Dietary Acid Load, IGF-1 Single Nucleotide Polymorphism and Bone Resorption among Postmenopausal Chinese Women

The interaction of dietary and genetic factors may affect the development of bone deterioration. This study investigated whether the effects of dietary acid load (DAL) on bone loss in postmenopausal Chinese women were moderated by the insulin-like growth factor-1 (IGF-1) single nucleotide polymorphism, a known gene that plays a role in the regulation of bone formation and bone remodeling. A total of 217 healthy participants were recruited from the National Council of Senior Citizens Organizations Malaysia. Serum collagen type 1 cross-linked C-telopeptide was used as a surrogate bone marker to assess bone resorption and Agena® MassARRAY genotyping analysis was used to identify the signaling of IGF-1 rs35767. The dietary acid load was measured by potential renal acid load score while physical activity was ascertained using the Global Physical Activity Questionnaire. Hierarchical regression was applied to test the main and interaction effects of DAL and IGF-1 genotypes in bone resorption. The result supported the diet-dependent acid-base balance theory that higher DAL was positively associated with bone resorption (β = 0.152, p = 0.031, F(6,207) = 2.11, sig-F = 0.036, R2 = 0.079). However, the results indicated that there was no significant correlation between IGF-1 and bone resorption, or any significant interaction between DAL and IGF-1. In conclusion, there was no moderating effect of IGF-1 on the relationship between DAL and bone resorption.

Download Full-text

No Interaction Effect between Interleukin-6 Polymorphisms and Acid Ash Diet with Bone Resorption Marker in Postmenopausal Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020827 ◽

2021 ◽

Vol 18 (2) ◽

pp. 827

Author(s):

Sook Yee Lim ◽

Yoke Mun Chan ◽

Vasudevan Ramachandran ◽

Zalilah Mohd Shariff ◽

Yit Siew Chin ◽

...

Keyword(s):

Bone Resorption ◽

Postmenopausal Women ◽

Interaction Effect ◽

Interleukin 6 ◽

Gene Polymorphisms ◽

Bone Resorption Marker ◽

Dietary Intakes ◽

Dietary Acid Load ◽

Dietary Acid ◽

Acid Load

Background: Evidence is growing that a high-acid diet might accelerate the rate of bone loss, and gene polymorphisms such as Interleukin 6 (IL6) -174G/C and -572G/C are related to bone deterioration. However, no study of the interaction between diet and IL6 polymorphisms has been conducted among Asians. Thus, the objective of this study was to determine whether IL6 gene polymorphisms modified the association between dietary acidity and the rate of bone resorption. Methods: This cross-sectional study recruited 203 postmenopausal women (age ranged from 51 to 85 years old) in community settings. The dietary intakes of the participants were assessed using a validated interviewer-administered semi-quantitative food frequency questionnaire (FFQ), while dietary acid load (DAL) was estimated using net endogenous acid production (NEAP). Agena® MassARRAY genotyping analysis and serum collagen type 1 cross-linked C-telopeptide (CTX1) were used to identify the IL6 genotype and as a bone resorption marker, respectively. The interactions between diet and single-nucleotide polymorphisms (SNPs) were assessed using linear regressions. Results: A total of 203 healthy postmenopausal women aged between 51 and 85 years participated in this study. The mean BMI of the participants was 24.3 kg/m2. In IL6 -174 G/C, all the participants carried the GG genotype, while the C allele was absent. Approximately 40% of the participants had a high dietary acid load. Dietary acid load (B = 0.15, p = 0.031) and the IL6 -572 CC genotype group (B = 0.14, p = 0.044) were positively associated with a higher bone resorption. However, there was no moderating effect of the IL6 genetic polymorphism on the relationship between and acid ash diet and bone resorption markers among the postmenopausal women (p = 0.79). Conclusion: High consumption of an acid ash diet and the IL6 -572 C allele seem to attribute to high bone resorption among postmenopausal women. However, our finding does not support the interaction effect of dietary acidity and IL6 (-174G/C and -572G/C) polymorphisms on the rate of bone resorption. Taken together, these results have given scientific research other candidate genes to focus on which may interact with DAL on bone resorption, to enhance planning for preventing or delaying the onset of osteoporosis among postmenopausal women.

