

Abstract Introduction/Objective Earlier studies speculated possible link between ABO blood type and risk of malignancies. Given recent increase in Colorectal cancer (CRC) cases in Nigeria amidst poor facilities for early diagnosis, unraveling measures for prevention and prognosis become critical options. This study aims at assessing the predictive association of ABO blood types with preoperative Carcinoembryonic antigen (CEA) levels and some markers of gut immunostasis among southern Nigerian population with CRC. Methods The retrospective study evaluated 200 patients, scheduled for resection surgery for CRC between July, 2018 and September 2019 in Federal medical center Yenegoa, Nigeria. The relationship between the ABO blood types and CEA, interleukins, IL(6 and 8,) and Short chain fatty acids, SCFA (butyrate and propionate) were evaluated preoperatively using immunoturbidimetric assay, ELISA, and GC-MS respectively. The mean age of the patients was 51 years. The distribution of the ABO blood types in the patients were 60 (30.1%) for A, 50 (25%) for B, 79 (39.5%) for O, and 11 (5.5%) for AB. Patients with CEA levels <5 ng/mL, 6-30 ng/mL, and >30 ng/mL were classified as CEA Group 1, group 2 and group 3 respectively. Patient’s blood types, demographic characteristics and tumor locations, were recorded. SPSS, 22 was employed for data analysis. Results We determined a significant correlation between CEA levels and IL 6 in different blood types of CRC patients. No significant correlation was observed between CEA and gender. Blood type A showed significant increase in mean levels of CEA and IL 6 when compared to blood type B and O. No significant difference was observed in the mean SCFA levels among different blood types. Conclusion ABO blood type demonstrated significant prognostic value with CEA in colorectal cancer, with blood type A being most unfavorable.

scholarly journals Orbitofrontal cortex volume prospectively predicts cannabis and other substance use onset in adolescents

2019 ◽  
Vol 33 (9) ◽  
pp. 1124-1131 ◽  
Author(s):  
Natasha E Wade ◽  
Kara S Bagot ◽  
Claudia I Cota ◽  
Aryandokht Fotros ◽  
Lindsay M Squeglia ◽  
...  
Keyword(s):  
Substance Use ◽  
Logistic Regression ◽  
Surface Area ◽  
Orbitofrontal Cortex ◽  
Odds Ratio ◽  
Multinomial Logistic Regression ◽  
Behavioral Approach ◽  
Cannabis User ◽  
Reward Responsiveness

Background: Identifying neural characteristics that predict cannabis initiation is important for prevention efforts. The orbitofrontal cortex is critical for reward response and may be vulnerable to substance-induced alterations. Aims: We measured orbitofrontal cortex thickness, surface area, and volume prior to the onset of use to predict cannabis involvement during an average nine-year follow-up. Methods: Adolescents ( n=118) aged 12–15 years completed baseline behavioral assessment and magnetic resonance imaging scans, then were followed up to 13 years with annual substance use interviews. Logistic regression examined baseline (pre-substance use) bilateral medial and lateral orbitofrontal cortex characteristics (volume, surface area, or cortex thickness) as predictors of regular cannabis use by follow-up. Post-hoc multinomial logistic regression assessed whether orbitofrontal cortex characteristics significantly predicted either alcohol use alone or cannabis+alcohol co-use. Brain-behavior relationships were assessed through follow-up correlations of baseline relationships between orbitofrontal cortex and executive functioning, reward responsiveness, and behavioral approach traits. Results: Larger left lateral orbitofrontal cortex volume predicted classification as cannabis user by follow-up ( p=0.025, odds ratio=1.808). Lateral orbitofrontal cortex volume also predicted cannabis+alcohol co-user status ( p=0.008, odds ratio=2.588), but not alcohol only status. Larger lateral orbitofrontal cortex volume positively correlated with greater baseline reward responsiveness ( p=0.030, r=0.348). There were no significant results by surface area or cortex thickness ( ps>0.05). Conclusions: Larger left lateral orbitofrontal cortex measured from ages 12–15 years and prior to initiation of substance use was related to greater reward responsiveness at baseline and predicted classification as a cannabis user and cannabis+alcohol co-user by final follow-up. Larger lateral orbitofrontal cortex volume may represent aberrant orbitofrontal cortex maturation and increasing vulnerability for later substance use.

