scholarly journals Hematological Alterations Related to Treatment with Teriflunomide and Dimethyl Fumarate in Multiple Sclerosis

NeuroSci ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 17-23
Author(s):  
Daniel Apolinar García-Estévez
Keyword(s):  
Multiple Sclerosis ◽  
Mechanism Of Action ◽  
Blood Cells ◽  
White Blood Cells ◽  
Dimethyl Fumarate ◽  
Acquired Immunity ◽  
First Year ◽  
Inherent Safety ◽  
Safety Risks ◽  
Hematological Alterations

The exact mechanism of action of different modifying treatments in the evolutionary course of multiple sclerosis (MS) remains unknown, but it is assumed that they act upon the cells involved in acquired immunity. One effect of these treatments is the development of lymphopenia, which carries inherent safety risks. This study was conducted to understand the alterations that teriflunomide (TERI) and dimethyl fumarate (DMF) exert upon white blood cells in a series of patients with MS. This study included a total of 99 patients; 44 treated with DMF and 55 patients treated with TERI. Blood counts were evaluated at baseline and every 6 months in order to track the absolute leukocyte, lymphocyte, and neutrophil counts. Twelve months after starting treatment, we observed a significant decrease in leukocytes (21.1%), lymphocytes (39.1%), and neutrophils (10%) in the DMF group. In the TERI group, leukocytes decreased by 11.1%, lymphocytes by 8.1%, and neutrophils by 15.7%. Both TERI and DMF produced a significant decrease in leukocytes during the first year of treatment and this was mainly related with a decrease in neutrophils in the TERI group and a decrease in lymphocytes in the DMF group.

scholarly journals Therapeutic Value of Single Nucleotide Polymorphisms on the Efficacy of New Therapies in Patients with Multiple Sclerosis

2021 ◽  
Vol 11 (5) ◽  
pp. 335
Author(s):  
María José Zarzuelo Romero ◽  
Cristina Pérez Ramírez ◽  
María Isabel Carrasco Campos ◽  
Almudena Sánchez Martín ◽  
Miguel Ángel Calleja Hernández ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mechanism Of Action ◽  
Dimethyl Fumarate ◽  
Response To Treatment ◽  
Nucleotide Polymorphisms ◽  
New Therapies ◽  
Therapeutic Value ◽  
The Impact

The introduction of new therapies for the treatment of multiple sclerosis (MS) is a very recent phenomenon and little is known of their mechanism of action. Moreover, the response is subject to interindividual variability and may be affected by genetic factors, such as polymorphisms in the genes implicated in the pathologic environment, pharmacodynamics, and metabolism of the disease or in the mechanism of action of the medications, influencing the effectiveness of these therapies. This review evaluates the impact of pharmacogenetics on the response to treatment with new therapies in patients diagnosed with MS. The results suggest that polymorphisms detected in the GSTP1, ITGA4, NQO1, AKT1, and GP6 genes, for treatment with natalizumab, ZMIZ1, for fingolimod and dimethyl fumarate, ADA, for cladribine, and NOX3, for dimethyl fumarate, may be used in the future as predictive markers of treatment response to new therapies in MS patients. However, there are few existing studies and their samples are small, making it difficult to generalize the role of these genes in treatment with new therapies. Studies with larger sample sizes and longer follow-up are therefore needed to confirm the results of these studies.

scholarly journals How Similar are Pharmacy Students and White Blood Cells? Curricular Content Reinforced Through Personification

2019 ◽  
Vol 10 (3) ◽  
pp. 12
Author(s):  
Kenric Ware
Keyword(s):  
Blood Cells ◽  
Statistical Significance ◽  
White Blood Cells ◽  
Pharmacy Education ◽  
Pharmacy Students ◽  
First Year ◽  
Roles And Responsibilities ◽  
Curricular Content ◽  
Article Type ◽  
And Gender

Description: This initiative sought to evaluate the use of personification to reinforce immunology concepts among pharmacy students.  A two-part question posed to first year pharmacy students asked if they could physically become two white blood cells (WBCs), which would they choose and why. Students received instruction in immunology prior to providing their feedback. Demographics included campus of enrollment and gender designation. Student ratings 1 to 5 reflected approval levels toward this activity’s usefulness (1: least; 5 most). Key Findings: One hundred and ten of 117 students selected two WBCs they would physically become if possible (94%). Less than two-thirds of students were female (63%) and the Columbia campus featured approximately a quarter of the students (24%). The most and least common WBCs chosen, as first selections by campus and gender, were statistically significant being neutrophils and basophils, lymphocytes and eosinophils, respectively. The median approval values of the WBC personification activity by campus and gender were similar and did not reach statistical significance, 4.5 and 5, respectively. Conclusion: Pharmacy students commended the personification activity for helping them learn the roles and responsibilities of WBCs. Unique and insightful rationales for the choices made for WBCs persisted among the students. In light of these favorable reviews, this type of activity can be adapted to other areas of pharmacy education.   Article Type: Note

scholarly journals Megaloblastosis Produced by a Cytosine Antagonist

Blood ◽  
1963 ◽  
Vol 21 (3) ◽  
pp. 352-362 ◽  
Author(s):  
R. W. TALLEY ◽  
V. K. VAITKEVICIUS
Keyword(s):  
Bone Marrow ◽  
Dna Synthesis ◽  
Mechanism Of Action ◽  
Cytosine Arabinoside ◽  
Peripheral Blood ◽  
Blood Cells ◽  
White Blood Cells ◽  
Structural Similarity ◽  
Mitotic Abnormalities ◽  
Temporary Decrease

