Three-Dimensional Hierarchical Reticular Nanostructure of Fulfora candelaria Wing Decorated by Ag Nanoislands as Practical SERS-Active Substrates

Although surface-enhanced Raman scattering (SERS) technology has been widely explored nowadays in various fields, the fabrication of practical SERS-active substrates with prominent recognition ability for various analyte molecules is still defective. Natural Fulfora candelaria wing (FCW) with three-dimensional (3D) hierarchical reticular nanostructure was selected as a new bioscaffold for rough silver (Ag) nanoislands to be assembled on to prepare a practical SERS substrate (Ag/FCW substrate). By adjusting the sputtering time of metal Ag, the morphology of the substrates could be easily tuned to control the formation and distribution of “hot spots”. Three-dimensional finite-difference time-domain (3D-FDTD) simulation indicated that the excellent SERS performance under optimal morphology was ascribed to the local enhanced electric field in rough Ag surface and effective “hot spot” areas. The SERS measurement results show that the optimal Ag/FCW substrates had high SERS performance in terms of Raman signal sensitivity, reproducibility, uniformity and recognition ability for various analyte molecules. Coupled with flexibility of the biological substrates and the cost effectiveness, the sensitive SERS detection of varied analytes based on Ag/FCW substrates offered great potential for practical applications.

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Magnetic Assembly Route to Construct Reproducible and Recyclable SERS Substrate

Nanoscale Research Letters ◽

10.1186/s11671-019-3184-7 ◽

2019 ◽

Vol 14 (1) ◽

Author(s):

Bingfang Zou ◽

Chunyu Niu ◽

Ming Ma ◽

Lu Zhao ◽

Yongqiang Wang

Keyword(s):

Noble Metal ◽

Reaction System ◽

Practical Interest ◽

Building Blocks ◽

Detection Sensitivity ◽

Sers Substrate ◽

Magnetic Assembly ◽

Surface Enhanced Raman ◽

Signal Sensitivity ◽

Uniform Array

AbstractThe fabrication of a uniform array film through assembly of colloidal building blocks is of practical interest for the integrated individual and collective functions. Here, a magnetic assembly route was put forward to organize monodisperse noble metal microspheres into a uniform array film for surface-enhanced Raman scattering (SERS) application, which demonstrated the integrated signal sensitivity of single noble metal microspheres and reproducibility of their assembled uniform array film. For this purpose, monodisperse multifunctional Fe3O4@SiO2@TiO2@Ag (FOSTA) colloidal microspheres as building blocks were successfully synthesized through a homemade ultrasonic-assisted reaction system. When used in SERS test, these multifunctional microspheres could firstly bind the analyte (R6G) from solution and then assembled into a uniform film under an external magnetic field, which exhibited high SERS detection sensitivity with good reproducibility. In addition, due to the TiO2 interlayer in FOSTA colloidal microspheres, the building blocks could be recycled and self cleaned through photocatalytic degradation of the adsorbed analyte for recycling SERS application.

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A Biomedical Surface Enhanced Raman Scattering Substrate: Functionalized Three-Dimensional Porous Membrane Decorated with Silver Nanoparticles

Journal of Spectroscopy ◽

10.1155/2015/561919 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Li Yuan ◽

Jinghuai Fang ◽

Yonglong Jin ◽

Chaonan Wang ◽

Tian Xu

Keyword(s):

Silver Nanoparticles ◽

Raman Scattering ◽

Three Dimensional ◽

Surface Enhanced Raman Scattering ◽

Porous Membrane ◽

Raman Signal ◽

Functional Surface ◽

Surface Enhanced ◽

Surface Enhanced Raman ◽

Enhanced Raman Scattering

We fabricated a simple, cheap, and functional surface enhanced Raman scattering substrate for biomedical application. Hot spots between two close silver nanoparticles distributed in the skeleton of a three-dimensional porous membrane, especially in the pores, were formed. The dual poles of micropores in the membrane were discussed. The pores could protect the silver nanoparticles in the pores from being oxidized, which makes the membrane effective for a longer period of time. In addition,Staphylococcus aureuscells could be trapped by the micropores and then the Raman signal became stronger, indicating that the functional surface enhanced Raman scattering substrate is reliable.

