scholarly journals Vitamin Status and Diet in Elderly with Low and High Socioeconomic Status: The Lifelines-MINUTHE Study

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2659
Author(s):  
Yinjie Zhu ◽  
Isidor Minović ◽  
Louise H. Dekker ◽  
Manfred L. Eggersdorfer ◽  
Sander K.R. van Zon ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Folic Acid ◽  
Vitamin B12 ◽  
Health Inequalities ◽  
Diet Quality ◽  
Vitamin B6 ◽  
Low Ses ◽  
Vitamin Deficiencies ◽  
Vitamin Status ◽  
Increased Risk

Socioeconomic health inequalities are an important global public health problem. However, it is not well known to what extent socioeconomic inequalities culminate in impaired vitamin status and whether this is mediated by diet. We, therefore, aimed to assess vitamin status in a population already at increased risk of micronutrient deficiency, i.e., elderly with high and low socioeconomic status (SES), and to investigate whether potential differences therein were mediated by diet quality. Vitamin status in 1605 individuals (60–75 years) from the Lifelines- Micronutrients and Health inequalities in Elderly (MINUTHE) Study was assessed by measuring folic acid and the vitamins B6, B12, D, A, E, and K. Multinomial logistic and linear regression analyses were applied to test the associations between SES and vitamin status. Mediation analysis was used to explore the interrelationship between SES, diet quality, and vitamin status. Low SES was associated with poorer status of vitamin B6, vitamin B12, and, notably, folic acid. Moreover, multivitamin deficiencies were more prevalent in the low SES group. Diet quality was found to mediate the associations of SES with folic acid (for 39.1%), vitamin B6 (for 37.1%), and vitamin B12 (for 37.2%). We conclude that low SES is a risk factor for a spectrum of vitamin deficiencies. Diet quality can partially explain the socioeconomic differences in vitamin status, suggesting that policymakers can mitigate socioeconomic inequality in nutritional status through improving diet quality.

scholarly journals Nutritional Status and Diet in Elderly with Low and High Socioeconomic Status

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
Y Zhu ◽  
I Minović ◽  
L H Dekker ◽  
M Eggersdorfer ◽  
S K R van Zon ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Risk Factor ◽  
Health Disparities ◽  
Folic Acid ◽  
Nutritional Status ◽  
Diet Quality ◽  
Vitamin B6 ◽  
The Elderly ◽  
Low Ses ◽  
Vitamin Status

Abstract Background Socioeconomic status (SES) patterned health disparities have been related to differences in dietary intake, especially in the elderly. Still, it is not known to what extent these differences culminate in vitamin deficiencies, as most studies have assessed nutrient intake, instead of measuring nutritional biomarkers. Hence, we aimed to objectively assess nutritional status in elderly with low and high SES and to investigate whether potential differences therein were mediated by diet. Methods 1605 individuals (60-75 years) were selected from the LifeLines Cohort Study to create two gender-matched groups with different SES. Nutritional status was assessed by measuring folic acid, vitamin B6, B12, D, A, E and K in the collected samples. SES-groups were defined according to highest completed education as high and low, and dietary quality was assessed the Lifelines Diet Score. Multiple linear regression and logistic regression were first used for the association between SES and vitamin status; and mediation analysis was used to explore the relationship of SES, diet and vitamin status. Results The overall prevalence of vitamin deficiency ranged from 4.1% (vitamin B6) to 19.5% (folic acid). The low SES group had significantly poorer status (p ≤ 0.04) of most vitamins, including the B vitamins (i.e., folic acid, B12 and B6) as well as multivitamin deficiencies (p ≤ 0.02). Low SES was independently associated with decreased folic acid, vitamin B6, vitamin B12, and vitamin A serum concentrations (p ≤ 0.03 for all). Diet quality was found to partially mediate the association between SES, and folic acid (39.1%), vitamin B6 (37.1%) and vitamin B12 (37.2%)(P ≤ 0.03). Conclusions Low SES is a risk factor for suboptimal nutritional status. The association between SES and nutritional status can be partially explained by diet quality, suggesting that policy makers can mitigate socioeconomic inequality in nutritional status by improving diet quality among elderly. Key messages Revealed that low SES was a risk factor for a suboptimal nutritional status among the elderly and a possible self-reinforcing trap has formed which causes low SES and hidden hunger to persist. Highlighted the importance of diet quality in socioeconomically patterned health disparities and indicating the need for SES-tailored public health strategies.

scholarly journals Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

TURKDERM ◽  
2017 ◽  
pp. 92-97
Author(s):  
Meltem Uslu ◽  
Neslihan Şendur ◽  
Ekin Şavk ◽  
Aslıhan Karul ◽  
Didem Kozacı ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Vitamin B6