Abstract 1. Cytosine arabinoside induced objective, but temporary, decrease of tumor masses in three patients with lymphosarcoma and slight decrease in some lesions in two out of ten treated patients with disseminated carcinomatosis. 2. In doses of 3 to 50 mg./Kg. given at varying intervals, cytosine arabinoside induced definite megaloblastic changes in the marrow of all patients studied. Mitotic abnormalities similar to those found in other megaloblastic anemias also occurred. 3. Associated with bone marrow changes, depressions of hemoglobin, white blood cells and platelets in the peripheral blood were observed. 4. The exact mechanism of action of cytosine arabinoside has not been elucidated. It is speculated that because of the close structural similarity between cytidylic acid, cytosine arabinoside could interfere with DNA synthesis.

scholarly journals Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis

2018 ◽  
Vol 9 ◽  
Author(s):  
Elizabeth A. Mills ◽  
Magdalena A. Ogrodnik ◽  
Andrew Plave ◽  
Yang Mao-Draayer
Keyword(s):  
Multiple Sclerosis ◽  
Mechanism Of Action ◽  
Dimethyl Fumarate

Effectiveness and side effects of dimethyl fumarate in multiple sclerosis after 12 months of follow up: An Iranian clinical trial

2020 ◽  
Author(s):  
Mohsen Foroughipour ◽  
Sahar Gazeran
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Complete Blood Count ◽  
Brain Magnetic Resonance Imaging ◽  
Dimethyl Fumarate ◽  
Liver Function Tests ◽  
First Year ◽  
Medical Sciences ◽  
Disability Status ◽  
Magnetic Resonance Imaging Mri

Background: Multiple sclerosis (MS) is a neurologic disorder with a considerable global burden. During the last decades, some pharmaceutical treatments have been approved for patients with MS. Dimethyl fumarate (DMF) is one of these drugs which has been reported to have early promising results in recent studies, but the efficacy of this drug in patients with MS is still being studied in different parts of the world. In the present study, we evaluated the effectiveness of DMF therapy on reducing relapses, lesions, and disability in Iranian patients with MS. Methods: The present single-arm before-after study was approved by the Ethics Committee of Mashhad University of Medical Sciences, Mashhad, Iran [Iranian Registry of Clinical Trial (IRCT) code: IRCT20190121042439N1]. Every patient who was diagnosed with relapsing MS was considered eligible to enroll in the present clinical trial. Before receiving DMF therapy, the baseline liver function tests and complete blood count were obtained from all individuals. Also, a baseline brain magnetic resonance imaging (MRI) was obtained and Expanded Disability Status Scale (EDSS) was documented from all patients. After receiving 240 mg DMF twice daily for 12 months, the laboratory and imaging measurements as well as EDSS were repeated. Furthermore, the total number of relapses within the study period was recorded. Satisfaction with DMF treatment was determined by answering a yes-no question. Results: A total number of 50 patients enrolled in the study and most of them were female (80%). There was a significant decrease in EDSS score and gadolinium (GD)-enhancing lesions after the study period (P < 0.001 for each). Moreover, the attacks significantly dropped after the study period (P < 0.001) and 86% of patients were satisfied with their treatment. Conclusion: The findings of this study showed that 240 mg DMF administered twice daily can effectively reduce disability and provide satisfaction within the first year of therapy in patients with MS.

Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis

2019 ◽  
Vol 97 (4) ◽  
pp. 463-472 ◽  
Author(s):  
Sudhir Kumar Yadav ◽  
Devika Soin ◽  
Kouichi Ito ◽  
Suhayl Dhib-Jalbut
Keyword(s):  
Multiple Sclerosis ◽  
Mechanism Of Action ◽  
Dimethyl Fumarate ◽  
Insight Into

scholarly journals Morphofunctional and Hematological Characteristics of Health in Students from the Northern and Southern Regions of Kazakhstan

2021 ◽  
Vol 9 (A) ◽  
pp. 753-759
Author(s):  
Saule Bazarbaeva ◽  
Aigul Dinmukhamedova ◽  
Gulnara Tleubergenova ◽  
Zhanar Rakhimzhanova ◽  
Kamila Sembekova ◽  
...  
Keyword(s):  
Health Status ◽  
Blood Cells ◽  
White Blood Cells ◽  
Health Condition ◽  
Northern Region ◽  
Climatic Conditions ◽  
Southern Region ◽  
First Year ◽  
First Year Students ◽  
Significant Difference

The study aimed at investigating morphofunctional and hematological features of the first-year students’ health condition. The health status for a total of 400 first-year students, who arrived for studying from the northern region (North Kazakhstan) and the southern region (Turkestan, Kyzylorda), was estimated during the study. The morphological (BMI, vital lung capacity, etc.) and hematological (the total number of red blood cells, white blood cells, the concentration of hemoglobin in the blood, etc.) indicators of the health status were investigated. By comparing the condition of physical health in students from both regions, a significant difference in main morphofunctional and hematological indices has been established. The functional indicators of the cardiovascular and respiratory systems were higher in students from the southern region, which reflects a good adaptive reaction to studying at a university, as well as new climatic and geographical conditions. Students from the southern region were reported to have lower red blood cell amounts and diagnosed with mild anemia compared to those from the northern region. Therefore, constant monitoring of the health condition among youth is required to develop effective tactics for the students’ smooth adjusting to living in new climatic conditions.

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