scholarly journals Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 517
Author(s):  
Calogera Pisano ◽  
Daniele Polisano ◽  
Carmela Rita Balistreri ◽  
Claudia Altieri ◽  
Paolo Nardi ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiovascular Diseases ◽  
Physical Inactivity ◽  
Relevant Literature ◽  
Accelerated Aging ◽  
Moderate Intensity ◽  
Physical Frailty ◽  
Biological Substrate ◽  
Frail Phenotype

Frailty is the major expression of accelerated aging and describes a decreased resistance to stressors, and consequently an increased vulnerability to additional diseases in elderly people. The vascular aging related to frail phenotype reflects the high susceptibility for cardiovascular diseases and negative postoperative outcomes after cardiac surgery. Sarcopenia can be considered a biological substrate of physical frailty. Malnutrition and physical inactivity play a key role in the pathogenesis of sarcopenia. We searched on Medline (PubMed) and Scopus for relevant literature published over the last 10 years and analyzed the strong correlation between frailty, sarcopenia and cardiovascular diseases in elderly patient. In our opinion, a right food intake and moderate intensity resistance exercise are mandatory in order to better prepare patients undergoing cardiac operation.

scholarly journals Caloric restriction mimetics for the treatment of cardiovascular diseases

2020 ◽  
Author(s):  
Sebastiano Sciarretta ◽  
Maurizio Forte ◽  
Francesca Castoldi ◽  
Giacomo Frati ◽  
Francesco Versaci ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Animal Models ◽  
Caloric Restriction ◽  
Molecular Mechanisms ◽  
Relevant Literature ◽  
Ischaemia Reperfusion Injury ◽  
Acute Ischaemia ◽  
Beneficial Effects ◽  
Mechanical Overload

Abstract Caloric restriction mimetics (CRMs) are emerging as potential therapeutic agents for the treatment of cardiovascular diseases. CRMs include natural and synthetic compounds able to inhibit protein acetyltransferases, to interfere with acetyl coenzyme A biosynthesis, or to activate (de)acetyltransferase proteins. These modifications mimic the effects of caloric restriction, which is associated with the activation of autophagy. Previous evidence demonstrated the ability of CRMs to ameliorate cardiac function and reduce cardiac hypertrophy and maladaptive remodelling in animal models of ageing, mechanical overload, chronic myocardial ischaemia, and in genetic and metabolic cardiomyopathies. In addition, CRMs were found to reduce acute ischaemia–reperfusion injury. In many cases, these beneficial effects of CRMs appeared to be mediated by autophagy activation. In the present review, we discuss the relevant literature about the role of different CRMs in animal models of cardiac diseases, emphasizing the molecular mechanisms underlying the beneficial effects of these compounds and their potential future clinical application.

scholarly journals Stroke és a cardiorespiratoricus fittség

2021 ◽  
Vol 162 (39) ◽  
pp. 1567-1572
Author(s):  
Péter Apor
Keyword(s):  
Physical Activity ◽  
Cardiovascular Diseases ◽  
Physical Inactivity ◽  
Metabolic Diseases ◽  
Significant Risk ◽  
Endurance Performance ◽  
Primary And Secondary Prevention ◽  
The Past ◽  
Intensity Physical Activity

Összefoglaló. A fizikai inaktivitás a cardiovascularis betegségek – így a stroke – jelentős kockázati tényezője. A rendszeres testmozgás növeli az aerob kapacitást, a cardiorespiratoricus fittséget – ezzel csökkenti a cardiovascularis betegségek, köztük a stroke kockázatát. Az elmúlt évek azon vizsgálataiból idéz a közlemény, amelyek a fizikai aktivitás, a cardiorespiratoricus teljesítőképesség szerepét ismertetik a stroke elsődleges és másodlagos prevenciójában. Említésre kerülnek az aerob kapacitás mérésének módszerei. A nemzetközi tapasztalatok azt igazolják, hogy magas cardiorespiratoricus fittség esetén közel harmadával csökken a stroke előfordulása. A WHO ajánlása mindenkinek a heti legalább 150 percnyi mérsékelten-közepesen meglihegtető testi tevékenység – ez a leggyakoribb krónikus betegségek ellen bizonyos védelmet ad. Orv Hetil. 2021; 162(39): 1567–1572. Summary. Physical inactivity is a significant risk for cardiovascular diseases, even for stroke. Regular physical activity improves aerobic capacity, cardiorespiratory fitness, aerob endurance performance (synonyms), diminishing the risk of cardiovascular diseases as well as the risk of stroke. We refer to previous literature data from the past two decades demonstrating the beneficial role of the higher aerob fitness in the primary and secondary prevention of stroke. Relevant methods of measuring aerob performance have been described previously. In the case of optimal aerobic fitness, the occurrence of stroke is lower by a third according to international experience. WHO advices moderate-medium intensity physical activity of minimum 150 minutes per week, which carries significant protection against the majority of chronic cardio-metabolic diseases. Orv Hetil. 2021; 162(39): 1567–1572.

