Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea

The gut microbiota has been suggested as an important factor in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether the intake of different kinds of dietary fiber was related to the disease progression rate (∆FS) and survival time. In total, 272 Korean sporadic ALS patients diagnosed according to the revised EI Escorial criteria were recruited starting in March 2011 and were followed until the occurrence of events or the end of September 2020. The events included percutaneous endoscopic gastrostomy, tracheostomy, and death. Dietary fiber intake was calculated based on a 24-h dietary recall and classified according to five major fiber-rich foods: vegetables, fruits, grains, legumes, and nuts/seeds. Among the total participants, the group with ∆FS values lower than the mean ∆FS (0.75) was noted in the highest tertiles of total and vegetable fiber intake. Participants in the highest tertile for vegetable fiber intake showed longer survival in the Kaplan–Meier analysis (p = 0.033). Notably, vegetable fiber intake was negatively correlated with pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1) levels in the cerebrospinal fluid. This study showed that vegetable fiber intake could influence the disease progression rate and survival time. Further clinical trials are needed to confirm whether dietary fiber supplementation improves the prognosis of ALS.

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Relationship between Dietary Fiber Intake and the Prognosis of Amyotrophic Lateral Sclerosis

10.20944/preprints202010.0466.v1 ◽

2020 ◽

Author(s):

Haelim Yu ◽

Seung Hyun Kim ◽

Min-Young Noh ◽

Sang-Gon Lee ◽

Yongsoon Park

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Survival Time ◽

Disease Progression ◽

Dietary Fiber ◽

Progression Rate ◽

Fiber Intake ◽

Dietary Fiber Intake ◽

Disease Progression Rate ◽

Lateral Sclerosis ◽

Vegetable Fiber

The gut microbiota has been suggested as an important factor in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether the intake of different kinds of dietary fiber was related to the disease progression rate (∆FS) and survival time. In total, 272 sporadic ALS patients diagnosed according to the revised EI Escorial criteria were recruited from March 2011 and were followed-up until the occurrence of events or the end of September 2020. The events included percutaneous endoscopic gastrostomy, tracheostomy, and death. Dietary fiber intake was calculated based on a 24-hour dietary recall and classified according to five major fiber-rich foods: vegetables, fruits, grains, legumes, and nuts/seeds. Among the total participants, the group with ∆FS values lower than the mean ∆FS (0.75) was noted in the highest tertiles of total and vegetable fiber intake. Participants with the highest tertile of vegetable fiber intake showed longer survival in the Kaplan–Meier analysis (p = 0.033). Notably, vegetable fiber intake was negatively correlated with pro-inflammatory cytokine (interleukin [IL]-1β, IL-6, and monocyte chemoattractant protein-1) levels in the cerebrospinal fluid. This study showed that vegetable fiber intake could influence the disease progression rate and survival time. Further clinical trials are needed to confirm whether dietary fiber supplementation improves the prognosis of ALS.

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Effect of Dietary Fiber Intake on the Prognosis of Amyotrophic Lateral Sclerosis

Current Developments in Nutrition ◽

10.1093/cdn/nzab053_100 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 1107-1107

Author(s):

Haelim Yu ◽

Seung Hyun Kim ◽

Min-Young Noh ◽

Sanggon Lee ◽

Yongsoon Park

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Survival Time ◽

Dietary Fiber ◽

Fiber Intake ◽

Negatively Associated ◽

Dietary Fiber Intake ◽

Sporadic Als ◽

Als Patients ◽

Lateral Sclerosis ◽

Vegetable Fiber

Abstract Objectives The gut microbiota has been suggested to associate with the pathophysiology of amyotrophic lateral sclerosis (ALS), and thus prebiotic effect of fiber could play an important role on pathophysiology of ALS. The present study aimed to investigate the effect of dietary fiber intake on the disease progression rate (∆FS) and survival time among Korean ALS patients. Methods A total of 272 Korean sporadic ALS patients diagnosed according to the revised EI Escorial criteria were recruited during 2011–2019, and were followed until the occurrence of events or the end of September 2020. The events were defined as percutaneous endoscopic gastrostomy, tracheostomy, or death. Intake of dietary fibers was calculated based on 24-hour dietary recall, and divided into five major fiber-rich foods: vegetables, fruits, grains, legumes, and nuts/seeds. Results There were higher proportion of participants with lower than the mean value of ∆FS (0.75) in the highest tertile of total fiber and vegetable fiber intake than those in the lowest tertile. Kaplan–Meier analysis showed that participants in the highest tertile for vegetable fiber intake had longer survival. Cox regression analysis showed that intake of vegetable fiber was negatively associated with risk for events after adjustment. Notably, vegetable fiber intake was negatively correlated with pro-inflammatory cytokine such as interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1 in the cerebrospinal fluid. Conclusions In conclusion, this study showed that vegetable fiber intake was negatively associated to the ∆FS and shorter survival time, suggesting that vegetable fiber intake could influence the prognosis of ALS. Further clinical trials are needed to confirm whether supplementation of dietary fiber improves the prognosis in ALS. Funding Sources This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT).