Clinical Factors Associated with the Diagnosis of Granulomatosis with Polyangiitis

2017 ◽  
Vol 156 (3) ◽  
pp. 484-488 ◽  
Author(s):  
Erdem Eren ◽  
Toygar Kalkan ◽  
Seçil Arslanoğlu ◽  
Mustafa Özmen ◽  
Kazım Önal ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Nasal Mucosa ◽  
Odds Ratio ◽  
Granulomatosis With Polyangiitis ◽  
Univariate Analysis ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Significant Difference ◽  
History Of

Objective To determine the predictive value of nasal endoscopic findings and symptoms in the diagnosis of granulomatosis with polyangiitis (GPA). Study Design A cross-sectional study. Setting A tertiary university hospital. Subjects and Methods A total of 116 adults were enrolled in the study: 19 patients with GPA, 29 patients with other rheumatic diseases, and 68 healthy volunteers. All patients were examined with a flexible endoscope, and nasal endoscopic images were recorded and evaluated blindly. The medical history of each patient was taken by a physician blinded to the patient’s diagnosis. Results Univariate analysis indicated a statistically significant difference in rhinorrhea ( P = .002), postnasal drip ( P = .015), epistaxis ( P < .001), and saddle nose ( P = .017). However, binary logistic regression analysis demonstrated that only history of epistaxis ( P = .012; odds ratio, 5.6) was statistically significant in predicting GPA. Univariate analysis showed a statistically significant difference in nasal secretion ( P = .028), nasal septal perforation ( P < .017), nasal crusting ( P < .001), nasal adhesion ( P < .001), nasal granuloma ( P = .017), and hemorrhagic fragile nasal mucosa ( P < .001). A binary logistic regression analysis demonstrated that only hemorrhagic fragile nasal mucosa ( P < .001; odds ratio, 52.9) was a statistically significant predictor of GPA. Conclusions Given the results of this study, we believe that hemorrhagic fragile nasal mucosa and history of recurrent epistaxis may put patients at risk for GPA and should be investigated accordingly.

scholarly journals Identifying metastasis-initiating miRNA-target regulations of colorectal cancer from expressional changes in primary tumors

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jongmin Lee ◽  
Hye Kyung Hong ◽  
Sheng-Bin Peng ◽  
Tae Won Kim ◽  
Woo Yong Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Progression ◽  
Cancer Biology ◽  
Mirna Target ◽  
Target Genes ◽  
Expression Profiles ◽  
Statistical Significance ◽  
Primary Tumors ◽  
Significant Difference

Abstract Colorectal cancer (CRC) is prevalent with high mortality, with liver metastasis contributing as a major factor that worsens the survival of patients. The roles of miRNAs in CRC have been elucidated, subsequent to recent studies that suggest the involvement of miRNAs in cancer biology. In this study, we compare the miRNA and gene expression profiles of primary tumors between two groups of patients (with and without liver metastasis) to identify the metastasis-initiating microRNA-target gene regulations. Analysis from 33 patients with metastasis and 14 patients without metastasis revealed that 17 miRNAs and their 198 predicted target genes are differentially expressed, where the target genes showed association with cancer progression and metastasis with statistical significance. In order to evaluate the clinical implications of the findings, we classified CRC patients of independent data into two groups based on the identified miRNA-target regulations, where one group was closer to primary tumors with metastasis than the other group. The comparison of survival showed statistically significant difference, thereby implying the roles of the identified miRNA-target regulations in cancer progression and metastasis. The identification of metastasis-initiating miRNA-target regulations in this study will lead to better understanding of the roles of miRNAs in CRC progression.

Carcinoembryonic antigen and matrix metalloproteinase 2 serum and peritoneal washes concentration in staging and prognosis in colorectal cancer patients

2018 ◽  
Vol 90 (5) ◽  
pp. 36-43
Author(s):  
Tomasz Guzel ◽  
Dagmara Mirowska-Guzel ◽  
Gustaw Lech ◽  
Marek Wroński ◽  
Marzena Iwanowska ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Matrix Metalloproteinase ◽  
Tumor Staging ◽  
Statistical Significance ◽  
Matrix Metalloproteinase 2 ◽  
Curative Surgery ◽  
P Concentration ◽  
Preoperative Serum ◽  
Significant Difference

Abstract Purpose: The aim of the study was to determine of carcinoembryonal antigen and matrix metalloproteinase 2 peritoneal washes and serum concentration in patients suffering from colorectal cancer concerning tumor staging and 5-year survival rate in these patients. Methods: 80 patients who underwent curative surgery for colorectal cancer were included into the study. Preoperative serum and intraoperative peritoneal washes CEA and MMP-2 concentrations were measured. Results: Concerning tumor penetration CEA-s and CEA-p concentration was higher in subsequent stages from T2 to T4. Both CEA-s and CEA-p concentration was lower in T2 comparing to T3 and T4. Significant difference of CEA-s and CEA-p was noted between T2 and T4 stages. MMP2-s concentration was higher in T3 comparing to T2, the highest MMP2-p concentration was in T4, with no statistical significance. Concerning nodular status significant difference of CEA-s was noted between N0 and N1. For CEA-p significance was found between N0 and N2 as between N1 and N2. MMP2-s concentration was the highest in N1, MMP2-p concentration was the highest in T4, with no statistical significance. 5-year survival rate for all patients was 63,53%. There were significant differences in CEA-s and CEA-p concentration between patients with negative and positive 5-year survival. Conclusion: Intraoperative peritoneal washes concentration of CEA may potentially serve as an important factor for more precise colorectal cancer staging. CEA-p and CEA-s concentration correlates with survival rate in patients suffering from colorectal cancer and can be useful as an additional prognostic factor. Usefulness of MMP2 measurement still requires further studies.