Risk factors for stroke after cardiac surgery: The role of screening carotid ultrasonography

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
U Boeken ◽  
P Akhyari ◽  
JP Minol ◽  
A Assmann ◽  
A Lichtenberg
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Carotid Ultrasonography

Systemic inflammatory complications in cardiac surgery – role of cytokines and complement

2005 ◽  
Vol 53 (S 3) ◽  
Author(s):  
U Boeken ◽  
P Feindt ◽  
J Litmathe ◽  
D Kindgen-Milles ◽  
S Loer ◽  
...  
Keyword(s):  
Cardiac Surgery

The Use of Posterior Pericardiotomy Technique to Prevent Postoperative Pericardial Effusion in Cardiac Surgery

2012 ◽  
Vol 15 (2) ◽  
pp. 84 ◽  
Author(s):  
Canturk Cakalagaoglu ◽  
Cengiz Koksal ◽  
Ayse Baysal ◽  
Gokhan Alici ◽  
Birol Ozkan ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Heart Surgery ◽  
Artery Bypass ◽  
Pericardial Tamponade ◽  
Anxiety Level ◽  
Control Group ◽  
Echocardiographic Study ◽  
Number Of Patients ◽  
Hospital Stays

<p><b>Aim:</b> The goal was to determine the effectiveness of the posterior pericardiotomy technique in preventing the development of early and late pericardial effusions (PEs) and to determine the role of anxiety level for the detection of late pericardial tamponade (PT).</p><p><b>Materials and Methods:</b> We divided 100 patients randomly into 2 groups, the posterior pericardiotomy group (n = 50) and the control group (n = 50). All patients undergoing coronary artery bypass grafting surgery (CABG), valvular heart surgery, or combined valvular and CABG surgeries were included. The posterior pericardiotomy technique was performed in the first group of 50 patients. Evaluations completed preoperatively, postoperatively on day 1, before discharge, and on postoperative days 5 and 30 included electrocardiographic study, chest radiography, echocardiographic study, and evaluation of the patient's anxiety level. Postoperative causes of morbidity and durations of intensive care unit and hospital stays were recorded.</p><p><b>Results:</b> The 2 groups were not significantly different with respect to demographic and operative data (<i>P</i> > .05). Echocardiography evaluations revealed no significant differences between the groups preoperatively; however, before discharge the control group had a significantly higher number of patients with moderate, large, and very large PEs compared with the pericardiotomy group (<i>P</i> < .01). There were 6 cases of late PT in the control group, whereas there were none in the pericardiotomy group (<i>P</i> < .05). Before discharge and on postoperative day 15, the patients in the pericardiotomy group showed significant improvement in anxiety levels (<i>P</i> = .03 and .004, respectively). No differences in postoperative complications were observed between the 2 groups.</p><p><b>Conclusion:</b> Pericardiotomy is a simple, safe, and effective method for reducing the incidence of PE and late PT after cardiac surgery. It also has the potential to provide a better quality of life.</p>

Role of intestinal microbiota in cardiovascular diseases

2020 ◽  
Vol 18 (1) ◽  
pp. 54-59
Author(s):  
R. A. FAYZULLINA ◽  
◽  
K. A. SAFINA ◽  
Keyword(s):  
Cardiovascular Diseases ◽  
Intestinal Microbiota
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