scholarly journals Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field

Nanomaterials ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 1457 ◽  
Author(s):  
Huangtao Xu ◽  
Yongxin Pan
Keyword(s):  
Magnetic Field ◽  
Relaxation Time ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Core Size ◽  
Hyperthermia Treatment ◽  
Field Frequency ◽  
Glycerol Water ◽  
Heating Efficiency ◽  
Néel Relaxation

The superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Under 805.5 kHz and 19.5 kA/m, temperature rise (ΔT) and specific loss power (SLP) measured on magnetoferritin nanoparticles with core size of 4.8 nm at 5 mg/mL were 14.2 °C (at 6 min) and 68.6 W/g, respectively. The SLP increased with core-size, Fe concentration, AMF frequency, and amplitude. Given that: (1) the SLP was insensitive to viscosity of glycerol-water solutions and (2) both the calculated effective relaxation time and the fitted relaxation time were closer to Néel relaxation time, we propose that the heating generation mechanism of magnetoferritin nanoparticles is dominated by the Néel relaxation. This work provides new insights into the heating efficiency of magnetoferritin and potential future applications for tumor magnetic hyperthermia treatment and heat-triggered drug release.

scholarly journals Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1203
Author(s):  
Hira Fatima ◽  
Tawatchai Charinpanitkul ◽  
Kyo-Seon Kim
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Hyperthermia Treatment ◽  
Coating Materials ◽  
Heating Efficiency ◽  
Hyperthermia Therapy ◽  
Corona Formation

The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.

scholarly journals Shape Effects of Iron Nanowires on Hyperthermia Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Wei-Syuan Lin ◽  
Hong-Ming Lin ◽  
Hsiang-Hsin Chen ◽  
Yeu-Kuang Hwu ◽  
Yuh-Jing Chiou
Keyword(s):  
Magnetic Field ◽  
Magnetic Anisotropy ◽  
Material Properties ◽  
Iron Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Hyperthermia Treatment ◽  
One Dimensional ◽  
Heating Efficiency ◽  
Shape Effects ◽  
Iron Nanowires

This research discusses the influence of morphology of nanomagnetic materials (one-dimensional iron nanowires and zero-dimensional iron nanoparticles) on heating efficiency of the hyperthermia treatment. One-dimensional iron nanowires, synthesized by reducing method in external magnetic field, are explored in terms of their material properties, magnetic anisotropy, and cytotoxicity of EMT-6 cells. The magnetic anisotropy of an array of nanowires is examined in parallel and perpendicular magnetic fields by VSM. For the magnetic hyperthermia treatment tests, iron nanowires and nanoparticles with different concentrations are heated in alternating magnetic field to measure their actual heating efficiency and SLP heating properties. The shape effects of iron nanomaterials can be revealed from their heating properties. The cytotoxicity of nanowires with different concentrations is measured by its survival rate in EMT-6 with the cells cultivated for 6 and 24 hours.

scholarly journals Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

2021 ◽  
Vol 2 (1) ◽  
pp. 51-60
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli ◽  
Siti Nur Amalina Mohamad Sukri
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Heating Efficiency ◽  
Heating Source ◽  
Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

scholarly journals Biocompatible and stable magnetosome minerals coated with poly-l-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors

2017 ◽  
Vol 5 (36) ◽  
pp. 7644-7660 ◽  
Author(s):  
Chalani Mandawala ◽  
Imène Chebbi ◽  
Mickael Durand-Dubief ◽  
Raphael Le Fèvre ◽  
Yasmina Hamdous ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Oleic Acid ◽  
Magnetic Nanoparticles ◽  
Citric Acid ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment ◽  
Carboxy Methyl

Magnetic hyperthermia in which magnetic nanoparticles are introduced into tumors and exposed to an alternating magnetic field, appears to be promising.

