scholarly journals The Synthesis Methodology of PEGylated Fe3O4@Ag Nanoparticles Supported by Their Physicochemical Evaluation

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1744
Author(s):  
Magdalena Kędzierska ◽  
Piotr Potemski ◽  
Anna Drabczyk ◽  
Sonia Kudłacik-Kramarczyk ◽  
Magdalena Głąb ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Arabic Gum ◽  
Functionalized Surfaces ◽  
Physicochemical Evaluation ◽  
Diffraction Peaks ◽  
Poly Ethylene ◽  
Agglomeration Of Nanoparticles ◽  
Synthesis Methodology ◽  
Peg Coating

Many investigations are currently being performed to develop the effective synthesis methodology of magnetic nanoparticles with appropriately functionalized surfaces. Here, the novelty of the presented work involves the preparation of nano-sized PEGylated Fe3O4@Ag particles, i.e., the main purpose was the synthesis of magnetic nanoparticles with a functionalized surface. Firstly, Fe3O4 particles were prepared via the Massart process. Next, Ag+ reduction was conducted in the presence of Fe3O4 particles to form a nanosilver coating. The reaction was performed with arabic gum as a stabilizing agent. Sound energy-using sonication was applied to disintegrate the particles’ agglomerates. Next, the PEGylation process aimed at the formation of a coating on the particles’ surface using PEG (poly(ethylene glycol)) has been performed. It was proved that the arabic gum limited the agglomeration of nanoparticles, which was probably caused by the steric effect caused by the branched compounds from the stabilizer that adsorbed on the surface of nanoparticles. This effect was also enhanced by the electrostatic repulsions. The process of sonication caused the disintegration of aggregates. Formation of iron (II, III) oxide with a cubic structure was proved by diffraction peaks. Formation of a nanosilver coating on the Fe3O4 nanoparticles was confirmed by diffraction peaks with 2θ values 38.15° and 44.35°. PEG coating on the particles’ surface was proven via FT-IR (Fourier Transform Infrared Spectroscopy) analysis. Obtained PEG–nanosilver-coated Fe3O4 nanoparticles may find applications as carriers for targeted drug delivery using an external magnetic field.

Fe3O4 nanoparticles functionalized with poly(ethylene glycol) for the selective separation and enrichment of Au(iii)

2020 ◽  
Vol 44 (4) ◽  
pp. 1313-1319
Author(s):  
Xu Yang ◽  
Kunhao Yang ◽  
Li Wu ◽  
Jingkui Yang ◽  
Yujian He
Keyword(s):  
Aqueous Solution ◽  
Magnetic Nanoparticles ◽  
Ethylene Glycol ◽  
Fe3o4 Nanoparticles ◽  
Selective Separation ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Mechanism of Fe3O4@CPTES@PEG magnetic nanoparticles for selectively adsorbing Au(iii) from aqueous solution at pH = 1.0.

scholarly journals The Development of the Innovative Synthesis Methodology of Albumin Nanoparticles Supported by Their Physicochemical, Cytotoxic and Hemolytic Evaluation

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4386
Author(s):  
Sonia Kudłacik-Kramarczyk ◽  
Anna Drabczyk ◽  
Magdalena Głąb ◽  
Paweł Gajda ◽  
Anna Czopek ◽  
...  
Keyword(s):  
Spherical Shape ◽  
Dermal Fibroblasts ◽  
Albumin Concentration ◽  
Salting Out ◽  
Tem Analysis ◽  
Albumin Nanoparticles ◽  
Vis Spectroscopy ◽  
Physicochemical Evaluation ◽  
Normal Human ◽  
Synthesis Methodology

