scholarly journals Virus-Incorporated Biomimetic Nanocomposites for Tissue Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 1014 ◽  
Author(s):  
Iruthayapandi Selestin Raja ◽  
Chuntae Kim ◽  
Su-Jin Song ◽  
Yong Cheol Shin ◽  
Moon Sung Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Phage Display ◽  
Tissue Regeneration ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Future Directions ◽  
Biomimetic Materials ◽  
Peptide Expression

Owing to the astonishing properties of non-harmful viruses, tissue regeneration using virus-based biomimetic materials has been an emerging trend recently. The selective peptide expression and enrichment of the desired peptide on the surface, monodispersion, self-assembly, and ease of genetic and chemical modification properties have allowed viruses to take a long stride in biomedical applications. Researchers have published many reviews so far describing unusual properties of virus-based nanoparticles, phage display, modification, and possible biomedical applications, including biosensors, bioimaging, tissue regeneration, and drug delivery, however the integration of the virus into different biomaterials for the application of tissue regeneration is not yet discussed in detail. This review will focus on various morphologies of virus-incorporated biomimetic nanocomposites in tissue regeneration and highlight the progress, challenges, and future directions in this area.

scholarly journals Virus-Based Nanomaterials and Nanostructures

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 567
Author(s):  
Jin-Woo Oh ◽  
Dong-Wook Han
Keyword(s):  
Energy Harvesting ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Special Issue ◽  
Future Directions ◽  
Biomimetic Materials ◽  
Recent Developments ◽  
Energy Harvesting Devices

This Special Issue highlights the recent developments and future directions of virus-based nanomaterials and nanostructures in energy and biomedical applications. The virus-based biomimetic materials formulated using innovative ideas presented herein are characterized for the applications of biosensors and nanocarriers. The research contributions and trends based on virus-based materials, covering energy-harvesting devices to tissue regeneration over the last two decades, are described and discussed.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

Chemical modification of enveloped viruses for biomedical applications

2018 ◽  
Vol 10 (11) ◽  
pp. 666-679 ◽  
Author(s):  
Pahweenvaj Ratnatilaka Na Bhuket ◽  
Jittima Amie Luckanagul ◽  
Pornchai Rojsitthisak ◽  
Qian Wang
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Vaccine Development ◽  
Enveloped Viruses ◽  
Bio Imaging

Chemistry enables scientists to use enveloped viruses in several biomedical applications including bio-imaging, drug delivery and vaccine development.

scholarly journals Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31777-31782 ◽  
Author(s):  
Rashmi Rashmi ◽  
Abhishek K. Singh ◽  
Katharina Achazi ◽  
Boris Schade ◽  
Christoph Böttcher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Transport Behaviour ◽  
Drug Delivery Applications

Non-ionic bolaamphiphiles as nanocarrier for biomedical applications.

scholarly journals Electrospinning of Nanofibers for Tissue Engineering Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Haifeng Liu ◽  
Xili Ding ◽  
Gang Zhou ◽  
Ping Li ◽  
Xing Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Fiber Morphology ◽  
Hard Tissue ◽  
Nanoscale Material ◽  
Considerable Potential ◽  
Recent Interest ◽  
Material Fabrication

Electrospinning is a method in which materials in solution are formed into nano- and micro-sized continuous fibers. Recent interest in this technique stems from both the topical nature of nanoscale material fabrication and the considerable potential for use of these nanoscale fibres in a range of applications including, amongst others, a range of biomedical applications processes such as drug delivery and the use of scaffolds to provide a framework for tissue regeneration in both soft and hard tissue applications systems. The objectives of this review are to describe the theory behind the technique, examine the effect of changing the process parameters on fiber morphology, and discuss the application and impact of electrospinning on the fields of vascular, neural, bone, cartilage, and tendon/ligament tissue engineering.

Nanofibres and their Influence on Cells for Tissue Regeneration

2005 ◽  
Vol 58 (10) ◽  
pp. 704 ◽  
Author(s):  
Yanping Karen Wang ◽  
Thomas Yong ◽  
Seeram Ramakrishna
Keyword(s):  
Phase Separation ◽  
Cell Growth ◽  
Tissue Regeneration ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Synthetic Polymer ◽  
Biocompatible Polymers ◽  
Mechanical Methods ◽  
The Matrix ◽  
Cell Growth And Proliferation

Synthetic polymer and biopolymer nanofibres can be fabricated through self-assembly, phase separation, electrospinning, and mechanical methods. These novel functional biocompatible polymers are very promising for a variety of future biomedical applications. There are many characteristics of nanofibres that would potentially influence cell growth and proliferation. As such, many studies have been carried out to elucidate the cell–nanofibre interaction with the purpose of optimizing the matrix for cell growth and tissue regeneration. In this Review, we present current literatures and our research on the interactions between cells and nanofibres, and the potentials of nanofibre scaffolds for biomedical applications.

Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self-Assembly for Potential Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Alice Kilner ◽  
Jean-Charles Eloi ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Hydrophobic Interactions ◽  
Gelation Mechanism ◽  
Swelling Behaviour ◽  
Assembly Mechanism ◽  
Significant Toxicity ◽  
Chitosan Hydrogels

<p><br></p><p> Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalised chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The <i>in vitro </i>stable hydrogels are injectable and showed pH-responsive swelling behaviour, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g. <i>endo</i>- or -<i>exo</i>). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm which could be further functionalised and showed no significant toxicity to human dermofibroblast cells. </p>

Nanofibrous Substrate For Tissue Engineering Applications—A Review

2021 ◽  
Vol 8 (6) ◽  
pp. 13-21
Author(s):  
Odia Osemwegie ◽  
Lihua Lou ◽  
Ernest Smith ◽  
Seshadri Ramkumar
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Culture ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
High Volume ◽  
Clinical Applications ◽  
Critical Factors ◽  
Engineering Applications

Nanofiber substrates have been used for various biomedical applications, including tissue regeneration, drug delivery, and in-vitro cell culture. However, despite the high volume of studies in this field, current clinical applications remain minimal. Innovations for their applications continuously generate exciting prospects. In this review, we discuss some of these novel innovations and identify critical factors to consider before their adoption for biomedical applications.

scholarly journals Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self-Assembly for Potential Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Alice Kilner ◽  
Jean-Charles Eloi ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Hydrophobic Interactions ◽  
Gelation Mechanism ◽  
Swelling Behaviour ◽  
Assembly Mechanism ◽  
Significant Toxicity ◽  
Chitosan Hydrogels

<p><br></p><p> Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalised chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The <i>in vitro </i>stable hydrogels are injectable and showed pH-responsive swelling behaviour, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g. <i>endo</i>- or -<i>exo</i>). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm which could be further functionalised and showed no significant toxicity to human dermofibroblast cells. </p>

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