Acrylamide–Hemoglobin Adduct Levels in a Japanese Population and Comparison with Acrylamide Exposure Assessed by the Duplicated Method or a Food Frequency Questionnaire

The levels of hemoglobin adducts of acrylamide (AA–Hb), a biomarker of acrylamide exposure, have not been reported for Japanese subjects. Herein, we determined the AA–Hb levels in a Japanese population and compared them with the estimated dietary intake from the duplicate diet method (DM) and a food frequency questionnaire (FFQ). One-day DM samples, FFQ, and blood samples were collected from 89 participants and analyzed for acrylamide. AA–Hb was analyzed using liquid chromatography tandem mass spectrometry and the N-alkyl Edman method. Participants were divided into tertiles of estimated acrylamide intake and geometric means (GMs) of AA–Hb adjusted for sex and smoking status. A stratified analysis according to smoking status was also performed. The average AA–Hb levels for all participants, never, past, and current smokers were 46, 38, 65, and 86 pmol/g Hb, respectively. GMs of AA–Hb levels in all participants were significantly associated with tertiles of estimated acrylamide intake from DM (p for trend = 0.02) and FFQ (p for trend = 0.04), although no association with smokers was observed. AA–Hb levels reflected smoking status, which were similar to values reported in Western populations, and they were associated with estimated dietary intake of acrylamide when adjusted for sex and smoking status.

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Evaluation of a food frequency questionnaire to determine dietary intake in a large cohort: The SAPALDIA study

Aktuelle Ernährungsmedizin ◽

10.1055/s-0032-1312542 ◽

2012 ◽

Vol 37 (03) ◽

Cited By ~ 1

Author(s):

N Steinemann ◽

IU Leonhäuser ◽

N Probst-Hensch ◽

L Grize ◽

C Brombach

Keyword(s):

Dietary Intake ◽

Food Frequency Questionnaire ◽

Large Cohort ◽

Food Frequency

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Validity of a food frequency questionnaire for the estimation of total polyphenol intake estimates and its major food sources in the Japanese population: the JPHC FFQ Validation Study

Journal of Nutritional Science ◽

10.1017/jns.2021.25 ◽

2021 ◽

Vol 10 ◽

Author(s):

Nagisa Mori ◽

Norie Sawada ◽

Junko Ishihara ◽

Ayaka Kotemori ◽

Ribeka Takachi ◽

...

Keyword(s):

Validation Study ◽

Food Frequency Questionnaire ◽

Japanese Population ◽

Alcoholic Beverages ◽

Food Sources ◽

Total Polyphenol ◽

Food Frequency ◽

Dietary Polyphenols ◽

Dietary Record ◽

Polyphenol Intake

Abstract We examine the validity and reproducibility of a food frequency questionnaire (FFQ) in a subsample of participants in the Japan Public Health Center-based Prospective Cohort Study using a database of polyphenol-containing foods commonly consumed in the Japanese population. Participants of the validation study were recruited from two different cohorts. In Cohort I, 215 participants completed a 28-d dietary record (DR) and the FFQ, and in Cohort II, 350 participants completed DRs and the FFQ. The total polyphenol intake estimated from the 28-d DR and FFQ were log-transformed and adjusted for energy intake by the residual method. Spearman correlation coefficients (CCs) between estimates from the FFQ and 28-d DR as well as two FFQs administered at a 1-year interval were computed. Median intakes of dietary polyphenols calculated from the DRs were 1172 mg/d for men and 1024 mg/d for women in Cohort I, and 1061 mg/d for men and 942 mg/d for women in Cohort II. The de-attenuated CCs for polyphenol intake between the DR and FFQ were 0⋅47 for men and 0⋅37 for women in Cohort I and 0⋅44 for men and 0⋅50 for women in Cohort II. Non-alcoholic beverages were the main contributor to total polyphenol intake in both men and women, accounting for 50 % of total polyphenol intake regardless of cohort and gender, followed by alcoholic beverages and seasoning and spices in men, and seasoning and spices, fruits and other vegetables in women. The present study showed that this FFQ had moderate validity and reproducibility and is suitable for use in future epidemiological studies.