Contribution of a 300 kHz alternating magnetic field on magnetic hyperthermia treatment of HepG2 cells

2012 ◽  
Vol 34 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Xiaowen Wang ◽  
Youping Chen ◽  
Changshuo Huang ◽  
Xufei Wang ◽  
Linyun Zhao ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Hepg2 Cells ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Hyperthermia Treatment

Mechanically Milled Co1-xFexO4 Nanocrystalline for Magnetic Hyperthermia Application

2019 ◽  
Vol 59 ◽  
pp. 25-34
Author(s):  
O.M Lemine ◽  
Sharif Abu Alrub
Keyword(s):  
Magnetic Field ◽  
Magnetic Measurements ◽  
Magnetic Hyperthermia ◽  
Annealed Sample ◽  
Alternating Magnetic Field ◽  
Mass Ratio ◽  
X Ray Diffraction ◽  
Heating Efficiency ◽  
Powder Mass

Mechanical alloying of a mixture of Fe2O3 and CoO powders has been applied for the preparation of nanocrystalline. Utilizing a ball-to-powder mass ratio of 20, milling time of 20 hours followed by annealing at 900°C, we could obtain a nanocrystalline of high crystallinity and composed of mainly CoFe2O4 phase with presence of Fe2O3 as revealed by X-ray diffraction (XRD) measurements. Magnetic measurements using vibrating sample magnetometer (VSM) reveal high saturation magnetization for the annealed sample close to CoFe2O4 phase value. The heating efficiency of the obtained nanocrystalline is studied under an alternating magnetic field and as a function of the concentration. It was found that the nanocrystalline generate a substantial amount of heat when exposed to an alternating magnetic field. In vitro hyperthermia experiment was carried out and our result clearly demonstrates the ability of the obtained nanocrystalline to kill cancer cell through magnetic hyperthermia.

scholarly journals Heat induction in two-dimensional graphene–Fe3O4 nanohybrids for magnetic hyperthermia applications with artificial neural network modeling

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21702-21715
Author(s):  
M. S. Dar ◽  
Khush Bakhat Akram ◽  
Ayesha Sohail ◽  
Fatima Arif ◽  
Fatemeh Zabihi ◽  
...  
Keyword(s):  
Neural Network ◽  
Magnetic Field ◽  
Artificial Neural Network ◽  
Network Modeling ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Neural Network Modeling ◽  
Two Dimensional ◽  
Artificial Neural Network Modeling ◽  
Heat Induction

Synthesis of Fe3O4–graphene (FG) nanohybrids and magnetothermal measurements of FxG100–x (x = 0, 25, 45, 65, 75, 85, 100) nanohybrids (25 mg each) at a 633 kHz alternating magnetic field of strength 9.1 mT.

scholarly journals Biophysical Characterization of (Silica-coated) Cobalt Ferrite Nanoparticles for Hyperthermia Treatment

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1713 ◽  
Author(s):  
Niklas Lucht ◽  
Ralf P. Friedrich ◽  
Sebastian Draack ◽  
Christoph Alexiou ◽  
Thilo Viereck ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Particle System ◽  
Medical Condition ◽  
Low Cost ◽  
Heat Stroke ◽  
Magnetic Hyperthermia ◽  
Modern Medicine ◽  
The Body ◽  
Jurkat Cells ◽  
Hyperthermia Treatment

Magnetic hyperthermia is a technique that describes the heating of material through an external magnetic field. Classic hyperthermia is a medical condition where the human body overheats, being usually triggered by a heat stroke, which can lead to severe damage to organs and tissue due to the denaturation of cells. In modern medicine, hyperthermia can be deliberately induced to specified parts of the body to destroy malignant cells. Magnetic hyperthermia describes the way that this overheating is induced and it has the inherent advantage of being a minimal invasive method when compared to traditional surgery methods. This work presents a particle system that offers huge potential for hyperthermia treatments, given its good loss value, i.e., the particles dissipate a lot of heat to their surroundings when treated with an ac magnetic field. The measurements were performed in a low-cost custom hyperthermia setup. Additional toxicity assessments on Jurkat cells show a very low short-term toxicity on the particles and a moderate low toxicity after two days due to the prevalent health concerns towards nanoparticles in organisms.

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