Download Full-text

Association of a single nucleotide polymorphism at 6q25.1,rs2046210, with endometrial cancer risk among Chinese women

Chinese Journal of Cancer ◽

10.5732/cjc.010.10516 ◽

2011 ◽

Vol 30 (2) ◽

pp. 138-143 ◽

Cited By ~ 5

Author(s):

Guoliang Li ◽

Yong-Bing Xiang ◽

Regina Courtney ◽

Jia-Rong Cheng ◽

Bo Huang ◽

...

Keyword(s):

Single Nucleotide Polymorphism ◽

Endometrial Cancer ◽

Cancer Risk ◽

Chinese Women ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Endometrial Cancer Risk

Download Full-text

The FTO rs17817449 Polymorphism is Not Associated With Sedentary Time, Physical Activity, or Cardiorespiratory Fitness: Findings From the GENADIO Cross-Sectional Study

Journal of Physical Activity and Health ◽

10.1123/jpah.2021-0076 ◽

2021 ◽

pp. 1-6

Author(s):

Miquel Martorell ◽

Lorena Mardones ◽

Fanny Petermann-Rocha ◽

Maria Adela Martinez-Sanguinetti ◽

Ana Maria Leiva-Ordoñez ◽

...

Keyword(s):

Physical Activity ◽

Single Nucleotide Polymorphism ◽

Cardiorespiratory Fitness ◽

Sedentary Time ◽

Risk Allele ◽

Cross Sectional Study ◽

Sectional Study ◽

Nucleotide Polymorphism ◽

Cross Sectional ◽

Single Nucleotide

Background: Genetic variants within the FTO gene have been associated with increased adiposity and metabolic markers; however, there is limited evidence regarding the association of FTO gene variants with physical activity-related variables. The authors aimed to investigate the association of the rs17817449 single-nucleotide polymorphism of FTO with physical activity, sedentary time, and cardiorespiratory fitness in Chilean adults. Methods: A total of 409 participants from the GENADIO study were included and genotyped for the rs17817449 single-nucleotide polymorphism of FTO in this cross-sectional study. Physical activity and sedentary time were measured with ActiGraph accelerometers. Cardiorespiratory fitness was assessed using the Chester step test. The associations were assessed by using multivariate regression analyses. Results: No associations were found for FTO variant with physical activity levels and cardiorespiratory fitness. The risk allele (G) of the FTO was found to be associated with sedentary time in the minimally adjusted model (β = 19.7 min/d; 95% confidence interval, 4.0 to 35.5, per each copy of the risk allele; P = .006), but the association was no longer significant when body mass index was included as a confounder (P = .211). Conclusion: The rs17817449 single-nucleotide polymorphism of the FTO gene was not associated with the level of physical activity, cardiorespiratory fitness, and sedentary behaviors in Chilean adults.

Download Full-text

Single Nucleotide Polymorphism of SREBF-1 Gene Associated with an Increased Risk of Endometrial Cancer in Chinese Women

PLoS ONE ◽

10.1371/journal.pone.0090491 ◽

2014 ◽

Vol 9 (3) ◽

pp. e90491 ◽

Cited By ~ 4

Author(s):

Chun-Ping Qiu ◽

Qing-Tao Lv ◽

Samina Dongol ◽

Chenguang Wang ◽

Jie Jiang

Keyword(s):

Single Nucleotide Polymorphism ◽

Endometrial Cancer ◽

Chinese Women ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Increased Risk

Download Full-text

Association of MicroRNA-502-Binding Site Single Nucleotide Polymorphism of Lysine Ethyltransferase8 Gene with Cervical Cancer Risk in Chinese Women

Journal of Bionanoscience ◽

10.1166/jbns.2014.1191 ◽

2014 ◽

Vol 8 (1) ◽

pp. 51-55 ◽

Cited By ~ 1

Author(s):

Haiyan Guo ◽

Yanlin Cai ◽

Shaodi Yang ◽

Pei Jiang

Keyword(s):

Cervical Cancer ◽

Single Nucleotide Polymorphism ◽

Cancer Risk ◽

Binding Site ◽

Chinese Women ◽

Nucleotide Polymorphism ◽

Single Nucleotide ◽

Cervical Cancer Risk

Download Full-text

Dietary Acid Load and Its Interaction with IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) Polymorphisms on Metabolic Traits among Postmenopausal Women

Nutrients ◽

10.3390/nu13072161 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2161

Author(s):

Sook Yee Lim ◽

Yoke Mun Chan ◽

Vasudevan Ramachandran ◽

Zalilah Mohd Shariff ◽

Yit Siew Chin ◽

...