Many studies are being performed to develop effective carriers for controlled cytostatic delivery wherein albumin is a promising material due to its tendency to accumulate near cancer cells. The novelty of this work involves the development of the synthesis methodology of albumin nanoparticles and their biological and physicochemical evaluation. Albumin particles were obtained via the salt-induced precipitation and K3PO4 was used as a salting-out agent. Various concentrations of protein and salting-out agent solutions were mixed using a burette or a syringe system. It was proved that the size of the particles depended on the concentrations of the reagents and the methodology applied. As a result of a process performed using a burette and 2 M K3PO4, albumin spheres having a size 5–25 nm were obtained. The size of nanospheres and their spherical shape was confirmed via TEM analysis. The use of a syringe system led to preparation of particles of large polydispersity. The highest albumin concentration allowing for synthesis of homogeneous particles was 2 g/L. The presence of albumin in spheres was confirmed via the FT-IR technique and UV-Vis spectroscopy. All samples showed no cytotoxicity towards normal human dermal fibroblasts and no hemolytic properties against human erythrocytes (the hemolysis did not exceed 2.5%).

scholarly journals Influence of expanded graphite (EG) and graphene oxide (GO) on physical properties of PET based nanocomposites

2014 ◽  
Vol 16 (4) ◽  
pp. 45-50 ◽  
Author(s):  
Sandra Paszkiewicz ◽  
Małgorzata Nachman ◽  
Anna Szymczyk ◽  
Zdeno Špitalský ◽  
Jaroslav Mosnáček ◽  
...  
Keyword(s):  
Physical Properties ◽  
In Situ Polymerization ◽  
Crystallization Rate ◽  
Expanded Graphite ◽  
Exfoliated Graphene ◽  
Poly Ethylene Terephthalate ◽  
Poly Ethylene ◽  
Agglomeration Of Nanoparticles ◽  
Graphite Sheets

Abstract This work is the continuation and refinement of already published communications based on PET/EG nanocomposites prepared by in situ polymerization1, 2. In this study, nanocomposites based on poly(ethylene terephthalate) with expanded graphite were compared to those with functionalized graphite sheets (GO). The results suggest that the degree of dispersion of nanoparticles in the PET matrix has important effect on the structure and physical properties of the nanocomposites. The existence of graphene sheets nanoparticles enhances the crystallization rate of PET. It has been confirmed that in situ polymerization is the effective method for preparation nanocomposites which can avoid the agglomeration of nanoparticles in polymer matrices and improve the interfacial interaction between nanofiller and polymer matrix. The obtained results have shown also that due to the presence of functional groups on GO surface the interactions with PET matrix can be stronger than in the case of exfoliated graphene (EG) and matrix.

scholarly journals Shape-controlled synthesis of magnetic Fe3O4 nanoparticles with different iron precursors and capping agents

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 22917-22923 ◽  
Author(s):  
Hira Fatima ◽  
Dae-Won Lee ◽  
Hyun Joong Yun ◽  
Kyo-Seon Kim
Keyword(s):  
Magnetic Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Controlled Synthesis ◽  
Capping Agents ◽  
Modified Method ◽  
Magnetic Fe3o4 Nanoparticles ◽  
Different Shapes ◽  
Shape Controlled ◽  
Magnetic Fe3o4

This paper describes a modified method to prepare monodisperse Fe3O4 magnetic nanoparticles with different shapes (cube, octahedron, and sphere).

“Design of Poly(ethylene glycol)-Polycaprolactone Diblock Micelles with RGD Targeting Ligands and Embedded Iron Oxide Nanoparticles for Thermally-activated Release”

2012 ◽  
Vol 1416 ◽  
Author(s):  
Christopher S. Brazel ◽  
James B. Bennett ◽  
Amanda L. Glover ◽  
Jacqueline A. Nikles ◽  
Maaike Everts ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Melting Transition ◽  
Release Mechanism ◽  
Poly Ethylene Glycol ◽  
Rgd Peptides ◽  
Thermally Activated ◽  
Poly Ethylene