Mean Platelet Volume as a Risk Factor for Deep Vein Thrombosis In An Ethnically Diverse Population

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4211-4211
Author(s):  
Sarah A Bennett ◽  
Lara N Roberts ◽  
Rosie Rogers ◽  
Lynda Bonner ◽  
Raj K Patel ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Risk Factor ◽  
Platelet Count ◽  
Relative Risk ◽  
Mean Platelet Volume ◽  
Odds Ratio ◽  
Smoking Status ◽  
Ethnically Diverse ◽  
Platelet Volume ◽  
Significant Difference

Abstract Abstract 4211 Platelet size is thought to reflect reactivity; Mean platelet volume (MPV) was recently reported as a possible predictor for VTE, but it is not clear whether ethnic origin impacts on this risk factor. King's serves an ethnically diverse community and to assess whether MPV is a predictor of VTE in our population, we conducted a retrospective analysis of consecutive patients referred to our DVT service between January 2007 and October 2009. Patients with a confirmed first lower limb DVT (provoked n=153, unprovoked n=110) were included as subjects and controls (n=151) were derived from consecutive patients referred with objective exclusion of a DVT and no previous history of VTE, active cancer or surgery in the previous 6 weeks. All patients had a full blood count at presentation analysed on an automated analyser (using optical light scatter for MPV) within 4 hours of collection. There was no difference in mean age (54.7 vs 54.8), smoking status or ethnic group (51% vs 52.3% white, 38.4% vs 33.8% black and 10.6% vs 13.9% other) between subjects and controls respectively. Males accounted for 47.5% of subjects and 27.2% of controls. DVTs were unprovoked in 41.8% with 13.7% associated with surgery, 7.6% cancer, 10.6% pregnancy or hormone therapy. The remainder (25.1%) were secondary to cast, trauma, immobilisation or travel. Mean MPV was significantly higher in subjects than controls (8.17 vs 7.79, p=0.001) with a more marked difference in those with unprovoked DVT compared with controls (8.28 vs 7.79, p<0.001). The platelet count was lower in the DVT group (median, range 270, 21–812 vs 293, 31–642 p=0.027), with a more marked difference in those with unprovoked DVT (median, range 250, 21–584 vs 293, 31–642 p<0.001). Relative risk associated with MPV > 9.18 (90th centile) was 1.26 (95% CI 1.08– 4.76, p=0.01) and increased to 1.59 (1.18-2.1, p=0.008) in those with unprovoked DVT. Relative risk associated with platelet count <210 (10th centile) was 1.21 (1.02-1.43, p=0.06) and increased with unprovoked DVT to 1.70 (1.3-2.2, p=0.002). An inverse correlation between MPV and platelet count was confirmed (-0.305, p<0.001). Logistic regression was undertaken to investigate effect of MPV, platelet count, age and smoking status. MPV was the only significant risk factor for DVT with odds ratio 1.39 (1.14-1.68). For unprovoked DVT, both MPV and platelet count contributed to risk with odds ratio of 1.36 (1.06-1.74, p=0.015) and 0.997 (0.994-1.0, p=0.037) respectively. Further analysis was undertaken to compare MPV in white (provoked 84, unprovoked 50, controls 79) and black (provoked 55, unprovoked 46, controls 51) subgroups. There was no difference in mean age between white and black subjects or controls. Interestingly, in the black subgroup 73.9% of males had an unprovoked DVT compared with 26.1% of females. This gender difference was not seen in the white subgroup (unprovoked 37.9% males, 36.8% females) and was not explained by the presence of pregnancy or hormone use (18 vs 18.4% black vs white females). There was no significant difference in MPV or platelet count between white and black subjects or white and black controls. There remained a significant difference between white subjects and white controls mean MPV (8.1 vs 7.7, p=0.014) accentuated in the unprovoked subgroup (8.3 vs7.7, P=0.007); median platelet count was only significantly lower for unprovoked DVT compared to controls (251.5, 21–509 vs 285, 31–687, p=0.02). MPV was also significantly higher in black subjects compared to controls (8.3 vs 7.8, p=0.011), and platelet count was significantly lower (256, 129–811 vs 293, 138–642 p=0.032). MPV was no different between unprovoked DVTs and controls, however the effect of platelet count was accentuated (244.5, 167–584 vs 293, 138–642 p<.001). Logistic regression confirmed male gender as the only predictive factor for unprovoked VTE in the black subgroup (OR 5.8, 95% CI 2.36–14, p<0.001); neither MPV nor platelet count contributed to DVT risk. Limitations include the retrospective nature of the study, number of subjects, unavailable body mass indices and the discrepant gender distribution between controls and subjects. In summary, MPV is a risk factor for DVT in both white and black populations, though this link appears to hold true for unprovoked DVT in white populations only. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Association of ABO Blood Types and Clinicopathological Features of Prostate Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Fang-Ming Wang ◽  
Yan Zhang ◽  
Gui-Ming Zhang ◽  
Ya-Nan Liu ◽  
Li-Jiang Sun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Regression Analysis ◽  
High Risk ◽  
Gleason Score ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
High Risk Group ◽  
Blood Type ◽  
Blood Types ◽  
Significant Difference