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SERS Background Imaging – a Versatile Tool Towards More Reliable SERS Analytics

10.26434/chemrxiv.12589013 ◽

2020 ◽

Author(s):

Paul Ebersbach ◽

Ute Münchberg ◽

Erik Freier

Keyword(s):

Sampling Error ◽

Hot Spot ◽

Measurement Procedure ◽

Sers Spectrum ◽

Sers Substrate ◽

Structure Property ◽

Contrast Imaging ◽

High Contrast Imaging ◽

Surface Enhanced Raman ◽

Versatile Tool

<div>Surface-enhanced Raman scattering (SERS) is a highly selective and sensitive straightforward analytical method, which is however not yet established in routine analysis due to a lack of reliability and reproducibility. Here we utilise the broad SERS continuum background (SERS-BG) accompanying every SERS measurement as a versatile tool towards more reliable SERS analytics. We apply a heterogeneous gold SERS substrate immersed with an adenosine triphosphate solution to show that the integrated SERS-BG distinctly correlates with the intensity of the analyte signals in the SERS spectrum. Based on this relationship we introduce an easy-to-handle, automatable and more reliable SERS measurement procedure starting with fast and high-contrast imaging of the SERS substrate followed by hot spot localisation and recording of highly enhanced SERS spectra at the centre of the diffraction-limited spot. We further demonstrate the applicability of SERS-BG imaging by combining it with other optical modalities and electron microscopy to assess structure-property relationships. Additionally, we perform Monte-Carlo simulations to evaluate the sampling error in SERS experiments highlighting the advantages of our method over conventional SERS experiments.</div>

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Bioscaffold arrays decorated with Ag nanoparticles as a SERS substrate for direct detection of melamine in infant formula

RSC Advances ◽

10.1039/c9ra01862j ◽

2019 ◽

Vol 9 (38) ◽

pp. 21771-21776 ◽

Cited By ~ 4

Author(s):

Nan Zhao ◽

Hefu Li ◽

Cunwei Tian ◽

Yanru Xie ◽

Zhenbao Feng ◽

...

Keyword(s):

High Performance ◽

Direct Detection ◽

Three Dimensional ◽

Sers Substrate ◽

Sers Substrates ◽

Plasmonic Structures ◽

Surface Enhanced ◽

Surface Enhanced Raman ◽

Enhanced Raman Scattering ◽

Performance Surface

Three-dimensional (3D) plasmonic structures have been intensively investigated as high performance surface enhanced Raman scattering (SERS) substrates.

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Liquid Surface-Enhanced Raman Spectroscopy (SERS) Sensor-Based Au-Ag Colloidal Nanoparticles for Easy and Rapid Detection of Deltamethrin Pesticide in Brewed Tea

Crystals ◽

10.3390/cryst12010024 ◽

2021 ◽

Vol 12 (1) ◽

pp. 24

Author(s):

Affi Nur Hidayah ◽

Djoko Triyono ◽

Yuliati Herbani ◽

Rosari Saleh

Keyword(s):

Raman Spectroscopy ◽

Liquid Surface ◽

Limit Of Detection ◽

Surface Enhanced Raman Spectroscopy ◽

Ease Of Use ◽

Raman Signal ◽

Colloidal Nanoparticles ◽

Sers Substrate ◽

Surface Enhanced ◽

Surface Enhanced Raman

Deltamethrin pesticides can cause inflammation, nephrotoxicity and hepatotoxicity as well as affect the activity of antioxidant enzymes in tissues. As a result of this concern, there is a rising focus on the development of fast and reliable pesticide residue testing to minimise potential risks to humans. The goal of this study is to use Au-Ag colloid nanoparticles as liquid surface-enhanced Raman spectroscopy (SERS) to improve the Raman signal in the detection of deltamethrin pesticide in a brewed tea. The liquid SERS system is fascinating to study due to its ease of use and its unlikeliness to cause several phenomena, such as photo-bleaching, combustion, sublimation and even photo-catalysis, which can interfere with the Raman signal, as shown in the SERS substrate. Our liquid SERS system is simpler than previous liquid SERS systems that have been reported. We performed the detection of pesticide analyte directly on brewed tea, without diluting it with ethanol or centrifuging it. Femtosecond laser-induced photo-reduction was employed to synthesise the liquid SERS of Au, Au-Ag, and Ag colloidal nanoparticles. The SERS was utilised to detect deltamethrin pesticide in brewed tea. The result showed that liquid SERS-based Ag NPs significantly enhance the Raman signal of pesticides compared with liquid SERS-based Au NPs and Au-Ag Nanoalloys. The maximum residue limits (MRLs) in tea in Indonesia are set at 10 ppm. Therefore, this method was also utilised to detect and improve, to 0.01 ppm, the deltamethrin pesticide Limit of Detection (LOD).