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Development and validation of a food frequency questionnaire for Japanese athletes (FFQJA)

Journal of the International Society of Sports Nutrition ◽

10.1186/s12970-021-00433-5 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Kazuko Ishikawa-Takata ◽

Kaori Okamoto ◽

Motoko Taguchi

Keyword(s):

Dietary Intake ◽

Food Frequency Questionnaire ◽

Kappa Statistic ◽

Portion Size ◽

Vitamin B ◽

Kappa Index ◽

Food Frequency ◽

Supplement Use ◽

Food Items ◽

Dietary Records

Abstract Background Food frequency questionnaires are considered an effective method for assessing habitual dietary intake, but they must be developed or validated with the target population. Portion size, supplement use and food choice are thought to be especially important methodological considerations for assessing athletes’ dietary intake. This study aimed to develop and validate a food frequency questionnaire for Japanese athletes using data from this population. Methods We used dietary records from 440 Japanese athletes involved in our previous projects. Food items were analyzed using cumulative percentage contributions and multiple regression analysis, to give a selection of 62 basic food items and four supplemental items. The validity of the questionnaire was evaluated among another 77 Japanese athletes by comparing nutrient intakes assessed using the questionnaire with dietary records. Reproducibility was evaluated by comparing a second questionnaire completed 2–3 weeks later by 36 of the athletes in the validation study. Validity was assessed using crude Spearman’s correlation coefficients (CCs), energy-adjusted CCs, intraclass CCs (ICCs), and Kappa index values. Reproducibility was assessed by CCs, energy-adjusted CCs, and ICCs. Results In the validation analysis, the median crude CC for all of the nutrients was 0.407, ranging from 0.222 for dietary fiber to 0.550 for carbohydrate. The median energy-adjusted CC was 0.478, and the median ICC was 0.369. When we divided the athletes into quartiles, 65% (vitamin B1) to 86% (iron) of athletes were classified into the same or adjacent categories using the questionnaire and dietary records, with a median Kappa statistic of 0.32. In the reproducibility analysis, the median crude CC between the two completed questionnaires was 0.654, ranging from 0.582 (carbohydrate) to 0.743 (vitamin B2). The median energy-adjusted CC was 0.643, and the median ICC was 0.647. Conclusions The new 62-item food frequency questionnaire is both reliable and valid and may be useful for assessing food intake in Japanese athletes.

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Apixaban concentration variability and relation to clinical outcomes in real-life patients with atrial fibrillation

Scientific Reports ◽

10.1038/s41598-021-93372-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Alenka Mavri ◽

Nina Vene ◽

Mojca Božič-Mijovski ◽

Marko Miklič ◽

Lisbeth Söderblom ◽

...

Keyword(s):

Atrial Fibrillation ◽

Clinical Outcomes ◽

Thromboembolic Event ◽

Real Life ◽

Individual Variability ◽

Blood Samples ◽

Chromatography Tandem Mass Spectrometry ◽

Significant Difference ◽

Liquid Chromatography Tandem Mass ◽

Peak Blood

AbstractIn some clinical situations, measurements of anticoagulant effect of apixaban may be needed. We investigated the inter- and intra-individual apixaban variability in patients with atrial fibrillation and correlated these results with clinical outcome. We included 62 patients receiving either 5 mg (A5, n = 32) or 2.5 mg (A2.5, n = 30) apixaban twice-daily. We collected three trough and three peak blood samples 6–8 weeks apart. Apixaban concentration was measured by liquid chromatography-tandem mass-spectrometry (LC–MS/MS) and by anti-Xa. Patients on A2.5 were older, had lower creatinine clearance, higher CHA2DS2VASc (4.7 ± 1.0 vs. 3.4 ± 1.7) and lower trough (85 ± 39 vs. 117 ± 53 ng/mL) and peak (170 ± 56 vs. 256 ± 91 ng/mL) apixaban concentrations than patients on A5 (all p < 0.01). In patients on A5, LC–MS/MS showed a significant difference between through levels and between peak levels (p < 0.01). During apixaban treatment, 21 patients suffered bleeding (2 major). There was no association between bleeding and apixaban concentrations or variability. Four patients who suffered thromboembolic event had lower peak apixaban concentrations than patients without it (159 ± 13 vs. 238 ± 88 ng/mL, p = 0.05). We concluded, that there was a significant intra- and inter-individual variability in apixaban trough and peak concentrations. Neither variability nor apixaban concentrations were associated with clinical outcomes.

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