6074Cardiorespiratory fitness, socioeconomic status and mortality in middle-aged men: a population-based prospective cohort study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Y Jae ◽  
S Kurl ◽  
B A Franklin ◽  
J Choo ◽  
H J Kim ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Heart Disease ◽  
Density Lipoprotein ◽  
Population Based ◽  
Lipoprotein Cholesterol ◽  
Low Ses ◽  
Risk Of Death ◽  
Increased Risk ◽  
Material Standard Of Living ◽  
Cvd Mortality

Abstract Background Although both low socioeconomic status (SES) and poor cardiorespiratory fitness (CRF) are associated with increased chronic disease and a heightened risk of death, it remains unclear whether moderate-to-high levels of CRF confer survival benefits in low SES populations. Purpose The present study evaluated the hypothesis that SES and CRF predict all-cause mortality (ACM), cardiovascular disease (CVD) mortality and sudden cardiac death (SCD), and that moderate-to-high levels of CRF may attenuate the associations between low SES and adverse cardiovascular outcomes. Methods This prospective study was based on a population-based sample of 2,368 men aged 42 to 61 years, who were followed in the Kuopio Ischemic Heart Disease cohort. CRF was directly measured by peak oxygen uptake (VO2peak) during progressive exercise testing to volitional fatigue. SES was characterized using self-reported questionnaires via combined measures of income, education, occupation, occupational prestige, material standard of living, and housing conditions. CRF and SES were divided into tertiles, and 4 combined groups (Fit-high SES, Fit-low SES, Unfit-high SES, and Unfit-low SES) based on the median values of CRF and SES. Results During a 25 year median follow-up (interquartile ranges: 18–27 years), 1116 ACM, 512 CVD mortality and 221 SCD events occurred. After adjusting for potential confounders (age, smoking, alcohol, body mass index, systolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glucose, diabetes, hypertensive medication, family history of coronary heart disease, and physical activity), the lowest levels of SES were at significantly increased risk for ACM (hazard ratio (HR) 1.49, 95% Confidence Interval (CI): 1.30–1.71), CVD mortality (HR 1.38, 1.13–1.69) and SCD (HR 1.34, 0.97–1.84). In contrast, higher levels of CRF were associated with lower risks of ACM (HR 0.56, 0.46–0.67), CVD mortality (HR 0.53, 0.40–0.71) and SCD (HR 0.53, 0.34–0.83). In combined associations of SES and CRF with mortality, unfit-low SES had significantly higher risks of ACM (HR 2.12, 1.75–2.57), CVD mortality (HR 2.20, 1.64–2.94) and SCD (HR 2.95, 1.79–4.86), but fit-low SES was not associated with a heightened risk of cardiovascular mortality or SCD (CVD mortality, 1.03, 0.73–1.46; SCD, 1.54, 0.87–2.72) as compared with their fit-high SES counterparts (reference). Conclusion Our findings indicate that both SES and CRF are independently associated with the risk of death; however, moderate-to-high levels of CRF appear to attenuate the risk of CVD mortality and SCD in low SES men. These unique data have important implications for public health interventions designed to enhance survival in underserved population cohorts.

scholarly journals Plasma Vitamin B6 Vitamers before and after Oral Vitamin B6 Treatment: A Randomized Placebo-controlled Study

2003 ◽  
Vol 49 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Mustafa Vakur Bor ◽  
Helga Refsum ◽  
Marianne R Bisp ◽  
Øyvind Bleie ◽  
Jorn Schneede ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Oral Treatment ◽  
Prolonged Treatment ◽  
Controlled Study ◽  
Plasma Vitamin ◽  
Additional Increase ◽  
Before And After ◽  
B Vitamin