Purpose. To investigate the association between ABO blood types and clinicopathological characteristics in patients with prostate cancer (PC). Methods. A total of 237 pathologically diagnosed PC patients were enrolled. All patients were classified as low–middle or high-risk group. The correlation of ABO blood types with high-risk PC was determined by univariate and multivariate regression analysis. Results. Data indicated 144 (85.7%) patients were stratified as high risk in the non-O group, while 50 (72.5%) patients in the O group (p=0.025). However, there was no significant difference regarding PSA, Gleason score, stage, or metastasis between O and non-O group (p>0.05). Univariate logistic regression analyses revealed PSA, Gleason score, and blood type non-O were all correlated with high-risk PC (OR = 1.139, p<0.001; OR = 9.465, p<0.001; OR = 2.280, p=0.018, resp.). In the stepwise multivariate regression analysis, the association between blood type non-O and high-risk PC remained significant (OR = 33.066, 95% CI 2.391–457.323, and p=0.009) after adjusting for confounding factors as well as PSA and Gleason score. Conclusion. The present study firstly demonstrated that non-O blood type was at higher risk of aggressive PC compared with O type, suggesting that PC patients with non-O blood type should receive more attention in clinical practice.

scholarly journals Effect of Intraoperative Blood Transfusion On Treg And Foxp3 In Patients With Digestive Tract Malignancies And Different Abo Blood Types

2020 ◽  
Author(s):  
Yajun Liu ◽  
Junzhi Sun ◽  
Yun Xia ◽  
Michael R. Lyaker ◽  
Jianshe Yu
Keyword(s):  
Blood Transfusion ◽  
Digestive Tract ◽  
Blood Group ◽  
Radical Resection ◽  
Foxp3 Expression ◽  
Blood Type ◽  
Foxp3 Mrna ◽  
Blood Types ◽  
Significant Difference ◽  
Group A

Abstract Background Blood transfusion can cause immunosuppression and lead to worse outcomes in patients with digestive tract malignancies; however, the specific mechanism behind this is not completely understood. One theory is that increased numbers of regulatory CD3 + CD4 + CD25 + FOXP3 + T cells (Tregs) and forkhead box protein-3 mRNA (FOXP3) expression in the blood after transfusion contribute to these outcomes. The effect of blood transfusion on immune function in patients with different ABO blood types is variable. This study investigates the effect of intraoperative blood transfusion on the number of Tregs and the expression of FOXP3 in the blood of patients with different ABO blood types and digestive tract malignancies. Methods Patients with digestive tract malignancies who underwent radical resection and received intraoperative blood transfusion were divided into four groups according to their blood types:blood group A, B, O and AB (n=20 ). Blood was collected before surgery, immediately after transfusion, 1 day after transfusion, and 5 days after transfusion. The number of Tregs was measured by flow cytometry. The expression of FOXP3 was detected by real time reverse transcription polymerase chain reaction (RT-PCR). Results There was no significant difference in the number of Tregs or expression of FOXP3 mRNA among patients with different blood types before surgery. However, the number of Tregs and the expression of FOXP3 increased after blood transfusion in all blood type groups. This increase was especially evident and statistically significant on the first day after blood transfusion when compared with measures obtained before the surgery. Measures returned to the preoperative level five days after surgery. There were significant differences in the increase of Tregs and expression of FOXP3 among patients with different blood types. The greatest increase was seen in patients with blood group B and the least in blood group A. Conclusions Intraoperative blood transfusion can lead to an increase in blood Tregs and FOXP3 expression in patients with digestive tract malignancies. Increases were greatest on the first day after surgery and differed among patients with different blood types. Increases were greatest in blood type B and least in blood type A.

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