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Enabling three-dimensional porous architectures via carbonyl functionalization and molecular-specific organic-SERS platforms

Nature Communications ◽

10.1038/s41467-021-26385-7 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Ibrahim Deneme ◽

Gorkem Liman ◽

Ayse Can ◽

Gokhan Demirel ◽

Hakan Usta

Keyword(s):

Film Growth ◽

Low Cost ◽

Three Dimensional ◽

Surface Enhanced Raman Spectroscopy ◽

Molecular Engineering ◽

Raman Signal ◽

Chemical Enhancement ◽

Out Of Plane ◽

Surface Enhanced Raman ◽

Anti Stokes

AbstractMolecular engineering via functionalization has been a great tool to tune noncovalent intermolecular interactions. Herein, we demonstrate three-dimensional highly crystalline nanostructured D(C7CO)-BTBT films via carbonyl-functionalization of a fused thienoacene π-system, and strong Raman signal enhancements in Surface-Enhanced Raman Spectroscopy (SERS) are realized. The small molecule could be prepared on the gram scale with a facile synthesis-purification. In the engineered films, polar functionalization induces favorable out-of-plane crystal growth via zigzag motif of dipolar C = O···C = O interactions and hydrogen bonds, and strengthens π-interactions. A unique two-stage film growth behavior is identified with an edge-on-to-face-on molecular orientation transition driven by hydrophobicity. The analysis of the electronic structures and the ratio of the anti-Stokes/Stokes SERS signals suggests that the π-extended/stabilized LUMOs with varied crystalline face-on orientations provide the key properties in the chemical enhancement mechanism. A molecule-specific Raman signal enhancement is also demonstrated on a high-LUMO organic platform. Our results demonstrate a promising guidance towards realizing low-cost SERS-active semiconducting materials, increasing structural versatility of organic-SERS platforms, and advancing molecule-specific sensing via molecular engineering.

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Cu-doping SnO2-NiO p-n Heterostructure for Significant Raman Enhancement with EF > 1010: Toward Ultrasensitive VOCs Sensing

10.21203/rs.3.rs-199935/v1 ◽

2021 ◽

Author(s):

Yang Tian ◽

Yan Zhou ◽

Qingyi Gu ◽

Tianzhu Qiu ◽

Xiao He ◽

...

Keyword(s):

Copper Phthalocyanine ◽

Chemical Mechanism ◽

Sers Substrate ◽

Trace Detection ◽

Reference Element ◽

Cu Doping ◽

Practical Applications ◽

Raman Enhancement ◽

Surface Enhanced Raman ◽

Enhanced Raman Scattering

Abstract Surface enhanced Raman scattering (SERS) based on chemical mechanism (CM) has attracted tremendous attention for its great selectivity and stability. However, extremely low enhancement factor (EF) limits its practical applications for trace detection. Here, a novel sponge-like Cu-doping SnO2-NiO p-n semiconductor heterostructure (SnO2-NiOx/Cu), was first designed and created as a CM-based SERS substrate with a significant EF of 1.66 × 1010. This remarkable EF was mainly attributed to the enhanced charge-separation efficacy of p-n heterojunction and charge transfer resonance resulted from Cu doping. Moreover, the porous sponge structure enriched the probe molecules, resulting in further SERS signals magnification. By immobilizing copper phthalocyanine as an inner-reference element, SnO2-NiOx/Cu was developed as a SERS nose for selective recognition of multiple lung cancer related-volatile organic compounds (VOCs) down to ppb level. The information of VOCs was recorded in a barcode, demonstrating practical potential of a desktop SERS device for biomarker screening.

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SERS properties of biogenic gold nanoparticles synthesized using Anemopsis californica extract.

MRS Advances ◽

10.1557/adv.2020.423 ◽

2020 ◽

Vol 5 (63) ◽

pp. 3397-3406

Author(s):

R. D. Ávila-Avilés ◽

Marco A. Camacho-López ◽

E. Castro-Longoria ◽

A. Dorazco-González ◽

N. Hernández-Guerrero ◽

...

