scholarly journals Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5679
Author(s):  
Qing-Wei Tan ◽  
Jian-Cheng Ni ◽  
Jian-Ting Shi ◽  
Jian-Xuan Zhu ◽  
Qi-Jian Chen
Keyword(s):  
Data Analysis ◽  
Herbal Medicine ◽  
Inhibitory Concentration ◽  
Biological Activities ◽  
Virus Multiplication ◽  
Ailanthus Altissima ◽  
Inhibitory Effects ◽  
Traditional Herbal Medicine ◽  
Virus Activity ◽  
Ic50 Values

Phytochemistry investigations on Ailanthus altissima (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C20 quassinoid is the most attractive for their significant and diverse pharmacological and biological activities. Our continuous study has led to the isolation of two novel quassinoid glycosides, named chuglycosides J and K, together with fourteen known lignans from the samara of A. altissima. The new structures were elucidated based on comprehensive spectra data analysis. All of the compounds were evaluated for their anti-tobacco mosaic virus activity, among which chuglycosides J and K exhibited inhibitory effects against the virus multiplication with half maximal inhibitory concentration (IC50) values of 56.21 ± 1.86 and 137.74 ± 3.57 μM, respectively.

scholarly journals PRODUKTIVITAS JAMU PADA MASYARAKAT ARGOMULYO DI MASA PANDEMI

2020 ◽  
Vol 17 (2) ◽  
pp. 60-69
Author(s):  
Nenden Susilowati
Keyword(s):  
Regression Analysis ◽  
Data Analysis ◽  
Herbal Medicine ◽  
Field Research ◽  
Sampling Technique ◽  
Research Data ◽  
Primary Data ◽  
Traditional Herbal Medicine ◽  
Purposive Sampling ◽  
The People

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh motivasi, disiplin dan pengalaman terhadap produktivitas jamu pada masyarakat Argomulyo di tengah pandemi. Penelitian ini berjenis eksplanatif. Populasi dari penelitian adalah masyarakat di Kelurahan Argomulyo. Sampel sejumlah 35 pedagang jamu tradisional dengan pengambilan sampel melalui teknik purposive sampling. Data yang digunakan adalah data primer dihasilkan dari penelitian lapangan. Data dikumpulkan lewat angket dan proses pengamatan. Analisis data menggunakan analisis regresi berganda. Hasil penelitian adalah sebagai berikut. Pertama, motivasi memberikan pengaruh yang signifikan terhadap produktivitas. Kedua, displin memberikan pengaruh yang signifikan terhadap produktivitas. Ketiga, pengalaman memberikan pengaruh signifikan terhadap produktivitas.  Abstract: This study aims to determine the effect of motivation, the discipline and experience on the productivity of herbal medicine in the Argomulyo community during a pandemic. This research is of an explanative type. The population of this research is the people in Argomulyo Village. The sample was 35 traditional herbal medicine traders with a purposive sampling technique. The data used are primary data generated from field research. Data were collected through questionnaires and observation processes. Data analysis using multiple regression analysis. The results of the study are as follows. First, motivation has a significant effect on productivity. Second, the discipline has a significant effect on productivity. The three, experiences have a significant influence on productivity. 

scholarly journals Antibacterial and Toxicity Activities of Indonesian Herbal Medicine Extracts Used for Postpartum Treatment

2021 ◽  
Vol 28 (3) ◽  
pp. 232
Author(s):  
Wiwit Denny Fitriana ◽  
Sri Banun Titi Istiqomah ◽  
Devi Anggraini Putri ◽  
Taslim Ersam ◽  
Adi Setyo Purnomo Purnomo ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Staphylococcus Epidermidis ◽  
Pathogenic Bacteria ◽  
Scientific Evidence ◽  
Rhodopseudomonas Palustris ◽  
Positive Control ◽  
Traditional Herbal Medicine ◽  
Ic50 Values ◽  
Ld50 Value

