Premix Membrane Emulsification: Preparation and Stability of Medium-Chain Triglyceride Emulsions with Droplet Sizes below 100 nm

Premix membrane emulsification is a promising method for the production of colloidal oil-in-water emulsions as drug carrier systems for intravenous administration. The present study investigated the possibility of preparing medium-chain triglyceride emulsions with a mean particle size below 100 nm and a narrow particle size distribution using sucrose laurate as an emulsifier. To manufacture the emulsions, a coarse pre-emulsion was repeatedly extruded through alumina membranes (Anodisc™) of 200 nm, 100 nm and 20 nm nominal pore size. When Anodisc™ membranes with 20 nm pore size were employed, nanoemulsions with z-average diameters of about 50 nm to 90 nm and polydispersity indices smaller than 0.08 could be obtained. Particle growth due to Ostwald ripening was observed over 18 weeks of storage. The Ostwald ripening rate linearly depended on the emulsifier concentration and the concentration of free emulsifier, indicating that micelles in the aqueous phase accelerated the Ostwald ripening process. Long-term stability of the nanoemulsions could be achieved by using a minimised emulsifier concentration or by osmotic stabilisation with soybean oil added in a mass ratio of 1:1 to the lipid phase.

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Formation of SiC nanoparticles in an atmospheric microwave plasma

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.2.71 ◽

2011 ◽

Vol 2 ◽

pp. 665-673 ◽

Cited By ~ 20

Author(s):

Martin Vennekamp ◽

Ingolf Bauer ◽

Matthias Groh ◽

Evgeni Sperling ◽

Susanne Ueberlein ◽

...

Keyword(s):

Particle Size ◽

Ostwald Ripening ◽

Microwave Plasma ◽

Rate Equations ◽

Process Conditions ◽

Sic Nanoparticles ◽

Precursor Material ◽

Atmospheric Argon ◽

20 Nm ◽

The Impact

We describe the formation of SiC nanopowder using an atmospheric argon microwave plasma with tetramethylsilane (TMS) as precursor. The impact of several process conditions on the particle size of the product is experimentally investigated. Particles with sizes ranging from 7 nm to about 20 nm according to BET and XRD measurements are produced. The dependency of the particle size on the process parameters is evaluated statistically and explained with growth-rate equations derived from the theory of Ostwald ripening. The results show that the particle size is mainly influenced by the concentration of the precursor material in the plasma.

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Synthesis and Characterization of TiO2 Nanoparticle Using Starch as a Template by Sol-Gel Method for the Application of UV Protection

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.789.237 ◽

2013 ◽

Vol 789 ◽

pp. 237-241 ◽

Cited By ~ 1

Author(s):

Maya Komalasari ◽

Bambang Sunendar

Keyword(s):

Aqueous Solution ◽

Particle Size ◽

Pore Size ◽

Surface Area ◽

Sol Gel ◽

Uv Protection ◽

Advanced Technology ◽

Narrow Particle Size Distribution ◽

Gel Method ◽

Sol Gel Method

Nanotechnology is one of the key technology had been developed since in all fields including textile industries for medical, hygienic, and technical textiles. Particle size with nanohad been indicated in particular for the application of controlled release material for functional textiles. TiO2nanopowder has remarkable photo-catalytic and semiconductor as material for various advanced technology fields of application such as UV Protection. In this research the synthesis of TiO2nanoparticle and characterization had been conducted successfully by sol-gel method. The starch was used as a template to get nanoparticles structure. TiO2sol with narrow particle size distribution using TiCl4as the starting material. The sol was prepared by a process where HCl was added to a gel of hydrated titanium oxide to dissolve it. The effect of preparation parameters were investigated, by deionized water : HCl 1 M was slowly added to TiCl4at 5 °C. In this study the production of anatase or rutile TiO2nanostructured powder by forced hydrolysis of aqueous Ti (IV) chloride solution and concentration from 0,3, 0,5 then 1 M. TiO2sphere were fabricated by a facile and low cost stable starch assisted by sol-gel method. Aqueous solution of starch was added and then heated in temperature 80°C and aqueous solution of ammonium hydroxide was added to adjust pH to 8. After aging period of time, the white precipitate was filtered and then calcined in temperature 5000C. The as-obtained samples were characterize,kjnhjd by SEM (Scanning Electron Microscope), UV-vis diffuse reflectance spectroscopy, X-Ray Diffraction (XRD) and Brunauer Emmett Teller (BET) analysis. The particle size is less than 100 nm and if it uses template particle TiO2more uniform distribution and spherical shape with particle size 170 200 nm. Crystalinity particle is 4 19 nm and the phase structure of anatase and rutile. The energy band gap semiconductor TiO2synthesis is 3.1 to 3.7 eV. Surface area without template starch 40.655 m2/g, with total for volume 0.278 cm3/g and pore size of 27 nm, and used template starch surface area 35.488m2/g with total for volume 0.196 cm3/g and pore size of 22 nm. Based on this research, the best a crystal phase for UV protection application is rutile phase.