Keyword(s):

Gold Nanoparticles ◽

Raman Signal ◽

Sers Substrate ◽

Anemopsis Californica ◽

Glass Slides ◽

Transmission Electron ◽

Vis Spectroscopy ◽

Surface Enhanced Raman ◽

Enhanced Raman Scattering ◽

Biological Methods

AbstractGold nanoparticles (AuNPs) have been classified as one of the most attractive nanotechnologies, thanks to their potential or already implemented applications; therefore, biological methods for their synthesis have been widely investigated. This study explores the synthesis of AuNPs using the extract of Anemopsis californica, and determinates the effect of the solvent used (water, methanol, and isopropanol) to obtain the AuNPs. Biogenic nanoparticles were analysed through UV-Vis spectroscopy and transmission electron microscopy (TEM, HRTEM, and SAED). Significant differences in polydispersity and morphology of AuNPs among the different methods used were found; the aqueous extract and the extract based on methanol formed nanotriangles and polyhedral nanoparticles; the shape of the nanoparticles is predominantly polyhedral when isopropanol is used as the solvent. The as obtained nanoparticles were placed on glass slides to perform Surface-Enhanced Raman Scattering (SERS) experiments, an amplification of the methylene blue Raman signal was observed when triangular nanoparticles cover the biogenic SERS substrate.

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Ag-coated cotton fabric as ultrasensitive and flexible SERS substrate

Journal of Industrial Textiles ◽

10.1177/15280837211027781 ◽

2021 ◽

pp. 152808372110277

Author(s):

Xueyan Bian ◽

Jiangtao Xu ◽

Yi Pu ◽

Jing Yang ◽

Ka-lam Chiu ◽

...

Keyword(s):

Cotton Fabric ◽

Flow Rate ◽

Ag Nanoparticles ◽

Fdtd Method ◽

Raman Signal ◽

Enhancement Effect ◽

Sers Substrate ◽

Argon Flow Rate ◽

Practical Applications ◽

Argon Flow

Surface enhanced Raman scattering (SERS) has proven to be increasingly valuable as an analytical tool since this phenomenon was first observed in 1973. However, challenges still exist to ensure their ability to access targeted analytes and adequate levels of sensitivity to them on irregular surfaces. Herein, silver (Ag) nanoparticles are deposited onto cotton fabric through magnetron sputtering to develop a flexible and ultrasensitive SERS-active substrate. To obtain a better enhancement effect, Ag nanoparticles of different sizes are produced by controlling the argon flow rate and the sputtering time. The finite-difference time-domain (FDTD) method and Raman mapping are used to explain the process behind Raman signal enhancement. The cotton fabric sample with Ag nanoparticles deposited at an argon flow rate of 200 sccm (labelled as AC-200) shows a high enhancement factor (EF) of 104 with a Methylene blue (MB) solution of 10−3 M, stability with a related standard deviation (RSD) of 1.03%, excellent reproducibility with an RSD of 1.92% and high sensitivity with 10−9 M of MB solution. Therefore, AC-200 demonstrates exceptional SERS signal reproducibility and stability for different types of chemical analytes and has the potential to be used in future practical applications.

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Genetic Algorithm-Driven Surface-Enhanced Raman Spectroscopy Substrate Optimization

Nanomaterials ◽

10.3390/nano11112905 ◽

2021 ◽

Vol 11 (11) ◽

pp. 2905

Author(s):

Buse Bilgin ◽

Cenk Yanik ◽

Hulya Torun ◽

Mehmet Cengiz Onbasli

Keyword(s):

Genetic Algorithm ◽

Raman Spectroscopy ◽

Strong Electric Field ◽

Surface Enhanced Raman Spectroscopy ◽

Raman Signal ◽

Sers Substrate ◽

Design Constraints ◽

Sers Substrates ◽

Surface Enhanced ◽

Surface Enhanced Raman

Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive and molecule-specific detection technique that uses surface plasmon resonances to enhance Raman scattering from analytes. In SERS system design, the substrates must have minimal or no background at the incident laser wavelength and large Raman signal enhancement via plasmonic confinement and grating modes over large areas (i.e., squared millimeters). These requirements impose many competing design constraints that make exhaustive parametric computational optimization of SERS substrates prohibitively time consuming. Here, we demonstrate a genetic-algorithm (GA)-based optimization method for SERS substrates to achieve strong electric field localization over wide areas for reconfigurable and programmable photonic SERS sensors. We analyzed the GA parameters and tuned them for SERS substrate optimization in detail. We experimentally validated the model results by fabricating the predicted nanostructures using electron beam lithography. The experimental Raman spectrum signal enhancements of the optimized SERS substrates validated the model predictions and enabled the generation of a detailed Raman profile of methylene blue fluorescence dye. The GA and its optimization shown here could pave the way for photonic chips and components with arbitrary design constraints, wavelength bands, and performance targets.

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