scholarly journals Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

Metabolites ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 37 ◽  
Author(s):  
Mohamed A. Salem ◽  
Leonardo Perez de Souza ◽  
Ahmed Serag ◽  
Alisdair R. Fernie ◽  
Mohamed A. Farag ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Sample Preparation ◽  
Plant Sample ◽  
Lead Compounds ◽  
Natural Extracts ◽  
Plant Natural Products ◽  
Single Compound ◽  
Indispensable Tool ◽  
Complex Chemistry

Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be represented by synergism between several metabolites. However, isolating every single compound from a natural extract is not always possible due to the complex chemistry and presence of most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug research. Analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) are used to comprehensively annotate the constituents of plant natural products for screening, drug discovery as well as for quality control purposes such as those required for phytomedicine. In this review, the current advancements in plant sample preparation, sample measurements, and data analysis are presented alongside a few case studies of the successful applications of these processes in plant natural product drug discovery.

scholarly journals UsingDrosophilaas a platform for drug discovery from natural products in Parkinson's disease

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 867-879 ◽  
Author(s):  
Urmila Maitra ◽  
Lukasz Ciesla
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural Products ◽  
Drug Discovery ◽  
Therapeutic Potential ◽  
Natural Extracts ◽  
New Drug ◽  
Screening Platform ◽  
Drug Leads

The review provides an overview of discovery of new drug leads from natural extracts usingDrosophilaas a screening platform to evaluate the therapeutic potential of phytochemicals against Parkinson's disease.

scholarly journals Natural products as lead compounds in drug discovery

2013 ◽  
Vol 15 (7) ◽  
pp. 764-788 ◽  
Author(s):  
Jabeena Khazir ◽  
Bilal Ahmad Mir ◽  
Shabir Ahmad Mir ◽  
Don Cowan
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Lead Compounds

scholarly journals Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2

2021 ◽  
Author(s):  
Oyere Tanyi Ebob ◽  
Smith B. Babiaka ◽  
Fidele Ntie-Kang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Infectious Diseases ◽  
Review Article ◽  
Literature Survey ◽  
Lead Compounds ◽  
The Past ◽  
The World ◽  
Bacteria And Fungi ◽  
New Vaccines

AbstractFor the past 2 years, the coronavirus responsible for the COVID-19 infection has become a world pandemic, ruining the lives and economies of several nations in the world. This has scaled up research on the virus and the resulting infection with the goal of developing new vaccines and therapies. Natural products are known to be a rich source of lead compounds for drug discovery, including against infectious diseases caused by microbes (viruses, bacteria and fungi). In this review article, we conducted a literature survey aimed at identifying natural products with inhibitory concentrations against the coronaviruses or their target proteins, which lie below 10 µM. This led to the identification of 42 compounds belonging to the alkaloid, flavonoid, terpenoid, phenolic, xanthone and saponin classes. The cut off concentration of 10 µM was to limit the study to the most potent chemical entities, which could be developed into therapies against the viral infection to make a contribution towards limiting the spread of the disease.

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

2020 ◽  
Author(s):  
Gina Porras ◽  
François Chassagne ◽  
James T. Lyles ◽  
Lewis Marquez ◽  
Micah Dettweiler ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Plant Natural Products ◽  
Antibiotic Drug

A stereolibrary of conformationally restricted amino acids based on pyrrolidinyl/piperidinyloxazole motifs

2015 ◽  
Vol 21 (6) ◽  
pp. 391-395 ◽  
Author(s):  
Oleksiy S. Artamonov ◽  
Taras Bulda ◽  
Tkhe Kyong Fam ◽  
Evgeniy Y. Slobodyanyuk ◽  
Dmitry M. Volochnyuk ◽  
...  
Keyword(s):  
Amino Acids ◽  
Natural Products ◽  
Drug Discovery ◽  
Carboxylic Acids ◽  
Building Blocks ◽  
Conformationally Restricted ◽  
Lead Compounds ◽  
Restricted Amino Acids

AbstractA stereolibrary of conformationally restricted oxazole-containing amino acids, namely all isomers of 5–pyrrolydinyl- and 5-piperidinyloxazole-4-carboxylic acids, were designed and synthesized in three steps by the reaction of the corresponding N-Boc-protected amino acids and ethyl isocyanoacetate. These natural products-inspired amino acids are valuable building blocks for the synthesis of peptidomimetics and potential lead compounds for drug discovery.

Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

2020 ◽  
Vol 20 ◽  
Author(s):  
Yongzhen Guo ◽  
Xuben Hou ◽  
Hao Fang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Anticancer Agents ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Great Influence ◽  
Parasitic Infections ◽  
Peptic Ulcers ◽  
Lead Compounds ◽  
Privileged Scaffold

: Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal chemistry. Many marketed drugs and natural products containing benzimidazole scaffolds exert great influence in fighting various diseases, such as hypertension, peptic ulcers, parasitic infections, and cancer. In this review, we introduce the pharmacological applications of some marketed drugs and lead compounds with a focus on anticancer agents, reporting the corresponding data to show the biological activities at their targets. The publications in this review encompass those from 2014 to 2019.

Sign in / Sign up

Export Citation Format

Share Document