Chemical and Bioactive Characterization of the Essential Oils Obtained from Three Mediterranean Plants

Cupressus sempervirens L., Juniperus communis L. and Cistus ladanifer L. are Mediterranean arboreal and shrub species that possess essential oils (EO) in their leaves and branches. This study aimed at characterizing the EOs obtained by steam distillation from the three species collected in different locations from Spain (Almazán, Andévalo, Barriomartín, Cerezal, Ermitas and Huéscar). For this purpose, volatiles composition was determined by GC-MS, and different bioactivities were evaluated. The highest content in terpenes was observed in C. sempervirens (Huéscar origin) followed by J. communis (Almazán origin), corresponding to 92% and 91.9% of total compounds, respectively. With exception of C. ladanifer from Cerezal that presented viridiflorol as the most abundant compound, all the three species presented in common the α-pinene as the major compound. The EOs from C. ladanifer showed high antibacterial potential, presenting MIC values from 0.3 to 1.25 mg/mL. Concerning other bioactivities, C. ladanifer EO revealed an oxidation inhibition of 83%, while J. communis showed cytotoxicity in the MCF-7 cell line, and C. sempervirens and C. ladanifer EOs exhibited the highest potential on NCI-H460 cell lines. Nevertheless, some EOs revealed toxicity against non-tumoral cells but generally presented a GI50 value higher than that of the tumor cell lines.

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Synthesis, Characterization and High In Vitro Antitumour Activity of Novel Triphenyltin Carboxylates

Metal-Based Drugs ◽

10.1155/mbd.1994.305 ◽

1994 ◽

Vol 1 (4) ◽

pp. 305-309 ◽

Cited By ~ 14

Author(s):

Marcel Gielen ◽

Abdelaziz El Khloufi ◽

Monique Biesemans ◽

Abdeslam Bouhdid ◽

Dick de Vos ◽

...

Keyword(s):

Colon Carcinoma ◽

Cell Lines ◽

Tumour Cell ◽

Antitumour Activity ◽

Human Tumour ◽

Tumour Cell Lines ◽

Human Tumour Cell Lines ◽

Mcf 7

The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7.

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Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines

Journal of Materials Science ◽

10.1007/s10853-017-1756-4 ◽

2017 ◽

Vol 53 (5) ◽

pp. 3106-3118 ◽

Cited By ~ 14

Author(s):

Roshanak Khandanlou ◽

Vinuthaa Murthy ◽

Dhananjaya Saranath ◽

Hetal Damani

Keyword(s):

Liver Cancer ◽

Anticancer Activity ◽

Cell Lines ◽

Cancer Cell ◽

Cancer Cell Lines ◽

Synthesis And Characterization ◽

Liver Cancer Cell ◽

Mcf 7

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Characterization of a red pigment from Fusarium chlamydosporum exhibiting selective cytotoxicity against human breast cancer MCF-7 cell lines

Journal of Applied Microbiology ◽

10.1111/jam.13756 ◽

2018 ◽

Vol 125 (1) ◽

pp. 148-158 ◽

Cited By ~ 1

Author(s):

K. Soumya ◽

K. Narasimha Murthy ◽

G.L. Sreelatha ◽

S. Tirumale

Keyword(s):

Breast Cancer ◽

Cell Lines ◽

Human Breast Cancer ◽

Red Pigment ◽

Human Breast ◽

Selective Cytotoxicity ◽

Fusarium Chlamydosporum ◽

Mcf 7

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Abstract 2110: Molecular characterization of everolimus-resistant cell lines established from estrogen depletion-resistant MCF-7

10.1158/1538-7445.am2014-2110 ◽

2014 ◽

Author(s):

Mariko Kimura ◽

Toru Hanamura ◽

Toshifumi Niwa ◽

Yuri Yamaguchi ◽

Itaru Endo ◽

...

Keyword(s):

Molecular Characterization ◽

Cell Lines ◽

Resistant Cell ◽

Estrogen Depletion ◽

Mcf 7

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Synthesis and Characterization of New Series of 1,3-5-Triazine Hydrazone Derivatives with Promising Antiproliferative Activity

Molecules ◽

10.3390/molecules25112708 ◽

2020 ◽

Vol 25 (11) ◽

pp. 2708 ◽

Cited By ~ 2

Author(s):

Hessa H. Al Rasheed ◽

Azizah M. Malebari ◽

Kholood A. Dahlous ◽

Ayman El-Faham

Keyword(s):