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Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2017-316605 ◽

2017 ◽

Vol 89 (4) ◽

pp. 367-373 ◽

Cited By ~ 37

Author(s):

Maxim De Schaepdryver ◽

Andreas Jeromin ◽

Benjamin Gille ◽

Kristl G Claeys ◽

Victor Herbst ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Cerebrospinal Fluid ◽

Motor Neuron ◽

Disease Progression ◽

Roc Curves ◽

Symptom Duration ◽

Progression Rate ◽

Alternative Source ◽

Disease Progression Rate ◽

Lateral Sclerosis

ObjectivePhosphorylated neurofilament heavy chain (pNfH) levels are elevated in cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). Instead of CSF, we explored blood as an alternative source to measure pNfH in patients with ALS.MethodsIn this single centre retrospective study, 85 patients with ALS, 215 disease controls (DC) and 31 ALS mimics were included. Individual serum pNfH concentrations were correlated with concentrations in CSF and with several clinical parameters. The performance characteristics of pNfH in CSF and serum of patients with ALS and controls were calculated and compared using receiver operating characteristic (ROC) curves.ResultsCSF and serum pNfH concentrations in patients with ALS correlated well (r=0.652, p<0.0001) and were significantly increased compared with DC (p<0.0001) and ALS mimics (p<0.0001). CSF pNfH outperformed serum pNfH in discriminating patients with ALS from DC and ALS mimics (difference between area under the ROC curves: p=0.0001 and p=0.0005; respectively). Serum pNfH correlated inversely with symptom duration (r=−0.315, p=0.0033). CSF and serum pNfH were lower when the disease progression rate was slower (r=0.279, p<0.01 and r=0.289, p<0.01; respectively). Unlike CSF, serum pNfH did not correlate with the burden of clinical and electromyographic motor neuron dysfunction.ConclusionsCSF and serum pNfH concentrations are elevated in patients with ALS and correlate with the disease progression rate. Moreover, CSF pNfH correlates with the burden of motor neuron dysfunction. Our findings encourage further pursuit of CSF and serum pNfH concentrations in the diagnostic pathway of patients suspected to have ALS.

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Cerebral degeneration in amyotrophic lateral sclerosis

Neurology Clinical Practice ◽

10.1212/cpj.0000000000000674 ◽

2019 ◽

Vol 9 (5) ◽

pp. 400-407 ◽

Cited By ~ 4

Author(s):

Ojas Srivastava ◽

Chris Hanstock ◽

Sneha Chenji ◽

Dennell Mah ◽

Dean Eurich ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Prefrontal Cortex ◽

Motor Cortex ◽

Disease Progression ◽

Progression Rate ◽

Healthy Controls ◽

Potential Biomarker ◽

Disease Progression Rate ◽

Lateral Sclerosis ◽

Cerebral Degeneration

BackgroundWe investigated cerebral degeneration and neurochemistry in patients with amyotrophic lateral sclerosis (ALS) using magnetic resonance spectroscopy (MRS).MethodsWe prospectively studied 65 patients and 43 age-matched healthy controls. Participants were recruited from 4 centers as part of a study in the Canadian ALS Neuroimaging Consortium. All participants underwent single-voxel proton MRS using a protocol standardized across all sites. Metabolites reflecting neuronal integrity (total N-acetyl aspartyl moieties [tNAA]) and gliosis (myo-inositol [Ino]), as well as creatine (Cr) and choline (Cho), were quantified in the midline motor cortex and midline prefrontal cortex. Comparisons were made between patients with ALS and healthy controls. Metabolites were correlated with clinical measures of upper motor neuron dysfunction, disease progression rate, and cognitive performance.ResultsIn the motor cortex, tNAA/Cr, tNAA/Cho, and tNAA/Ino ratios were reduced in the ALS group compared with controls. Group differences in tNAA/Cr and tNAA/Cho in the prefrontal cortex displayed reduced ratios in ALS patients; however, these were not statistically significant. Reduced motor cortex ratios were associated with slower foot tapping rate, whereas only motor tNAA/Ino was associated with finger tapping rate. Disease progression rate was associated with motor tNAA/Cho. Verbal fluency, semantic fluency, and digit span forwards and backwards were associated with prefrontal tNAA/Cr.ConclusionsThis study demonstrates that cerebral degeneration in ALS is more pronounced in the motor than prefrontal cortex, that multicenter MRS studies are feasible, and that motor tNAA/Ino shows promise as a potential biomarker.

