scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

scholarly journals Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31777-31782 ◽  
Author(s):  
Rashmi Rashmi ◽  
Abhishek K. Singh ◽  
Katharina Achazi ◽  
Boris Schade ◽  
Christoph Böttcher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Transport Behaviour ◽  
Drug Delivery Applications

Non-ionic bolaamphiphiles as nanocarrier for biomedical applications.

scholarly journals Frontiers in Bioengineering and Biotechnology: Plant Nanoparticles for Anti-Cancer Therapy

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 830
Author(s):  
Erum Shoeb ◽  
Uzma Badar ◽  
Srividhya Venkataraman ◽  
Kathleen Hefferon
Keyword(s):  
Drug Delivery ◽  
Cancer Research ◽  
Cancer Therapy ◽  
Plant Virus ◽  
Biomedical Applications ◽  
Plant Viruses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Stimuli Response

Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. The following review describes how plant virus architecture facilitates the use of VNPs for imaging and a variety of therapeutic applications, with particular emphasis on cancer. Examples of plant viruses which have been engineered to carry drugs and diagnostic agents for specific types of cancer are provided. The drug delivery system in response to the internal conditions is known as stimuli response, recently becoming more applicable using plant viruses based VNPs. The review concludes with a perspective of the future of plant VNPs and plant virus-like particles (VLPs) in cancer research and therapy.

Non-covalent modification of graphene oxide nanocomposites with chitosan/dextran and its application in drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 9328-9337 ◽  
Author(s):  
Meng Xie ◽  
Hailin Lei ◽  
Yufeng Zhang ◽  
Yuanguo Xu ◽  
Song Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Self Assembly ◽  
Covalent Modification ◽  
Cancer Drug ◽  
Graphene Oxide Nanosheets ◽  
Drug Delivery Application ◽  
Anti Cancer ◽  
Assembly Technique ◽  
Cancer Drug Delivery

Graphene oxide nanosheets non-covalent functionalized with chitosan/dextran was successfully developed via LbL self-assembly technique for anti-cancer drug delivery application.

scholarly journals Novel Drug Formulation for the Treatment of Hepatic Cancer- A Review

2020 ◽  
Vol 11 (3) ◽  
pp. 4395-4401
Author(s):  
Komala M ◽  
Sathesh Kumar S ◽  
Padmavathy J
Keyword(s):  
Drug Delivery ◽  
Polar Lipid ◽  
Self Assembly ◽  
Drug Carrier ◽  
Global Market ◽  
Drug Formulation ◽  
Drug Uptake ◽  
Bioactive Materials ◽  
The Core ◽  
Regenerative Medicines

For metabolic transformation, uptake, detoxification, and excretion liver is the primary organ that is highly equipped. Thus, the liver requires targeting by means like a carrier-mediated mechanism to take xenobiotics into the bile, though high hepatic concentration is achieved by most of the drugs. Thus resulting in high first-pass metabolism displayed by the drugs and thus resulting in rapid clearance of the drugs. Uptake of particulate materials is highly contributed by the kupffer cells largely. However, drug uptake by the liver is highly dependent on hepatocytes. In drug delivery, tissue engineering and regenerative medicines which are various biomedical applications construction of nanoscale based bioactive materials is a desirable approach of self-assembly. By using a targeting moiety, we can decrease the side effects of the drug and increases the therapeutic effect of the drug. Lipoproteins are potential drug carrier to target the organs. Lipoproteins consist of cholesterol, polar lipid core surrounding phospholipid monolayer and apoproteins are embedded in it, and these lipoproteins are spherical. The core is a polar lipid in nature so that highly hydrophobic drugs are easily incorporated into the core. Lipoproteins are completely non-immunogenic, biodegradable nature. The present review should be regularly inspected to beat into the global market at an affordable price as well, particularly the vehicles which are proven to be efficacious in drug delivery systems used to treat liver diseases like cancer.

Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self-Assembly for Potential Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Alice Kilner ◽  
Jean-Charles Eloi ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Hydrophobic Interactions ◽  
Gelation Mechanism ◽  
Swelling Behaviour ◽  
Assembly Mechanism ◽  
Significant Toxicity ◽  
Chitosan Hydrogels

<p><br></p><p> Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalised chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The <i>in vitro </i>stable hydrogels are injectable and showed pH-responsive swelling behaviour, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g. <i>endo</i>- or -<i>exo</i>). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm which could be further functionalised and showed no significant toxicity to human dermofibroblast cells. </p>

scholarly journals Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self-Assembly for Potential Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Alice Kilner ◽  
Jean-Charles Eloi ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Hydrophobic Interactions ◽  
Gelation Mechanism ◽  
Swelling Behaviour ◽  
Assembly Mechanism ◽  
Significant Toxicity ◽  
Chitosan Hydrogels

<p><br></p><p> Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalised chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The <i>in vitro </i>stable hydrogels are injectable and showed pH-responsive swelling behaviour, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g. <i>endo</i>- or -<i>exo</i>). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm which could be further functionalised and showed no significant toxicity to human dermofibroblast cells. </p>

scholarly journals Biodegradable Polycaprolactone Nanoparticles Based Drug Delivery Systems: A Short Review

2018 ◽  
Vol 15 (3) ◽  
pp. 679-685 ◽  
Author(s):  
Ranjith Ramanujam ◽  
Balraj Sundaram ◽  
Ganesh Janarthanan ◽  
Elamparithi Devendran ◽  
Moorthy Venkadasalam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Drug Carrier ◽  
Short Review ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Simple Method ◽  
Nanoprecipitation Method

Nanoparticles based drug delivery systems showing greater potential in various biomedical applications to deliver the drugs/bioactive molecules in controlled manner to the targeted site. Polycaprolactone, biodegradable polyester, owing its tailorable properties, various forms of polycaprolactone are used as drug carrier for a range of biomedical applications. Nanoprecipitation is a simple method to prepare the polycaprolactone nanoparticles to improve the bioavailability and therapeutic potential of various drugs/bioactive molecules. This short review focused on the preparation of polycaprolactone nanoparticles using nanoprecipitation method, nanoparticles-drug formulations and its use in various drug delivery applications.

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