ABSTRACTA thermally-activated micelle consisting of a crystallizable poly(caprolactone), PCL, core and a poly(ethylene glycol), PEG, corona was developed to contain magnetic nanoparticles and anti-cancer agent doxorubicin as well as display a targeting RGD peptide. This system has the potential to target cancer cells, deliver combination hyperthermia and chemotherapy, and offer magnetic resonance imaging contrast. The micelles self-assemble in aqueous solutions and form a crystalline core with a melting transition ranging from 40 to 50 °C, depending on the length of the PCL blocks, with dynamic light scattering showing micelle sizes typically ranging from 20 to 100 nm, depending on block lengths and added drug or nanoparticles. The micelles become unstable as they are heated above their melting point, creating a thermally-activated drug release mechanism. By adding magnetite (Fe3O4) nanoparticles into the PCL core, the micelles can be heated using an externally applied AC magnetic field to induce hyperthermia in combination with the thermally-activated drug release. The polymers and magnetic nanoparticles (MNPs) were synthesized and characterized in our laboratories. The melting transitions of the PCL micelle cores were investigated using microcalorimetry. The heating of nanoparticles and magnetomicelles was conducted using a custom-built hyperthermia coil capable of generating fields of several hundred Oersteds at frequencies ranging from 50 to 450 kHz. Heating of MNPs was maximized at high field intensities. RGD peptides were attached to the PEG corona using maleimide chemistry, and the ability of the RGD-derivatized micelles to target integrin-expressing cells was investigated using fluorescent dye PKH26 to identify the localization of micelles in cultured human kidney (293) cells in vitro. The crystallizable (and meltable) cores in these micelles were designed to overcome drug leakage common in liposome systems and release the drug on demand after a period of time for localization to integrin receptors.

Magnetic Fe3O4 nanoparticles supporting Macmillan with controlled shell structure as an efficient and reusable catalyst for asymmetric reaction

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86531-86539 ◽  
Author(s):  
Xinjuan Li ◽  
Suli Zhang ◽  
Beilei Yang ◽  
Chunna Lv ◽  
Xianbin Jia ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Homogeneous Catalysis ◽  
Fe3o4 Nanoparticles ◽  
Polymer Brushes ◽  
Reusable Catalyst ◽  
Asymmetric Reaction ◽  
Magnetic Fe3o4 Nanoparticles ◽  
Heterogeneous And Homogeneous Catalysis ◽  
Chiral Polymer ◽  
Magnetic Fe3o4

Magnetic nanoparticles grafted with chiral polymer brushes offer an effective way to bridge the gap between heterogeneous and homogeneous catalysis.

Development of multifunctional folate-poly(ethylene glycol)-chitosan-coated Fe3O4 nanoparticles for biomedical applications

2013 ◽  
Vol 22 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Shuifan Zhou ◽  
Yang Li ◽  
Fei Cui ◽  
Mengmeng Jia ◽  
Xiangrui Yang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Fe3o4 Nanoparticles ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Glycol Chitosan ◽  
Poly Ethylene

scholarly journals Structure and Properties of Poly(ethylene terephthalate) Fiber Webs Prepared via Laser-Electrospinning and Subsequent Annealing Processes

Materials ◽  
2020 ◽  
Vol 13 (24) ◽  
pp. 5783
Author(s):  
Tomoki Tokuda ◽  
Ryo Tsuruda ◽  
Takuya Hara ◽  
Haruki Kobayashi ◽  
Katsufumi Tanaka ◽  
...  
Keyword(s):  
Ethylene Terephthalate ◽  
Fiber Axis ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Melt Electrospinning ◽  
Poly Ethylene Terephthalate ◽  
Diffraction Peaks ◽  
Poly Ethylene ◽  
Uniform Diameter ◽  
High Orientation

Melt-electrospinning is an eco-friendly method for producing ultra-fine fibers without using any solvent. We prepared webs of poly(ethylene terephthalate) (PET) through melt-electrospinning using CO2 laser irradiation for heating. The PET webs comprised ultra-fine fibers of uniform diameter (average fiber diameter = 1.66 μm, coefficient of variation = 19%). The co-existence of fibers with high and low molecular orientation was confirmed through birefringence measurements. Although the level of high orientation corresponded to that of commercial highly oriented yarn, crystalline diffraction was not observed in the wide-angle X-ray diffraction (WAXD) analysis of the webs. The crystallinity of the webs was estimated using differential scanning calorimetry (DSC). The fibers with higher birefringence did not exhibit any cold crystallization peak. After annealing the web at 116 °C for 5 min, a further increase in the birefringence of the fibers with higher orientation was observed. The WAXD results revealed that the annealed webs showed crystalline diffraction peaks with the orientation of the c-axis along the fiber axis. In summary, the formation of fibers with a unique non-crystalline structure with extremely high orientation was confirmed.

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