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Chiral separations with crosslinked cellulose derivatives attached onto hybrid silica monolith particles via the thiol–ene click reaction

Analytical Methods ◽

10.1039/d0ay00772b ◽

2020 ◽

Vol 12 (21) ◽

pp. 2727-2734

Author(s):

Yuhong Zhou ◽

Qian Liang ◽

Zhilun Zhang ◽

Zhaodi Wang ◽

Mingxian Huang

Keyword(s):

Particle Size ◽

Pore Size ◽

Click Reaction ◽

Sol Gel ◽

Chiral Separations ◽

Cellulose Derivatives ◽

Gel Method ◽

Silica Monolith ◽

Hybrid Silica ◽

20 Nm

A hybrid silica monolith containing vinyl groups was synthesized by a sol–gel method, and then ground and treated, yielding silica particles with a 3–5 μm particle size and a 10–20 nm pore size.

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Preparation of Nanoemulsions by Premix Membrane Emulsification: Which Parameters Have a Significant Influence on the Resulting Particle Size?

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.04.066 ◽

2017 ◽

Vol 106 (8) ◽

pp. 2068-2076 ◽

Cited By ~ 11

Author(s):

Sandra Gehrmann ◽

Heike Bunjes

Keyword(s):

Particle Size ◽

Significant Influence ◽

Membrane Emulsification ◽

Premix Membrane Emulsification

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Polymerization of Styrene in the Presence of Polybutadiene as a Stabilizer

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.899.232 ◽

2021 ◽

Vol 899 ◽

pp. 232-238

Author(s):

Nadezhda Lobanova

Keyword(s):

Particle Size ◽

Light Scattering ◽

Particle Size Distribution ◽

Pore Size ◽

Optical Microscopy ◽

Film Formation ◽

Narrow Particle Size Distribution ◽

Practical Application ◽

Calibration Standards ◽

Polymer Carriers

The problem of synthesis of polymer suspensions with a narrow particle size distribution is relevant, since the field of their practical application is extremely wide. They are used as calibration standards in electron and optical microscopy and light scattering, for determining the pore size of filters and biological membranes, as model colloids, for studying the kinetics and mechanism of film formation from latex, as well as as polymer carriers of biological ligands in immunochemical studies [1].

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The effect of Tin additionon on Structural and magnetic properties of the stannoferrite Li0.5+0.5XFe2.5-1.5XSnXO4

JOURNAL OF ADVANCES IN PHYSICS ◽

10.24297/jap.v12i3.9 ◽

2016 ◽

Vol 12 (3) ◽

pp. 4307-4321 ◽

Cited By ~ 1

Author(s):

Ahmed Hassan Ibrahim ◽

Yehia Abbas

Keyword(s):

