scholarly journals Characterization and Evaluation of 3D-Printed Connectors for Microfluidics

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 874
Author(s):  
Qianwen Xu ◽  
Jeffery C. C. Lo ◽  
Shiwei Ricky Lee
Keyword(s):  
Normal Pressure ◽  
Process Window ◽  
Microfluidic Chips ◽  
Channel Diameter ◽  
Flow Paths ◽  
Outer Flow ◽  
Flow Rates ◽  
Time Consumption ◽  
3D Printed ◽  
Inner Channel

3D printing is regarded as a useful tool for the fabrication of microfluidic connectors to overcome the challenges of time consumption, clogging, poor alignment and bulky fixtures existing for current interconnections. 3D-printed connectors without any additional components can be directly printed to substrate with an orifice by UV-assisted coaxial printing. This paper further characterized and evaluated 3D-printed connectors fabricated by the proposed method. A process window with an operable combination of flow rates was identified. The outer flow rate could control the inner channel dimensions of 3D-printed connectors, which were expected to achieve less geometric mismatch of flow paths in microfluidic interfaces. The achieved smallest inner channel diameter was around 120 µm. Furthermore, the withstood pressure of 3D-printed connectors was evaluated to exceed 450 kPa, which could enable microfluidic chips to work at normal pressure.

scholarly journals Preparation of emulsion for nutrient delivery using 3D printed microfluidic chips

2021 ◽  
Vol 10 (2) ◽  
pp. 490-494
Author(s):  
C Drishya ◽  
M Maria Leena ◽  
JA Moses ◽  
C Anandharamakrishnan
Keyword(s):  
Microfluidic Chips ◽  
Nutrient Delivery ◽  
3D Printed

Simulation and practice of particle inertial focusing in 3D-printed serpentine microfluidic chips via commercial 3D-printers

Soft Matter ◽  
2020 ◽  
Vol 16 (12) ◽  
pp. 3096-3105
Author(s):  
Pengju Yin ◽  
Lei Zhao ◽  
Zezhou Chen ◽  
Zhiqiang Jiao ◽  
Hongyan Shi ◽  
...  
Keyword(s):  
Microfluidic Chips ◽  
Inertial Focusing ◽  
Particle Focusing ◽  
3D Printers ◽  
3D Printed

Inertial microfluidic chips were fabricated using commercial 3D-printers and the particle focusing was implemented in channels.

scholarly journals Typography-Like 3D-Printed Templates for the Lithography-Free Fabrication of Microfluidic Chips

2019 ◽  
Vol 25 (1) ◽  
pp. 82-87
Author(s):  
Wenqiong Su ◽  
Yulong Li ◽  
Lulu Zhang ◽  
Jiahui Sun ◽  
Shuopeng Liu ◽  
...  
Keyword(s):  
Processing Time ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Cost Effective ◽  
Microfluidic Channels ◽  
3D Printer ◽  
Microfluidic Chips ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

Typography-like templates for polydimethylsiloxane (PDMS) microfluidic chips using a fused deposition modeling (FDM) three-dimensional (3D) printer are presented. This rapid and fast proposed scheme did not require complicated photolithographic fabrication facilities and could deliver resolutions of ~100 μm. Polylactic acid (PLA) was adopted as the material to generate the 3D-printed units, which were then carefully assembled on a glass substrate using a heat-melt-curd strategy. This craft of bonding offers a cost-effective way to design and modify the templates of microfluidic channels, thus reducing the processing time of microfluidic chips. Finally, a flexible microfluidic chip to be employed for cell-based drug screening was developed based on the modularized 3D-printed templates. The lithography-free, typography-like, 3D-printed templates create a modularized fabrication process and promote the prevalence of integrated microfluidic systems with minimal requirements and improved efficiency.

scholarly journals Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Lab on a Chip ◽  
2017 ◽  
Vol 17 (16) ◽  
pp. 2785-2792 ◽  
Author(s):  
Pedro F. Costa ◽  
Hugo J. Albers ◽  
John E. A. Linssen ◽  
Heleen H. T. Middelkamp ◽  
Linda van der Hout ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Computed Tomography Angiography ◽  
Arterial Thrombosis ◽  
Blood Clotting ◽  
Microfluidic Chips ◽  
Vascular Model ◽  
Model Based ◽  
3D Printed ◽  
Vascular Structures

Studying blood clotting in stereolithography 3D-printed microfluidic chips with endothelialised vascular structures.

Direct, one-step molding of 3D-printed structures for convenient fabrication of truly 3D PDMS microfluidic chips

2015 ◽  
Vol 19 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Ho Nam Chan ◽  
Yangfan Chen ◽  
Yiwei Shu ◽  
Yin Chen ◽  
Qian Tian ◽  
...  
Keyword(s):  
Microfluidic Chips ◽  
One Step ◽  
3D Printed

scholarly journals Portable all-in-one automated microfluidic system (PAMICON) with 3D-printed chip using novel fluid control mechanism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yushen Zhang ◽  
Tsun-Ming Tseng ◽  
Ulf Schlichtmann
Keyword(s):  
Active Control ◽  
Microfluidic Chip ◽  
Control Mechanism ◽  
State Of The Art ◽  
Low Cost ◽  
Microfluidic System ◽  
Microfluidic Chips ◽  
Microfluidic Systems ◽  
3D Printed ◽  
Pdms Chip

AbstractState-of-the-art microfluidic systems rely on relatively expensive and bulky off-chip infrastructures. The core of a system—the microfluidic chip—requires a clean room and dedicated skills to be fabricated. Thus, state-of-the-art microfluidic systems are barely accessible, especially for the do-it-yourself (DIY) community or enthusiasts. Recent emerging technology—3D-printing—has shown promise to fabricate microfluidic chips more simply, but the resulting chip is mainly hardened and single-layered and can hardly replace the state-of-the-art Polydimethylsiloxane (PDMS) chip. There exists no convenient fluidic control mechanism yet suitable for the hardened single-layered chip, and particularly, the hardened single-layered chip cannot replicate the pneumatic valve—an essential actuator for automatically controlled microfluidics. Instead, 3D-printable non-pneumatic or manually actuated valve designs are reported, but their application is limited. Here, we present a low-cost accessible all-in-one portable microfluidic system, which uses an easy-to-print single-layered 3D-printed microfluidic chip along with a novel active control mechanism for fluids to enable more applications. This active control mechanism is based on air or gas interception and can, e.g., block, direct, and transport fluid. As a demonstration, we show the system can automatically control the fluid in microfluidic chips, which we designed and printed with a consumer-grade 3D-printer. The system is comparably compact and can automatically perform user-programmed experiments. All operations can be done directly on the system with no additional host device required. This work could support the spread of low budget accessible microfluidic systems as portable, usable on-the-go devices and increase the application field of 3D-printed microfluidic devices.

scholarly journals Light-based 3D printing of functional polydimethylsiloxane- based microfluidic chips

2021 ◽  
Vol 4 (s1) ◽  
Author(s):  
Gustavo A. Gonzalez ◽  
Annalisa Chiappone ◽  
Kurt Dietliker ◽  
Pirri C. Fabrizio ◽  
Ignazio Roppolo
Keyword(s):  
3D Printing ◽  
Microfluidic Chips ◽  
Digital Light Processing ◽  
3D Printed

The objective of the work is to fabricate and functionalize 3D printed PDMS-based microfluidic chips through digital light processing DLP-3D printing.

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