Keyword(s):

Postmenopausal Women ◽

Fasting Blood Glucose ◽

Community Dwelling ◽

Nucleotide Polymorphisms ◽

Significant Interaction Effect ◽

Single Nucleotide ◽

Dietary Acid Load ◽

Metabolic Traits ◽

Dietary Acid ◽

Acid Load

The objective of this study was to explore the effects of dietary acid load (DAL) and IGF1 and IL6 gene polymorphisms and their potential diet–gene interactions on metabolic traits. A total of 211 community-dwelling postmenopausal women were recruited. DAL was estimated using potential renal acid load (PRAL). Blood was drawn for biochemical parameters and DNA was extracted and Agena® MassARRAY was used for genotyping analysis to identify the signalling of IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) polymorphisms. Interactions between diet and genetic polymorphisms were assessed using regression analysis. The result showed that DAL was positively associated with fasting blood glucose (FBG) (β = 0.147, p < 0.05) and there was significant interaction effect between DAL and IL6 with systolic blood pressure (SBP) (β = 0.19, p = 0.041). In conclusion, these findings did not support the interaction effects between DAL and IGF1 and IL6 single nucleotide polymorphisms (rs35767, rs7136446, and rs1800796) on metabolic traits, except for SBP. Besides, higher DAL was associated with higher FBG, allowing us to postulate that high DAL is a potential risk factor for diabetes.

Download Full-text

Higher dietary acid load is associated with a higher prevalence of frailty, particularly slowness/weakness and low physical activity, in elderly Japanese women

European Journal of Nutrition ◽

10.1007/s00394-017-1449-4 ◽

2017 ◽

Vol 57 (4) ◽

pp. 1639-1650 ◽

Cited By ~ 5

Author(s):

Yuki Kataya ◽

◽

Kentaro Murakami ◽

Satomi Kobayashi ◽

Hitomi Suga ◽

...

Keyword(s):

Physical Activity ◽

Japanese Women ◽

Dietary Acid Load ◽

Elderly Japanese Women ◽

Dietary Acid ◽

Acid Load ◽

Elderly Japanese

Download Full-text

Association of Dietary Acid Load with the Risk of Insulin Resistance in Middle-Aged and Older Korean Adults

Current Developments in Nutrition ◽

10.1093/cdn/nzaa043_074 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 223-223

Author(s):

Kyung Won Lee ◽

Dayeon Shin

Keyword(s):

Physical Activity ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Metabolic Acidosis ◽

Dietary Acid Load ◽

Korean Adults ◽

Dietary Acid ◽

Acid Load ◽

Low Levels

Abstract Objectives Prospective studies on the relationship between diet-induced acid-base imbalance and insulin resistance among Asian populations have been limited. Thus, we investigated weather diet-induced metabolic acidosis was prospectively associated with insulin resistance risk in middle-aged and older Korean adults. Methods A total of 5663 participants from the Korean Genome and Epidemiology Study without type 2 diabetes, insulin resistance, or cancer at baseline were included in this study. To estimate diet-induced metabolic acidosis, we used potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. They were calculated from the usual dietary intake assessed by a validated 103-item food frequency questionnaire at baseline. Multivariable Cox proportional hazard models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of the future risk of insulin resistance after adjusting for covariates. Results During a mean of 7.4-year of follow-up, we documented 3623 insulin resistance cases. In the fully adjusted model, the future risks of insulin resistance were significantly higher among participants in the highest quartiles of PRAL (HR: 1.28, 95% CI: 1.12–1.46, Ptrend = 0.0002) and NEAP (HR: 1.28, 95% CI: 1.12–1.46, Ptrend = 0.0013) compared with those in the lowest. Associations were slightly strengthened among men, adults aged <50 years, those having obesity or low levels of physical activity. Conclusions Diet-induced metabolic acidosis is associated with an increased risk of insulin resistance, irrespective of other type 2 diabetes risk factors. Moreover, we observed effect modifiers of associations between dietary acid load scores and insulin resistance, suggesting stronger effects among men, those aged <50 years, obese individuals, or individuals with low levels of physical activity. Funding Sources None.

Download Full-text