Particle Size ◽

Fine Particles ◽

Magnetic Moments ◽

Lithium Ferrite ◽

Tem Analysis ◽

Weiss Temperature ◽

X Ray ◽

Two Phases ◽

Nanocrystalline Ferrite ◽

20 Nm

The physical properties of ferrites are verysensitive to microstructure, which in turn critically dependson the manufacturing process.Nanocrystalline Lithium Stannoferrite system Li0.5+0.5XFe2.5-1.5XSnXO4,X= (0, 0.2, 0.4, 0.6, 0.8 and 1.0) fine particles were successfully prepared by double sintering ceramic technique at pre-sintering temperature of 500oC for 3 h andthepre-sintered material was crushed and sintered finally in air at 1000oC.The structural and microstructural evolutions of the nanophase have been studied using X-ray powder diffraction (XRD) and the Rietveld method.The refinement results showed that the nanocrystalline ferrite has a two phases of ordered and disordered phases for polymorphous lithium Stannoferrite.The particle size of as obtained samples were found to be ~20 nm through TEM that increases up to ~ 85 nmand isdependent on the annealing temperature. TEM micrograph reveals that the grains of sample are spherical in shape. (TEM) analysis confirmed the X-ray results.The particle size of stannic substituted lithium ferrite fine particle obtained from the XRD using Scherrer equation.Magneticmeasurements obtained from lake shoreâ€™s vibrating sample magnetometer (VSM), saturation magnetization ofordered LiFe5O8 was found to be (57.829 emu/g) which was lower than disordered LiFe5O8(62.848 emu/g).Theinterplay between superexchange interactions of Fe3+ ions at A and B sublattices gives rise to ferrimagnetic ordering of magnetic moments,with a high Curie-Weiss temperature (TCW ~ 900 K).

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Nanostructured Polymetallic Powders to Create New Functional Materials on its Base

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.670.49 ◽

2015 ◽

Vol 670 ◽

pp. 49-54 ◽

Cited By ~ 7

Author(s):

Yuriy A. Zaharov ◽

Valeriy M. Pugachev ◽

Kseniya A. Datiy ◽

Anna N. Popova ◽

Anastasiya S. Valnyukova ◽

...

Keyword(s):

Particle Size ◽

Phase Diagrams ◽

Spatial Organization ◽

Functional Materials ◽

Particle Morphology ◽

Cloud Type ◽

Synthesis Conditions ◽

Micron Size ◽

Common Nature ◽

20 Nm

In the paper, the particle morphology is considered and the slices of phase diagrams of nanosystems agreeable to the synthesis conditions are constructed according to the data obtained earlier by authors, as well as new results of the study of nanostructured Fe-Co, Fe-Ni, Co-Ni, Fe-Co-Ni, Fe-Pt, Cu-Ni and Ni-Cd powders. It is found that all considered polymetallic systems have common nature of the particle size spatial organization, i.e., 7-20 nm nanocrystals (for different systems) form highly compact aggregates (40-100 nm) which put together into loose porous agglomerates (up to 200-250 nm) and then into unconsolidated micron size formation of cloud type. It is classified uncovered features of nanostructured polymetallic phase diagrams in comparison with phase diagrams of bulk systems. Magnetic properties of nanosystems are studied.

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Stabilisation of Lutein and Lutein Esters with Polyoxyethylene Sorbitan Monooleate, Medium-Chain Triglyceride Oil and Lecithin

Foods ◽

10.3390/foods10030500 ◽

2021 ◽

Vol 10 (3) ◽

pp. 500

Author(s):

Zala Gombač ◽

Ilja Gasan Osojnik Črnivec ◽

Mihaela Skrt ◽

Katja Istenič ◽

Andreja Knez Knafelj ◽

...

Keyword(s):

Aqueous Solutions ◽

Medium Chain Triglyceride ◽

Storage Conditions ◽

Sorbitan Monooleate ◽

Medium Chain ◽

Poorly Soluble

Lutein is a challenging compound to incorporate into food, as it is poorly soluble and unstable in aqueous solutions. In this study, the aim was to prepare stable encapsulates of lutein and lutein esters using feasible and straightforward techniques. Fine suspensions based on polyoxyethylene sorbitan monooleate and medium-chain triglyceride oil micelle-like units with 3.45% lutein esters or 1.9% lutein equivalents provided high encapsulation efficiencies of 79% and 83%, respectively. Lutein encapsulated in fine suspensions showed superior stability, as 86% was retained within the formulation over 250 days at 25 °C in the dark. Under the same storage conditions, only 38% of lutein remained in corresponding formulations. Higher encapsulation efficiencies were achieved with lecithin emulsions, at up to 99.3% for formulations with lutein, and up to 91.4% with lutein esters. In lecithin emulsions that were stored for 250 days, 17% and 80% of lutein and lutein esters, respectively, were retained within the formulations.

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