Cell Lines ◽

Antiproliferative Activity ◽

Human Cancer ◽

Human Cancer Cell Lines ◽

Triazine Derivatives ◽

Ic50 Values ◽

Hct 116 ◽

Benzaldehyde Derivatives ◽

Mcf 7

A new series of s-triazine hydrazone derivatives was prepared based on the reaction of 6-hydrazino-2,4-disubstituted-s-triazine with p-substituted benzaldehyde derivatives using a straightforward synthetic pathway. The antiproliferative activity of all synthesized compounds was evaluated against two human cancer cell lines; breast cancer MCF-7 and colon carcinoma HCT-116 using MTT assay. Among all, 11 compounds have shown strong to moderate antiproliferative activity with IC50 values in the range 1.01–18.20 µM in MCF-7 and 0.97–19.51 µM in HCT-116. The best results were obtained with 4,4’-(6-(2-(pyridin-2-ylmethylene)hydrazinyl)-1,3,5-triazine-2,4-diyl) dimorpholine 11 (IC50 = 1.0 µM and 0.98 µM in MCF-7 and HCT-116 cell lines, respectively). The substituents on the s-triazine core as well as the substituent at the benzylidene moiety have a great effect on the antiproliferative activity. Whereas compounds containing dimorpholino-s-triazine derivatives 8a–e showed more potent antiproliferative in MCF-7 compared to their analogs 7a–f (compounds containing two-piperidine rings), compounds containing one piperidine and one morpholine ring 9a–f showed better IC50 values in the range 10.4–22.2 µM. On the other hand, compounds containing two-piperidine rings 7a–f showed more potent antiproliferative in HCT-116 (IC50 values in the range 8.8–19.5 µM) than their analogs 8a–e and 9a–f.

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Uptake and Cytotoxicity Characterization of Radioiodine in MCF-7 and SKBR3 Breast Cancer Cell Lines

Atom Indonesia ◽

10.17146/aij.2016.586 ◽

2016 ◽

Vol 42 (3) ◽

pp. 145 ◽

Cited By ~ 1

Author(s):

A. Elliyanti ◽

V.Y. Susilo ◽

S. Setiyowati ◽

M. Ramli ◽

J.S. Masjhur ◽

...

Keyword(s):

Breast Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Cancer Cell Lines ◽

Breast Cancer Cell Lines ◽

Skbr3 Breast Cancer Cell ◽

Mcf 7

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PERBANDINGAN AKTIVITAS SITOTOKSIK EKSTRAK DAN MINYAK ATSIRI RIMPANG Curcuma mangga Val. TERHADAP SEL MCF-7

Jurnal Penelitian Saintek ◽

10.21831/jps.v26i1.39977 ◽

2021 ◽

Vol 26 (1) ◽

pp. 85-94

Author(s):

Purwanto Purwanto ◽

Putri Khaerani Cahyaningrum ◽

Retno Sunarminingsih Sudibyo

Keyword(s):

Breast Cancer ◽

Essential Oil ◽

Essential Oils ◽

Cytotoxic Activity ◽

Cancer Cells ◽

Mtt Assay ◽

Breast Cancer Cells ◽

Steam Distillation ◽

Mcf 7

Rimpang Curcuma mangga Val. banyak digunakan sebagai obat herbal antikanker payudara. Penelitian aktivitas sitotoksik terhadap sel kanker payudara banyak dilakukan utamanya untuk minyak atsiri rimpang, dan hanya sedikit penelitian terhadap ekstraknya. Walaupun demikian belum ada yang membandingkan aktivitas sitotoksik dari ekstrak dan minyak atsiri tersebut terhadap sel kanker payudara; meskipun kandungan senyawa keduanya berbeda. Oleh karena itu penelitian ini bertujuan membandingkan aktivitas sitotoksik dari ekstrak dan minyak atsiri rimpang C. mangga Val. secara in vitro terhadap sel kanker payudara MCF7. Ekstrak rimpang dibuat secara maserasi menggunakan pelarut n-heksana; sedangkan minyak atsiri dibuat melalui destilasi uap irisan rimpang selama 5 jam. Uji aktivitas sitotoksik in vitro dilakukan menggunakan metoda MTT Assay. Rendemen minyak dari ekstrak n-heksana rimpang C. mangga Val. adalah 1,15 x 10-2 % sedangkan rendemen minyak atsiri adalah 6,3 x 10-2 %. Hasil uji sitotoksik menghasilkan IC50 ekstrak 106,414 µg/ml (R2=0,9677) dan minyak atsiri 198,557 µg/ml (R2=0,8037). Hal ini menunjukkan bahwa ekstrak rimpang C. mangga Val. lebih sitotoksik terhadap sel kanker payudara MCF-7 daripada minyak atsirinya, karena kandungan ekstrak mayoritas diterpenoid (53,18%) sedangkan minyak atsiri mayoritas monoterpenoid (51,34%).THE COMPARISON BETWEEN THE ACTIVITIES OF CYTOTOXIC EXTRACTS AND ESSENTIAL OILS OF RHIZOME Curcuma mango Val. TOWARD MCF-7 CELLSCurcuma mangga Val. rhizome has been used as herbal anti breast cancer. Researches on cytotoxic activity towards breast cancer cells have been done especially to the rhizome’s essential oil; and only few researches done to the extract. However there is no cytotoxic activity comparation of the extract and essential oil towards breast cancer cells; even tough their substance contents are different. Therefore, this study aimed to compare the cytotoxic activity in vitro of the extract and essential oil of C. mangga Val. rhizomes towards breast cancer cells of MCF-7. The rhizome extract was prepared by maceration using N-hexane; while the essential oil was prepared by steam distillation for 5 hours of the sliced rhizomes. The in vitro cytotoxic test was carried out using MTT Assay. The yield of oil from rhizome extract was 1.15 x 10-2 %; while the yield of essential oil was 6.3 x 10-2 %. The IC50 of extract oil was 106.414 µg/ml (R2=0.9677) and the IC50 of essential oil was 198.557 µg/ml (R2=0.8037). It shows that rhizome extract of C. mangga Val. was more cytotoxic towards MCF-7 than the oil because the majority content of extract were diterpenoids (53.18%) while the oil were monoterpenoids (51.34%).

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