Abstract Background: Vitamin B6 has attracted renewed interest because of its role in homocysteine metabolism and its possible relation to cardiovascular risk. We examined the plasma B6 vitamers, pyridoxal 5′-phosphate (PLP), pyridoxal (PL), pyridoxine (PN), and 4-pyridoxic acid (4-PA) before and after vitamin B6 supplementation. Methods: Patients (n = 90; age range, 38–80 years) undergoing coronary angiography (part of the homocysteine-lowering Western Norway B-Vitamin Intervention Trial) were allocated to the following daily oral treatment groups: (A), vitamin B12 (0.4 mg), folic acid (0.8 mg), and vitamin B6 (40 mg); (B), vitamin B12 and folic acid; (C), vitamin B6; or (D), placebo. EDTA blood was obtained before treatment and 3, 14, 28, and 84 days thereafter. Results: Before treatment, PLP (range, 5–111 nmol/L) and 4-PA (6–93 nmol/L) were the predominant B6 vitamers identified in plasma. During the 84-day study period, the intraindividual variation (CV) in patients not treated with vitamin B6 (groups B and D) was 45% for PLP and 67% for 4-PA. Three days after the start of treatment, the increases in concentration were ∼10-, 50-, and 100-fold for PLP, 4-PA, and PL, respectively. No significant additional increase was observed at the later time points. The PLP concentration correlated to the concentrations of 4-PA and PL before treatment, but not after treatment. The PL concentration correlated with 4-PA before and after treatment. Conclusions: Vitamin B6 treatment has an immediate effect on the concentrations and the forms of B6 vitamers present in plasma, and the changes remain the same during prolonged treatment. Our results suggest that the B6 vitamers in plasma reflect vitamin B6 intake.

Bread fortification with folic acid, vitamin B12, and vitamin B6 in Hungary

The Lancet ◽  
1998 ◽  
Vol 352 (9135) ◽  
pp. 1225 ◽  
Author(s):  
Andrew E Czeizel ◽  
Zoltan Merhala
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Vitamin B6

Optimization of folic acid, vitamin B12, and vitamin B6 supplements in pediatric patients with sickle cell disease

2002 ◽  
Vol 69 (4) ◽  
pp. 239-246 ◽  
Author(s):  
Fey P.L. van der Dijs ◽  
M. Rebecca Fokkema ◽  
D.A. Janneke Dijck-Brouwer ◽  
Bram Niessink ◽  
Thaliet I.C. van der Wal ◽  
...  
Keyword(s):  
Folic Acid ◽  
Sickle Cell Disease ◽  
Vitamin B12 ◽  
Sickle Cell ◽  
Vitamin B6 ◽  
Pediatric Patients ◽  
Cell Disease

Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Rima Obeid ◽  
Wolfgang Herrmann
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Plasma Homocysteine ◽  
Vitamin B ◽  
Total Plasma ◽  
Vitamin Status ◽  
B Vitamin ◽  
Early Abortion

AbstractStudies linking hyperhomocysteinemia (HHCY) and B-vitamin deficiency to some health aspects in children have been accumulating. Low B-vitamin status inearly life, even as early as the time of conception, may endanger the potential for new life and may negatively influence the health of the offspring. Early abortion, pregnancy complications and poor pregnancy outcomes have been linked to elevated concentrations of total plasma homocysteine (tHcy) and low folate or vitamin B

scholarly journals The role of increased levels of homocysteine in the development of cardiovascular diseases

2006 ◽  
Vol 59 (3-4) ◽  
pp. 143-147 ◽  
Author(s):  
Zoran Ceperkovic
Keyword(s):  
Folic Acid ◽  
Amino Acid ◽  
Cardiovascular Diseases ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Heart Diseases ◽  
Daily Intake ◽  
Cholesterol Oxidation ◽  
Total Risk ◽  
Homocysteine Concentration

Introduction. Homocysteine is a sulphur amino acid produced by demethylation of the essential amino acid methionine. Dysfunction of certain enzymes or insufficient intake of nutrients may cause increase of intracellular homocysteine, which is then exported into plasma. Etiopathogenesis of cardiovascular diseases accompanied with higher level of homocysteine. McCully's theory suggests that high levels of homocysteine are associated with cardiovascular diseases, arteriosclerosis and endothelial dysfunction. Harmful effects of homocysteine are associated with LDL cholesterol oxidation, increased production of collagen, lower availability of nitric oxide as well as prothrombotic activity. Reduction of homocysteine levels. The most recent researches show that hyperhomocysteinemia is responsible for about 10% of total risk of cardiovascular diseases. Vitamin BJ2 plays a major role in the remethylation of homocysteine. Reducing the homocysteine concentration in blood by 3 mol/l (with daily intake of 0.8 mg of folic acid) reduces the risk of ishemic heart diseases by 16%, vein thrombosis by 25%, and stroke by 24%. A six-month therapy with folic acid (Img/d), vitamin B12 (400g/d) and vitamin B6 (10mg/d), reduces the frequency of cardiovascular occurrences after successful PTCA. Plasma homocysteine concentration over 12/1 doubles the risk of myocardial infarction. Conclusion. A lack of folates, vitamin B6 and vitamin B12 increases the level of homocysteine and thus increases the risk of cardiovascular diseases. Changes in lifestyle and diet, as well as intake of food supplements, are of great importance in reducing homocysteine levels in plasma and therefore in reducing the occurrence and acceleration of arteriosclerosis. .

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