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Exploration of the Association between Dietary Fiber Intake and Hypertension among U.S. Adults Using 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines: NHANES 2007–2014

Nutrients ◽

10.3390/nu10081091 ◽

2018 ◽

Vol 10 (8) ◽

pp. 1091 ◽

Cited By ~ 7

Author(s):

Baoqi Sun ◽

Xiaoyan Shi ◽

Tong Wang ◽

Dongfeng Zhang

Keyword(s):

Blood Pressure ◽

Dietary Fiber ◽

American Heart Association ◽

Family Income ◽

American Heart ◽

Smoking Status ◽

Heart Association ◽

Fiber Intake ◽

Dietary Fiber Intake ◽

Vegetable Fiber

This study aimed to explore the association between dietary fiber intake and hypertension risk using 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. Data from the National Health and Nutrition Examination Survey 2007–2014 were used in this study. Dietary fiber data were obtained through two 24-h dietary recall interviews. Hypertension was defined as systolic blood pressure (SBP) ≥ 130 mmHg or diastolic blood pressure (DBP) ≥ 80 mmHg or treatment with hypertensive medications. Logistic regression models and restricted cubic spline models were applied to evaluate the associations between dietary intakes of total, cereal, vegetable, and fruit fiber and hypertension. A total of 18,433 participants aged 18 years or older were included in the analyses. After adjustment for age, gender, body mass index (BMI), race, educational level, smoking status, family income, and total daily energy intake, compared with the lowest tertile, the odds ratios (95% confidence intervals) of hypertension for the highest tertile intakes of total, cereal, vegetable, and fruit fiber were 0.62 (0.52–0.75), 0.80 (0.67–0.96), 0.82 (0.69–0.98), and 0.86 (0.71–1.04), respectively. Dose-response analyses revealed that the risk of hypertension was associated with total fiber intake in a nonlinear trend, while the relationships were linear for cereal and vegetable fiber intakes. Our results suggested that the intakes of total, cereal, and vegetable fiber, but not fruit fiber, were associated with a decreased risk of hypertension in U.S. adults.

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Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis: a longitudinal cohort study

10.1101/2021.10.05.21264570 ◽

2021 ◽

Author(s):

Can Cui ◽

Caroline Ingre ◽

Li Yin ◽

Xia Li ◽

John Andersson ◽

...

Keyword(s):

T Cells ◽

Amyotrophic Lateral Sclerosis ◽

Nk Cells ◽

Functional Status ◽

Disease Progression ◽

Lymphocyte Subpopulations ◽

Progression Rate ◽

Risk Of Death ◽

Disease Progression Rate ◽

Lateral Sclerosis

Background: Immune response changes have been reported in amyotrophic lateral sclerosis (ALS), but their clinical relevance remains undetermined. Therefore, we aim to evaluate the relationships between blood leukocyte subpopulations and prognosis of ALS.<br />Methods: A longitudinal cohort of 288 ALS patients with up to 5 years of follow-up during 2015-2020 were recruited at the only tertiary referral center for ALS in Stockholm, Sweden. Routine differential leukocyte counts, and determination of lymphocyte subpopulations including an extended T cell panel with flow cytometry, collected at diagnosis and at regular intervals thereafter. The primary outcome was risk of death (alternatively use of invasive ventilation) after diagnosis of ALS. The secondary outcomes included repeatedly measured functional status - through Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-R) score and disease progression rate. Cox model was used to evaluate the associations between leukocytes and risk of death. Generalized estimating equation model (GEE) was used to assess the correlation between leukocytes and ALSFRS-R score<br />and disease progression rate.<br />Results: The counts of leukocytes, neutrophils and monocytes increased gradually over time since diagnosis and were negatively correlated with ALSFRS-R score, but not associated with risk of death or disease progression rate. Focusing on lymphocyte subpopulations, increasing counts of natural killer (NK) cells (HR=0.61, 95% CI= [0.42-0.88] per SD increase) and proportions of Th2-diffrentiated CD4+ central memory (CM) T cells (HR=0.64, 95% CI= [0.48-0.85] per SD increase) were correlated with a lower risk of death. Increasing proportions of CD4+ effector memory cells re-expressing CD45RA (EMRA) T cells (HR=1.39, 95% CI= [1.01-1.92] per SD increase) and CD8+ T cells (HR=1.38, 95% CI= [1.03-1.86] per SD increase) were associated with a higher risk of death. None of the lymphocyte subpopulations was correlated with ALSFRS-R score or disease progression rate.<br />Conclusion: Our findings suggest a dual role of immune responses in ALS prognosis, where neutrophils and monocytes primarily reflect functional status whereas NK cells and different T lymphocyte populations act as prognostic markers for survival.

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