The FTO rs17817449 Polymorphism is Not Associated With Sedentary Time, Physical Activity, or Cardiorespiratory Fitness: Findings From the GENADIO Cross-Sectional Study

2021 ◽  
pp. 1-6
Author(s):  
Miquel Martorell ◽  
Lorena Mardones ◽  
Fanny Petermann-Rocha ◽  
Maria Adela Martinez-Sanguinetti ◽  
Ana Maria Leiva-Ordoñez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Single Nucleotide Polymorphism ◽  
Cardiorespiratory Fitness ◽  
Sedentary Time ◽  
Risk Allele ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Nucleotide Polymorphism ◽  
Cross Sectional ◽  
Single Nucleotide

Background: Genetic variants within the FTO gene have been associated with increased adiposity and metabolic markers; however, there is limited evidence regarding the association of FTO gene variants with physical activity-related variables. The authors aimed to investigate the association of the rs17817449 single-nucleotide polymorphism of FTO with physical activity, sedentary time, and cardiorespiratory fitness in Chilean adults. Methods: A total of 409 participants from the GENADIO study were included and genotyped for the rs17817449 single-nucleotide polymorphism of FTO in this cross-sectional study. Physical activity and sedentary time were measured with ActiGraph accelerometers. Cardiorespiratory fitness was assessed using the Chester step test. The associations were assessed by using multivariate regression analyses. Results: No associations were found for FTO variant with physical activity levels and cardiorespiratory fitness. The risk allele (G) of the FTO was found to be associated with sedentary time in the minimally adjusted model (β = 19.7 min/d; 95% confidence interval, 4.0 to 35.5, per each copy of the risk allele; P = .006), but the association was no longer significant when body mass index was included as a confounder (P = .211). Conclusion: The rs17817449 single-nucleotide polymorphism of the FTO gene was not associated with the level of physical activity, cardiorespiratory fitness, and sedentary behaviors in Chilean adults.

scholarly journals Objectively measured sedentary time and physical activity in women with fibromyalgia: a cross-sectional study

BMJ Open ◽  
2013 ◽  
Vol 3 (6) ◽  
pp. e002722 ◽  
Author(s):  
Jonatan R Ruiz ◽  
Víctor Segura-Jiménez ◽  
Francisco B Ortega ◽  
Inmaculada C Álvarez-Gallardo ◽  
Daniel Camiletti-Moirón ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sedentary Time ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Objectively Measured

scholarly journals Cardiometabolic risk in children and adolescents: mediation analysis of crosssectional study. [Riesgo cardiometabólico en niños y adolescentes: análisis de mediación de un estudio transversal].

2021 ◽  
Vol 17 (65) ◽  
pp. 204-220
Author(s):  
Noelia González-Gálvez ◽  
◽  
Jose Carlos Ribeiro ◽  
Jorge Mota ◽  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Children And Adolescents ◽  
Cardiorespiratory Fitness ◽  
Cardiometabolic Risk ◽  
Cross Sectional Study ◽  
Mean Blood Pressure ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fitness Level

The aims of this study were a) to assess whether obesity acts as a mediator between i) cardiorespiratory fitness (CRF) and mean blood pressure; and ii) between between physical activity (PA) and mean blodd pressure in children and adolescents. A cross-sectional study was conducted with a 632 children and adolescents. It was measured mean blood pressure, body mass index, fat mass and waist circumference. CRF and PA was assessing with Course Navette test and ActiGraph. The analysis of the mediation was performed using Process macro for SPSS. The results indicate that obesity acts as a partial mediation in the association between CRF and mean blood pressure in 10-12 years old children (z=from -5.81 to -5.40; all p˂0.000). These results indicate that obesity acts as a complete mediator in the association between PA and mean blood pressure in 10-12 years old children (z=from -4.49 to -1.94; all p˂0.000). Our result reinforces the relevance of prevent weight increse and improve cardiorespiratory fitness level since erly age in children and adolescents to prevent high mean blood pressure. Increasing the level of physical activity can influence on obesity and cardiorespiratory fitness.

scholarly journals The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study

2019 ◽  
Vol 16 (19) ◽  
pp. 3697 ◽  
Author(s):  
Fernanda M. Silva ◽  
João Petrica ◽  
João Serrano ◽  
Rui Paulo ◽  
André Ramalho ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Fitness ◽  
Upper Limb ◽  
Sedentary Time ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Active Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Inactive Group

Background: Ageing is a life-long process characterized by a progressive loss of physical fitness compromising strength, flexibility, and agility. The purpose of this study was to use accelerometry to examine the relationship between sedentary time, light physical activity (LPA), and moderate to vigorous physical activity (MVPA) with the elderly’s physical fitness. Additionally, we aimed to examine the association between the aforementioned variables on older adults who fulfilled global recommendations on physical activity for health and on those who did not fulfil these recommendations. Methods: Eighty-three elderly (mean ± SD: 72.14 ± 5.61 years old) of both genders volunteered to participate in this cross-sectional study, being divided into an active group (n = 53; 71.02 ± 5.27 years old) and an inactive group (n = 30; 74.13 ± 5.72 years old) according to the established guidelines. Sedentary and physical activity times were assessed using an ActiGraph® GT1M accelerometer, whereas physical fitness was evaluated with the Senior Fitness Test. Results: MVPA time was correlated with lower body mass index (BMI) ((rs = −0.218; p = 0.048; −0.3 < r ≤ −0.1 (small)) and shorter time to complete the agility test ((rs = −0.367; p = 0.001; −0.5 < r ≤ −0.3 (low)). Moreover, MVPA time was positively correlated with aerobic endurance ((rs = 0.397; p = 0.000; 0.5 < r ≤ 0.3 (low)) and strength ((rs = 0.243; p = 0.027; 0.3 < r ≤ 0.1 (small)). In the inactive group, MVPA time was positively correlated with upper limb flexibility ((rs = 0.400; p = 0.028; 0.5 < r ≤ 0.3 (low)); moreover, sedentary time was negatively correlated with upper limb flexibility ((r = −0.443; p = 0.014; −0.5 < r ≤ −0.3 (low)), and LPA time was negatively correlated with BMI ((r = −0.423; p = 0.020; −0.5 < r ≤ −0.3 (low)). In the active group, MVPA time was correlated with lower BMI ((rs = −0.320; p = 0.020; −0.5 < r ≤ −0.3 (low)), and shorter time to complete agility test ((rs = −0.296; p = 0.031; −0.3 < r ≤ −0.1 (small)). Conclusions: Our results reinforce the importance of promoting MVPA practice among the elderly, thereby allowing physical fitness maintenance or improvement.

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