Postpartum treatments have been used by local women in Indonesia for some time now. One commonly used postpartum treatment is the consumption of a traditional herbal medicine called PHM-1 during the first 40 days after childbirth. In addition, a second medicine known as PHM-2 is taken for days 41-80. However, sufficient scientific evidence about the benefits of this postpartum herbal medicine does not exist. In this study, the antibacterial abilities of PHM-1 and PHM-2 therefore was evaluated and showed positive potential for both. Low IC50 values were obtained against pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Rhodopseudomonas palustris, Ralstonia pickettii, and Staphylococcus epidermidis and compared with chloramphenicol as a positive control. The antibacterial activity of both PHM-1 and PHM-2 against R. pickettii had the highest inhibitory activity as evidenced by the lowest IC50 values of 11.16 and 6.26 μg/ml, respectively. Furthermore, an in vivo acute toxicity test showed that PHM-1 produced a low LD50 value of 3.28 g/kg BW for both of male and female mice. These results support the use of both PHM-1 and PHM-2 as antibacterial treatments for postpartum women.

scholarly journals Effects of (-)-epigallocatechin gallate and quercetin on the activity and structure of α-amylase

2021 ◽  
Vol 18 (3) ◽  
pp. 585-590
Author(s):  
Jianhui Su ◽  
Zhe Tang
Keyword(s):  
Fluorescence Spectroscopy ◽  
Inhibitory Concentration ◽  
Epigallocatechin Gallate ◽  
Hydrophobic Hydration ◽  
Inhibitory Effects ◽  
Functional Factors ◽  
Ic50 Values ◽  
Antidiabetic Effects

Purpose: To investigate the effects of (-)-epigallocatechin gallate (EGCG) and quercetin on the activity and structure of α-amylase. Methods: The inhibitory effects of 7 functional factors were compared by measuring half maximal inhibitory concentration (IC50) values. Lineweaver-Burk plots were used to determine the type of inhibition exerted by EGCG and quercetin against α-amylase. The effect of EGCG and quercetin on the conformation of α-amylase was investigated using fluorescence spectroscopy. Results: Quercetin and EGCG inhibited α-amylase with IC50 values of 1.36 and 0.31 mg/mL, respectively, which were much lower than the IC50 values of the other compounds (puerarin, paeonol, konjac glucomannan and polygonatum odoratum polysaccharide). The Lineweaver−Burk plots indicated that EGCG and quercetin inhibited α-amylase competitively, with ki values of 0.23 and 1.28 mg/mL, respectively. Fluorescence spectroscopy revealed that treatment with EGCG and quercetin led to formation of a loosely-structured hydrophobic hydration layer. Conclusion: This study has unraveled the mechanism underlying the inhibition of α-amylase activity by EGCG and quercetin in vitro. This should make for better understanding of the mechanisms that underlie the antidiabetic effects of EGCG and quercetin in vivo.

scholarly journals Glycosylated Coumarins, Flavonoids, Lignans and Phenylpropanoids from Wikstroemia nutans and Their Biological Activities

2021 ◽  
Author(s):  
Meifang Wu ◽  
Xiangdong Su ◽  
Yichuang Wu ◽  
Yuanjing Luo ◽  
Ying Guo ◽  
...  
Keyword(s):  
Biological Activities ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
No Production ◽  
Inhibitory Effects ◽  
Traditional Herbal Medicine ◽  
First Time ◽  
Raw264.7 Macrophage ◽  
Structure Diversity

Wikstroemia nutans Champ. ex Benth., a traditional herbal medicine collected at the Lingnan region of China, was chemically investigated. A new bis-coumarin glucoside, wikstronutin (1), along with three known bis- and tri-coumarin glucosides (2–4), two flavonoid glycosides (5–6), and eleven lignan glucosides (7–17) were isolated from the stems and roots of W. nutans. The new structure including its absolute configuration was elucidated based on a combination of 1D- and 2D-NMR, UV, IR, HRESIMS spectroscopic data, as well as chemical transformation. Compounds (1–17) were first isolated from the plant species W. nutans, while compounds 1–3, 8, and 11 was reported from the genus Wikstroemia for the first time. All co-isolates were evaluated for their in vitro inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells. The antibacterial activity of the selected compounds was also tested. Our work enriches the structure diversity of the secondary metabolites from the genus Wikstroemia.

scholarly journals Identification of Effective Component from a Traditional Herbal Medicine and the Inhibitory Effects on Experimental Glomerular Lesion in Mice.

1992 ◽  
Vol 54 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Koji SUGIMOTO ◽  
Nobuo SAKURAI ◽  
Yutaka FUJISE ◽  
Haruyuki SHIRASAWA ◽  
Kiyoshi SHIBATA ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Inhibitory Effects ◽  
Traditional Herbal Medicine ◽  
Glomerular Lesion ◽  
Effective Component
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